Negative / Null Result ReportOpen accessMedicine
Toru Hashimoto, Vidhya Sivakumaran, Ricardo Carnicer et al. · 2016 · Journal of the American Heart Association
BACKGROUND: Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure…
View details →Negative / Null Result ReportMedicine
Jeanne E. Barthold, Kaitlin P. McCreery, Jaylene Martinez et al. · 2022 · Biofabrication
Abstract Articular cartilage is a layered tissue with a complex, heterogeneous structure and lubricated surface which is challenging to reproduce using traditional tissue engineering methods. Three-dimensional printing techniques have…
View details →Negative / Null Result ReportOpen accessMedicine
Narendra Kumar, Pankaj Kumar, Shabab Angurana et al. · 2013 · Journal of Neurosciences in Rural Practice
AIMS: We present retrospective analysis of patients of glioblastoma multiforme (GBM) and discuss clinical characteristics, various treatment protocols, survival outcomes, and prognostic factors influencing survival. MATERIALS AND METHODS:…
View details →Negative / Null Result ReportOpen accessMedicine
Péter Kupó, T Riesz, László Sághy et al. · 2023 · Journal of Cardiovascular Electrophysiology
INTRODUCTION: Routine ultrasound (US) guidance for femoral venous access to decrease vascular complications of atrial fibrillation (AF) ablation procedures has been advocated. However, the benefit has not been unequivocally demonstrated by randomized-trial data. METHODS: Consecutive patients undergoing pulmonary vein isolation (PVI) on uninterrupted anticoagulant treatment were included. A quasi-random allocation to either US-guided or conventional puncture group was based on which of the two procedure rooms the patient was scheduled in, with only one of the rooms equipped with a US machine in
View details →Negative / Null Result ReportMedicine
Helmut Schoellnast, Ajita Deodhar, Meier Hsu et al. · 2012 · Acta Radiologica
BACKGROUND: Radiofrequency ablation (RFA) is a potential application as a salvage tool after failure of surgery, chemotherapy, or radiotherapy of non-small cell lung cancer (NSCLC). Although several studies have evaluated the use of RFA in…
View details →Negative / Null Result ReportOpen accessMedicine
Janet M. Boekhout, Brenda Berendsen, Denise A. Peels et al. · 2018 · International Journal of Environmental Research and Public Health
This study explores the effectiveness of the Active Plus65 intervention designed to stimulate physical activity among single older adults with a chronic physical impairment. A quasi-experimental pre-test post-test study was performed. The intervention group (n = 411; mean age = 76.75; SD = 7.75) was assessed at baseline, three months, and six months. Data of comparable older adults who completed the original Active Plus intervention served as reference group (n = 87; mean age = 74.36; SD = 6.26). Multilevel regression analyses were applied: outcome measures were weekly minutes of moderate to v
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Terence Fullerton, Brendon Binneman, William David et al. · 2018 · Alzheimer s Research & Therapy
Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in humans at a dose of 30 mg. This was a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial evaluating the efficacy and safety of SAM-760 30 mg once daily (QD) for 12 weeks in subjects with AD on a stable regimen of donepezil 5 to 10 mg QD. The study included an interim analysis with stopping rules for futility or efficacy after 180 subjects comp
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Shruti Agashe, David B. Burkholder, Keith Starnes et al. · 2022 · Frontiers in Human Neuroscience
There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy (GGE). Centromedian nucleus of the thalamus (CM) deep brain stimulation (DBS) may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic (GTC) seizures. At baseline she had 4-8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve stimulation. A multidisciplin
View details →Negative / Null Result ReportMedicine
Jinbo Bi, Jiangwen Sun, Yu‐Wei Wu et al. · 2013 · ACM Transactions on Intelligent Systems and Technology
