12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Stapleton JR, Heilmann NZ, Cattell K et al. · 2026 · JBMR plus
As HR-pQCT increases in popularity for studying bone dynamics, it becomes increasingly important to quantify the factors that impact rigor and reproducibility in research, particularly for longitudinal studies. Previously reported data for…
View details →Abdul-Kafi O, Chedid M, Ansani T et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions
Background Patients with severe aortic valve stenosis and concomitant mild to moderate mitral stenosis (MS) or mitral regurgitation (MR) from mitral annular calcification (MAC) often undergo aortic valve replacement (AVR) while sparing the…
View details →Morishita T, Takada D, Itoshima H et al. · 2026 · Cardiovascular intervention and therapeutics
Japan introduced nationwide physician work-hour limits in April 2024. Because cardiovascular emergencies require continuous in-hospital availability, concerns existed that restricting duty hours could reduce access to revascularization or…
View details →Kucukosmanoglu M, Ardıc ML, Koca F et al. · 2026 · Journal of cardiovascular development and disease
Introduction: Prolongation of the QT interval and QRS duration, which are markers of ventricular repolarization and depolarization, has been reported in patients receiving flecainide therapy. However, the effects of flecainide on the QRS-T…
View details →Khwanes SA, Mohamed RA, Abd El-Rahman HA et al. · 2026 · Scientific reports
Imidacloprid (IM), a systemic neonicotinoid pesticide, is widely used globally due to its high effectiveness against a broad range of insects at minimal application rates. The current study aimed to examine how this insecticide can induce…
View details →Okuda DT, Stanley TA, McCreary MC et al. · 2026 · AJNR. American journal of neuroradiology
Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is a chronic condition driven by selective injury to aquaporin 4 (AQP4) channels. Accurate diagnosis and effective disease surveillance are critical to preventing…
View details →Siggard LD, Rytter D, Lildholdt T · 2026 · Acta oto-laryngologica
Tongue-tie may interfere with infant feeding, but diagnosis remains challenging due to lack of objective criteria. To evaluate the clinical utility of the electronic baby bottle (EBB), a novel device recording intraoral forces during…
View details →Abdalqadir M, Raouf L, Mohammed K et al. · 2026 · Polymers
This study aimed to investigate the effect of time and different disinfecting agents on nanocomposite filler composed of natural clay nanoparticles (modified and non-modified) added to maxillofacial silicone elastomers and readymade…
View details →Gulec A, Eravsar E, Ciftci S et al. · 2026 · Journal of clinical medicine
Background : UBE has gained popularity as a minimally invasive alternative to open spinal procedures. However, it raises concerns about potential ocular complications. Despite these concerns, there is a lack of studies evaluating UBE's…
View details →Nicola-Ducey L, Ward L, Holland A et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Prior to delivery, there are postpartum pelvic floor recovery topics to provide education on; however, because of a variety of factors, the majority of these are commonly unaddressed, leaving a patient unknowledgeable and…
View details →Ying Z, Kondo A, De D et al. · 2026 · Journal of transcultural nursing : official journal of the Transcultural Nursing Society
Introduction We evaluated a Collaborative Online International Learning (COIL) programme in enhancing nursing students' intercultural sensitivity and understanding of cultural safety. Methods From April to May 2024, nursing students in…
View details →Dutta P, Verma S, Patni P et al. · 2026 · The British journal of ophthalmology
Automated pupillometry (AP) has been studied in established optic neuropathies. This prospective, sequential AP evaluation of 62 newly diagnosed adult patients with pulmonary/extra-pulmonary tuberculosis, showed a statistically significant…
View details →Zhang H, Zhao Y · 2026 · Pakistan journal of pharmaceutical sciences
Background Narlumosbart is a key agent for modulating bone cell function. Given the potential of curcumin nanoparticles to inhibit cell growth when applied alone. Objectives This study aims to investigate the role of their combination with…
View details →Arfaee F, Shariati S, Armin A · 2026 · Veterinary ophthalmology
Objective Mydriatic and cycloplegic agents are widely used in veterinary ophthalmology to enable posterior segment examination. This study evaluated the effects of topical 1% cyclopentolate on intraocular pressure (IOP), horizontal pupil…
View details →Xu HJ, Liu QL, Zhang YF et al. · 2026 · International journal of molecular sciences
Dendrobium huoshanense water extract (DHWE) exhibits hypoglycemic effects in streptozotocin-induced type 1 diabetic (STZ-T1D) rats. However, its regulatory impact on the gut microbiota of T1D rats remains largely unclear. In this study,…
