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Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Short-term outcomes of selective laser trabeculoplasty in pseudophakic primary angle-closure glaucoma after iridotomy: a retrospective pilot comparison with primary open-angle glaucoma.

Hsieh YC, Lu WY, Chen YL et al. · 2026 · BMC ophthalmology

Background Selective laser trabeculoplasty (SLT) is a widely accepted treatment for primary open-angle glaucoma (POAG), but its role in primary angle-closure glaucoma (PACG) remains less defined. This study aimed to evaluate the short-term…

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Negative / Null Result ReportMedicine

Impact of ERAS on morbidity and length of stay in elderly patients undergoing elective laparoscopic colorectal cancer surgery: a two-center comparative study.

Verbo A, Verbo I · 2026 · Langenbeck's archives of surgery

Background Enhanced Recovery After Surgery (ERAS) protocols are widely implemented in colorectal surgery to improve postoperative recovery and reduce hospital stay. However, their impact on postoperative morbidity in elderly and clinically…

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Negative / Null Result ReportMedicine

Targeting triglycerides for cardiovascular risk reduction.

Maiorca C, Tramontano D, Di Costanzo A et al. · 2026 · Internal and emergency medicine

Residual cardiovascular risk persists in many patients despite optimal control of established factors such as low-density lipoprotein cholesterol (LDL-C), blood pressure and glycaemia. Mounting evidence indicates that hypertriglyceridemia…

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Negative / Null Result ReportMedicine

Evaluation of exposure incidents in PET-CT examinations through root cause analysis.

Osorio Oliveros AV, Velasco Jaramillo JA, Alejo-Martínez H et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Purpose To implement a continuous improvement cycle aimed at identifying and reducing radiation exposure incidents in patients undergoing PET-CT scans. Methods A comparative quasi-experimental study was conducted within a nuclear medicine…

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Negative / Null Result ReportOpen accessMedicine

Comparison of antimicrobial photodynamic therapy protocols as adjunct treatment in the management of initial pericoronitis: a randomized, controlled, double-blind clinical trial.

Schalch TO, Ando-Suguimoto ES, Ferreira BS et al. · 2026 · Clinical oral investigations

Objectives The aim of this study was to compare the effectiveness of two antimicrobial photodynamic therapy (aPDT) protocols using different methylene blue formulations in the treatment of initial pericoronitis. The research question was…

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Negative / Null Result ReportMedicine

ASSOCIATION BETWEEN BASELINE GLYCATED HEMOGLOBIN LEVELS AND FUNCTIONAL AND ANATOMICAL OUTCOMES AFTER FARICIMAB LOADING PHASE IN DIABETIC MACULAR EDEMA.

Scampoli A, Governatori L, Solimeo A et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To evaluate whether baseline glycosylated hemoglobin (HbA1C) levels play a predictive role in faricimab loading phase outcomes. In addition, the authors assessed the efficacy of faricimab loading phase for diabetic macular edema…

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Negative / Null Result ReportMedicine

Analgesic efficacy of equal-dose bupivacaine diluted to 20 vs. 30 mL for anterior quadratus lumborum block after cesarean delivery: a randomized double-blind trial.

Pajina B, Leurcharusmee P · 2026 · Minerva anestesiologica

Background The anterior quadratus lumborum (QL) block provides effective post-cesarean delivery analgesia, but the optimal local anesthetic (LA) volume remains unknown. This is critical for balancing efficacy and safety in pregnant…

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Negative / Null Result ReportMedicine

A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.

Shah M, Burshtein J, Zakria D et al. · 2026 · Journal of drugs in dermatology : JDD

Background Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. Objective This study measured the whitening effect of…

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Negative / Null Result ReportOpen accessMedicine

Impact of Routine Intraoperative Lithotripsy on Surgical Strategy and Outcomes in Laparoscopic Bile Duct Exploration: A Single-Centre Cohort Study.

Elsamalouty I, Gupta A, Whitmore M et al. · 2026 · Cureus

Background Laparoscopic bile duct exploration (LBDE) enables single-stage management of common bile duct (CBD) stones. However, large or impacted stones often necessitate choledochotomy, which is associated with increased morbidity and…

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Negative / Null Result ReportMedicine

Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.

Dobrzycka M, Wołoszyn P, Prud M et al. · 2026 · Journal of clinical medicine

Background : Frailty is associated with adverse postoperative outcomes and functional decline in older adults undergoing colorectal cancer (CRC) surgery. The long-term course of frailty and functional outcomes among patients undergoing…

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Negative / Null Result ReportMedicine

Acute effects of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic function and blood pressure in sedentary older adults: A pilot randomized controlled trial.

Ladriñán-Maestro A, Sánchez-Sierra A, Elfoukahi O et al. · 2026 · PloS one

The aim of this study was to evaluate the acute effects of a single session of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic regulation, blood pressure, and arterial oxygen saturation in sedentary older adults. A…

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Negative / Null Result ReportMedicine

Effectiveness of gaseous ozone in reducing microbial contamination: evaluation of environmental disinfection in healthcare settings.

Mastrantonio R, Romantini A, Lombardo C et al. · 2026 · Infection control and hospital epidemiology

Objective Environmental contamination is a significant factor in the transmission of healthcare-associated infections. This study evaluated the effectiveness of gaseous ozone in reducing microbial contamination within hospital settings,…

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Negative / Null Result ReportMedicine

Colonoscopic and oral microbiota transplant therapy yield similar stool and neoterminal ileal engraftment profiles in a single-blind pilot randomized trial.

Moutsoglou D, Staley C, Kabage AJ et al. · 2026 · Inflammatory bowel diseases

Background The intestinal microbiota play a key role in Crohn's disease (CD) and postoperative recurrence following ileocecal resection. Microbiota transplant therapy (MTT) could impact postoperative CD recurrence. This study aimed to…

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Negative / Null Result ReportOpen accessMedicine

A randomized controlled pilot trial comparing peri-implant tissue health beneath CAD/CAM-milled PEEK versus cobalt-chromium telescopic crowns for mandibular overdentures.

El Asfahani IA, Khalifa A, Tawfik D et al. · 2026 · International journal of implant dentistry

Purpose This pilot randomized clinical trial compared peri-implant tissue health around milled cobalt-chromium (CoCr) versus polyether ether ketone (PEEK) secondary telescopic crowns in implant-retained mandibular overdentures over 12…

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Negative / Null Result ReportOpen accessMedicine

<i>Pseudomonas aeruginosa</i> gene expression changes during established biofilm infection in a cystic fibrosis lung model.

Harrington NE, Allen F, Garcia Maset R et al. · 2026 · Microbiology (Reading, England)

The opportunistic pathogen Pseudomonas aeruginosa forms biofilm infections in the lungs of people with the genetic condition cystic fibrosis (CF) that can persist for decades. There are numerous P. aeruginosa lifestyle changes associated…

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Negative / Null Result ReportOpen accessMedicine

Early Weight Loss After Sleeve Gastrectomy Selectively Improves Intermetatarsal Angle Without Affecting Hallux Valgus Angle.

Türkoğlu F, Sarı S, Gencer EN et al. · 2026 · Journal of clinical medicine

Background/Objectives : While bariatric surgery is known to improve plantar pressure distribution and reduce foot-related symptoms, its impact on radiographic forefoot alignment parameters, such as the intermetatarsal angle (IMA) and…

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