Negative / Null Result ReportOpen accessMedicine
Noura A. Almadhi, Ayman M. Sulimany, Hamad A. Alzoman et al. · 2021 · Saudi Dental Journal
Objective: To evaluate parents’ knowledge about halitosis, and to compare parents’ perception of halitosis in their children to the presence of halitosis clinically. Methods: Children between 3 and 8 years attended to Dental University Hospital, King Saud University, were screened. Children satisfying inclusion criteria and their parents agreed to participate were included. Questionnaires regarding parents’ knowledge and perception about halitosis in their children were filled by attending parents. Then, the assessment of halitosis in the participating children carried out by portable gas chro
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Patil PB, Chougule PG, Kamat SB et al. · 2026 · Journal of conservative dentistry and endodontics
Aim The aim of this in vitro study was to evaluate the effect of antacid syrup on surface roughness and microhardness of composites. Materials and methods Two different composite resin materials, Nanofilled and Suprananofilled were used.…
View details →Negative / Null Result ReportOpen accessMedicine
Piyusha Milani Atapattu, Chemindra Biyanwila, Manamalabaduge Upul Jerard Fernando · 2017 · American Journal of Experimental and Clinical Research
Chest radiographs are widely available, even in most hospitals in developing countries, and can detect a variety of lung pathologies. When adults are admitted to hospital with acute asthma, chest radiographs are often obtained. Studies on the usefulness of chest radiographs in acute asthma have shown varying results. This study aimed at evaluating the usefulness of chest radiographs in the management of acute asthma in adult asthmatics in a developing country. Plain chest radiographs performed within 24 hours of admission in 115 consecutive adult asthmatic patients (asthma defined by Asthma Ed
View details →Negative / Null Result ReportOpen accessMedicine
Hawra Al-Ghafli, Bright Varghese, Mushira Enani et al. · 2019 · PLoS ONE
Despite low infectious potential of extrapulmonary tuberculosis (EPTB), it poses significant clinical challenges in terms of diagnosis and treatment monitoring. Understanding the main demographical risk factors for disease characteristics of EPTB plays a crucial role in speeding up diagnosis process and improving overall clinical experience. The aim of this study was to investigate the main demographical and clinical risk factors for EPTB among adults and adolescents for the first time in Saudi Arabia. A cross-sectional multicenter study was carried out on a collection of 902 extrapulmonary My
View details →Negative / Null Result ReportOpen accessMedicine
Martin Söderholm, Yan Borné, Bo Hedblad et al. · 2015 · PLoS ONE
Increased red cell distribution width (RDW) has been related to poor prognosis in patients with cardiovascular disease, and is a predictor of cardiovascular mortality in the general population. The purpose of the present study was to investigate if RDW is associated with increased incidence of stroke and its subtypes in individuals from the general population.Red cell distribution width was measured in 26,879 participants (16,561 women and 10,318 men aged 45-73 years) without history of coronary events or stroke, from the population-based Malmö Diet and Cancer Study. Incidences of total stroke
View details →Negative / Null Result ReportMedicine
Lauer, Leng, Chembe et al. · 2026 · The British journal of nutrition
Small-quantity lipid-based nutrient supplements (SQ-LNS) have been shown to improve growth, development, and survival among young children in low-resource settings. One hypothesized pathway is through improvements in intestinal health,…
View details →Negative / Null Result ReportOpen accessMedicine
Marjolein M Iversen, Giesje Nefs, Grethe S Tell et al. · 2016 · PLoS ONE
