12,264 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Dalbeni A, Vicardi M, Natola LA et al. · 2026 · Oncology research
Objectives The combination of atezolizumab plus bevacizumab (A+B) represents one of the standards first-line treatments for unresectable hepatocellular carcinoma (HCC). Metformin has garnered attention for its potential antitumour and…
View details →Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…
View details →Cai J, Li W, Xu S · 2025 · BMC medical education
Introduction To explore the impact of teaching by clinical educators and faculty educators on the academic performance of vocational medical students, this study analyzed the final exam scores of four classes in the General Surgery course…
View details →Shankar DA, Bosch NA, Jafarzadeh SR et al. · 2025 · CHEST pulmonary
Background Corticosteroids are a mainstay of treatment for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), but dosing practices vary. We leveraged between-hospital variation in propensity to administer pulse dose…
View details →Saithna A · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Evaluations of practice patterns after rotator cuff repair reveal that both simple slings and abduction braces are commonly used, with the latter most frequently preferred in the United States. A preference for a shoulder abduction brace…
View details →Stróżyk A, Horvath A, Kozłowska-Jalowska A et al. · 2026 · Frontiers in pediatrics
Objective Evidence supporting the effectiveness of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet in treating functional abdominal pain disorders remains limited. We aimed to assess the…
View details →Tabaru A, Yigit O, Akyel S et al. · 2025 · Ear, nose, & throat journal
Objective The use of mastoid pressure dressings (MPDs) after otologic surgery has been a standard practice for decades, believed to minimize complications such as hematoma and wound infection. However, the efficacy of MPDs in improving…
View details →Tsubakimoto Y, Takahara M, Soga Y et al. · 2025 · Cardiovascular intervention and therapeutics
Drug-coated balloon (DCB) angioplasty is an effective endovascular therapy for femoropopliteal artery (FPA) disease in patients with peripheral artery disease (PAD). However, the long-term impact of statin and anticoagulant therapy on…
View details →Feliberti J, Alam A, Maulion C · 2025 · Current opinion in cardiology
Purpose of review Hypertension is one of the most common comorbidities affecting patients after solid organ transplantation. Here we review the mechanisms leading to hypertension, along with common practices in terms of medical management.…
View details →Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist
Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…
View details →Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)
Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…
View details →Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…
View details →Schonhaut EB, Scherpereel KL, Young AJ · 2026 · IEEE transactions on bio-medical engineering
Objective Accurate, non-invasive methods for estimating joint and muscle physiological states have the potential to greatly enhance control of wearable devices during real-world ambulation. Traditional modeling approaches and current…
View details →Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…
View details →Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology
The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…
View details →Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery
Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…
View details →Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews
Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…
View details →Bi Z, Ren T, Wang Y · 2025 · Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human…
View details →Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation
Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…
View details →Wee YC, Hewage U, Horwood C et al. · 2026 · Journal of clinical medicine
Background : Statins have anti-inflammatory properties beyond their lipid-lowering effects, but their impact on skin and soft tissue infections (SSTIs) remains unclear. This study evaluated whether statins improve clinical outcomes in…
View details →Robertson NP · 2025 · Journal of neurology
The first of several phase 3 trials examining efficacy in relapsing MS has not been able to demonstrate a significant benefit and has also raised important safety concerns. More results are on their way and it will be important to…
View details →Tabibian K, Vadlakonda A, Coaston T et al. · 2025 · The American journal of cardiology
Despite advancements in cardiogenic shock (CS) management, mortality remains high. While hospital volume has been linked to reduced mortality across myriad complex procedures, the cross-volume effects of mechanical circulatory support…
View details →Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports
Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…
View details →Corbett A, Taylor R, Llewellyn D et al. · 2025 · Journal of the American Medical Directors Association
Objectives Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with…
View details →Kallash M, Frishman WH · 2025 · Cardiology in review
Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil's benefits in ED and BPH have been…
View details →Elscot JJ, Kakar H, den Dekker WK et al. · 2025 · International journal of cardiology
Background Recent randomized trials have suggested that immediate complete revascularization (ICR) is a viable alternative to staged complete revascularization (SCR) in patients with acute coronary syndrome (ACS) and multivessel disease.…
View details →Šitum I, Mihaljević S, Blivajs I et al. · 2026 · Acta stomatologica Croatica
Objectives To compare the quality of recovery between total intravenous anaesthesia (TIVA) with propofol and balanced inhalational anaesthesia with sevoflurane in patients undergoing intraoral surgical procedures. Materials and methods We…
View details →Viswanath YKS, Mbarushimana S, Ammar A et al. · 2025 · Surgical endoscopy
Background Gastroesophageal reflux disease (GERD) is a common chronic condition affecting millions all over the world. It occurs due to the reflux of gastric acid into the oesophagus. Endoscopic therapies like STRETTA offer minimally…
View details →Villanova V, Martinino A, Stanzani E et al. · 2025 · Surgical oncology
Extended pelvic lymph node dissection (EPLND) for rectal cancer is common in Asian countries to reduce local recurrence and improve survival. This umbrella review investigates the benefit of adding extended lymphadenectomy to the standard…
View details →Kooli N, Ben Mansour H, Zenzri Y et al. · 2026 · Frontiers in oncology
Background Ewing's sarcoma (ES) is the second most common malignant bone tumor in patients under 20 years of age. The "Euro-Ewing 2012" trial established induction therapy with the 2-week-interval VDC/IE…
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