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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of different durations of high-intensity interval training or continuous training with/without metformin on lipid profile and malondialdehyde level in a rat model of polycystic ovary syndrome.

Zolfaghari, Nouri Habashi, Aghazadeh · 2026 · Veterinary research forum : an international quarterly journal

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder. Exercise is one of the interventions that leads to PCOS improvement. This study aimed to investigate the potential of different durations of high-intensity interval training…

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Negative / Null Result ReportMedicine

Multidimensional Assessment of Fall Risk Using the Timed Up and Go Test and Complementary Measures in a Charcot-Marie-Tooth Type 1A Neuropathy.

Ferrandon-Berne, Pelletier Visa, Dobija et al. · 2026 · Archives of rehabilitation research and clinical translation

To investigate the relationship between the occurrence of falls and the time taken to perform the Timed Up and Go (TUG) test in a population of patients with Charcot-Marie-Tooth disease type 1A (CMT1A). We conducted a longitudinal,…

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Negative / Null Result ReportMedicine

A Comparison of Tegileridine Fumarate versus Sufentanil on the Quality of Postoperative Recovery After Laparoscopic Sleeve Gastrectomy: A Preliminary Randomized Controlled Trial.

Zheng, Chen, Sui et al. · 2026 · Drug design, development and therapy

Laparoscopic sleeve gastrectomy (LSG) is associated with substantial postoperative pain and a high rate of postoperative nausea and vomiting. Tegileridine fumarate, a biased µ-opioid receptor agonist, may offer effective analgesia…

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Negative / Null Result ReportMedicine

Efficacy and Safety of Ultrasound-Guided Erector Spinae Plane Block at Different Injection Depths for Percutaneous Kyphoplasty: A Randomized Controlled Trial.

Liu, Yu, Gao et al. · 2026 · Drug design, development and therapy

To compare the analgesic efficacy and safety of deep, superficial and combined deep-superficial erector spinae plane block (ESPB) combined with subanesthetic-dose esketamine in patients undergoing percutaneous kyphoplasty (PKP). A total of…

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Negative / Null Result ReportMedicine

Monthly versus Bimonthly Bioelectrical Impedance Analysis for Dry Weight Assessment and Intradialytic Hypotension: A Randomized Crossover Trial.

Mokkongphai, Pattharanitima, Jeerangsapasuk et al. · 2026 · Kidney diseases (Basel, Switzerland)

Intradialytic hypotension (IDH) is a major complication during hemodialysis (HD), leading to arrhythmias and increased mortality. Inaccurate dry weight (DW) adjustment contributes to IDH. Bioelectrical impedance analysis (BIA) is commonly…

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Negative / Null Result ReportMedicine

Comparison of clinical outcomes between cruciate-retaining and posterior-stabilized total knee arthroplasty in patients with mild to moderate patellofemoral joint osteoarthritis.

Jia, Xu, Xu et al. · 2026 · Frontiers in surgery

The clinical results of a total knee arthroplasty (TKA) without patellar resurfacing for knee osteoarthritis have been reported; however, not regarding comparison patellofemoral joint (PFJ) clinical outcomes using different prosthesis…

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Negative / Null Result ReportMedicine

Effect of ultrasound-guided bilateral rectus sheath block on postoperative pain control after robotic single-site gynecologic surgery: a randomized study.

Moon, Cho, Kim et al. · 2026 · Ewha medical journal

Rectus sheath block (RSB) is a simple abdominal wall block that can be readily applied. This study evaluated the postoperative analgesic efficacy of ultrasound-guided bilateral RSB in robotic single-site gynecologic surgery. Sixty patients…

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Negative / Null Result ReportMedicine

Influence of simulated tear flow on ocular penetration of transfersomes.

Barbalho, Brugger, Gratieri et al. · 2026 · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Transfersomes are deformable lipid vesicles extensively evaluated for transdermal drug delivery. However, the ocular penetration mechanism of transfersomes is poorly understood as the effect of tear flow, which by altering osmotic…

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Negative / Null Result ReportMedicine

Initial pN and differentiation at recurrence as prognostic factors in patients with recurrent or metastatic tongue squamous cell carcinoma undergoing re-resection.

