12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Shen R, Yu Y, Ma Y et al. · 2026 · Biomolecules
Gatifloxacin (GTFX), a fourth-generation fluoroquinolone, causes metabolic disturbances in mammals, but its hepatotoxic mechanisms in aquatic vertebrates remain unclear. This study investigated whether GTFX induces liver injury in…
View details →Yıldırım Erdal BD, Bayraktar S · 2026 · Turkish journal of ophthalmology
Objectives To investigate the effects of selective laser trabeculoplasty (SLT) on the iridocorneal angle, anterior chamber, and iris in patients with pseudoexfoliation glaucoma (PEXG) and to evaluate the relationship between these…
View details →Streese L, Ritter ET, Schoch R et al. · 2026 · Journal of vascular research
Purpose We aimed to investigate the effect of different exercise modes on retinal microvascular endothelial function in patients with HF with preserved ejection fraction (HFpEF). Methods Twenty-eight patients were randomly allocated to…
View details →Kumar D S, Dandekar S, Prakash GH · 2026 · BMC medical education
Background Antimicrobial resistance is a major global public health threat, necessitating improved antibiotic stewardship. India's Competency-Based Medical Education (CBME) framework requires robust methods to assess and cultivate clinical…
View details →Hornemann A, Bosserhoff M, Coltan L et al. · 2026 · International urogynecology journal
Introduction and hypothesis This study investigates the postoperative mobility following partial semitendinosus tendon harvesting performed during pelvic organ prolapse (POP) repair using the Hornemann Tendon Transplantation (HoTT®)…
View details →Sethi D, Prajapati S, Garg G · 2026 · Anesthesia and pain medicine
Background A few studies investigating the perioperative use of lung ultrasound (LUS) have shown loss of lung aeration with decline in diaphragmatic function after general anesthesia. We aimed to measure changes in lung aeration and…
View details →Kume D, Horiuchi M, Nishiwaki M · 2026 · Microvascular research
Acute mental stress (MS) can impair macrovascular function, causing increased arterial stiffness and endothelial dysfunction; however, its effect on microvascular function remains largely unclear. This study examined the impact of acute MS…
View details →Oliver CJ, Del Vecchio L, Climstein M et al. · 2026 · Clinical nutrition ESPEN
Background Accurate assessment of body composition beyond BMI is necessary in clinical care. Bioelectrical impedance analysis (BIA) and 3D scanning (3DS) are practical two-compartment (2C) methods estimating % body fat (%BF), fat mass…
View details →Diego-Navarro O, Copete S, Moreno-Martínez A et al. · 2026 · European journal of ophthalmology
PurposeTo evaluate functional and anatomical outcomes after intravitreal dexamethasone implant (DEXI) in macular edema secondary to retinal vein occlusion (ME-RVO), comparing treatment-naïve eyes with early-switch (ES) and late-switch (LS)…
View details →Şafak A, Karakaya E, Yıldırım S et al. · 2026 · Transplantation proceedings
Introduction Although liver biopsy in patients with acute cellular rejection (ACR) is the gold standard for diagnosis, its invasive nature highlights the need for reliable noninvasive biomarkers. With evidence suggesting that peripheral…
View details →Parapiboon W, Pattanapongpaibool A, Sanprasert S · 2026 · International urology and nephrology
Purpose The benefits of incremental peritoneal dialysis (IPD) with days off remain controversial. This study aimed to compare the survival rate between IPD with days off and standard-dose peritoneal dialysis (PD). Methods Participants who…
View details →Musbahi O, Pouris K, Hadjixenophontos S et al. · 2025 · World journal of methodology
Background Relieving pain is central to the early management of knee osteoarthritis, with a plethora of pharmacological agents licensed for this purpose. Intra-articular corticosteroid injections are a widely used option, albeit with…
View details →Bushaibah O · 2026 · Environmental monitoring and assessment
Understanding long-term microbial dynamics in semi-enclosed coastal systems is essential for evaluating wastewater-related impacts and informing management responses. This study applies an integrated nonparametric diagnostic framework to…
View details →Torres K, Terzi S, Simón L · 2026 · Scientific reports
Healthier diets are associated with fewer mental health symptoms, whereas higher consumption of ultra-processed foods is associated with psychological distress. This pilot study aimed to evaluate the impact of a nutrition education…
View details →Aytekin AM, Ulusoy HE, Efe MA et al. · 2026 · The journal of obstetrics and gynaecology research
Objective To evaluate the impact of bilateral salpingectomy added to hysterectomy performed via different surgical routes on ovarian reserve, ovarian stromal blood flow, and sexual function in premenopausal women. Methods This prospective…