View details →Sayyed-Hosseinian SH, Samadi S, Yazdi P et al. · 2026 · BMC musculoskeletal disorders
Background Calcaneal fractures, the most common tarsal fractures, often result in significant long-term disability and impose substantial healthcare burdens. Surgical intervention aims to restore hindfoot anatomy, but the role of…
View details →Parikh P, Zeilani M, Pieret A et al. · 2026 · Nutrition reviews
Malaria and malnutrition adversely affect maternal and neonatal health in Sub-Saharan Africa. While intermittent preventive treatment of malaria in pregnancy (IPTp) is widely used to reduce malaria incidence, the potential additional…
View details →Eze CE, Alveo R, Barria L et al. · 2026 · Functional plant biology : FPB
Mitigating the negative impact of climate change on tropical forests requires a comprehensive understanding of the direct and indirect effects of climate variables such as temperature and vapor pressure deficit (VPD). We investigated the…
View details →Cheung J, Huang T, Tarar A et al. · 2026 · Clinical nutrition ESPEN
Background Neurocritically ill patients often face challenges in achieving adequate nutrition due to hypermetabolism and feeding difficulties, which may influence neurological recovery and overall clinical outcomes. Methods This…
View details →Emori H, Shiono Y, Yamanobe H et al. · 2026 · International journal of cardiology
Background Intravascular lithotripsy (IVL) and rotational atherectomy (RA) are established plaque-modifying strategies for heavily calcified coronary lesions. Despite their different mechanisms, the incidence of significant periprocedural…
View details →Yushanaji B, Zhang X, Tian T et al. · 2026 · Animals : an open access journal from MDPI
This study tested the hypothesis that dietary L. acidophilus would improve nutrient utilization in yellow-feathered broilers mainly through intestinal changes rather than a consistent increase in growth performance. A total of 195…
View details →Alom MM, Zamir MR, Islam N et al. · 2026 · In silico pharmacology
Herbal medicines, including traditional formulations such as Carmina, a polyherbal remedy widely prescribed for gastric ailments, require rigorous safety validation to support their clinical use. Here, we evaluate the hepato-renal toxicity…
View details →Shaju A, Mishra BR, Mohapatra D et al. · 2026 · Journal of psychopharmacology (Oxford, England)
BackgroundRecent evidence increasingly links schizophrenia to mitochondrial dysfunction, implicating altered mitochondrial respiratory and metabolic processes in its pathophysiology. Preclinical data suggest that atypical antipsychotics…
View details →Le Basle Y, Sautou V, Sarraute S et al. · 2026 · Biomedical materials (Bristol, England)
The study of extractable chemicals is used to evaluate whether a medical device contains harmful substances susceptible to migrate and contaminate the patients they are used in. The analysis of the biomaterial itself after extraction is…
View details →Yılmaz T, Özdemir S · 2026 · Heart & lung : the journal of critical care
Background Norepinephrine is widely used as a first-line vasopressor in acute hypotension and septic shock. Its acute effects on electrocardiographic (ECG) parameters, particularly the frontal QRS-T angle, remain unclear. Objectives To…
View details →Wentink N, van Gent M, Borns C · 2026 · The British journal of radiology
Objectives To quantify the reduction in effective dose achieved through organ dose modulation (ODM) on a General Electric Revolution Apex CT scanner, while preserving image quality. Methods First, the noise index (NI) corresponding to…
View details →Abid R, Murphy RF, Hogue GD et al. · 2026 · Journal of pediatric orthopedics
Background Treatment options for early-onset scoliosis (EOS) are confounded by the risks associated with intervention at a younger age. Spinal instrumentation must be considered carefully due to potentially adverse effects to the spine,…
View details →Hooper L, Erridge S, Clarke E et al. · 2026 · Brain and behavior
Introduction Migraine is a primary headache disorder, which leads to diminished health-related quality of life (HRQoL). There is limited evidence assessing efficacy of cannabis-based medicinal products (CBMPs) for migraine. This study…
View details →Chaudhary H, Saeed S, Carroll A · 2026 · Irish medical journal
Aim This retrospective study aimed to evaluate changes in body mass index (BMI) and haemoglobin A1c (HbA1c) levels among children and adolescents with type 1 diabetes mellitus (T1DM) transitioning from multiple daily injections (MDI) to…
View details →Fuse Y, Tsukada N, Yamaguchi M et al. · 2026 · Biological trace element research
Adequate iodine intake is essential for maintaining thyroid function. School meal iodine content (SMIC) is one of the main sources of iodine for schoolchildren. The median urinary iodine concentration (mUIC) in spot urine samples is a…
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