Alcohol misuse is one of the most serious public health problems facing adolescents and young adults in the United States. National statistics shows that nearly 90% of alcohol consumed by youth under 21 years of age involves binge drinking…
View details →Negative / Null Result ReportOpen accessMedicine
Miklós Lipcsey, Mia Furebring, Sten Rubertsson et al. · 2010 · Upsala Journal of Medical Sciences
BACKGROUND: Renal dysfunction is associated with increased morbidity and mortality in intensive care patients. In most cases the glomerular filtration rate (GFR) is estimated based on serum creatinine and the Modification of Diet in Renal Disease (MDRD) formula, but cystatin C-estimated GFR is being used increasingly. The aim of this study was to compare creatinine and MDRD and cystatin C-estimated GFR in intensive care patients. METHODS: Retrospective observational study was performed, on patients treated within the general intensive care unit (ICU) during 2004-2006, in a Swedish university h
View details →Negative / Null Result ReportMedicine
Takeo Ishii, Takashi Angata, Emily S. Wan et al. · 2016 · Respirology
BACKGROUND AND OBJECTIVE: The exacerbation-prone phenotype of COPD is particularly important, as exacerbations lead to poor quality of life and disease progression. We previously found that COPD patients who lack Siglec-14, a myeloid cell…
View details →Negative / Null Result ReportOpen accessMedicine
Leah Wetherill, Manav Kapoor, Arpana Agrawal et al. · 2013 · Alcoholism Clinical and Experimental Research
BACKGROUND: Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes…
View details →Negative / Null Result ReportMedicine
Sarah Moody, Leire Escudero‐Ibarz, Ming Wang et al. · 2017 · The Journal of Pathology
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends…
View details →Negative / Null Result ReportOpen accessMedicine
Chao Gao, Bin Zhu, Fan Ouyang et al. · 2025 · BMJ
Abstract Objectives To investigate whether a less intense antiplatelet regimen could be used for people receiving drug coated balloons. Design Multicentre, randomised, open label, assessor blind, non-inferiority trial (REC-CAGEFREE II).…
View details →Negative / Null Result ReportOpen accessMedicine
Christof A. Leicht, Victoria L. Goosey‐Tolfrey, Nicolette C. Bishop · 2026 · PubMed
A spinal cord injury (SCI) can increase the risk of infection by impacting on many aspects of immune function; one particularly well-documented observation is a reduction in lymphocyte numbers. The vast majority of lymphoid cells express…
View details →Negative / Null Result ReportOpen accessMedicine
Jung Sun Kim, Eun Joo Kang, Dae Sik Kim et al. · 2018 · BMC Cancer
BACKGROUND: This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated. METHODS: A total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated. RESULTS: VTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed p
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Constance Wose Kinge, Christine Espiritu, Nishi Prabdial‐Sing et al. · 2014 · Antimicrobial Agents and Chemotherapy
Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In…
View details →Negative / Null Result ReportOpen accessMedicine
Arjan Kol, Anton Terwisscha van Scheltinga, Martin Pool et al. · 2017 · Oncotarget
// Arjan Kol 1 , Anton Terwisscha van Scheltinga 2 , Martin Pool 1 , Christian Gerdes 3 , Elisabeth de Vries 1 , Steven de Jong 1 1 Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 3 Roche Pharma Research & Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland Correspondence to: Steven de Jong, email: s.de.jong@umcg.nl Keywords: non-small cell lung cancer,
View details →Negative / Null Result ReportOpen accessMedicine
Romelia Barba Bernal, Bryan W. Ferrigno, Esli Medina Morales et al. · 2023 · The Turkish Journal of Gastroenterology
Primary biliary cholangitis is an autoimmune cholestatic liver disease characterized by progressive destruction of bile ducts, which can ultimately progress to chronic liver disease and cirrhosis. Ursodeoxycholic acid and obeticholic acid are the only 2 Food and Drug Administration (FDA)-approved medications for primary biliary cholangitis. Unfortunately, up to 40% of patients with primary biliary cholangitis have an incomplete response to ursodeoxycholic acid, warranting an essential need for additional therapeutics. Peroxisome proliferator-activated receptor agonists have shown promising dat
