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WASTE Journal

Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

[Translated article] Is one year follow-up sufficient to assess functional outcomes after rotator cuff repair?

Pasqualini I, Lucero Viviani N, Turan O et al. · 2026 · Revista espanola de cirugia ortopedica y traumatologia

Background Arthroscopic rotator cuff repair (ARCR) traditionally requires a 2-year follow-up to report results. However, most of the recovery occurs within the first year. The aim of this study was to determine if there are clinically…

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Negative / Null Result ReportOpen accessMedicine

IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression.

Pérez-González A, Alonso-Domínguez J, Martínez-Barros I et al. · 2026 · Frontiers in immunology

Introduction Modern antiretroviral treatment allowed a significant improvement in the life expectancy of people with HIV (PWH), exhibiting robust and sustained efficacy with scarce toxicities, both in two-drug regimens (2DRs) and…

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Negative / Null Result ReportMedicine

Condylar Positional Changes Following Manual Proximal Segment Positioning During Bilateral Sagittal Split Ramus Osteotomy: A Cephalometric Study.

Tanrısever NC, Gökalp H · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Maintenance of condylar position during bilateral sagittal split ramus osteotomy (BSSRO) is important for preserving temporomandibular joint biomechanics and skeletal stability. During surgery, loss of muscle…

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Negative / Null Result ReportMedicine

Efficacy of nonablative radiofrequency on sexual function in postmenopausal women: a randomized clinical trial.

Quezada-Bascuñán C, Ferri-Morales A, Martínez-Vizcaíno V et al. · 2026 · Menopause (New York, N.Y.)

Objective To evaluate the efficacy of nonablative capacitive-resistive monopolar radiofrequency on sexual function and vaginal health in postmenopausal women with genitourinary syndrome of menopause. Methods This was a single-blind,…

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Negative / Null Result ReportOpen accessMedicine

Effect of <i>Bacillus coagulans</i> DSM 32016 (TechnoSpore<sup>®</sup>) Supplementation on Growth Performance and Selected Blood Parameters and Serum Urea in Weaning Danube White Pigs.

Eneva K, Yordanova G, Petrova M et al. · 2026 · Life (Basel, Switzerland)

The present study evaluated the effects of dietary supplementation with Bacillus coagulans DSM 32016 on growth performance, hematological and biochemical parameters, and nitrogen metabolism in weaned Danube White pigs reared under standard…

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Failed Experiment ReportOpen accessMedicine

Probiotics alleviate oral microbiota disruptions induced by <i>Helicobacter pylori</i> eradication with vonoprazan-amoxicillin dual therapy: a randomized double-blind placebo-controlled trial. (An exploratory study).

Wei W, Chen W, Peng R et al. · 2026 · Frontiers in cellular and infection microbiology

Background Helicobacter pylori ( H. pylori ) infection affects approximately half of the global population and has been linked to oral microbiota dysbiosis, while eradication therapies may further disrupt microbial balance. This…

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Negative / Null Result ReportOpen accessMedicine

Salivary responses to an experimental activation of the HPA axis in pigs: Effects of ACTH on analytes related to stress, immune system, inflammation, redox status and metabolism.

Botía M, Cerón JJ, Martínez-Subiela S et al. · 2026 · Veterinary and animal science

Non-invasive biomarkers are essential for assessing stress and welfare. Saliva is a suitable sample type because it can reflect endocrine, immune, inflammatory and redox responses without causing stress from handling. This study examined…

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Negative / Null Result ReportMedicine

No evidence for depletion of circulating lymphocyte populations in primary brain tumor patients receiving radiotherapy alone.

Beekman C, Morita S, Neibart S et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose To investigate the impact of radiotherapy (RT) for brain tumors on circulating lymphocyte populations and understand this from a dosimetric perspective. Methods This prospective study enrolled primary brain tumor patients treated…

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Negative / Null Result ReportMedicine

Comparison of the Effects of Incubator and Radiant Environments on Physiological Criteria and Pain-Stress Levels during Heel Lance in Neonates in the Neonatal Intensive Care Unit: A Randomized Controlled Trial.