Aim To examine whether elevated anxiety and/or depressive symptoms are related to all-cause mortality in people with Type 2 diabetes, not using insulin. Methods 948 participants in the community-wide Nord-Trøndelag Health Survey conducted during 1995-97 completed the Hospital Anxiety and Depression Scale with subscales of anxiety (HADS-A) and depression (HADS-D). Elevated symptoms were defined as HADS-A or HADS-D ≥8. Participants with type 2 diabetes, not using insulin, were followed until November 21, 2012 or death. Cox regression analyses were used to estimate associations between baseline e
View details →Negative / Null Result ReportMedicine
Stokbro, Liebregts, Baan et al. · 2026 · Scientific reports
The aim of this study was to evaluate the influences of surgical sequencing on the postoperative occlusion in bimaxillary osteotomies. Patients who underwent bimaxillary surgery without maxillary segmentation, based on a virtual surgical…
View details →Negative / Null Result ReportOpen accessMedicine
Fauziyyah Ramadhani, Mohammad Ghozali, Leni Lismayanti · 2018 · Global Medical & Health Communication
Dengue hemorrhagic fever (DHF) is still the leading cause of hospitalization and death among children in Indonesia because of plasma leakage leading to shock syndromes. This study aimed to associate the hematocrit difference (first and second) from serial hematocrit (Hct) examination just after admission with DHF severity. A analytical cross-sectional study was involving medical records of pediatric patients with DHF admitted at the pediatric ward and the Pediatric Intensive Care Unit (PICU) of Dr. Hasan Sadikin General Hospital, Bandung in January–December 2015. The subjects excluded if other
View details →Negative / Null Result ReportOpen accessMedicine
Tamás Sebestyén, Zita Iloskics · 2020 · PLoS ONE
The spread of economic shocks in an increasingly interconnected global economy has been subject to several studies recently. These studies mostly focus on the synchronization of business cycles among economies and search for the relationship between trade linkages and shock contagion. In contrast to previous studies in the field, this paper focuses on the topological properties of the shock contagion network as measured by pairwise Granger causality between economic output of countries. This topological approach can bring new insights into the dynamics of contagion and the relationship between
View details →Negative / Null Result ReportOpen accessMedicine
Paschalina C Ezechukwu, Emmanuel O Ugwu, Samuel N Obi et al. · 2023 · International Journal of Medicine and Health Development
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in Nigeria and worldwide. It is not yet concluded as to whether or not elevated levels of serum creatinine and/or uric acid could be regarded as a predictive indicator for the severity of the disease. Objectives: To compare the mean serum levels of uric acid and creatinine in preeclamptic and normotensive pregnant women and assess for any associations between these renal biomarkers and the severity of preeclampsia in Nigeria. Materials and Methods: It was a cross-sectional analytical study o
View details →Negative / Null Result ReportOpen accessMedicine
Kibum Kim, Linda Kaitlyn Craft · 2022 · BMJ Open
Objective Non-invasive prenatal testing (NIPT) is a front-line screening for fatal chromosomal aneuploidy. In pregnant women with a risk of having fetal congenital disorders, NIPT is anticipated to reduce the needs of invasive prenatal diagnostic test (IPD). The objective of this study was to understand the acceptance of NIPT and the utility of NIPT to mitigate concerns about IPD in the US high-risk pregnancy management.Design and setting This was a retrospective observational research using healthcare records obtained from an academic healthcare system in the US. The study consisted of site-l
View details →Negative / Null Result ReportOpen accessMedicine
Haure Osman Muhammad Hamadamin, Samir Mahmood Othman · 2026 · Zanco Journal of Medical Sciences
Background and objective: Obesity is a chronic, multifactorial condition characterized by an excessive accumulation of body fat that presents significant health risks. Community pharmacists, for instance, are highly accessible and often serve as the first point of contact for patients seeking advice on weight management. This study aims to fill a research gap by evaluating community pharmacists’ knowledge, attitudes, and practices related to obesity and weight management. Methods: A cross-sectional study was carried out among 331 community pharmacists among different pharmacy settings in Erbil
