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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Management of stiffness after total knee arthroplasty: influence of intervention timing and surgical technique on clinical outcomes.

Peretó Villaescusa, Coelho, Grillo et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Postoperative knee stiffness following total knee arthroplasty (TKA) is a challenging complication that may require surgical intervention when conservative treatment fails. Although manipulation under anesthesia (MUA) and arthroscopic…

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Negative / Null Result ReportMedicine

Comparison of the effectiveness of 30% Aloe vera cream and 20% urea cream as topical treatment for xerosis cutis in chronic kidney disease: a randomized clinical trial.

Fajriani, Djawad, Tabri et al. · 2026 · Dermatology reports

Xerosis is a prevalent skin disorder among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). While both Aloe vera cream 30% and urea cream 20% have been shown to improve skin hydration in cases of xerosis cutis,…

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Negative / Null Result ReportMedicine

Clinical performance of a flowable bulk-fill composite compared with highly viscous glass ionomer cement in class II restorations of primary molars: A 1-year randomized clinical trial.

Fahmy, El-Geleel, Anwar et al. · 2026 · Journal of the American Dental Association (1939)

Caries is the most prevalent chronic disease in children, affecting more than 530 million people worldwide. Timely restoration of primary molars is critical for maintaining function and preventing premature tooth loss. The choice of…

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Negative / Null Result ReportMedicine

Comparison of Prognostic Performance Between a Machine Learning Model and Manually Measured Grey-White-Matter Ratio on Early Brain Computed Tomography After Out-of-Hospital Cardiac Arrest.

Inoue, Ono, Okazaki et al. · 2026 · Cureus

Objectives Early prediction of neurological outcomes in patients with out-of-hospital cardiac arrest (OHCA) is critical for guiding treatment decisions. Machine learning (ML) model and grey-white matter ratio (GWR), both derived from brain…

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Negative / Null Result ReportMedicine

Ultrasound Assessment of Talar, Femoral and Metacarpal Cartilage Thicknesses in Hemiplegic Patients and their Relationship with Functional Parameters.

Eroğlu, Taş, Ekici · 2026 · Zeitschrift fur Orthopadie und Unfallchirurgie

In hemiplegic patients, joint cartilage alterations may arise from impaired balance reactions, decreased selective motor control, abnormal muscle tone, or reduced weight shifting toward the affected limb. This study aimed to investigate…

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Negative / Null Result ReportMedicine

Diversion proctitis during staged restorative proctocolectomy with ileal pouch anal anastomosis is not associated with subsequent cuffitis.

Dharia, Plietz, Hahn et al. · 2026 · International journal of colorectal disease

The aim of this study was to assess the impact of diversion proctitis (DP) between the first and second surgical stage on pouch outcomes in patients with ulcerative colitis (UC) who underwent three-stage restorative proctocolectomy (RPC)…

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Negative / Null Result ReportMedicine

Police Reporting After Sexual Assault: Victim and Assault Characteristics That Predict Reporting Among Victims Who Seek Medical Forensic Care.

Goodman-Williams, Smith, Volz et al. · 2026 · Journal of interpersonal violence

Many sexual assault victims choose not to report their assault to police, and identifying characteristics that predict non-reporting can highlight areas for improvement in the criminal legal system's response to sexual assault. In the…

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Negative / Null Result ReportMedicine

A Cross-Cultural Examination of Intrasexual Competition: The Links Between Mating Competition, Aggression, Appearance Enhancement, and Sexuality.

Meskó, Davis, Arnocky et al. · 2026 · Archives of sexual behavior

In the context of mating, individuals of the same sex often act as rivals in the pursuit, attraction, and retention of desirable partners. This study explored the relationships between intrasexual competition and various aspects of human…

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Negative / Null Result ReportMedicine

Predictors of challenging initial intubation and association with outcomes in congenital diaphragmatic hernia.

Beverstock, Hagan, Fernandes et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

To assess for differences in congenital diaphragmatic hernia patient characteristics between those requiring single or multiple intubation attempts, and to determine the relationship between number of intubation attempts and time to…

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Negative / Null Result ReportMedicine

Does the Addition of Images to the Medication Dosage Calculation Exam Improve Metacognitive Components and Performance? A Randomized Prospective Study.

Weil-Lotan, Solnica, Benbenishty et al. · 2026 · Nurse educator

Accurate dosage calculation is vital for patient safety, making effective instructional methods a priority in nursing education. This study investigated whether embedding images of medications or syringes in medication calculation exams…

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