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WASTE Journal

Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Acute and Long-Term Effects of Spinning-Based High-Intensity Interval Training on Inducible Nitric Oxide Synthase: A Randomized Controlled Trial.

Uysal A, Soslu R, Soslu R · 2026 · Journal of strength and conditioning research

Abstract Uysal, A and Soslu, R. Acute and long-term effects of spinning-based high-intensity interval training on inducible nitric oxide synthase: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2026-This study…

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Negative / Null Result ReportOpen accessMedicine

Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives.

Zainuddin MS, Pamidi N, Azman AS et al. · 2026 · Redox report : communications in free radical research

Alzheimer's disease (AD) is a major global neurodegenerative disorder associated with high morbidity and mortality, yet current treatments remain largely symptomatic and ineffective in halting neurodegeneration. Growing evidence links…

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Negative / Null Result ReportMedicine

Effects of Janus kinase inhibition and interleukin 6 inhibition on serum cytokine/chemokine in idiopathic multicentric Castleman disease.

Fukui S, Sumiyoshi R, Koga T et al. · 2026 · Drug discoveries & therapeutics

Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disease characterized by systemic inflammation. Although IL-6 receptor blockade with tocilizumab is an established treatment, Janus kinase (JAK) inhibition may…

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Negative / Null Result ReportMedicine

Patient participation in supervised exercise therapy and its impact on outcomes and quality of life in peripheral arterial disease.

Garabet W, Beckamp KH, Shabes P et al. · 2026 · VASA. Zeitschrift fur Gefasskrankheiten

Background: Supervised Exercise Therapy (SET) improves walking performance in patients with peripheral arterial disease (PAD) and intermittent claudication, yet implementation and adherence remain inconsistent. This study evaluated…

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Negative / Null Result ReportMedicine

Cerebellar iTBS Modulates Cortical Network Properties: An fNIRS Study.

Guo C, Geng A, Wang Q et al. · 2026 · Journal of integrative neuroscience

Background The cortex and cerebellum have a closely connected closed-loop circuit. Intermittent theta burst stimulation (iTBS) targeting the cerebellum has shown promise in improving balance function and inducing neuroplasticity. This…

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Negative / Null Result ReportMedicine

Cortical-Subthalamic Interplay During Eyes-Open and Eyes-Closed Resting States in Parkinson's Disease Patients.

Sanmartino F, Rashid-López R, López-Sosa F et al. · 2026 · International journal of neural systems

Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes…

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Negative / Null Result ReportOpen accessMedicine

Periodontal health of endodontically treated molars restored with composite CAD/CAM endocrowns versus stainless steel crowns in Egyptian children: a randomized controlled trial.

Mabkhot BA, Taha SEE, Kamel MH et al. · 2026 · BMC oral health

BACKGROUND: Subgingival crown margins have been linked to chronic gingival inflammation in pediatric patients. This clinical trial evaluated periodontal outcomes in first permanent molars that had undergone root canal therapy and were…

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Negative / Null Result ReportMedicine

Long-Term Betaine Supplementation Increases Creatinine Clearance and Upregulates MAS and AT2 Receptor Expression in Spontaneously Hypertensive Rat Kidneys.

Koper M, Jaworska K, Kopacz W et al. · 2026 · Kidney & blood pressure research

Hypertension contributes to renal dysfunction, partly through dysregulation of the renin-angiotensin system (RAS). Betaine, an osmolyte that helps maintain medullary osmotic gradients, has demonstrated renoprotective effects in models of…

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Negative / Null Result ReportMedicine

The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period.

Schuckit MA, Smith TL, Danko G et al. · 2026 · Alcohol, clinical & experimental research

Objectives The retrospective self-report of the effects of alcohol (SRE) questionnaire generates three scores reflecting drinking quantities required for effects: SRE-5 (first five times of drinking), SRE-3 (recent 3 months of drinking),…

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Negative / Null Result ReportMedicine

Desiccation, but not shading, substantially shifts the microbial community composition of benthic microbial mats in meltwater ponds near Bratina Island, Antarctica.

Noell SE, Colville EC, Marshall A et al. · 2026 · FEMS microbiology ecology

The Bratina Island meltwater ponds (McMurdo Ice Shelf, Antarctica) host complex microbial communities in the form of benthic microbial mats. These ponds are long-lasting but can experience significant alterations in physicochemistry on an…

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Negative / Null Result ReportMedicine

A lifespan study on body schema and perceived reaching distance.

Jahanian Najafabadi A, Rastegari A, Imani H et al. · 2026 · Acta psychologica

The plasticity of body representation in response to tool use is a dynamic process that evolves across the lifespan. Research has shown that tools can become integrated into the body representation, effectively being treated as extensions…

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