12,222 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Leah Wetherill, Manav Kapoor, Arpana Agrawal et al. · 2013 · Alcoholism Clinical and Experimental Research
BACKGROUND: Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes…
View details →Sarah Moody, Leire Escudero‐Ibarz, Ming Wang et al. · 2017 · The Journal of Pathology
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends…
View details →Chao Gao, Bin Zhu, Fan Ouyang et al. · 2025 · BMJ
Abstract Objectives To investigate whether a less intense antiplatelet regimen could be used for people receiving drug coated balloons. Design Multicentre, randomised, open label, assessor blind, non-inferiority trial (REC-CAGEFREE II).…
View details →Jung Sun Kim, Eun Joo Kang, Dae Sik Kim et al. · 2018 · BMC Cancer
BACKGROUND: This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated. METHODS: A total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated. RESULTS: VTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed p
View details →Constance Wose Kinge, Christine Espiritu, Nishi Prabdial‐Sing et al. · 2014 · Antimicrobial Agents and Chemotherapy
Hepatitis C virus (HCV) exists as six major genotypes that differ in geographical distribution, pathogenesis, and response to antiviral therapy. In vitro replication systems for all HCV genotypes except genotype 5 have been reported. In…
View details →Arjan Kol, Anton Terwisscha van Scheltinga, Martin Pool et al. · 2017 · Oncotarget
// Arjan Kol 1 , Anton Terwisscha van Scheltinga 2 , Martin Pool 1 , Christian Gerdes 3 , Elisabeth de Vries 1 , Steven de Jong 1 1 Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 3 Roche Pharma Research & Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland Correspondence to: Steven de Jong, email: s.de.jong@umcg.nl Keywords: non-small cell lung cancer,
View details →Romelia Barba Bernal, Bryan W. Ferrigno, Esli Medina Morales et al. · 2023 · The Turkish Journal of Gastroenterology
Primary biliary cholangitis is an autoimmune cholestatic liver disease characterized by progressive destruction of bile ducts, which can ultimately progress to chronic liver disease and cirrhosis. Ursodeoxycholic acid and obeticholic acid are the only 2 Food and Drug Administration (FDA)-approved medications for primary biliary cholangitis. Unfortunately, up to 40% of patients with primary biliary cholangitis have an incomplete response to ursodeoxycholic acid, warranting an essential need for additional therapeutics. Peroxisome proliferator-activated receptor agonists have shown promising dat
View details →Ian Roberts · 2016 · Transfusion
Administration of tranexamic acid (TXA) to bleeding trauma patients who are within 3 hours of injury has been shown to safely reduce mortality in bleeding trauma patients. However, some believe that thromboelastography (TEG or ROTEM) can…
View details →Sonia Tejada, Ricardo Díez-Valle, Guillermo Aldave et al. · 2013 · Journal of Neuro-Oncology
Our purpose was to analyze the pattern of failure in glioblastoma (GBM) patients at first recurrence after radiotherapy and temozolomide and its relationship with different factors. From 77 consecutive GBM patients treated at our institution with fluorescence guided surgery and standard radiochemotherapy, 58 first recurrences were identified and included in a retrospective review. Clinical data including age, Karnofsky performance score, preoperative tumor volume and location, extend of resection, MGMT promoter methylation status, time to progression (PFS), overall survival (OS) and adjuvant t
View details →Gonçalo N. Petrucci, Joaquim Henriques, Luís Lobo et al. · 2020 · Veterinary and Comparative Oncology
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical…
View details →Mauro Cignarelli, Ettore Cicinelli, Mónica Corso et al. · 2010 · Gynecologic and Obstetric Investigation
Thermocutaneous, vascular, metabolic and hormonal changes were investigated during 11 hot flashes from 6 postmenopausal women. The first detectable change was an increase in finger blood flow with a concomitant enhancement of skin…
View details →Daisuke Nakamura, Tomohiro Suzuki, Mikinobu Yasumatsu et al. · 2011 · The Journal of Strength and Conditioning Research
Several investigators have reported the effects of reduced training and interrupted training on athletic performance, but few reports are available for soccer players. The purpose of this study was to examine, using the Yo-Yo intermittent…
View details →Valérie Fonteyne, Piet Dirix, Charles Van Praet et al. · 2021 · European Urology Focus
BACKGROUND: High-risk muscle-invasive bladder cancer (MIBC) has a poor prognosis. Old trials showed that external beam radiotherapy (EBRT) after radical cystectomy (RC) decreases the incidence of local recurrences but induces severe…
View details →Bradford L. McRae, Alon D. Levin, Manon E. Wildenberg et al. · 2015 · Journal of Crohn s and Colitis
BACKGROUND AND AIMS: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of patients with Crohn's disease whereas a TNF receptor fusion protein [etanercept] is…
View details →Jawed Alam, Sankar Maiti, Prachetash Ghosh et al. · 2012 · Journal of Medical Microbiology
A novel virulence factor, duodenal ulcer-promoting gene A (dupA), in Helicobacter pylori has been found to be associated with disease in certain populations but not in others. This study analysed a South-east Indian population as part of…
