12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Dixit NM, Chau E, Schaefer S · 2024 · American journal of preventive cardiology
Screening trials for cardiovascular disease have not demonstrated a reduction in all-cause mortality. The Danish Cardiovascular Screening trial (DANCAVAS) involved men aged 65-74 years old who were randomized to an invitation to undergo…
View details →Dolińska E, Starosz A, Grubczak K et al. · 2026 · Scientific reports
This study aimed to evaluate the effects of non-surgical periodontal therapy (SRP) and SRP with an amino acid-buffered hypochlorite solution (NaOCl/AA + SRP) on subgingival plaque bacteria. Quantitative changes in Porphyromonas gingivalis,…
View details →Chiara RF, Letizia L, Francesca G et al. · 2026 · Orthodontics & craniofacial research
Objectives The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the…
View details →Affat SH, Kamoona HR · 2026 · Journal of molecular histology
Sleep amount and quality are important to maintain health, light exposure transported to the pineal gland via suprachiasmatic nucleus pineal pathway, and this affect melatonin synthesis. Melatonin exerts its action by receptors called MT1,…
View details →Moor-Smith M, Kozak N, McCue M et al. · 2026 · The western journal of emergency medicine
Background Musculoskeletal back pain is a common presenting complaint to emergency departments (ED) worldwide. In this study we aimed to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) as an adjunct to…
View details →Almosfer M, Sabico S, Wani K et al. · 2026 · Aging clinical and experimental research
Background The metabolic effects of Metformin (Met) and lifestyle modification in early type 2 diabetes mellitus (T2DM) management are well established, but their influence on bone remodeling remains uncertain in under-investigated…
View details →Darmon J, Bastelica P, Huard M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Purpose To evaluate the 12-month efficacy and safety of open bleb revision (OBR) for Preserflo ® MicroShunt (PMS) (Santen, Osaka, Japan) bleb failure. Patients and methods All consecutive patients who underwent PMS OBR for primary bleb…
View details →Orso F, Basile C · 2026 · European heart journal supplements : journal of the European Society of Cardiology
Vericiguat is a soluble guanylate cyclase stimulator that acts by restoring the nitric oxide-cyclic guanosine monophosphate pathway, which is markedly impaired in heart failure with reduced ejection fraction (HFrEF). The VICTORIA trial…
View details →Odeleye V, Singh N, Gautam S et al. · 2026 · Current cardiology reports
PURPOSE OF REVIEW: This article reviews the evidence for cardiovascular and renal risk reduction with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in type 2 diabetes mellitus (T2DM), based on randomized controlled trials,…
View details →Sampaio GKML, Sette-de-Souza PH, Vieira BR et al. · 2026 · Biomaterial investigations in dentistry
Objective The present study aimed to evaluate the surface roughness (SR) and color stability of conventional restorative glass ionomer cements (GICs) modified with the addition of red propolis ethanolic extract (RPEE) as an antimicrobial…
View details →Neto SOP, Rosalen PL, da Cruz Pegoraro JV et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a…
View details →Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy
Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…
View details →Wang AI, Duong MP, Frohlich JR et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS
Systemic analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, may be contraindicated in certain studies due to their mechanisms of action and risk for systemic effects. Local anesthetics (LAs) are therefore crucial in…
View details →Mongia N, Mohammed AI, McCullough M et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease…
View details →Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases
Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…
View details →de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T
Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…
View details →Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy
Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…
View details →Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…
View details →Camargo A, Kaya I, Sturchio A et al. · 2026 · Translational psychiatry
Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct…
View details →Kilaru KR · 2026 · Journal of conservative dentistry and endodontics
Background Postoperative sensitivity (POS) and marginal integrity (MI) are common concerns in Class V restorations because of dentin exposure and polymerization shrinkage stress. Composite-reinforced glass ionomer liners have been…
View details →Deepa Y, Vijay A, Padmavathi K et al. · 2026 · Journal of bodywork and movement therapies
Objective Chronic kidney disease (CKD) is characterized by kidney damage persisting for 3 months or more. Hypertension (HTN) is a common cause of CKD progression. Previous studies had shown that aroma massage can effectively reduce…
View details →Hendy J, Bereznicki H, Lundin RM · 2026 · Frontiers in psychiatry
Addictive disorders remain important contributors to the overall burden of disease, and although many have established treatments, stimulant use disorders (StUDs) still lack effective management options. Neurostimulation techniques, such…
View details →Kosys V, Streimikyte G, Sidlauskas M · 2026 · Cureus
Background Fluoride-containing mouth rinses are widely used in orthodontic patients to prevent enamel demineralization. However, fluoride exposure may influence the mechanical properties of nickel-titanium (NiTi) orthodontic archwires,…
View details →Ronaldson A, Henderson C · 2026 · BJPsych open
Using data from the Attitudes to Mental Illness (AMI) survey, we previously reported positive change in mental health stigma in England between 2008 and 2019. However, following the conclusion of the Time to Change campaign in 2021, 2023…
View details →Amarante V, Colacce M · 2026 · Longitudinal and life course studies : international journal
Evaluating deprivation among individuals transitioning to older ages requires a multidimensional approach to evaluate their diverse needs. Despite its importance, research on this topic remains limited in the developing world, particularly…
View details →Kim J, Lee J, Kim J · 2026 · International journal of aging & human development
Objectives: We investigated whether participating in moderate-intensity leisure-time physical activity (MLTPA) or vigorous-intensity leisure-time physical activity (VLTPA) moderate the relationship between alcohol consumption and…
View details →Kocamış Ö, Sütiçen H · 2026 · BMC ophthalmology
To evaluate corneal endothelial morphology and anterior segment parameters in patients with vitiligo and to investigate the potential impact of periocular involvement on endothelial characteristics. In this cross-sectional observational…
View details →Gadapani Pathak B, Vats P, Manna S et al. · 2026 · BMJ open
Objectives To collate and appraise evidence from existing systematic reviews and meta-analyses on interventions to prevent stillbirth and reduce perinatal mortality across the reproductive continuum, including preconception, antenatal,…
View details →Celik C, Celik MS · 2026 · Human psychopharmacology
Background and objective Isotretinoin is a systemic agent widely used in the treatment of severe acne vulgaris. Previous studies have reported that isotretinoin use may be associated with depression, anxiety, and sleep disorders. The aim…
View details →Ayerbe L, Barbero-Pablos E, Foguet-Boreu Q et al. · 2026 · Journal of psychosomatic research
Introduction Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The…
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