Yang, Ye, Cao et al. · 2026 · BMC oral health

This study primarily aimed to identify prognostic factors for patients with recurrent/metastatic tongue squamous cell carcinoma (R/M TSCC) undergoing re-resection and to preliminarily explore the value of baseline metabolic parameters in…

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Negative / Null Result ReportMedicine

Partial repair versus superior capsular reconstruction: comparable mid-term outcomes in non-pseudoparalytic massive irreparable rotator cuff tears.

Bayram, Kirac, Yozgatli et al. · 2026 · BMC musculoskeletal disorders

Both partial rotator cuff repair (PRCR) and superior capsular reconstruction (SCR) are frequently performed arthroscopically to treat non-pseudoparalytic massive irreparable rotator cuff tears (MIRCT). The purpose of this study was to…

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Negative / Null Result ReportMedicine

Fatigue lifetime and microbial inhibition at the implant-abutment interface of 5Y-PSZ zirconia abutments coated with experimental glass.

da Silva, Alves, Jalkh et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials

To evaluate microbial inhibition at the implant-abutment interface of 5Y-PSZ zirconia abutments coated with boron-doped soda-lime glass, with or without silver, and to evaluate the fatigue lifetime of boron-doped soda-lime glass-coated…

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Negative / Null Result ReportMedicine

Effects of temperature on biofiltration of ammonia-containing waste gas: Removal efficiency, nitrous oxide generation, and microbial communities.

Shang, Ma, Chen et al. · 2026 · Waste management (New York, N.Y.)

Ammonia (NH 3 ) is a key odorous gas emitted from livestock and poultry farming, and biofiltration has been widely used for NH 3 removal. Temperature plays a critical role in regulating microbial activity and greenhouse gas emissions in…

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Negative / Null Result ReportMedicine

Efgartigimod Versus Lymphoplasmapheresis as Preoperative Rapid Antibody-Clearing Therapies for Thymectomy in Generalized Myasthenia Gravis: Effectiveness, Safety and Cost Outcomes Compared to Conventional Preparation.

Zhou, He, Cheng et al. · 2026 · CNS neuroscience & therapeutics

To compare the real-world effectiveness, surgical and economic outcomes of preoperative rapid antibody clearance therapy (RACT: lymphoplasmapheresis (LPE), efgartigimod (EFG)) versus oral immunosuppressants (Oral IS) in generalized…

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Negative / Null Result ReportMedicine

Evaluation of the Deep Reality Viewer for teaching slit-lamp examination of the anterior segment and the optic nerve head.

Tran, Padda, Sharma et al. · 2026 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

A major challenge in teaching slit-lamp biomicroscopy is providing adequate depth perception and anatomical detail; the Deep Reality Viewer (DRV) addresses this by enabling stereopsis. This study evaluated the utility of DRV for slit-lamp…

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Negative / Null Result ReportMedicine

Photon-counting CT: image quality evaluation in patients with tibial plateau fracture treated with metallic osteosynthesis material.

Björkman, Malusek, Persson et al. · 2026 · European radiology experimental

The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify optimal…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of a Web-Based Medication Reconciliation Application Within a Primary Care Setting: Cluster-Randomized Controlled Trial

Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research

BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th

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Failed Experiment ReportOpen accessMedicine

Evaluation of quantitative polymerase chain reaction for detecting BRCA1 or BRCA2 copy number loss in high-grade serous ovarian cancer

A. J. Oswald, R. L. Hollis, M. Churchman et al. · 2026 · Scientific Reports

Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective detection methods are desirable. This study assessed quantitative PCR (qPCR) as a method of BRCA1/2 CNL detection in HGSOC, in two patient cohorts (cohort 1 n = 355, cohort 2 n = 86) and a cell line panel (n = 10) using sequencing-based copy number (CN) assessment as a comparator (panel-based sequenci

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