View details →Negative / Null Result ReportOpen accessMedicine
Michinobu Umakoshi, Akiko Nakamura, Hiroyuki Tsuchie et al. · 2023 · Scientific Reports
Abstract Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important for clarifying pathophysiology. Here, we examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas to increase our knowledge about the pathophysiology. Seventy-five sarcoma specimens (not limited to a single histological type), resected at our institution, were collected, and the number of CD68-, CD163-, and CD204-posit
View details →Negative / Null Result ReportOpen accessMedicine
N Bushra Thasneem, Resmi S. Kaimal, Abdul Hakeem Thengu Murichathil · 2025 · Journal of Family Medicine and Primary Care
Introduction: Anaemia is one of the significant public health problems faced by developing countries. It occurs more frequently in women of childbearing age. Anaemia causes poor work capacity, and severe forms may even cause cardiac failure. In pregnant women, anaemia may lead to preterm labour, low-birth-weight babies, and increased risk of maternal mortality due to post-partum haemorrhage. Even though there are national programmes to supply iron free of cost and other measures to tackle anaemia, it is still prevalent in our country. Anaemia prevalence has increased between NFHS-4 and NFHS-5,
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Esmee M. Breddels, Johanna Simin, Romina Fornes et al. · 2022 · BMC Medicine
Abstract Background Approximately half of all women suffer from heartburn at some stage during pregnancy. The most effective treatment is proton pump inhibitors, but the safety of use during pregnancy cannot be guaranteed. This study aimed to elucidate the effect of proton pump inhibitors on the risk of pre-eclampsia, gestational diabetes mellitus, preterm birth, an Apgar score at 5 min below 7, and a child being small or large for its gestational age. Methods This Swedish population-based study included 1,089,514 live singleton deliveries between July 2006 and December 2016 in Sweden. Multipl
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Muhammad Hussain Iqbal, Tanveer Hussain, Fariha Khalid et al. · 2020 · Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of diastasis recti abdominis and its associated risk factors in postpartum women. Study Design: Cross-sectional study. Place and Duration of Study: Omar Medical Center Lahore, Yaseen Medical Center Lahore and Social Security Hospital Lahore, from Sep 2019 to Dec 2019. Methodology: This study included 128 participants fulfilling the eligibility criteria. The assessment of diastasis recti abdominis was done manually by a female physiotherapist using single finger, double finger and three finger methods on abdomen at three levels: at the umbilicus, 4.5 cm bel
View details →Short NoteOpen accessMedicine
Camelia C. Diaconu · 2019 · Archives of the Balkan Medical Union
Oxidative stress is involved in the pathophysiology of many chronic diseases, including heart failure. Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense. The overproduction of ROS can lead to cellular damage and eventually cellular death. This applies also in patients with chronic heart failure, who present a dramatic increase of oxidative stress associated with a pronounced decrease of the antioxidant defense mechanisms. The components of the antioxidant defense mechanism of myocardial cells are superoxide dismutase (SOD), cat
View details →Failed Experiment ReportMedicine
Lertwiram P, Fuangfa P, Kijkunasathian C et al. · 2026 · Scientific reports
Arthroscopic rotator cuff repair (ARCR) generally improves clinical outcomes, but the impact of pre-existing glenohumeral osteoarthritis (GHOA) severity on these outcomes remains unclear. This study aims to evaluate the correlation between…
View details →Negative / Null Result ReportMedicine
Li L, You C, Yan X et al. · 2026 · Echocardiography (Mount Kisco, N.Y.)
