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WASTE Journal

Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Safety and efficacy of Esculin and Digitalis glycosides eye drops in individuals with presbyopia.

Zhang Y, Wang J, Hao M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This proof-of-concept study aimed to detect preliminary signals of efficacy and assess the short-term safety of Esculin and Digitalis glycoside eye drops for the management of presbyopia. METHODS: This study was a 30-day,…

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Negative / Null Result ReportMedicine

Comparison of sesame oil wafers and lozenges as saliva substitutes for dry mouth in head and neck cancer patients: A crossover randomized control trial.

Abbas Amanat M, Srichana T, Takahashi Yupanqui C et al. · 2026 · Pakistan journal of pharmaceutical sciences

Background Dry mouth is a condition associated with significant morbidity. It not only causes discomfort but also increases risk of many health and oral health problems. Objectives This study compared the efficacy and patient satisfaction…

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Negative / Null Result ReportMedicine

Feasibility and advantages of delivering radiofrequency ablation treatment for haemorrhoids under local anaesthesia in the outpatient setting in the UK: our initial experience.

Rajendiran A, Maharjan A, Gerrard AD et al. · 2026 · Techniques in coloproctology

Introduction Radiofrequency ablation (RFA) for haemorrhoids has emerged as a minimally invasive treatment for grade II-III haemorrhoids, offering reduced postoperative pain and faster recovery compared with conventional surgery. However,…

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Negative / Null Result ReportOpen accessMedicine

Patterns of recovery after arthroscopic repair of the rotator cuff over a 2-year follow-up period: are they similar regardless of the tear size?

Seok HG, Park SG · 2026 · Archives of orthopaedic and trauma surgery

INTRODUCTION: The recovery patterns following arthroscopic rotator cuff repairs are influenced by several factors, including the size of the tear and the degree of patient compliance. This study aimed to ascertain whether a correlation…

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Negative / Null Result ReportMedicine

Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients.

Ikuma H, Hirose T, Kawasaki K et al. · 2026 · Acta medica Okayama

We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of 980nm diode laser as adjunct to flap surgery.

Patil S, Raju KN, S Kotnoor S et al. · 2026 · Bioinformation

The additional clinical benefit of diode laser irradiation as an adjunct to open flap debridement (OFD) in the treatment of chronic periodontitis remains uncertain. Therefore, it is of interest to evaluate the impact of diode laser…

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Negative / Null Result ReportMedicine

Maintenance of occupational therapy for individuals with dementia: Findings from a pragmatic randomized controlled trial.

Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…

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Negative / Null Result ReportMedicine

Motivational interviewing and air cleaners for smokers with COPD (MOVE): a randomized, double-blind, placebo-controlled trial.

Hansel NN, Putcha N, Woo H et al. · 2026 · American journal of respiratory and critical care medicine

Rationale Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive -pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of a Telemedicine Exercise Program to Improve Lung Function in Young Adults After COVID-19: A Pilot Study.

Wong ECH, Lo RWM, Kwan RLC et al. · 2026 · Healthcare (Basel, Switzerland)

Background : COVID-19 can have adverse effects on individuals' lung functions for up to 6 months or more after the episode. As a result, people may be reluctant to exercise, and this can have further adverse effects on their lung capacity…

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Negative / Null Result ReportMedicine

Adolescents Who Underwent Revision Hip Arthroscopy Showed Comparable Magnitude of Improvement but Had Lower Clinical Benefit Rates and Higher Risk of Subsequent Surgeries Compared to a Propensity-Matched Primary Group at 2-Year Follow-Up.

Maldonado DR, Schab AR, Sikligar D et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purposes To compare minimum 2-year patient-reported outcomes measures (PROMs) between adolescents undergoing primary and revision hip arthroscopy. Methods Data were prospectively collected and retrospectively reviewed for adolescents who…

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Negative / Null Result ReportMedicine

Outcomes of Maximal Conventional Therapy Before Biological Treatment in Recurrent Chronic Rhinosinusitis With Nasal Polyps.

Topan YE, Bayar Muluk N, Yavuz R et al. · 2026 · The Journal of craniofacial surgery

Objective To determine whether biological therapy is a viable option for individuals with recurrent chronic rhinosinusitis with nasal polyps (CRSwNP), we will assess the clinical outcomes of maximal conventional therapy (MCT). Methods For…

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Negative / Null Result ReportMedicine

Eustachian Tube Balloon Dilation in Children: Prospective Clinical Outcomes of a Low-Cost Endovascular Balloon.

Hassan AM, Elgarem HF, Sheta E et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective Balloon dilation of the Eustachian tube (BDET) is increasingly used to treat pediatric obstructive Eustachian tube dysfunction (OETD); however, its broader adoption is limited by the cost of commercially available devices.…

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Negative / Null Result ReportMedicine

Maltodextrin as sucrose replacer: Effect of dextrose equivalence and sucrose/maltodextrin ratio on physical and sensory properties of non-fat whipped cream analogue

Yang J, Han Y · 2026 · Food Hydrocolloids.

The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…

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Negative / Null Result ReportMedicine

Efficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.

Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…

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Negative / Null Result ReportMedicine

Outcomes of secondary interventions in treatment of post-traumatic stiff shoulder in conservatively managed proximal humeral fractures: a scoping review.

Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science

Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…

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Negative / Null Result ReportMedicine

Postoperative syphilitic scleritis following strabismus surgery.

Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…

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Negative / Null Result ReportMedicine

Comparative Outcomes of the Modified Woodward Procedure Versus Conservative Management in Sprengel Deformity: A Retrospective Cohort Study.

Jia Y, Dong Y, Jiang R et al. · 2026 · Journal of pediatric orthopedics

Background Sprengel deformity is a rare congenital malformation of the scapula. To date, there have been limited reports analyzing the clinical outcomes of the modified Woodward procedure and conservative management in the treatment of…

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Negative / Null Result ReportMedicine

Fortitude as a Key to Reducing Burnout: Its Critical Role in Influencing the Relationship Between Organizational Support and Burnout.

Weinzimmer LG, Hippler SE · 2026 · Journal of healthcare management / American College of Healthcare Executives

Goal Burnout in healthcare remains a significant problem, with implications not only for physicians and advanced practice providers but also for the entire US healthcare system, including patients and payers. Significant work has been done…

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