View details →Negative / Null Result ReportOpen accessMedicine
Ian Roberts · 2016 · Transfusion
Administration of tranexamic acid (TXA) to bleeding trauma patients who are within 3 hours of injury has been shown to safely reduce mortality in bleeding trauma patients. However, some believe that thromboelastography (TEG or ROTEM) can…
View details →Negative / Null Result ReportOpen accessMedicine
Sonia Tejada, Ricardo Díez-Valle, Guillermo Aldave et al. · 2013 · Journal of Neuro-Oncology
Our purpose was to analyze the pattern of failure in glioblastoma (GBM) patients at first recurrence after radiotherapy and temozolomide and its relationship with different factors. From 77 consecutive GBM patients treated at our institution with fluorescence guided surgery and standard radiochemotherapy, 58 first recurrences were identified and included in a retrospective review. Clinical data including age, Karnofsky performance score, preoperative tumor volume and location, extend of resection, MGMT promoter methylation status, time to progression (PFS), overall survival (OS) and adjuvant t
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Gonçalo N. Petrucci, Joaquim Henriques, Luís Lobo et al. · 2020 · Veterinary and Comparative Oncology
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical…
View details →Negative / Null Result ReportMedicine
Mauro Cignarelli, Ettore Cicinelli, Mónica Corso et al. · 2010 · Gynecologic and Obstetric Investigation
Thermocutaneous, vascular, metabolic and hormonal changes were investigated during 11 hot flashes from 6 postmenopausal women. The first detectable change was an increase in finger blood flow with a concomitant enhancement of skin…
View details →Negative / Null Result ReportMedicine
Daisuke Nakamura, Tomohiro Suzuki, Mikinobu Yasumatsu et al. · 2011 · The Journal of Strength and Conditioning Research
Several investigators have reported the effects of reduced training and interrupted training on athletic performance, but few reports are available for soccer players. The purpose of this study was to examine, using the Yo-Yo intermittent…
View details →Negative / Null Result ReportOpen accessMedicine
Valérie Fonteyne, Piet Dirix, Charles Van Praet et al. · 2021 · European Urology Focus
BACKGROUND: High-risk muscle-invasive bladder cancer (MIBC) has a poor prognosis. Old trials showed that external beam radiotherapy (EBRT) after radical cystectomy (RC) decreases the incidence of local recurrences but induces severe…
View details →Negative / Null Result ReportOpen accessMedicine
Bradford L. McRae, Alon D. Levin, Manon E. Wildenberg et al. · 2015 · Journal of Crohn s and Colitis
BACKGROUND AND AIMS: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of patients with Crohn's disease whereas a TNF receptor fusion protein [etanercept] is…
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Jawed Alam, Sankar Maiti, Prachetash Ghosh et al. · 2012 · Journal of Medical Microbiology
A novel virulence factor, duodenal ulcer-promoting gene A (dupA), in Helicobacter pylori has been found to be associated with disease in certain populations but not in others. This study analysed a South-east Indian population as part of…
View details →Negative / Null Result ReportOpen accessMedicine
Yumiko Matsuoka, Amorsolo L. Suguitan, Marlene S. Orandle et al. · 2014 · Journal of Virology
Live attenuated cold-adapted (ca) H5N1, H7N3, H6N1, and H9N2 influenza vaccine viruses replicated in the respiratory tract of mice and ferrets, and 2 doses of vaccines were immunogenic and protected these animals from challenge infection…
View details →Negative / Null Result ReportOpen accessMedicine
Lindsay Rosenbeck, Patrick J. Kiel, Iftekhar Kalsekar et al. · 2010 · Biology of Blood and Marrow Transplantation
Methotrexate (MTX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared…
View details →Negative / Null Result ReportOpen accessMedicine
Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
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