12,263 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Karabulut Ü, Yolaçan R, Ebik B et al. · 2026 · BMC gastroenterology
Background Duodenogastric reflux (DGR), defined as the retrograde flow of duodenal contents into the stomach, has an incompletely understood pathophysiology. This study aimed to evaluate the relationship between DGR and clinical,…
View details →Maher AA, Maad AH, Al-Jaufy AY et al. · 2026 · Frontiers in medicine
Background Burn wound infections (BWIs) represent a major cause of morbidity and mortality among hospitalized burn patients. Pseudomonas aeruginosa is recognized for its ability to acquire multidrug resistance (MDR) and form biofilms that…
View details →Böckels L, Lisnic V, Alexa D et al. · 2026 · Journal of clinical medicine
Background/Objectives: Relapsing-remitting multiple sclerosis (RRMS) is frequently associated with anxiety and depressive symptoms, which significantly impact quality of life and clinical outcomes. The Hospital Anxiety and Depression Scale…
View details →Shimada H, Lee S, Doi T et al. · 2026 · Gerontology
Introduction Walking speed is widely recognized as an informative indicator of physical capability in later life and is frequently used to evaluate mobility and functional health in older adults. Although the measurement of community…
View details →Rosi Júnior J, Telles JPM, Santana LS et al. · 2026 · Arquivos de neuro-psiquiatria
Background Alpha 1-antitrypsin (A1AT) helps maintain vascular-wall integrity, but its role in the formation and rupture of intracranial aneurysms is unclear. Objective To compare A1AT levels between patients with ruptured and unruptured…
View details →Kavrul Kayaalp G, Balcı MC, Kürkçü Güneş D et al. · 2026 · Cardiology in the young
Background Early identification of familial hypercholesterolaemia is critical to prevent long-term cardiovascular complications. This study assessed diagnostic features and age at diagnosis in children with familial hypercholesterolaemia…
View details →Shinkawa K, Yoshida S, Nakao YM et al. · 2026 · Clinical and experimental nephrology
Introduction The clinical characteristics of patients with nephrotic syndrome undergoing in-hospital rehabilitation are not well-understood, and the effects of exercise on acute kidney injury (AKI) or venous thromboembolism (VTE) in this…
View details →Kim T, Oh SB, Choi HJ et al. · 2025 · Genes
Objective Suicide attempts have become one of the most serious problems worldwide in recent years. Suicide attempts are known to be genetically highly associated with serotonin and BDNF in international studies. Methods In this study, we…
View details →Devi Krishna RB, Mathews SG, Agarwal P et al. · 2026 · Biochemical genetics
To assess the potential association between LRP1 (rs715948) and PAI1 (rs2227631, rs1799889) gene variation and ovarian cancer (OC) susceptibility. This study evaluated the genotypic and allelic distributions of LRP1 gene and PAI1 gene…
View details →Majmudar IP, Aggarwal S, Hamzeh N et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
Purpose To determine if there is an association between surgeon-patient sex concordance and post-surgical complications for cataract surgeries. Patients and methods In this 16-year retrospective cohort study, data was collected from the…
View details →Foo JF, Haddow K, Jones S et al. · 2026 · The Journal of laryngology and otology
Objectives To investigate whether socioeconomic deprivation is associated with residual or recurrent cholesteatoma following primary mastoidectomy. Methods A retrospective cohort study included all patients undergoing primary mastoidectomy…
View details →Peng P, Guo Y, Zhu Y · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Background Given that long-term anticoagulant therapy is required in many clinical scenarios, continuous safety monitoring of direct factor Xa inhibitors is of great importance. To date, the renal safety of these agents remains a subject…
View details →Zhai L, Fang C, Wang L et al. · 2026 · Scientific reports
There is little evidence about the susceptible exposure window of maternal depression during pregnancy and preterm birth in China. We aimed to assess the trimester-specific association of depression during pregnancy with preterm birth, and…
View details →Metwally YF, Zahran RF, El Sadda RR et al. · 2026 · Discover oncology
Background Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are diagnosed at advanced stages. Genetic variants such as single nucleotide polymorphisms…
View details →Aryal SB, Raj Joshi D · 2026 · Journal of Nepal Health Research Council
Background Homocysteine (Hcy) contributes to oxidative stress and renal injury by generating reactive oxygen species and reducing heme oxygenase-1 levels. Elevated Hcy (Hhcy) may worsen outcomes after acute renal failure(ARF), promoting…
