Failed Experiment ReportMedicine
Li P, Xu S, Chen C et al. · 2026 · Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Objectives To evaluate whether early antifungal prophylaxis reduces the incidence of influenza-associated pulmonary aspergillosis (IAPA) in critically ill adults with influenza. Methods We emulated a target trial using a multicentre cohort…
View details →Negative / Null Result ReportOpen accessMedicine
Mehmet Mahir Fersahoğlu, Ahmet Çakmak, Hüseyin Çiyiltepe et al. · 2022 · İstanbul Tıp Fakültesi Dergisi
Objective: To evaluate the effects of using different doses of ursodeoxycholic acid (UDCA) for six months in prevention of gallstones after Laparoscopic Sleeve Gastrectomy (LSG) on the formation of gallstones in the 6th and 12th months. Materials and Methods: The data of patients who underwent LSG for morbid obesity were analyzed. Three groups of 20 people were formed. These were the control group, Group I who were treated with UCDA 500 mg/day for six months after LSG, and Group II who were treated with UCDA 1000 mg/day for 6 months after LSG. Demographic characteristics, co-morbid diseases, c
View details →Negative / Null Result ReportOpen accessMedicine
Videnović Nebojša, Mladenović Jovan, Pavlović Aleksandar et al. · 2019 · Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. In this study, the effects of applied anesthetic techniques were investigated in a retrospective analysis of obese patients and those with normal body mass index undergoing in vitro fertilization, using bispectral index as an indicator of anesthetic depth. Methods. In total 116 patients with normal body mass index were allocated to group N. Another 116 patients with body mass index > 30 kg/m2 were allocated to group O. Anesthetic protocol comprised midazolam for premedication, diclofenac for pre-emptive analgesia, propofol for induction and maintenance, alfentanil for a
View details →Negative / Null Result ReportOpen accessMedicine
Ryogo Minamimoto, Toshiyuki Saginoya, Chisato Kondo et al. · 2015 · PLoS ONE
The aim of this multi-center study was to assess the diagnostic capability of visual assessment in L-methyl-11C-methionine positron emission tomography (MET-PET) for differentiating a recurrent brain tumor from radiation-induced necrosis after radiotherapy, and to compare it to the accuracy of quantitative analysis.A total of 73 brain lesions (glioma: 31, brain metastasis: 42) in 70 patients who underwent MET-PET were included in this study. Visual analysis was performed by comparison of MET uptake in the brain lesion with MET uptake in one of four regions (around the lesion, contralateral fro
View details →Negative / Null Result ReportOpen accessMedicine
Mayuri Biccodu Shivashankar, Nandini Thippannanavar Niranjan, Arun Jayasheel et al. · 2016 · Journal of Clinical and Diagnostic Research
Introduction: Complete cleaning and shaping of root canal system is of paramount importance to achieve a successful root canal treatment. There are various rotary Ni-Ti systems available in the market to achieve mechanical goal of root canal preparation. But aggressive preparation of root canal with such systems would result in canal transportation and excess root dentin removal that would be one of the major reasons to decide the prognosis of root canal treated tooth. Aim: The present study was conducted to compare the root canal preparation in terms of canal transportation and volumetric cha
View details →Negative / Null Result ReportMedicine
Wang Z, Yang J, Duan L · 2026 · Cognitive neurodynamics
Based on the important function of the thalamic reticular nucleus(TRN) in epileptic seizures, we explore how changes in TRN information affect epileptic seizures across the entire brain nervous system by adjusting the excitatory coupling…
View details →Negative / Null Result ReportOpen accessMedicine
Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori et al. · 2019 · Journal of Biomedical Science
Abstract Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the association between maternal TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms and PE. In addition, we examined the effects of promoter methylation and TP53 and P21 polymorphisms on placental mRNA expression in PE women. Methods The blood of 226 PE women and 228 normotensive pregnant women wa
View details →Negative / Null Result ReportOpen accessMedicine
Oliver Hendricks, Mikkel Østergaard, Susanne Juhl Pedersen et al. · 2026 · RMD Open
Introduction Evidence of treat-to-target strategies including secukinumab dose escalation in patients with axial spondyloarthritis (axSpA) remains limited. We investigated the effect of a treat-to-target approach aiming for Axial Spondyloarthritis Disease Activity Score (ASDAS) remission, assessed by clinical and MRI outcomes over 24 weeks.Methods TRACE was a multicentre study including biologic-naïve patients with active axSpA. Sixteen weeks after secukinumab 150 mg initiation, patients in ASDAS remission (<1.3)(week 16 remitters) continued the same dose, while non-remitters (week 16 non-remi
View details →Negative / Null Result ReportOpen accessMedicine
Serkan Oner, Yusuf Secgin, Zulal Oner et al. · 2022 · Medicine Science
The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were
View details →Negative / Null Result ReportOpen accessMedicine
Roman Panovský, Martina Doubková, Mary Luz Mojica-Pisciotti et al. · 2021 · Orphanet Journal of Rare Diseases
Abstract Background Sarcoidosis is a systemic granulomatous disease affecting different organs including the heart. Myocardial strain analysis could potentially detect the early stages of cardiac dysfunction in sarcoidosis patients. The present study aims to assess the use of cardiac magnetic resonance (CMR) strain analysis using feature tracking (FT) in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred and thirteen CMR studies of patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis without pre-existing kno
View details →Negative / Null Result ReportOpen accessMedicine
Huang C, Wu M, Li Y et al. · 2026 · Clinical, cosmetic and investigational dermatology
Background Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. Objective To compare buffy coat…
