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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Direct and indirect assessment: comparison of different methods to estimate staff equivalent dose to the lens during different interventional procedures.

Fedeli L, Magistrelli A, Vaiano A et al. · 2026 · Journal of radiological protection : official journal of the Society for Radiological Protection

The reduction of the annual equivalent dose limit to the lens of the eye from 150 to 20 mSv has increased the need for reliable assessment of occupational eye lens exposure, particularly in interventional radiology. Lens absorbed dose is…

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Negative / Null Result ReportMedicine

Immunohistochemical Assay Variability and Human Epidermal Growth Factor Receptor 2 (HER2)-Low Breast Cancer Detection: A Laboratory Comparison in the Netherlands.

Kain ZE, Schuurman E, Baez-Navarro X et al. · 2026 · Laboratory investigation; a journal of technical methods and pathology

Purpose HER2-low breast cancer has gained clinical relevance owing to the efficacy of trastuzumab deruxtecan. However, variability in detecting low HER2 expression may affect patient eligibility. This nationwide study in the Netherlands…

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Negative / Null Result ReportMedicine

Dynamic navigation system accuracy in orthodontic miniscrew insertion in the palatal vault: a prospective single-arm clinical study.

Brilli D, Giansanti M, Bertoldo S et al. · 2026 · International journal of computerized dentistry

Aim The aim of the present study was to evaluate the accuracy of dynamic navigation (DN) in miniscrew insertion in the palatal vault by comparing the deviation between planned and placed miniscrew positions. The secondary outcome was to…

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Negative / Null Result ReportOpen accessMedicine

Discordance in diagnostic assessment of Achilles tendon thickening between soft X-ray radiography and ultrasonography among patients with coronary artery disease.

Itagaki T, Ueki Y, Oyama Y et al. · 2026 · Scientific reports

Achilles tendon (AT) xanthomas are characteristic manifestations of familial hypercholesterolemia (FH). Although soft X-ray radiography (XR) and ultrasonography (US) are used to assess AT thickness, data comparing their diagnostic…

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Negative / Null Result ReportOpen accessMedicine

p53 Immunohistochemistry Expression in Epithelial Ovarian Tumors.

Madini S, Suresh TN, Kattepur AK · 2026 · Cureus

Introduction Epithelial ovarian carcinoma usually has TP53 expression. The TP53 gene is the most frequently mutated gene in ovarian cancer and therapies targeting these mutations may improve treatment outcomes, but there are only few…

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Negative / Null Result ReportMedicine

Pd-L1 Expression in Oral Cavity Squamous Cell Carcinomas.

Nalwa A, Visakhan A, Elhence PA et al. · 2026 · Indian journal of surgical oncology

Programmed cell death ligand-1 (PD-L1) is involved in T-cell regulation by acting as an immune checkpoint inhibitor, and its expression is being widely studied in various malignancies. The following study was designed to examine the role…

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Negative / Null Result ReportMedicine

Significant Correlation Between White Matter Hyperintensity Volume and Rare NOTCH3 Variants in the General Japanese Population.

Mizuta I, Yamashita F, Sutoh Y et al. · 2026 · Geriatrics & gerontology international

Aim Cerebral small vessel disease (CSVD)-related MRI findings, including white matter hyperintensities (WMHs), are not rare in general elderly populations. The aim of this study was to elucidate the contribution of hereditary CSVD-related…

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Negative / Null Result ReportMedicine

Chondrolabral junction pathology in Femoroacetabular Impingement Syndrome is underestimated by pre-operative MRI and have no significant correlation with baseline outcomes.

Samim M, Jardon M, Vonck C et al. · 2026 · Journal of orthopaedics

Purpose To assess correlation of pre-operative symptoms, labral damage and chondrolabral junction pathology on MRI with intra-operative findings in patients undergoing hip arthroscopy for femoroacetabular impingement (FAI). Methods…

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Negative / Null Result ReportOpen accessMedicine

Exploratory Analysis of the Neutrophil-to-Lymphocyte Ratio (NLR) and Mucositis Severity in Head and Neck Cancer Patients Undergoing Radiotherapy-Based Treatment: A Retrospective Study.

Santo B, Romanello M, De Franco P et al. · 2026 · Journal of clinical medicine

Background/Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker reflecting systemic inflammatory status and has been investigated in head and neck cancer (HNC) as a potential prognostic indicator. Its role in relation…

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Negative / Null Result ReportMedicine

Influence of vertical X-ray beam angulation and receptor-holders on the radiographic detection of implant abutment-prosthesis misfit.

Alves TG, Bonadiman EA, Ruiz DC et al. · 2026 · The Journal of prosthetic dentistry

Statement of problem Periapical radiographs have been the primary adjunctive diagnostic method of evaluating abutment-prosthesis misfit. However, whether different radiographic receptor‑holders interfere with diagnostic accuracy depending…

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Negative / Null Result ReportOpen accessMedicine

Heterotopic Ossification Following Total Elbow Arthroplasty in Geriatric Distal Humerus Fractures: A Retrospective Cohort Study.

Merritt C, Zackula R, Bollinger A · 2026 · Kansas journal of medicine

Introduction The purposes of this study were to determine (1) whether delay to total elbow arthroplasty (TEA) after traumatic distal humerus fracture affects heterotopic ossification (HO) formation and (2) whether HO is associated with…

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Negative / Null Result ReportOpen accessMedicine

AI-Assisted UBM versus Conventional Sizing Approaches for ICL Implantation: A Retrospective Analysis of Vault Outcomes.

Ang RET, Glipo CER, Martinez GHA et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Introduction To compare the effectiveness of an ultrasound biomicroscopy (UBM)-based nomogram with a white-to-white (WTW) nomogram in predicting postoperative vault in myopic patients undergoing implantable collamer lens (ICL)…

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Negative / Null Result ReportMedicine

Knowledge, attitude, and practice of family physicians about quaternary prevention and related factors in Southeastern Iran: a cross-sectional study.

Mongolian Shahrbabaki P, Hesamarefi F, Safizadeh H · 2026 · BMC primary care

Background and objectives Quaternary prevention is a new concept of prevention whose main objective is to prevent harms that unnecessary medical services can cause to patients. Family physicians, as gatekeepers of the healthcare system,…

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Negative / Null Result ReportMedicine

Clinical significance of diastolic wall strain in heart failure with preserved ejection fraction: A cross-sectional observational analysis.

Krishnamurthy P, Gnanaraj JP, Ganesan P · 2026 · JRSM cardiovascular disease

Background Diastolic wall strain (DWS) is based on linear elastic theory, which shows that impaired diastolic wall thinning reflects resistance to deformation in diastole and thus, increased diastolic myocardial stiffness. We aim to…

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Negative / Null Result ReportMedicine

Correlation Between the Severity of Low Back Pain and Sitting Posture Parameters Among Female Bharatanatyam Dancers.

Satishkumar SD, Meganathan S · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Background and purpose Bharatanatyam, a venerable and highly structured classical dance form from India, requires significant physical strength, postural control, and precise movements. Dancers often begin to training during adolescence, a…

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