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WASTE Journal

Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Editorial Commentary: Lumbar Pathology Likely Negatively Affects Surgical Outcomes in Patients With Femoroacetabular Impingement Syndrome, Though the Strength of the Relationship is Unclear.

Kaplan DJ · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

A complex interplay exists between the hip joint and the lumbosacralpelvis. As a patient moves from a standing to seated position, the lower back, pelvis, and hips must move in concert to properly function. Conceptually, any deviation from…

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Negative / Null Result ReportMedicine

Comparative Evaluation of Unilateral Recession-Plication Versus Bilateral Three-Muscle Surgery for Large-Angle Exotropia.

Anand K, Nagpal V, Dutta P et al. · 2026 · Journal of pediatric ophthalmology and strabismus

Purpose To evaluate and compare unilateral recession-plication versus bilateral three-muscle surgery for large-angle exotropia. Methods A prospective interventional non-randomized comparative study was conducted involving 66 patients with…

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Negative / Null Result ReportOpen accessMedicine

Precision in Medial pivot total knee arthroplasty: A retrospective study on mechanical axis alignment and functional outcomes with CT-guided patient-specific instrumentation.

Mat Salleh F, Nizam I · 2026 · SICOT-J

Background Total Knee Arthroplasty (TKA) is the standard treatment for end-stage osteoarthritis, with optimal outcomes dependent on precise mechanical alignment and accurate implant positioning. Patient-specific instrumentation (PSI),…

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Negative / Null Result ReportMedicine

Olfactory outcomes after primary endoscopic sinus surgery and dupilumab for post-operative recurrence in eosinophilic chronic rhinosinusitis.

Saito T, Hirose T, Haruna T et al. · 2026 · The Journal of laryngology and otology

Objective. To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for…

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Negative / Null Result ReportOpen accessMedicine

The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.

Song X, Wang Y, Chen H · 2026 · International journal of cardiology. Cardiovascular risk and prevention

Objective To identify distinct multi-year cognitive function trajectories in middle-aged and older Chinese adults with established cardiovascular disease (CVD) and evaluate their independent associations with all-cause mortality. Methods…

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Negative / Null Result ReportMedicine

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction.

Espehana A, Macfarlane G, Garden EM et al. · 2026 · Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Objectives Tumour Necrosis factor antagonists is a potent anti-inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in…

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Negative / Null Result ReportMedicine

Asialoglycoprotein receptor-1 promotes hyperandrogenism in polycystic ovary syndrome through direct interaction with FSHR, leading to the cAMP-PKA-CREB pathway inhibition.

Liu X, Shi J, Wang T · 2026 · Reproduction (Cambridge, England)

Polycystic ovary syndrome (PCOS) is a prevalent multifactorial disorder characterized by hormone dysregulation and follicular development defects. Asialoglycoprotein receptor 1 (ASGR1), a C-type lectin predominantly expressed on the…

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Negative / Null Result ReportOpen accessMedicine

No Difference Between Open and Arthroscopic ATFL Repair, Both Yielding Clinically Significant Improvement in Chronic Ankle Instability: A Randomized Controlled Trial.

Vuurberg G, Maria PA, Baalbaki R et al. · 2026 · Orthopaedic journal of sports medicine

Background Lateral ligament repair is a reliable surgical approach for the treatment of chronic ankle instability (CAI). Although the open technique has shown success over time, technological advancements have enabled the increasing use of…

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Negative / Null Result ReportMedicine

Effects of Photobiomodulation Therapy in Lateral Luxation of Anterior Permanent Teeth: A Randomized, Double-Blind Clinical Trial.

Belmonte FM, Soares PC, Azevedo LH et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background Among the traumatic dental injuries (TDIs), lateral luxation may present poor prognosis due to frequent root resorption and consequent tooth loss. Photobiomodulation therapy (PBMT) modulates cellular activities (proliferation,…

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Negative / Null Result ReportOpen accessMedicine

Mid-Term Outcomes of Posterior Pelvic Reconstruction Combined with Lateral Abdominal Wall Suspension versus Sacrocolpopexy for Advanced Pelvic Organ Prolapse: A Retrospective Comparative Study.

Chu G, Hu C, Deng Q · 2026 · International journal of women's health

Purpose To compare mid-term efficacy, safety, and functional outcomes of laparoscopic sacrocolpopexy (LSC) versus laparoscopic lateral abdominal wall suspension (LAWS), both combined with standardized posterior repair, for advanced…

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Negative / Null Result ReportMedicine

The Effects of Personalized Observation, Execution, and Mental Imagery (POEM) Therapy in Logopenic Primary Progressive Aphasia: A Telepractice-Based Single-Case Study.

