12,263 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Sowinska N, Ochota M, Partyka A et al. · 2026 · Animal reproduction science
The domestic cat (Felis catus) provides a valuable model for developing assisted reproductive technologies (ART) that can be applied to the conservation of endangered wild felids. A major limitation in the application of ART is the…
View details →Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio et al. · 2022 · BMJ Open
Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD
View details →Lara Kakabas, Krzysztof Piersiala, Aeneas Kolev et al. · 2023 · Scientific Reports
Abstract A history of allergies has been said to be associated with a lower risk of head and neck cancer compared to the general population. However, it is not known whether having an allergic sensitization influences the prognosis and advancement of cancer disease. Thus, the aim of the study was to investigate the relationship between allergic sensitization and oral cancer advancement and patient survival. Allergen-specific IgE antibodies were investigated by ImmunoCAP™ Rapid in consecutive 80 patients with oral cancer. ImmunoCAP Rapid system tests a mix of representative inhalant allergens s
View details →Alberta Simona Tinu, Doina Lucia Ghergic, Mirel Stoian et al. · 2018 · Romanian Journal of Stomatology
Objectives. We performed a retrospective observational analytical study to determine the incidence of complications in the oral cavity in a group of patients diagnosed with diabetes mellitus. Material and method. We have studied 68 diabetic patients, who have been referred to dental practices seeking specialized treatment. Patient data sheets were centralized, categorized, and statistically processed with IBM SPSS Statistics 22 and Microsoft Excel 2010 depending on: sex of patients, age, type of diabetes, time elapsed from diagnosis of diabetes, the environment of origin of the patients, the l
View details →Yunsur Çevik, Fatma Nur Karaarslan, Şeref Kerem Çorbacıoğlu et al. · 2022 · Eurasian Journal of Emergency Medicine
Aim:The aim of this study was to examine the relationship between immature granulocyte (IG) counts and the severity of the disease and to evaluate the effectiveness of IG in predicting the poor outcomes in polymerase chain reaction-confirmed Coronavirus disease-2019 (COVID-19) cases.Materials and Methods:The study was conducted prospectively and observationally at the emergency department. Patients were divided into three groups according to the clinical severity indicators such as mild, moderate and severe. The IG level was measured from the whole blood samples taken at the admission to the e
View details →Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė et al. · 2017 · Acta Medica Lituanica
Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium. However, the etiology of AMD and drusen formation is not fully understood. Recent studies suggest that CYP2C8-related metabolic processes might play an important role in the development of AMD. The aim of our study is to investigate CYP2C8 rs10509681 and CYP2C8 rs11572080 genotype frequencies in patients with early AMD and to compare them with healthy controls. Materials and Methods.
View details →Damkoeng Purnindu · 2023 · Siriraj Medical Journal
Dissection of one-half of adult pelvis in 197 Thai and 44 Chinese cadavers disclosed that the obturator artery arose from the internal iliac and umbilical arteries in 34.9%, from the inferior gluteal artery in 10.4%, from the internal pudendal artery in 8.7%, from the superior gluteal - inferior gluteal trunk in 4.2%, from the inferior gluteal - internal pudendal trunk in 9.1%, from the inferior epigastric artery in 12.0%, from the external iliac artery in 1.2%, and from the superior gluteal and the inferior epigastric arteries in 0.4%. There were no statistically significant differences of fi
View details →Tasić Danijela, Kovačević Zorana, Mitrović Miroslav et al. · 2021 · Scripta Medica
Background/Aim: Orthostatic hypotension (OH) is considered to be a drop in the systolic and diastolic blood pressure (> 20 mmHg; > 10 mmHg) 3 minutes from postural changes. The objective of this study was to analyse the correlation of body mass index (BMI) and OH during the treatment with trandolapril, as a single-drug treatment of hypertension. Methods: The study involved 255 patients (average age 54.3 ± 11.7; 54.1 % men) with poorly regulated hypertension, who were given trandolapril as a single-drug treatment. The patients were divided into two groups regarding stage of hypertension: first-
View details →Hall, Natalie J, Berry, Sameer K, Aguilar, Jack et al. · 2021 · JMIR Formative Research
BackgroundA potential benefit of electronic health records (EHRs) is that they could potentially save clinician time and improve documentation by auto-generating the history of present illness (HPI) in partnership with patients prior to the clinic visit. We developed an online patient portal called AEGIS (Automated Evaluation of Gastrointestinal [GI] Symptoms) that systematically collects patient GI symptom information and then transforms the data into a narrative HPI that is available for physicians to review in the EHR prior to seeing the patient. ObjectiveThis study aimed to compare whether
View details →Priscila Lima de Luna FREIRE, Priscila Hernández CAMPOS, Fabíola Galbiatti CARVALHO et al. · Revista de Odontologia da UNESP
Abstract Introduction Methods of decontamination or sanitization of toothbrushes have been questioned. Objective This study assessed the effectiveness of pomegranate peels infusion as a disinfectant of toothbrushes against Streptococcus mutans. Material and method A sample of 16 schoolchildren aged between 7 and 9 years performed brushing 5 days/week, with a careful brushing once a day. After each day of brushing, the toothbrushes were washed and sprayed with one disinfectant solution. This procedure was repeated for 4 weeks using one of the different solutions per week: distilled water (G1; n
View details →Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
View details →Sarah M. Alghamdi, Paul N. Schofield, Robert Hoehndorf · 2022 · Disease Models & Mechanisms
Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past decade, cross-species phenotype comparisons have proven valuble, and several ontologies have been developed for this purpose. The relative contribution of different model organisms to computational identification of disease-associated genes is not fully explored. We used phenotype ontologies to semantically relate phenotypes resulting from loss-of-function mu
View details →Christopher B Estopinal, Janneke H van Dijk, Stanley Sitali et al. · 2012 · PLoS ONE
Background We assessed the impact of home-based care (HBC) for HIV+ patients, comparing outcomes between two groups of Zambians receiving antiretroviral therapy (ART) who lived in villages with and without HBC teams. Methods We conducted a retrospective cohort study using medical charts from Macha Mission Hospital, a hospital providing HIV care in Zambia's rural Southern Province. Date of birth, date of ART initiation, place of residence, sex, body mass index (BMI), CD4+ cell count, and hemoglobin (Hgb) were abstracted. Logistic regression was used to test our hypothesis that HBC was associate
View details →Simson Tarigan, Gita Sekarmila, Apas et al. · 2024 · PLoS ONE
Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines. In this study, we constructed two fusion proteins containing CTA1, tandem repeat linear epitopes of the SARS-CoV-2 spike protein (S14P5 or S21P2), a
View details →Blow KE, Quigley D, Sosso GC · 2026 · The Journal of chemical physics
Molecular dynamics is routinely used to investigate crystal nucleation rates via computer simulations. According to classical nucleation theory, the size of the largest cluster should be the best approximation of the reaction coordinate.…
View details →Zehra Abdul Muhammad, Tashfeen Ahmad · 2025 · Journal of the Pakistan Medical Association
Objective: To assess the safety and pain reduction profile of routinely prescribed oral analgesics in patients of hip fracture surgery. Method: The single-centre, prospective, cohort study was conducted from June 2022 to July 2023 at the Aga Khan University Hospital, Karachi and comprised adult patients of either gender with hip fractures. The analgesics prescribed at the time of hospital discharge and 1-week follow-up were recorded along with pain and adverse effects till the 2-week post-discharge follow-up. Pain was recorded using the visual analogue scale, with the target score set at 3/10.
View details →Niroshica Mohanathas, Lianna Montanari, Rachel Downey et al. · 2026 · PLoS ONE
Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Hearing loss is linked to increased risks of both falls and cognitive decline. Improving cognitive processing through executive function (EF) training may support balance, especially in older adults with hearing loss. This randomized controlled study conducted across age groups and hearing abilities, examined the effects of a 12-week EF training program on postural outcomes (center of pressure (COP)) using an auditory-cog
View details →Schmidt TP, Jütten K, Bertram U et al. · 2026 · World neurosurgery
Degenerative cervical myelopathy (DCM) is the leading cause of chronic spinal cord dysfunction and can lead to severe neurological impairment if untreated. While decompressive surgery is the standard treatment, predicting postoperative…
View details →Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery
Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…
View details →Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…
View details →Hopkins S, Banks E, Bentley SA et al. · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To evaluate whether luminance-matching of non-target elements (Study 1) and incorporating artwork (Study 2) within the newly designed turtle optotype would impact visual acuity (VA) measures. Methods Study 1 evaluated the…
View details →Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing
Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…
View details →Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…
View details →Shirmohammadi P, Fazeli F, Zoghi A et al. · 2026 · Scientific reports
Spirulina platensis is a potential alternative food ingredient due to its bioactive compounds, nutritional composition, and a sustainable protein source. This study evaluated the effects of adding S. platensis powder (0, 0.5, 0.75, 1, 3,…
View details →Day M, Kearney S · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To explore methods of evaluating success of optical myopia control interventions, and to apply these methods retrospectively to a clinical population. Methods A retrospective cohort study was conducted on pediatric patients…
View details →Chaudhary D, Mukhopadhyay I · 2026 · Applied health economics and health policy
Background Universal health coverage has become central to health policy debates, particularly as a strategy to protect households from financial hardship and impoverishment related to out-of-pocket (OOP) spending. Many low- and…
View details →Guevara-Freire D, Escudero RM, Calvo L et al. · 2026 · Meat Science.
This study evaluated the effect of dietary linoleic acid (C18:2) inclusion on fat deposition and fatty acid composition in barrows and gilts. A total of 960 Danbred pigs (half barrows, half gilts) were assigned to two dietary treatments…
View details →Amırlı H, Gurbanli E · 2026 · BMC psychology
The purpose of this study is to investigate the mediating roles of job satisfaction (JS) and life satisfaction (LS) in the relationship between psychological resilience (PR) and employee performance (EP). Data for this study, which…
View details →Jager G, de Wild VWT, Camps G et al. · 2026 · Appetite
Eating rate (ER), the amount of food consumed per unit of time, is a key determinant of food intake, with faster ER associated with larger meal size. Research in adults has shown that both sensory properties like texture, and instructions…
View details →Katzer M · 2026 · Advances in health sciences education : theory and practice
The article critically examines Georg Lind's Moral Competence Test, which is often used to assess the moral abilities of healthcare professionals and students. Test results have purportedly shown that students' moral competence declines…
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