12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Dong ZH, Zhang Y, Lu J et al. · 2026 · Journal of hazardous materials
Acetaminophen (APAP) is frequently detected in municipal wastewater, yet its effect on heterotrophic denitrification remains insufficiently resolved. Here, Paracoccus denitrificans was exposed to 0.5 and 7.5 ppm APAP, representing lower…
View details →Dhurat RS, Sharma R, Shetty C et al. · 2025 · Skin appendage disorders
Introduction Prostaglandin D2 (PGD2) is elevated in the bald scalp of men with androgenetic alopecia (AGA) and inhibits hair growth. Cetirizine, an H1-antihistamine, reduces PGD2 production and has anti-inflammatory effects, making it a…
View details →Kober M, Livingston JA, Barrick C et al. · 2026 · Journal of holistic nursing : official journal of the American Holistic Nurses' Association
Background: Emergency department (ED) nurses are routinely exposed to high-stress clinical environments, increasing their risk for burnout and emotional exhaustion. In holistic nursing, self-care is viewed as a professional and ethical…
View details →Žilytė A, Petrikaitė V · 2026 · Cells
In this study, we evaluated the impact of different in vitro 3D culture modelling methods on the activity of doxorubicin (DOX) and 5-fluorouracil (5-FU) in human melanoma spheroids. Human melanoma A375 and IGR39 spheroids were generated…
View details →Jamal H, LaLoggia M, Boggarapu S et al. · 2025 · JACC. Case reports
Background The overuse of telemetry without indication leads to alarm fatigue, unnecessary costs, and reduced patient satisfaction. Unnecessary telemetry use does not improve patient outcomes. Rationale We hypothesized that a…
View details →Kayin Y, Oztas B · 2026 · Nurse education in practice
Aim This study examined the effects of PechaKucha and Teach-Back teaching techniques on nursing students' knowledge, self-efficacy and satisfaction regarding discharge education. Background Effective discharge education requires strategies…
View details →Hirsch T, Moser U, Wolf A et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Purpose This prospective pilot study aimed to evaluate whether dupilumab therapy induces measurable changes in the sinonasal microbiome of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Methods Eight CRSwNP patients…
View details →Parakkal T, Kuriakose MJ, Natarajan PV et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie
Surgically facilitated anterior maxillary distraction (AMD) is used for the treatment of maxillary hypoplasia secondary to cleft lip and palate (CLP). In this study, the soft and hard tissue changes following AMD in growing patients with…
View details →Stanford K, Cain RM, Millis D et al. · 2026 · American journal of veterinary research
Objective To identify the effects of incline and decline treadmill trotting on forelimb muscle activity in dogs using electromyography (EMG). Methods Data were collected for a prospective within-subject, repeated-measures study in January…
View details →da Silva PCH, Faria TV, Galvani LD et al. · 2026 · The Angle orthodontist
Objectives To evaluate the effect of different antimicrobial solutions on the mechanical properties of aligners (Invisalign, Align Technology Inc., San Jose, CA, USA). Material and methods Invisalign aligners were used, originating from an…
View details →Ayazi H, Kalani N, Rabiee M et al. · 2026 · Musculoskeletal care
Background and purpose Lumbopelvic rhythm describes the relationship between the lumbar spine and hip motion during trunk bending tasks, while the lumbar lordosis angle represents the normal sagittal curvature of the lumbar spine. This…
View details →Bhavya ML, Bayati M, Poojary MM et al. · 2026 · Food chemistry
Ultrasound (US) processing is a promising food technology to improve protein solubility, reduce particle size, and modify functional properties. However, concerns exist regarding US-induced protein oxidation due to reactive oxygen species…
View details →Wolinsky D, Blaine S, Strickland JC et al. · 2026 · Journal of cannabis research
Background This Phase I randomized controlled trial aimed to assess the safety and tolerability of cannabidiol (CBD) and alcohol co-administration among moderate alcohol consumers in acute laboratory and chronic outpatient settings.…
View details →Celik C, Celik MS · 2026 · Cutaneous and ocular toxicology
Background and objective Acne vulgaris is a chronic inflammatory skin disease frequently treated with systemic agents such as isotretinoin and doxycycline. Although these treatments are known to modulate inflammatory pathways, their…
View details →Qasim MSA, Kang P, Evans B et al. · 2026 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose To investigate the utility of in vivo confocal microscopy (IVCM) combined with standardized image grading for identifying early morphological changes in the central corneal and superior limbal basal epithelial cells during…
