Negative / Null Result ReportMedicine
Aragon KE, Vrabec JT · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To discuss the effect of round window drill-out for otosclerosis cases with radiographic evidence of round window obliteration. Patients Four adult patients (5 ears) were included with audiometric findings of a mixed hearing loss…
View details →Negative / Null Result ReportMedicine
Welch HF, Rajendran M, Thorn CA · 2026 · Scientific reports
Stimulation of the left cervical vagus nerve (l-VNS) paired with motor training is FDA-approved to improve upper limb function after stroke. However, recent preclinical studies have revealed a striking asymmetry in engagement of the…
View details →Failed Experiment ReportMedicine
Rançon A, Rançon U, Ivek T et al. · 2026 · Physical review. E
We explore how minimal neural networks can invert the renormalization group (RG) coarse-graining procedure in the two-dimensional Ising model, effectively dreaming up microscopic configurations from coarse-grained states. This task,…
View details →Replication FailureMedicine
Wang C, Li S, Lu H et al. · 2026 · BMC gastroenterology
Background While routine use of abdominal drainage in cases of perforated appendicitis is not generally recommended, there exists a paucity of evidence regarding the detailed stratification of its necessity based on varying degrees of…
View details →Replication FailureOpen accessMedicine
Baxi SM, Igbinosa II, Main EK et al. · 2026 · AJOG global reports
Background Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent that has been shown to reduce hemorrhage-related mortality in trauma, is used…
View details →Replication FailureMedicine
Lin MC, Jiang X, Qiu ZC et al. · 2026 · Head & neck
Background Management of the clinically node-negative (cN0) neck in intermediate-grade mucoepidermoid carcinoma (MEC) of the head and neck remains controversial. Methods We retrospectively reviewed patients with cN0 intermediate-grade MEC…
View details →Negative / Null Result ReportMedicine
Brand J, Hughes M, Turner KE et al. · 2026 · Orthopedics
Background and objective Locked intramedullary (IM) nails are the primary treatment modality for femoral shaft fractures. This study aimed to determine the risk of developing a femur nonunion as a function of nail-to-bone diameter…
View details →Negative / Null Result ReportMedicine
Chang HH, Chun YM, Kim SJ et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Purpose To compare clinical and radiologic outcomes among patients undergoing double-row suture bridge (DRSB) repair alone, DRSB with platelet-rich plasma (PRP) augmentation, and DRSB with bone marrow stimulation (BMS) augmentation.…
View details →Negative / Null Result ReportMedicine
El Ayat N, Boutalline M, Tannouche A · 2026 · BMC psychiatry
Background Autism Spectrum Disorder (ASD) affects 1 in 100 children globally, yet early detection remains challenging due to reliance on subjective behavioral assessments and limited specialist availability, particularly in…
View details →Negative / Null Result ReportMedicine
Schneider BS, Pfaehler CD, Hao KA et al. · 2026 · The Journal of the American Academy of Orthopaedic Surgeons
Background Although os acromiale is often noted on preoperative imaging in patients undergoing reverse total shoulder arthroplasty (rTSA), its clinical significance is ill-defined. The purpose of this study was to compare the clinical…
View details →Negative / Null Result ReportMedicine
Cacciatore S, Abbatecola G, Calvani R et al. · 2026 · Medical sciences (Basel, Switzerland)
Background/objectives Ozone therapy has been proposed across multiple clinical conditions based on hormetic, antioxidant, and immunomodulatory effects, but its efficacy and safety remain controversial. We conducted an umbrella review to…
View details →Negative / Null Result ReportMedicine
Maseroli E, Alfaroli C, Cirillo M et al. · 2026 · Journal of endocrinological investigation
Purpose To assess whether the Ketogenic Diet (KD) is associated with improvements in biochemical markers of hyperandrogenism in women diagnosed with Polycystic Ovary Syndrome (PCOS) with obesity or overweight. Methods A systematic search…
View details →Negative / Null Result ReportMedicine
Cooke T, Soderquist CR, Mansukhani MM et al. · 2026 · The journal of applied laboratory medicine
Background JAK2, CALR, and MPL mutations are defining features of myeloproliferative neoplasms (MPNs). Molecular testing for variants in these genes is standard of care in the diagnosis of MPNs. A high reimbursement denial rate led to…
View details →Negative / Null Result ReportMedicine
Magee GA, Mussa FF · 2026 · Seminars in vascular surgery
Dissection morphology is important when considering landing zones for thoracic endovascular aortic repair. Landing proximally in a healthy aorta, free of dissection and intramural hematoma, is generally recommended. For the most common…
View details →Negative / Null Result ReportMedicine
Hirai Y, Fujimoto A, Sasaki M et al. · 2026 · Endoscopy international open
