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WASTE Journal

Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

An In Vitro Investigation Into the Wear Effects of Lithium Disilicate, Zirconia, and Zirconia Reinforced Lithium Disilicate Ceramic Materials on an Opposing Material.

U'wais MY, Al-Wahadni A, Tabnjh AK · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective The aim of the present study was to evaluate the surface roughness and wear effect of three different ceramic materials. Materials and methods Thirty ceramic discs (10/group) were fabricated: Lithium disilicate (IPS e.max CAD,…

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Negative / Null Result ReportOpen accessMedicine

Prostaglandin E-major urinary metabolite as a potential biomarker of muscle inflammation following physical exercise, considering gender differences.

Okayasu I, Huang J, Fujita Z et al. · 2026 · Scientific reports

Prostaglandin E-major urinary metabolite (PGE-MUM) may be a useful biomarker for assessing muscle inflammation caused by physical exercise. To explore this, both male and female volunteer university students (n = 18) performed gradual…

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Negative / Null Result ReportOpen accessMedicine

Context-Dependent Association Between Serum 25-Hydroxyvitamin D and Romosozumab Bone Mineral Density Response: A Stratified Analysis by Renal Function Category and Prior Treatment History in a Real-World Japanese Cohort.

Nakano R, Ichisawa A, Saruta K et al. · 2026 · Nutrients

Background/Objectives: Serum 25-hydroxyvitamin D (25OHD) is a key determinant of calcium-phosphorus homeostasis and bone metabolism; however, its role as a modifier of the bone mineral density (BMD) response to romosozumab, a dual-action…

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Negative / Null Result ReportMedicine

Investigating the relationship between the difference in gingival color and denture base color on patient satisfaction with complete dentures.

Amini-Pozveh M, Nazarifar AM, Karimipoor M et al. · 2026 · BMC oral health

Background Patient satisfaction with complete dentures is multifactorial, with aesthetics being a key determinant. The color match between the denture base and the patient's natural gingiva is a critical aspect of denture aesthetics;…

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Negative / Null Result ReportOpen accessMedicine

Value of Blood Count-Derived Inflammatory Markers for Evaluating Psoriasis Severity: Pilot Cross-Sectional Observational Study.

Wang L, Zhang X, Xia C et al. · 2026 · Interactive journal of medical research

Background Objective indicators are urgently needed to evaluate and monitor disease progression in patients with psoriasis. Objective This study aimed to verify the correlations between blood count-derived inflammatory markers and the…

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Negative / Null Result ReportOpen accessMedicine

McArdle Disease (Glycogen Storage Disease Type 5)

Lam JR, Anastasopoulou C, Khattak ZE et al. · 2026

McArdle disease, also known as glycogen storage disorder (GSD) type 5, is a rare inherited metabolic disorder primarily affecting skeletal muscles. This condition arises from a deficiency or complete lack of the enzyme muscle glycogen…

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Negative / Null Result ReportOpen accessMedicine

Acoustic Radiation Force Impulse (ARFI) Elastography as a diagnostic and monitoring tool for Bell's palsy: A Prospective Study.

Toprak M, Toprak N, Oncu MR et al. · 2026 · Journal of musculoskeletal & neuronal interactions

Objective To evaluate ARFI elastography as a diagnostic and monitoring tool in Bell's palsy by comparing affected and unaffected facial muscles, pre- and post-treatment. Methods Thirty patients with Bell's palsy (17 females and 13 males,…

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Negative / Null Result ReportMedicine

Femoral component internal rotation in functionally aligned robotic-assisted total knee arthroplasty does not impair functional outcomes.

Philpott A, Lambers A, Lee S et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Femoral component internal rotation tightens the medial flexion gap and medialises femoral trochlea position, thus influencing patellofemoral tracking and function. Therefore, one of the tenets of mechanically aligned total knee…

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Negative / Null Result ReportMedicine

Evaluating the Respiratory Muscle Function in Patients with Cleft Lip and Palate: Maximal Inspiratory and Expiratory Pressure Analysis.

Venkatasamy NS, Ayub II, Kailasam V et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo evaluate the respiratory muscle strength in patients with cleft lip and palate (CLP) and correlate with airway dimensions.DesignCross-sectional.SettingThe study was conducted at a Sri Ramachandra Dental College and hospital in…

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Negative / Null Result ReportMedicine

Occupational noise exposure and thyroid health: The role of oxidative stress and PI3K/AKT/Foxo3 signaling.

Mohammed RS, Ramadan MA, Abdelgwad MM et al. · 2026 · Journal of occupational and environmental medicine

Objectives The study investigated thyroid function, oxidative stress and PI3K/AKT/FoxO3 pathway in employees occupationally exposed to a noise. Methods Environmental noise levels were measured along with assessment of Serum levels of T3,…

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Negative / Null Result ReportMedicine

Assessment of Lobule Thickness and Nasal Skin Thickness in Rhinoplasty: Is Lobule Thickness a Good Indicator for Estimating Nasal Skin Thickness?

Konukçu-Kayar B, Karaalioğlu B, Demir B et al. · 2026 · The Journal of craniofacial surgery

Nasal skin thickness is a key determinant of surgical planning, postoperative healing, and aesthetic outcomes in rhinoplasty (RNP). However, objective assessment of nasal skin thickness is not always feasible in routine clinical practice.…

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Negative / Null Result ReportOpen accessMedicine

No Evidence of Association Between Human 24-Hour Urinary Dopamine and Weight, BMI or Glucose Homeostasis in a Retrospective Analysis.

Mattelaer N, David S, Steenackers N et al. · 2026 · International journal of endocrinology and metabolism

Background Dopamine is an essential neurotransmitter involved in motivation and reward. In obesity, altered dopaminergic responses to food may drive excess energy intake, implicating dopamine in the pathophysiology of obesity.…

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Negative / Null Result ReportMedicine

Relationship between hamstring flexibility (askling H-test) and isokinetic strength ratios in elite soccer players with prior hamstring strain injury: A cross-sectional study.

Takla MKN, Rageh MRM, Aboalata MAM et al. · 2026 · Journal of back and musculoskeletal rehabilitation

BackgroundRecurrent hamstring strain injuries are associated with deficits in eccentric strength and altered muscle-tendon extensibility, which may persist and contribute to reinjury risk.ObjectiveTo examine the relationship between…

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Negative / Null Result ReportOpen accessMedicine

Correlation Between Baseline Serum Testosterone Levels and Cognitive Gain Following Combined Oral Contraceptive Treatment in Patients With Polycystic Ovary Syndrome.

Kumari S, Marwah S, Manna S et al. · 2026 · Cureus

Background Combined oral contraceptives (COCs) are the cornerstone therapy for polycystic ovary syndrome (PCOS). While COCs have been shown to improve cognitive performance, the relationship between these gains and hormonal profiles,…

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Negative / Null Result ReportMedicine

A Comparative Analysis of Differences in Salivary hBD-2 Levels and Their Correlation with Dental Caries and Unstimulated Saliva pH in Children with Primary and Permanent Dentition.

Stojković B, Igić M, Jevtović Stoimenov T et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This exploratory study aimed to investigate potential differences and associations between salivary hBD-2 levels and dental caries, as well as between unstimulated salivary pH and salivary hBD-2 levels, in children…

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