View details →Alenezi BM, Khoyratty F, Biswas S et al. · 2026 · Translational vision science & technology
Purpose To investigate the effect of corneal cross-linking (CXL) on corneal curvature and thickness in two different keratoconic populations, one based in the Middle East (Saudi Arabia) and one in Europe (UK), and to explore whether age…
View details →Zhuang SR, Leong PY, Chiang HP et al. · 2026 · Nutrients
Objective This study aimed to evaluate the effects of 12 weeks of Astragalus membranaceus saponins (AMS) supplementation on functional performance, knee joint mobility, self-reported outcomes, and biomarkers of inflammation and cartilage…
View details →Kniha K, Scholz K, Kohnert E et al. · 2026 · Scientific reports
To evaluate the effect of the implant material-either titanium or zirconia-on the development of bacterial deposits. In this one-year prospective split-mouth study, 20 patients with an edentulous lower jaw were treated with two zirconia…
View details →Ormsbee LT, Akhavan NS, Munoz J et al. · 2026 · Nutrients
Background/Objectives : Approximately 53.4 million U.S. adults aged 50 or older have low bone mass, yet male bone health remains under-researched. This study evaluated the effects of one year of prune supplementation on bone health in…
View details →Sangermani M, Desiati I, Quattrini N et al. · 2026 · Scientific reports
Reanalysing previously collected samples to address new research questions offers a time-efficient alternative to initiating new cohort studies. However, concerns remain regarding the stability of the faecal microbiome following repeated…
View details →Karahan M, Uluçam E · 2026 · Work (Reading, Mass.)
BackgroundSleep deprivation, common among physicians working long shifts, affects sensory integration, motor coordination, and cognitive performance. While its impact on cognitive and motor skills is well-documented, its effect on gait…
View details →Perović A, Juričić G, Bratičević MN et al. · 2026 · Medicine and science in sports and exercise
Purpose During scuba diving, breathing under elevated pressure leads to hyperoxia, which may induce oxidative stress and erythrocyte damage. Hyperoxia may also influence erythropoietin (EPO) production, a phenomenon referred to as the…
View details →Dobariya A, Patel R, Patel M · 2026 · European journal of hospital pharmacy : science and practice
Objective The study aimed to analyse the physicochemical stability and compatibility of ceftriaxone sodium (CEF) (2mg/mL) with pantoprazole sodium (PAN) (0.08mg/mL) and ondansetron hydrochloride (OND) (0.008mg/mL) in different infusion…
View details →Amiri D, Hellmann PH, Thyssen JP et al. · 2026 · JAMA dermatology
Importance Increased intraocular pressure (IOP) is a known adverse effect of corticosteroid use and may lead to corticosteroid-induced glaucoma. However, clinical evidence on the impact of topical corticosteroids (TCS) on IOP is limited.…
View details →Nechemya Y, Shames J · 2026 · Harefuah
Introduction Background: Chronic pain syndrome is a common disease with major economic costs. The aim of this study is to examine the effect of outpatient multidisciplinary pain rehabilitation on the utilization of medical services in…
View details →Nemes A, Ambrus N, Szili-Török T et al. · 2026 · Journal of clinical medicine
Introduction : The left ventricular (LV) function can be characterized by the spatial displacement of the aortic valve annulus (AVA), represented by the AVA plane systolic excursion (AAPSE). AAPSE, measured using 3DSTE, has been shown to…
View details →Ozden H · 2026 · Open life sciences
Perfluorooctanoic acid (PFOA) is widely utilized perfluoroalkyl substance (PFAS) in various industrial and household applications, known for its persistence in the environment. Due to the limited toxicity data for PFOA in edible vegetable…
View details →Kathpalia A, Vlachos I, Hlinka J et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Objective Finding indicators of early response to antidepressant treatment in EEG signals recorded from patients suffering from major depressive disorder. Methods Functional brain connectivity networks based on weighted imaginary coherence…
View details →Putos J, Atkinson HF, Walton DM · 2026 · Osteoarthritis and cartilage open
Objectives The acute response of lumbar intervertebral discs (IVD) to spinal rotation mobilization (SRM) is poorly understood. We evaluated sustained morphological changes in lumbar IVDs following a rotation mobilization commonly used to…
View details →Ajiki H, Tanaka M · 2026 · Journal of imaging
Even when an object's color is accurately reproduced in a colorimetrically reproduced image (CRI), the perceived material appearance does not necessarily match that of the original object. This mismatch remains a challenge for faithfully…
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