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WASTE Journal

Browse the failure-mode index

12,264 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Preoperative Management of Patients With Myasthenia Gravis: A Review of the Evidence.

Alhammadi S, Chalk C · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable weakness and increased perioperative vulnerability. Postoperative myasthenic crisis, defined as respiratory failure requiring prolonged ventilation…

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Negative / Null Result ReportMedicine

Beta-blocker therapy and all-cause mortality after a coronary event: A matched nested case-control study using the Victorian Cardiac Outcomes Registry linked data.

Cataldo-Miranda P, Koh HJW, Stub D et al. · 2026 · Current problems in cardiology

Aims Beta-blocker therapy has traditionally been recommended following coronary events based on clinical trials involving patients with systolic dysfunction. Its survival benefit in patients with preserved left ventricular ejection…

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Negative / Null Result ReportMedicine

A comparison of hysteroscopic tubal electrocoagulation and laparoscopic salpingectomy for hydrosalpinx: short- and long-term pregnancy outcomes.

Tan W, Chen L, Li X et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Purpose Hydrosalpinx impairs embryo implantation and development, leading to infertility or miscarriage. Therefore, the effective treatment of hydrosalpinx is crucial for improving pregnancy outcomes. Here, we investigated the comparative…

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Negative / Null Result ReportMedicine

Evaluating the Impact of Ursodeoxycholic Acid on Hepatic Clearance of [<sup>99m</sup>Tc]Tc-Sestamibi: A Randomized Controlled Trial to Improve Myocardial Perfusion Imaging.

Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals

Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…

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Negative / Null Result ReportMedicine

Baseline body mass index modifies the effects of digital health interventions compared with usual care on cardiovascular disease risk in people with type 2 diabetes: a secondary analysis of the SMARTDiabetes trial.

Ren J, Sun X, Zhang Z et al. · 2026 · The American journal of clinical nutrition

Background Body weight is a critical determinant of cardiovascular disease (CVD) risk among people with type 2 diabetes mellitus (T2DM), substantially contributing to the incidence of and outcomes from CVD. However, the impact of body…

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Negative / Null Result ReportOpen accessMedicine

Effect of HEPA filtration air purifiers on cognitive function from a secondary outcome analysis of a pragmatic randomized crossover trial.

Pellegrino N, Eliasziw M, Fortinsky R et al. · 2026 · Scientific reports

Exposure to particulate matter is associated with adverse health outcomes such as cardiovascular and neurological diseases. However, there are few intervention studies that have examined short-term changes in air particulate exposure and…

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Failed Experiment ReportMedicine

Efficacy and safety of adjunctive treatment with the fatty acid amide hydrolase inhibitor JNJ-42165279 in participants with major depressive disorder with anxious distress: A double-blind, placebo-controlled, randomised study.

Schmidt ME, Gargano C, Zhou X et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…

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Negative / Null Result ReportMedicine

Real world experience of intraoperative radiation therapy (IORT) during lumpectomy for early-stage breast cancer: retrospective data from a single large institutional observational study.

Scherer C, Fung V, Anzellini D et al. · 2026 · Breast cancer (Tokyo, Japan)

Background We report outcomes of patients who received intraoperative radiation therapy (IORT) using 50 kV after lumpectomy and sentinel lymph node biopsy. Methods Women with age > 45 and post-menopausal status, localized, unifocal,…

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Negative / Null Result ReportMedicine

Dual Antiplatelet Therapy beyond 1 Year after a Myocardial Infarction Compared with Low-Dose Aspirin Alone: A 3-Year Follow-Up Cohort Study Within the French SNDS Nationwide Claims Database.

Blin P, Danchin N, Benichou J et al. · 2026 · American journal of cardiovascular drugs : drugs, devices, and other interventions

Introduction Antiplatelet therapy with low-dose aspirin, alone or as dual antiplatelet therapy (DAPT) with a P2Y 12 inhibitor, is used in secondary prevention following myocardial infarction (MI). However, the optimal duration of DAPT is…

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Negative / Null Result ReportMedicine

[Analysis of the reimbursement times of antitumor drugs in Italy in relation to the clinical benefit expressed by the European Society for Medical Oncology (ESMO-MCBS)].