Background Little is known about the differences in left atrial (LA) volume and strain assessed with two-dimensional (2DE) and three-dimensional echocardiography(3DE). Therefore, this study aimed to compare 2DE and 3DE parameters in…
View details →Negative / Null Result ReportMedicine
Kralj R, Barčot Z, Kurtanjek M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
The primary aim of this study was to determine whether a significant correlation exists between the relative decline in serum concentrations of interleukin-6 (IL-6) and interleukin-8 (IL-8) between the third and eighth days after injury…
View details →Negative / Null Result ReportMedicine
Vasiliu RD, Porojan L, Bejan FR et al. · 2026 · Polymers
The optical stability and aesthetic performance of dental polymers are critical for the longevity of restorative treatments. This study aims to evaluate the influence of different polymerisation conditions and maintenance…
View details →Negative / Null Result ReportMedicine
Yaka H, Küçükşen MF, Adem A et al. · 2026 · Early human development
Background Adolescent idiopathic scoliosis (AIS) exhibits a marked sexual dimorphism, with females up to ten times more likely than males to develop curves exceeding 30°, strongly implicating sex hormone signalling in its pathogenesis. The…
View details →Negative / Null Result ReportOpen accessMedicine
Abida Shaheen, Syed Mahboob Alam, Fahad Azam et al. · 2022 · PLoS ONE
Background and objective Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to investigate the possible influence of the single nucleotide polymorphism (SNP) of OCTN1 on therapeutic efficacy and safety of gabapentinoids in neuropathic pain patients of the Pakistani po
View details →Negative / Null Result ReportOpen accessMedicine
Al-mustafa Mahmoud, Massad Islam, Alsmady Moaath et al. · 2010 · Saudi Journal of Kidney Diseases and Transplantation
Vertical infraclavicular brachial plexus block is utilized in patients with chronic renal failure at the time of creation of an arterio-venous fistula (AVF). The aim of this study is to test the effect of impaired renal function, with the resulting deranged serum electrolytes and blood gases, on the success rate and the onset of action of the local anesthetics used. In this prospective clinical study, we investigated the effect of the serum levels of sodium, potassium, urea, crea-tinine, pH, and bicarbonate on the onset of action of a mixture of lidocaine and bupivacaine administered to create
View details →Negative / Null Result ReportMedicine
Selma Celen Yuceturk, Sumeyye Aydogan Turkoglu, F. Kockar et al. · 2021 · Zeitschrift für Naturforschung C - A Journal of Biosciences
Abstract In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using…
View details →Negative / Null Result ReportOpen accessMedicine
Anjali B Susan, Uttam B George, Jeyaraj D Pandian · 2022 · Journal of Clinical and Diagnostic Research
Introduction: Arterial Spin Labeling-Perfusion Weighted Imaging (ASL-PWI) assesses cerebral blood flow using magnetically labeled inflowing arterial blood water protons as freely diffusible tracer without exogenous contrast agent. Seizures are one of the sequelae of stroke with its mechanism not well studied. Aim: Qualitative assessment of cerebral perfusion in post stroke seizure patients using ASL-PWI and comparison of perfusion patterns in post stroke seizure patients and stroke patients. Materials and Methods: This was a case-control study among 100 stroke patients who underwent Magnetic R
View details →Negative / Null Result ReportOpen accessMedicine
Zoya maqsood , Shahid Jamal Siddiqui, Nimarta Bai et al. · 2025 · Journal of the Dow University of Health Sciences
Objective: To determine the frequency of raised intraocular pressure (IOP) following neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy in pseudophakic patients and to compare outcomes between high- and low-energy procedures. Methods: This descriptive cross-sectional study was conducted at the Department of Ophthalmology, Khairpur Medical College / Civil Hospital, Khairpur Mirs, Pakistan from April to September 2024. A total of 139 pseudophakic patients with posterior capsular opacification (PCO) undergoing Nd:YAG capsulotomy were enrolled. Baseline demographic and clinical dat
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Ayman Mohammed Baabdullah, Abdulmalik Ghassan Abumohssin, Yara Aedh Alqahtani et al. · 2019 · Journal of Nature and Science of Medicine
Background: The use of smartphones has increased exponentially. Excessive usage of smartphones has been shown to have a negative impact on ocular health. This study aimed to evaluate the relationship between smartphone addiction and dry eye disease (DED) and determine the risk factors of DED in participants associated with smartphone addiction. Materials and Methods: This cross-sectional study was conducted in May 2017. Participants were selected from the Faculty of Medicine at King Abdulaziz University in Jeddah, Saudi Arabia. Stratified random sampling technique was used to recruit participa
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Cristina Novo-Rodríguez, Beatriz García-Fontana, Juan De Dios Luna-Del Castillo et al. · 2018 · PLoS ONE
Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and it has recently been linked to vascular biology. The current study aimed to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardiovascular mortality in individuals with and without type 2 diabetes. We followed up a cohort of 130 participants (mean age 56.8 years; 48.5% fem
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