Basaglia-Pappas S, Solignac H, Durand É · 2026 · Brain sciences

Background/Objectives: Verb anomia is a common symptom of primary progressive aphasia (PPA), particularly in the logopenic variant (lvPPA). Despite the central role of verbs in sentence construction, interventions specifically targeting…

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Negative / Null Result ReportMedicine

Practice Effects and the Lanthony D15.

Ho J, Ng JS · 2026 · Vision (Basel, Switzerland)

Purpose Recent studies have shown that subjects with congenital colour vision deficiency (CVD) can pass the saturated Farnsworth D15 (FD15) through practice. The Lanthony D15 (LD15) uses desaturated colours and is a difficult test even for…

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Negative / Null Result ReportMedicine

Enhancing Resilience and Well-Being Among Nurse Leaders: A Randomized Controlled Trial of Mindfulness and Narrative Interventions.

Kim M, Owens R, Tucker S et al. · 2026 · The Journal of nursing administration

Objective Evaluate the short-term effectiveness of interventions to address nurse leader resilience and well-being. Background Nurse leaders face unique stressors in their role. Evidence-based, feasible interventions are urgently needed.…

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Negative / Null Result ReportOpen accessMedicine

Preliminary Evidence of Motor Outcomes in Children with Autism Spectrum Disorder Following Equine-Assisted Therapy and Dual-Task Training: A Pilot Study.

Della Valle C, Di Martino G, Melis A et al. · 2026 · Sports (Basel, Switzerland)

Background Equine-assisted therapy (EAT) is a supportive intervention for children with autism spectrum disorder (ASD). Aim This pilot study evaluated the feasibility of a cognitive-motor EAT intervention to explore its preliminary effects…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Results of Medial Fixed-Bearing Unicompartmental Knee Arthroplasty with Miller-Galante Prosthesis: A Minimum 10-Year Follow-Up Study.

Lim S, Kim TH, Park DY et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Medial unicompartmental knee arthroplasty (UKA) has emerged as an effective surgical option for isolated medial compartment osteoarthritis (OA), offering advantages in bone preservation, knee kinematics, and…

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Negative / Null Result ReportOpen accessMedicine

Impact of hearing aid use on cognitive function in elderly individuals with hearing loss: a prospective study.

Velho HC, Schichi MASC, da Silveira Sassi TS et al. · 2026 · Brazilian journal of otorhinolaryngology

Objective To evaluate the cognition and the depressive symptoms of elderly individuals with hearing impairment before and after the use of Hearing Aids (HA), in order to determine whether auditory rehabilitation can influence cognition and…

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Negative / Null Result ReportMedicine

Developing facilitative interpersonal skills: A randomized controlled study of an apprenticeship training for first-year clinical psychology students.

Fagerbakk SA, Brattland H, Laugen NJ et al. · 2026 · Psychotherapy research : journal of the Society for Psychotherapy Research

Objective This study aimed to evaluate whether apprenticeship training could enhance facilitative interpersonal skills (FIS) in first-year students enrolled in a six-year integrated clinical psychology study program, compared to…

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Negative / Null Result ReportMedicine

Development of virtual reality in the upper extremities function in children with Cerebral Palsy. A pilot randomized controlled trial.

Iamchaimongkol A, Sangkrai S, Alberts P et al. · 2026 · Journal of neuroengineering and rehabilitation

Objective To evaluate the effect of the Virtual Reality (VR) in upper extremities function in children with Cerebral Palsy (CP). Study design Pilot randomization study. Methods A total of 42 children with CP, aged 10 to15 years, were…

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Negative / Null Result ReportOpen accessMedicine

Functional and Radiological Benefits of Adding Fibular Osteotomy to Supramalleolar Osteotomy in Ankle Osteoarthritis.

Li P, Liu H, Huang F et al. · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Ankle arthritis is a chronic degenerative disease; its typical symptom is pain in the ankle joint. This retrospective study of 65 patients with mid-stage ankle osteoarthritis aimed to compare clinical outcomes from…

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Negative / Null Result ReportMedicine

Short-Term Effects of Four Common Semioccluded Vocal Tract Exercises in Primary Muscle Tension Dysphonia: A Randomized Controlled Trial.

Aziz R, Khoddami SM, Jalaie S et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objectives This study investigated the effects of four common semioccluded vocal tract exercises (SOVTEs)-tongue trill, lip trill, straw phonation, and water resistance therapy (WRT)-in primary muscle tension dysphonia (MTD). Study design…

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Negative / Null Result ReportOpen accessMedicine

Types of physical activity and applied outcome measures in physical activity interventions among patients with inflammatory bowel disease: a scoping review.

Fromberg EB, Brink MT, Villumsen M et al. · 2026 · BMC gastroenterology

BACKGROUND: While pharmacological treatments remain essential in inflammatory bowel disease (IBD), complementary approaches such as physical activity are increasingly being explored for their potential benefits. This scoping review aimed…

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