Background and study aims It is desirable to develop a safe, cost-effective, and easy approach to prevent strictures after esophageal endoscopic submucosal dissection (ESD). We explored use of a novel rebamipide solution, an anti-ulcer…
View details →Negative / Null Result ReportMedicine
Yamaguchi K, Watanabe O, Mitsuki T et al. · 2026 · Transplantation and cellular therapy
The clinical benefit of adding high-dose cytarabine (HDCA) to fludarabine (FLU), busulfan (BU), and melphalan (MEL)-based conditioning for cord blood transplantation (CBT) in acute myeloid leukemia (AML) remains unclear. We aimed to…
View details →Negative / Null Result ReportMedicine
Ye L, Yue W, Lin K et al. · 2026 · Scientific reports
Triple therapy combining transarterial chemoembolisation (TACE), tyrosine kinase inhibitors (TKIs), and immune checkpoint inhibitors (ICIs) has shown efficacy in unresectable hepatocellular carcinoma (HCC), but evidence in elderly patients…
View details →Negative / Null Result ReportMedicine
Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery
Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…
View details →Negative / Null Result ReportMedicine
Kakoudaki T, Poon SS, Kumar P · 2026 · Cardiovascular revascularization medicine : including molecular interventions
Background Surgical ventricular reconstruction (SVR) is not always feasible in patients with ischaemic cardiomyopathy and left ventricular (LV) aneurysm, due to high surgical risk. The Revivent-TC Transcatheter Ventricular Enhancement…
View details →Replication FailureMedicine
Wang J, Du L, Wang Y et al. · 2026 · Cellular oncology (Dordrecht, Netherlands)
Purpose Combinations of anti-PD-1/PD-L1 immunotherapy (IO) and anti-VEGF tyrosine kinase inhibitor (TKI) are recommended as first-line therapy for metastatic renal cell carcinoma (RCC). We aimed to evaluate the predictive value of tissue…
View details →Negative / Null Result ReportMedicine
Kang KM, Lee HY, Ahn HM et al. · 2026 · Cancer research and treatment
Purpose The role of adjuvant chemotherapy (ACT) in pathologic T3N0 (pT3N0) rectal cancer, which has a favorable prognosis, remains controversial because high-risk groups for recurrence are not well defined. This study investigated…
View details →Negative / Null Result ReportMedicine
Narayan P · 2026 · Indian journal of thoracic and cardiovascular surgery
There has been controversy over the ideal management strategy for asymptomatic carotid artery stenosis. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials (CREST-2) evaluated whether adding carotid…
View details →Negative / Null Result ReportOpen accessMedicine
Belgioia L, D'Onofrio I, Filauro M et al. · 2026 · Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
Objective To evaluate the impact of postoperative radiotherapy (PORT) on survival outcomes in patients with laryngeal cancer treated with partial laryngectomy. Methods In this retrospective multicentre study, 312 patients with supraglottic…
View details →Negative / Null Result ReportMedicine
Cui Y, Liu JL, Jiang CH et al. · 2026 · Diabetes, obesity & metabolism
Background Early dual antiplatelet therapy (DAPT) after intravenous thrombolysis is safe but ineffective in improving 90-day functional outcomes in minor stroke. Given the effect of diabetes mellitus (DM) with antiplatelet treatment, we…
View details →Negative / Null Result ReportMedicine
Chi SY, Chou SE, Chou FF et al. · 2026 · World journal of surgery
Background Thyroidectomy for Graves' disease (GD) is associated with an increased risk of intraoperative bleeding, particularly in patients with enlarged and hypervascular thyroid glands. This retrospective cohort study evaluated factors…
View details →Negative / Null Result ReportMedicine
Honda K, Furukawa S · 2026 · JASA express letters
This study addresses methodological issues in the modulation-masking paradigm for future clinical applications for assessing modulation filters. The aim of the paradigm is to determine a target-modulation threshold in a fixed-depth masker.…
View details →Negative / Null Result ReportMedicine
Hayes MW, Porter WM, Snider JL et al. · 2026 · Field Crops Research.
The rising cost of crop inputs has driven farmers to reduce costs. One area they have focused on is the seeding rate in an effort to minimize seed cost. Numerous studies have been completed every few years to evaluate optimum seeding rates…
View details →Negative / Null Result ReportMedicine
Goda S, Yamada T, Goto Y et al. · 2026 · BMC pulmonary medicine
Background The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation, with prognostic value in interstitial lung disease (ILD). However, the association between baseline NLR and the therapeutic efficacy of nintedanib…
View details →Negative / Null Result ReportMedicine
Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology
Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…
View details →Negative / Null Result ReportMedicine
Alhammadi S, Chalk C · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable weakness and increased perioperative vulnerability. Postoperative myasthenic crisis, defined as respiratory failure requiring prolonged ventilation…
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