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WASTE Journal

Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils.

Fereydouni S, Jabbari-Azad F, Bakhshaee M et al. · 2026 · Iranian journal of otorhinolaryngology

Introduction Chronic rhinosinusitis with nasal polyps is a heterogeneous inflammatory disorder often driven by type 2 inflammation. Identification of non-invasive biomarkers, such as fractional exhaled nitric oxide (FeNO), may support the…

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Negative / Null Result ReportMedicine

Associations Between Dynamic Quantitative Sensory Testing and Physical Therapy Outcomes in Chronic Low Back Pain: An Exploratory, Prospective Longitudinal Cohort Study.

Petrey K, Golden A, Durbin J et al. · 2026 · European journal of pain (London, England)

Background The primary objective of this study was to determine whether baseline conditioned pain modulation (CPM) is associated with pain and disability outcomes following a 6-week course of physical therapy intervention. Secondary…

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Negative / Null Result ReportMedicine

Different effect of aldosterone on corrected HCO<sub>3</sub><sup>-</sup> across primary aldosteronism subtypes.

Yasuda H, Yokota K, Katabami T et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Primary aldosteronism (PA) causes biochemical abnormalities such as hypokalemia and metabolic alkalosis. This study aimed to compare the effects of aldosterone on serum potassium and corrected bicarbonate (cHCO 3 - , defined as Na - Cl -…

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Negative / Null Result ReportMedicine

Axial length, anterior chamber parameters, and white-to-white corneal diameter: Their inter-correlations with intraocular pressure among young Saudis.

Alotaibi W, Alrasheed S · 2026 · JPMA. The Journal of the Pakistan Medical Association

Objective To evaluate axial length, anterior chamber angle, anterior chamber depth, refractive errors and white-to-white corneal diameter, and to assess their inter-correlations with intraocular pressure among young individuals. Methods…

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Negative / Null Result ReportMedicine

Correlation between blood biomarkers and patient-reported outcomes (PROs) of depression and mental health scores in individuals with multiple sclerosis (iwMS).

Baharnoori M, Glanz B, Polgar-Turcsanyi M et al. · 2026 · Journal of the neurological sciences

Background Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising biomarkers for Multiple Sclerosis (MS) disease activity. There is less known about their association with the symptomatic…

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Negative / Null Result ReportOpen accessMedicine

Positive correlation between IL-6 levels and lumbar bone mineral density in menopausal women diagnosed with osteoporosis in comparison to menopausal women without osteoporosis.

Alhosseini R, Aghaie M, Ghorbani S et al. · 2026 · BMC research notes

BACKGROUND: Osteoporosis is a common bone disorder characterized by decreased bone density. Interleukin-6 (IL-6), plays a crucial role in bone homeostasis. This study aimed to evaluate the relationship between serum levels of IL-6 and…

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Negative / Null Result ReportMedicine

Multiple sclerosis and related disorders multiple sclerosis across Isfahan Province, Iran: Urban-rural disparities and no association with air quality measures.

Etemadifar M, Bagheri S, Dehghani A et al. · 2026 · Multiple sclerosis and related disorders

Background Multiple sclerosis (MS) prevalence varies worldwide and appears to be rising in Iran. Environmental factors like air pollution have been hypothesized to contribute to MS risk. This study aimed to map MS prevalence across Isfahan…

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Negative / Null Result ReportMedicine

Association of Triglyceride-glucose Index and Obesity Metrics with Cardiovascular Disease Among U.S. Adults with Hyperlipidemia: Findings from the NHANES 2007-2016.

Lan P, Lan T · 2026 · Metabolic syndrome and related disorders

Background Hyperlipidemia constitutes a systemic metabolic disorder. The correlation of cardiovascular disease [CVD] with the triglyceride-glucose index [TyG] in individuals with hyperlipidemia remains unclear. The current study examined…

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Negative / Null Result ReportMedicine

Does Remodeling of Distal Femoral Extension Osteotomy Cause Recurrence of Knee Flexion Deformity in Children With Cerebral Palsy?