Gürsu S, Saydam BK, Kalkanlı O · 2026 · Saudi medical journal

Objectives To compare the effects of incubator and radiant heat on physiological criteria and pain-stress levels during heel prick procedures in newborns in the neonatal intensive care unit (NICU). Methods This randomized controlled…

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Negative / Null Result ReportMedicine

Serum and synovial lactate dehydrogenase levels after allogeneic mesenchymal stem cell implantation in rabbit cartilage defects.

Anatolitou A, Mavrogenis AF, Sideri KI et al. · 2026 · Polish journal of veterinary sciences

Cartilage defects have limited regenerative potential and remain a significant clinical challenge. Mesenchymal stem cell (MSC) therapy offers promise in tissue engineering, yet monitoringpost-implantation responses remains difficult.…

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Negative / Null Result ReportMedicine

Assessing the effects of high concentration of pure Cry proteins exposure on the Eisenia fetida by allying transcriptome analysis with toxicological evaluation.

He M, Huang Z, Pooe OJ et al. · 2026 · Ecotoxicology (London, England)

Most of eco-toxicity studies of Bacillus thuringiensis (Bt) proteins on terrestrial organism were conducted with Bt-crops straw or leaves on earthworm Eisenia fetida. Nevertheless, extra nutrition from straw or leaves degradation affected…

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Negative / Null Result ReportMedicine

Efficacy of a nurse-led frailty prevention program on frailty reduction and functional health improvement in community-dwelling older adults in Taiwan: a quasi-experimental longitudinal study.

Lin CH, Liu MY · 2026 · Geriatric nursing (New York, N.Y.)

Objectives Frailty negatively impacts quality of life and increases pressure on healthcare systems. This study aimed to evaluate the effects of a nurse-led Frailty Prevention Care Management Program (FPCMP-Old Age), based on the Chronic…

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Negative / Null Result ReportOpen accessMedicine

Effect of Moderate-to-High-Intensity Interval Aerobic Exercise on Clinical Symptoms During the Menstrual Cycle: A Pilot Randomized Controlled Trial.

Pio-Soria A, Zahran D, Roldán-Ruiz A · 2025 · Healthcare (Basel, Switzerland)

Introduction Primary dysmenorrhea is one of the most prevalent gynecological disorders. It has been shown to negatively impact quality of life and overall wellbeing, as recent studies have associated stress and physical inactivity with…

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Negative / Null Result ReportMedicine

Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants.

Ramli FF, Villa LM, Martens MAG et al. · 2026 · Scientific reports

Ebselen has been shown to induce a positive emotional processing bias and brain neurochemistry in healthy volunteers. However, little is known about its effects on resting-state functional connectivity (rs-FC) in depressed patients who…

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Negative / Null Result ReportMedicine

Autonomic Nervous System Response to Intermittent Theta-Burst Transcranial Magnetic Stimulation in Those With Major Depressive Disorder​​​: A Randomized Sham-Controlled Comparison of Heart Rate Variability and Pupillary Light Reflex.

Sharma M, McCall WV, Rosenquist PB · 2026 · The journal of ECT

Objectives To examine the acute and longitudinal effects of repetitive transcranial magnetic stimulation (rTMS) on-autonomic nervous system measures (ANS)-heart rate variability (HRV) and pupillary light reflex (PLR)-in adults with major…

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Negative / Null Result ReportMedicine

[Weight change following a self-selected, type-tailored lifestyle modification program for employees with suspected visceral fat accumulation: A single-arm before-after study].

Hari S, Kumamoto M, Suzuki M et al. · 2026 · Sangyo eiseigaku zasshi = Journal of occupational health

Objectives This single-arm before-after study examined short-term changes in body weight following a 28-day self-selected, type-tailored lifestyle modification program implemented before workplace health checkups. Participants…

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Negative / Null Result ReportMedicine

Sun Safety Intervention for Elementary School Students.

Moeckel C, Anderson R, Krnajic L et al. · 2026 · Pediatric dermatology

This study evaluated the impact of an elementary school-based intervention that aimed to improve sun safety knowledge and behaviors among third- and fourth-grade students in Pennsylvania through an educational video, t-shirt design…

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