View details →Lee YJ, Clement ND, Asopa V et al. · 2026 · The Journal of arthroplasty
Background The objectives were to evaluate whether the EQ-5D-3L questionnaire demonstrated a ceiling effect after total hip arthroplasty (THA), identify which patients were more likely to reach the ceiling score, and determine whether this…
View details →Bowman J, Cornelius JM, Schoen A et al. · 2026 · Journal of experimental zoology. Part A, Ecological and integrative physiology
The release of waterborne chemical cues is a well-documented anti-predator strategy in teleost fish, allowing individuals to detect, and respond to, predation threats. However, little is known about whether an ancient group of fishes,…
View details →Booth SE, Rubins D, O'Donoghue AL et al. · 2026 · Applied clinical informatics
Intravenous (IV) and oral (PO) acetaminophen have equivalent bioavailability and effectiveness, but IV formulations are significantly more expensive. Clinical decision support (CDS) tools can encourage cost-effective prescribing. We…
View details →Seijas R, Vázquez M, Barastegui D et al. · 2026 · International orthopaedics
Purpose To characterise recovery trajectories across nine patient-reported outcomes (PROs) during the first twelve months after hip arthroscopy for femoroacetabular impingement syndrome (FAIS), and to determine whether six-month assessment…
View details →Aftabi S, Leslie WD · 2026 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing bone mineral density (BMD), but technical factors such as acquisition mode may affect measurement. On GE Healthcare DXA systems, Thin and Thick modes are often…
View details →Singh PK, Kumar BS, Nandi S et al. · 2026 · Veterinary medicine international
Bisphenol A (BPA), an organic environment chemical, has extensive presence in consumer goods and food/feed items. The present study aimed to explore how BPA influenced the viability, proliferation, apoptosis, and steroidogenic activity of…
View details →Lin YH, Teng MMH · 2026 · PloS one
Monitoring bone mineral density (BMD) changes can be challenging when both the spine and hips are included in follow-up assessments. This study aimed to evaluate BMD changes using different monitoring approaches, including comparisons…
View details →Abd Elghany AA, Kamel Eyada MM, Maher SA et al. · 2026 · Cytokine
Background Alopecia areata (AA) is a common autoimmune disease which causes non-scarring patches of hair loss and has a 2% lifetime risk. Its chronic, recurrent nature makes treatment difficult. Potential roles of the JAK/STAT pathway,…
View details →García-Moronta C, Rodríguez-Sanna A, Muñoz-Barba D et al. · 2026 · Dermatitis : contact, atopic, occupational, drug
Background Conventional systemic therapies, including cyclosporine and methotrexate, have traditionally been used for moderate-to-severe atopic dermatitis (AD). However, their real-world effectiveness and treatment persistence in the era…
View details →Yavuz M, Unalp A, Gulagız F et al. · 2026 · Seizure
Background Ketogenic diet (KD) is an established treatment option for pediatric drug-resistant epilepsy; however, early indicators of treatment response are limited. This study aimed to explore whether early changes in routine…
View details →Boonperm P, Buaboon N, Vatanavilai C et al. · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association
Background Breastfeeding is a key strategy for improving maternal and infant health; however, Thailand continues to fall short of national and international breastfeeding targets. Village Health Volunteers (VHVs) play an essential role in…
View details →Seward M, Puiras E, Crocker CE et al. · 2026 · BMC psychiatry
Background 30% of individuals with schizophrenia do not respond to first line dopamine-blocking antipsychotic medications and meet criteria for treatment resistant schizophrenia (TRS). Elevated glutamate levels in the anterior cingulate…
View details →Sinha R, Sabir M, Tripathi M et al. · 2026 · Indian journal of ophthalmology
Objective To evaluate the role of local oxygen supplementation in accelerated collagen cross-linking (CXL) in human subjects. Method Patients with progressive keratoconus were enrolled and randomized to undergo accelerated CXL in either…
View details →Vasamsetti SR, Guddeti A, Kumar S et al. · 2026 · Nigerian journal of clinical practice
Background Hypothyroidism is a common condition, and thyroid hormones play a key role in metabolism and fat regulation. We examined how levothyroxine affects visceral adipose tissue (VAT) and body composition using dual-energy X-ray…
View details →Kim S, Kim YJ, Yoon YH et al. · 2026 · International journal of retina and vitreous
Purpose This study aimed to investigate the spatial correlation between retinal structure and function in macular telangiectasia type 2 (MacTel) using Compass fundus-tracked microperimetry. Methods Medical records of 54 eyes from 28…
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