Gahukamble A, Arikrishnan AM, Thuppale VE et al. · 2026 · Journal of pediatric orthopedics

Background Distal femoral extension osteotomy (DFEO) is an established surgical option for correcting knee flexion deformity (KFD) in children with cerebral palsy. However, the extension deformity created at the distal femur may remodel…

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Replication FailureMedicine

Mean Platelet Volume Shows Distinct Patterns Between Mitral and Aortic Valve Replacement Patients but Does Not Predict Anticoagulation Quality in Mechanical Heart Valves.

Can V, Polat F, Kaya AF et al. · 2026 · Journal of cardiovascular pharmacology

Abstract Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This study evaluated whether mean…

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Negative / Null Result ReportMedicine

Phthalate esters and microplastics in sediments of Haomeiliao Wetland, Southwestern Taiwan: Occurrence, spatial distribution, and management implications.

Bandola AM, Wang MH, Guo BF et al. · 2026 · Marine pollution bulletin

Phthalate esters (PAEs) and microplastics (MPs) are emerging contaminants in aquatic environments. However, their co-occurrence in wetland sediments remains poorly understood. This study aimed to quantify PAE concentrations and MP…

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Negative / Null Result ReportMedicine

Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics.

Yokoyama S, Shimada M, Nakagawa J et al. · 2026 · European journal of drug metabolism and pharmacokinetics

Background and objective Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is transported into hepatocytes via OATP1B1, which is encoded by the SLCO1B1 gene. Although interindividual variability in vadadustat…

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Negative / Null Result ReportOpen accessMedicine

The role of Spexin and Phoenixin-20 in girls during puberty.

Koca SB, Kırkgöz T, Kara L et al. · 2026 · BMC endocrine disorders

BACKGROUND: Spexin has an inhibitory effect on the hypothalamus (GnRH expression), pituitary (LH and FSH expression) and ovary (estradiol expression). However, Phoenixin potentiate GnRH-stimulated GnRH receptor expression. Our aim is to…

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Negative / Null Result ReportMedicine

A structured teaching module for postoperative follow-up in urology residency training: development and evaluation of an IMDB-based educational tool.

Sun X, Zhou Q, Qian W et al. · 2026 · BMC medical education

Background Teaching postoperative follow-up for renal cell carcinoma (RCC) is challenging during brief urology rotations. We evaluated a structured module based on a simplified risk model (IMDB: venous invasion, tumor size ≥ 7 cm, systemic…

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Negative / Null Result ReportOpen accessMedicine

Are HDAC and Glutamine Synthetase Expression Levels Associated with Ga68-DOTATATE PET/CT Data and Prognosis in Gastroenteropancreatic Neuroendocrine Tumours?

Ulas O, Yuceer RO, Hasbek Z et al. · 2025 · Medicina (Kaunas, Lithuania)

Background and Objectives : Neuroendocrine neoplasms are heterogeneous tumours arising from endocrine gland cells and the neuroendocrine system. Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) constitute two-thirds of this tumour…

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Negative / Null Result ReportMedicine

Right ventricular systolic function in dogs with pulmonary hypertension can be assessed using tissue motion annular displacement.

Silva VBC, Lucina SB, Wolf M et al. · 2026 · American journal of veterinary research

Objective To assess right ventricular (RV) systolic function using conventional echocardiography and advanced techniques, including strain and tissue motion annular displacement (TMAD), in dogs with and without pulmonary hypertension (PH).…

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Negative / Null Result ReportMedicine

From Mother-Infant Dyad to Mother-Father-Infant Triad: A Cross-Sectional Study on Fathers' Breastfeeding Attitudes and Participation.

Çerçer Z, Biçer Şahin F, Kanarya T · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association

Background and aim It is important to include fathers in the evaluation of the breastfeeding process. This study aimed to assess fathers' breastfeeding attitudes and participation. Methods The cross-sectional study data were collected…

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Negative / Null Result ReportMedicine

Early postoperative corneal thickness and 12-month endothelial cell outcomes after descemet membrane endothelial keratoplasty: A multicentre analysis.

Igarashi A, Rekate A, Fujiwara K et al. · 2026 · Acta ophthalmologica

Purpose To evaluate whether early postoperative corneal thickness is associated with 12-month endothelial cell and visual outcomes after Descemet membrane endothelial keratoplasty (DMEK). Methods This retrospective multicentre study…

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