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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Medication reminder use and medication adherence among patients with chronic conditions in a Malaysian teaching hospital.

Md Kasim NA, Shirinal Izuan US, Karuppannan M · 2026 · BMC health services research

BACKGROUND: Healthcare providers commonly recommend medication reminders as a strategy to enhance adherence to prescribed medications. Patient demographic characteristics may influence medication adherence and incorporating patient-centred…

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Negative / Null Result ReportOpen accessMedicine

Tracheotomy Before Total Laryngectomy as a Risk Factor for Stoma Recurrence.

Prates AJ, Curioni OA, Ramos DM et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: Laryngeal cancer has a high incidence and mortality rate, especially in advanced stages. Stoma recurrence after total laryngectomy is rare but lethal, and its risk factors remain controversial. We aimed to assess…

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Negative / Null Result ReportMedicine

Periaortic inflammation after endoleak repair: a risk to watch.

Voigt MB, Böhner A, Bahaaeldin M et al. · 2026 · CVIR endovascular

To evaluate the occurrence of periaortic inflammation, including abscess formation, as a complication following endoleak repair after endovascular aortic repair. This retrospective single-center study analyzed 88 EVAR revisions for…

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Negative / Null Result ReportOpen accessMedicine

Association between Serum Vitamin D Levels and <i>VDR</i> <i>BsmI</i> Polymorphism in Temporomandibular Joint Dysfunction Patients (in the Iranian Population).

Mostafavi M, Rezazadeh F, Fattahi MJ et al. · 2026 · Journal of dentistry (Shiraz, Iran)

Background Multiple studies have revealed an association between vitamin D levels, genetic polymorphisms of the VDR (vitamin D receptor) gene, and the underlying causes of various bone and cartilage disorders. Purpose This study aimed to…

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Negative / Null Result ReportMedicine

The risk of type 1 diabetes mellitus after COVID-19 and influenza infection: A nationwide cohort and self-controlled case series study.

Ozaki K, Nishioka Y, Kamitani F et al. · 2026 · Diabetes research and clinical practice

It has been controversial whether COVID-19 increases the risk of new-onset type 1 diabetes mellitus. Using large-scale claims data, we found no statistically significant association between COVID-19 and incident type 1 diabetes mellitus in…

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Negative / Null Result ReportOpen accessMedicine

The association of pathological findings in HPV-31 positive women with high-grade squamous intraepithelial lesions.

Buran A, Altaş H, Özkaya Uçar Y et al. · 2026 · Journal of the Turkish German Gynecological Association

Objective To evaluate pathological findings in patients positive for human papillomavirus (HPV)-31. Material and methods This retrospective study included patients evaluated in a tertiary colposcopy clinic. The 3,546 patients tested for…

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Negative / Null Result ReportOpen accessMedicine

A high rate of falls and traumatic fractures occurs after extensor mechanism reconstruction: a cohort study including both allograft and synthetic mesh grafts.

Braun S, Selkridge I, Nocon A et al. · 2026 · Arthroplasty (London, England)

Background Extensor mechanism disruption following total knee arthroplasty (TKA) significantly impairs knee function and quality of life. Extensor mechanism reconstruction (EMR) is effective but carries risks, including post-operative…

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Negative / Null Result ReportMedicine

rs6897932 (C>T) and rs987106 (A>T) variants in the <i>IL7RA</i> gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus.

Sarpeleh F, Ehtesham N, Mirjani R et al. · 2026 · Lupus

ObjectiveThe dysfunction of interleukin-7 receptor alpha (IL-7Rα), which is encoded by the IL7RA gene, has been implicated in the development of systemic lupus erythematosus (SLE). This study aimed to investigate the relationship between…

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Negative / Null Result ReportOpen accessMedicine

Impact of weekend admission on in-hospital mortality in chronic kidney disease: a nationwide analysis of 184 299 hospitalisations in Poland (2017-2021).

Mazurek A, Jankowski M, Grudziąż-Sękowska J · 2026 · BMC nephrology

BACKGROUND: The weekend effect refers to the observation that patients admitted to the hospital on the weekend experience poorer clinical outcomes than patients admitted during the workweek. This effect has not been previously studied…

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Negative / Null Result ReportOpen accessMedicine

Plantar Heel Pain Is Not Associated With Fatty Infiltration of the Abductor Digiti Minimi Muscle on Magnetic Resonance Imaging: A Cross-Sectional Observational Study.

Chen JSC, Osborne JWA, Menz HB et al. · 2026 · Journal of foot and ankle research

Background Fatty infiltration, or fatty atrophy, of the abductor digiti minimi (ADM) muscle of the foot is proposed to be associated with entrapment of the first branch of the lateral plantar nerve (i.e., Baxter's neuropathy) as part of…

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Negative / Null Result ReportMedicine

Relationship between <i>APOE</i> Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy.

Vejdani-Jahromi M, Calle E, Ganem O et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Alzheimer disease (AD) is a progressive neurodegenerative disorder that predominantly affects the aging population. Anti-amyloid β (anti-Aβ) therapies, such as lecanemab, have been developed to slow disease…

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Negative / Null Result ReportOpen accessMedicine

Intubation exposure associated with first-pass success - understanding practitioner-related characteristics in South African EMS.

Brown J, Abdullah N, Sobuwa S · 2026 · International journal of emergency medicine

BACKGROUND: Endotracheal intubation is a critical life-saving intervention in prehospital emergency care, yet evidence supporting its safe implementation by prehospital practitioners in lower- to middle-income countries remains limited.…

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Negative / Null Result ReportOpen accessMedicine

Associations of physical fitness with sleep quality and anxiety Among university students: a cross-sectional regression analysis.

Xu G, Li X, Song G et al. · 2026 · Frontiers in sports and active living

Background Poor sleep quality and anxiety are prevalent among university students and pose growing public health concerns. Physical fitness is often assumed to be associated with better sleep and mental health outcomes; however, evidence…

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Negative / Null Result ReportMedicine

Changes in myeloid-derived suppressor cells and cytokine expression during mother-to-child transmission prevention in HBeAg-positive pregnant women with chronic hepatitis B.

Pan S, Xiao L, Li Y et al. · 2026 · BMC infectious diseases

Objective The objective of this study was to investigate the changes of Myeloid-derived suppressor cells (MDSCs) and cytokines expression during mother-to-child blockade in chronic HBV infected patients. Method This was a single-center,…

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Negative / Null Result ReportMedicine

The diameter of malformation capillaries does not influence the efficacy of photodynamic therapy for facial port-wine stains: a pilot study.

Hao L, Ju W, Huang Y · 2026 · The Journal of dermatological treatment

Background Photodynamic therapy (PDT) is an effective treatment for port-wine stains (PWS). However, the relationship between the diameter of malformed capillaries and the efficacy of PDT in PWS has been rarely studied. Objective This…

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Negative / Null Result ReportMedicine

Emotion Perception in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease: The Parahippocampal Conundrum.

Morais RF, Duro D, Pires R et al. · 2026 · Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Background Emotion perception is the capacity that enables humans to correctly identify the cues that guide interpersonal interactions, forming the basis for social behavior. The parahippocampal cortex may contribute to emotion perception…

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Negative / Null Result ReportOpen accessMedicine

Changes in Upper Airway Anatomy and Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea Undergoing Bariatric Surgery: A Pilot Study.

Nithya M, Titiyal R, Ajayababu A et al. · 2026 · Journal of clinical medicine

Background: Obstructive sleep apnea (OSA) is common in individuals with obesity, largely due to increased soft tissue causing upper airway narrowing. However, mechanisms of OSA improvement following weight loss are incompletely understood,…

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