View details →Yumiko Matsuoka, Amorsolo L. Suguitan, Marlene S. Orandle et al. · 2014 · Journal of Virology
Live attenuated cold-adapted (ca) H5N1, H7N3, H6N1, and H9N2 influenza vaccine viruses replicated in the respiratory tract of mice and ferrets, and 2 doses of vaccines were immunogenic and protected these animals from challenge infection…
View details →Lindsay Rosenbeck, Patrick J. Kiel, Iftekhar Kalsekar et al. · 2010 · Biology of Blood and Marrow Transplantation
Methotrexate (MTX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared…
View details →Robert G. Miller, Rongzhen Zhang, Paige M. Bracci et al. · 2022 · Muscle & Nerve
INTRODUCTION/AIMS: ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the…
View details →Cyril Messaraa, Nicola J. Robertson, Melissa Walsh et al. · 2019 · Journal of Cosmetic Dermatology
BACKGROUND: The use of a skin care routine is commonly promoted by the cosmetic industry, yet there is a lack of clinical evidence to support this practice over the use of a single skin care product. AIMS: In the present study, we aimed at…
View details →Evan M. Graboyes, Kevin Y. Zhan, Elizabeth Garrett‐Mayer et al. · 2017 · Cancer
BACKGROUND: The current study was conducted to determine the effect of postoperative radiotherapy (PORT) on overall survival in patients with surgically managed pT3-T4aN0 laryngeal squamous cell carcinoma (SCC). METHODS: A review of the…
View details →Byung Kook Lee, In Soo Cho, Joo Suk Oh et al. · 2018 · PLoS ONE
INTRODUCTION: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM). METHODS: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM. The primary outcome was serum lactate levels at 24 hours after drug infusion. The secondary ou
View details →Federica Albanese, Daniela Mercatelli, Luca Finetti et al. · 2021 · Neurobiology of Disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since…
View details →Taro Oshikiri, Hodaka Numasaki, Junya Oguma et al. · 2021 · Annals of Surgery
OBJECTIVE: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. SUMMARY OF BACKGROUND DATA: Although TD resection can cause nutritional disadvantage…
View details →Kazunari Misawa, Yoshinari Mochizuki, Munetoshi Sakai et al. · 2019 · British journal of surgery
BACKGROUND: A survival benefit of extensive intraoperative peritoneal lavage (EIPL) has been reported in patients with gastric cancer with positive peritoneal cytology. The hypothesis of this study was that EIPL may reduce peritoneal…
View details →Manuel Blesa, Paola Galdi, Gemma Sullivan et al. · 2020 · Frontiers in Neurology
Preterm birth is closely associated with cognitive impairment and generalized dysconnectivity of neural networks inferred from water diffusion MRI (dMRI) metrics. Peak width of skeletonized mean diffusivity (PSMD) is a metric derived from histogram analysis of mean diffusivity across the white matter skeleton, and it is a useful biomarker of generalized dysconnectivity and cognition in adulthood. We calculated PSMD and five other histogram based metrics derived from diffusion tensor imaging (DTI) and neurite orientation and dispersion imaging (NODDI) in the newborn, and evaluated their accurac
View details →Pierre‐Édouard Bollaert, Alexandra Monnier, Francis Schneider et al. · 2023 · Critical Care
BACKGROUND: In critically ill patients, positive fluid balance is associated with excessive mortality. The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ill patients. METHODS: POINCARE-2 was a stepped wedge cluster open-label randomized controlled trial. We recruited critically ill patients in twelve volunteering intensive care units from nine French hospitals. Eligible patients were ≥ 18 years old, under mechanical ventilation, admitted to one of the 12 recruiting units for > 48 and ≤ 72 h, and had an expected length of stay
View details →Morten Vester‐Andersen, Tina Waldau, Jørn Wetterslev et al. · 2015 · British journal of surgery
BACKGROUND: Emergency abdominal surgery carries a considerable risk of death and postoperative complications. Early detection and timely management of complications may reduce mortality. The aim was to evaluate the effect and feasibility…
View details →Xuelian He, Junhong Xia, Chunming Wang et al. · 2011 · Animal Genetics
Prolactin (encoded by PRL) is a multifunctional hormone involved in osmoregulation, reproduction, growth, development, immunomodulation, endocrine and metabolic regulation. We cloned the full-length cDNA of Asian seabass PRL, searched for…
View details →Tasneem Zaihra, Christopher J. Walsh, Sara Ahmed et al. · 2016 · BMC Pulmonary Medicine
BACKGROUND: Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lacking. Our objective was to assess the longitudinal stability of clusters derived from repeated measures of airway and physiological data over a 1-year period in moderate and severe asthmatics. METHODS: A total of 125 subjects, 48 with moderate asthma (MA) and 77 with severe asth
View details →Mikko T. Holmberg, Aleksi Tornio, Maria Paile‐Hyvärinen et al. · 2018 · Clinical Pharmacology & Therapeutics
CYP3A enzymes participate in the elimination of ticagrelor and the bioactivation of clopidogrel and prasugrel. We studied the effects of functional CYP3A genetic variants (CYP3A4*22; rs35599367 and CYP3A5*3; rs776746) on the…
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