View details →Bellos I, Marinaki S, Benetou V · 2026 · Journal of clinical medicine
Background/Objectives : Composite endpoints are commonly used in chronic kidney disease (CKD) trials to enhance statistical efficiency but may not reflect clinically meaningful outcomes. We assessed agreement between composite endpoints…
View details →Pires E Silva C, Malaspina OA, Basting RT · 2026 · General dentistry
Light transmission during photopolymerization is reduced by the intrinsic optical properties of ceramics, which vary with material and thickness. The higher translucency of lithium disilicate contrasts with the chemical inertness and…
View details →Hakim MS, Hashimi MH, Saeed KM et al. · 2026 · Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
Background Viral hepatitis and HIV infections are common public health concerns among injecting drug users, however, there is limited evidence on their seroprevalence in Afghanistan. Aim To determine the seroprevalence of hepatitis B,…
View details →Popovic R, Cvitanovic S, Sarac I et al. · 2026 · Cureus
Objective To assess parents' knowledge of recommended oral-hygiene practices for children and to describe oral-hygiene behaviors within families (parents and children), as well as factors associated with children's oral-hygiene outcomes.…
View details →Famuyide L, Patel J, Nembhard WN · 2026 · Birth defects research
Background Hypospadias is one of the most common genital defects in boys, affecting about 1 in 125 live-born boys. Several studies have examined the association between a single environmental exposure and risk of hypospadias, but few have…
View details →Ye B, Liu Y, Zhang J et al. · 2026 · Frontiers in nutrition
Background To investigate the associations between consumption of sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and natural juices (NJs) and incident kidney stone disease (KSD), and to assess whether genetic…
View details →Kılıç A, Koçak Ulucaköy R, Osmanov Z et al. · 2026 · Biomarkers in medicine
Objective Biomarkers that accurately reflect disease activity and inflammatory burden are needed, particularly in the early stages of spondyloarthropathy (SpA). This study aimed to evaluate the association between serum neopterin levels…
View details →Sussadee M, Jarudecha T, Muikaew R et al. · 2026 · Animals : an open access journal from MDPI
Feline hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats, causing morbidity and mortality. Recently, a variant in the Alström syndrome protein 1 ( ALMS1 ) gene has been reported to be associated with HCM in…
View details →Choi SJ · 2026 · BMC public health
Background Walking is a widely accessible form of physical activity and has been consistently associated with improved health-related quality of life (HRQoL) at the individual level. However, less is known about how walking participation…
View details →McCaw K, Fink B, Danis D et al. · 2026 · American journal of veterinary research
Objective To compare the accuracy of a tibial plateau-leveling osteotomy (TPLO) using a modular guide (OssAbility) compared to the traditional freehand method. We hypothesized that guide use would improve TPLO centering and accuracy in the…
View details →Gaba K, Kumar K, Kaushik R et al. · 2026 · Cureus
Background The use of post-mortem blood culture as a diagnostic tool in medico-legal autopsies is limited. Differentiating true infection from contamination or post-mortem bacterial translocation remains a challenge. This study aimed to…
View details →Chaudhry A, Moin M, Malik TG et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association
To determine the shape and size of foveal avascular zone in terms of perimeter, circularity, roundness and axial ratio using optical coherence tomography angiography. The retrospective study was conducted at the Yaqeen Vison Clinic,…
View details →He L, Wang K · 2026 · Medicine
Total bilirubin possesses antioxidant and immunomodulatory properties, and its role in childhood asthma is a topic of ongoing debate. We employed both a cross-sectional study and Mendelian randomization (MR) analysis to explore the link…
View details →Wei W, Shaibi GQ, Temkit H et al. · 2026 · Journal of pediatric hematology/oncology
Introduction Alkylators are gonadotoxic in a cumulative manner, with overall exposure quantified as the cyclophosphamide equivalent dose (CED). Inhibin B is used as a surrogate marker of fertility in adult male childhood cancer survivors…
View details →Barghash M, Obayi E, Itaman U et al. · 2025 · Cureus
Background Hiatal hernia is commonly associated with gastro-oesophageal reflux disease (GORD). However, the relationship between hernia size and reflux severity remains unclear. This study aimed to assess the impact of the hiatal hernia…
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