Romagnoli A, Marcellusi A, Lasala R · 2025 · Recenti progressi in medicina

Introduction Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose,…

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Negative / Null Result ReportOpen accessMedicine

Propensity score-matched evaluation of prophylactic hyperthermic intraperitoneal chemotherapy in geriatric patients with locally advanced colorectal cancer: safety and survival benefits.

Yang M, Yang S, Zhang W et al. · 2026 · BMC cancer

AIM: The role of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with locally advanced colorectal cancer (LACRC) remains controversial. This study aimed to evaluate the perioperative safety and survival…

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Negative / Null Result ReportMedicine

Computer-aided polyp detection multicenter international randomized controlled study with a focus on community clinics: Geriatric Assessment-Driven Intervention clinical trial.

Leggett CL, Plowman RS, Surace L et al. · 2026 · Gastrointestinal endoscopy

Background and aims Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at academic rather than community practices. This randomized controlled trial evaluated…

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Negative / Null Result ReportMedicine

Immune Checkpoint Inhibitor Therapy for Advanced, Unresectable Esophageal Squamous Cell Carcinoma: A Series of Patient-level Meta-analyses From Phase III Trials.

Beshr MS, Shembesh RH, Nounou MV et al. · 2026 · Clinical oncology (Royal College of Radiologists (Great Britain))

Aim This study reconstructed patient-level data to provide updated evidence on survival outcomes across PD-L1 expression subgroups. Materials and methods A systematic search was conducted on March 2, 2025, using PubMed, Embase, Web of…

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Negative / Null Result ReportMedicine

Effect of vaginal estrogen supplementation for luteal phase support in the GnRH antagonist protocol on pregnancy outcomes for IVF/ICSI cycles: a randomized controlled trial.

Yang X, Zhu L, Chen R et al. · 2026 · Human reproduction open

Study question Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? Summary answer The addition of vaginal…

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Negative / Null Result ReportMedicine

Energy restriction and iron supplementation improve iron status in women with obesity regardless of red meat consumption: a randomized controlled trial.

Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports

Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…

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Negative / Null Result ReportMedicine

Leptomeningeal carcinomatosis in gastric cancer: a single-center retrospective analysis of 86 cases.

Byun SH, Kim TS, Ahn S et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Background Leptomeningeal carcinomatosis (LMC) is a rare but highly lethal manifestation of gastric cancer. We sought to describe its clinical features and define prognostic factors in a large single-center cohort. Methods We…

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Negative / Null Result ReportMedicine

Evaluation of betaxolol in improving the glasgow outcome scale extended (GOSE) of the acute phase of patients with mild to moderate Traumatic Brain Injury: a double blinded randomized clinical trial.

Zeynodini Meimand H, Anbarloui MR, Eslamian M et al. · 2025 · Neurological research

Background Traumatic brain injury (TBI) is one of the most important causes of morbidity and mortality. It is important to have an effective treatment that can improve the quality of life and cognitive functions of these patients.…

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Negative / Null Result ReportMedicine

Dose-Response Relationships of Tea, Coffee, and Alcohol Consumption With Cognitive Function in Middle-Aged and Older Adults: Analysis Based on the China Health and Nutrition Survey (CHNS).

Zeng Z, Ye X, He H et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society

This study examined the associations of tea, coffee, and alcohol consumption with cognitive function in Chinese adults aged ≥45 years ( n = 1326), using data from the China Health and Nutrition Survey (1997-2006). Multiple linear…

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Negative / Null Result ReportMedicine

Computer-Assisted Versus Freehand Surgery in Oncological Margins Control for Oral Squamous Cell Carcinomas: A Retrospective Case-Control Clinical Study.

Marzi Manfroni A, Scaccini OP, Ceccariglia F et al. · 2026 · Head & neck

Background Margin control is a crucial prognostic factor in head and neck oncological surgery. This retrospective case-control study aims to assess the superiority of computer-assisted surgery compared to traditional surgery in achieving…

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