View details →Negative / Null Result ReportOpen accessMedicine
Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · F1000Research
Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…
View details →Negative / Null Result ReportMedicine
Mehrabi A, Mohamadi-Nejad A, Ghorbani M et al. · 2026 · Brazilian journal of biology = Revista brasleira de biologia
Contract farming has gained popularity in recent years. Understanding farmers' preferences for contracts can help make contracts more sustainable and profitable. Therefore, the present study aimed to investigate farmers' preferences for…
View details →Negative / Null Result ReportMedicine
Kim J, Cho Y · 2026 · Archives of environmental & occupational health
This study explored the impact of exposure to nonstandard work on workers' depression and suicidal ideation. Using data from the 12th to 18th waves of the Korea Welfare Panel Study, longitudinal analyses were conducted employing cox…
View details →Negative / Null Result ReportMedicine
Bayrami M, Dadashi Mazraeh S · 2026 · Acta psychologica
This study compared the effects of cognitive rehabilitation and binaural beats on creativity, psychological well-being, and academic performance in 45 undergraduate students using a quasi-experimental pretest-posttest design with a control…
View details →Negative / Null Result ReportMedicine
Agbajelola VI, Roachell WD, Lane GS et al. · 2026 · Acta tropica
Chagas disease remains an important public health concern across the Americas, affecting both human and animal populations. The triatomine bug Rhodnius prolixus, an obligate hematophagous vector of Trypanosoma cruzi, is commonly associated…
View details →Negative / Null Result ReportOpen accessMedicine
Csontos J, Brown N, Edwards A et al. · 2026 · BMC public health
BACKGROUND: Adults (age 18–64 years) are recommended 150–300 min of moderate-to-vigorous or 75–150 min of vigorous-intensity physical activity per week. Irrespective, the number of women not meeting recommended physical activity is 5%…
View details →Negative / Null Result ReportOpen accessMedicine
Corcoran E, Samuel Z, Force A et al. · 2026 · Orthopaedic journal of sports medicine
Background Osteochondral defects (OCDe) of the knee in pediatric patients can significantly impact long-term joint function. This study aimed to evaluate the impact of lesion size on patient characteristics, treatment decisions, and…
View details →Negative / Null Result ReportOpen accessMedicine
Castro M, Carrasco-Zambrano N, Pezo F et al. · 2026 · Frontiers in veterinary science
The routine prophylactic use of antibiotics in sperm preservation for reproductive biotechnologies poses increasing concerns due to its potential role in promoting antimicrobial resistance. Therefore, developing storage systems that…
View details →Replication FailureMedicine
Ye C, Sheng Y, Zhang X et al. · 2026 · Plant Science.
Gene editing has emerged as a powerful tool in crop breeding, particularly for rice, enabling the creation of germplasm and trait improvement. A thorough understanding of gene functions is essential for precise and efficient crop…
View details →Negative / Null Result ReportOpen accessMedicine
Belnap MA, Witkiewitz K, Schacht JP et al. · 2026 · Alcohol, clinical & experimental research
Background The U.S. Food and Drug Administration (FDA) recommends a minimum duration of 6 months for randomized controlled trials (RCTs) evaluating pharmacotherapies for alcohol use disorder (AUD). The relationship between trial length and…
View details →Negative / Null Result ReportMedicine
Orihuela CA, Dotson B, Sharff A · 2026 · Journal of health psychology
Food insecurity continues to be a critical social determinant of health in the United States. Existing research on food insecurity within clinical populations has focused on specific health conditions. However, this approach may limit the…
View details →Negative / Null Result ReportMedicine
Noll D, Stapleton P, O'Callaghan M · 2026 · BJU international
Objective To calculate additional information from urological trials which do not report statistically significant results, and assess whether language manipulation is used when such studies were reported. Materials and methods Many…
View details →Negative / Null Result ReportMedicine
Cai X, Zhou L, Lü M et al. · 2026 · Chaos (Woodbury, N.Y.)
We study resilience in collective behaviors of "next-generation reservoir computers" in terms of transmitted signal distortion. Specifically, we introduce an interactive communication scheme and achieve synchronization between two…
View details →Negative / Null Result ReportOpen accessMedicine
Lisnanti EF, Lokapirnasari WP, Al-Arif MA et al. · 2025 · Open veterinary journal
Background Broiler livestock supports the fulfillment of animal protein in a country where the meat price is affordable for the wider population. However, its progress faces numerous challenges, with colibacillosis, induced by APEC, being…
View details →Negative / Null Result ReportOpen accessMedicine
Ben Maaoui K, Delleli S, Jebabli A et al. · 2026 · Nutrients
Background/Objectives : Although creatine (Cr) supplementation is well established for enhancing strength exercise adaptations, limited evidence exists regarding whether the timing of a single Cr dose relative to exercise acutely…
View details →Negative / Null Result ReportMedicine
Arslan G, Karaçul FE · 2026 · Psychological reports
Childhood adversity is consistently associated with long-term psychological challenges, most notably impaired self-regulatory capacities and lower levels of subjective well-being (SWB). The present study examined the associations among…
View details →Negative / Null Result ReportMedicine
Ninomiya S, Koh S, Ueshima S et al. · 2026 · Eye & contact lens
Objectives To evaluate the efficacy of extended depth-of-focus (EDOF) soft contact lenses with different optical profiles in controlling myopia progression and their effect on visual function in Japanese children. Methods In this 12-month…
View details →Negative / Null Result ReportMedicine
Sears J, Garlea VO, Lederman D et al. · 2026 · Physical review letters
FeF_{2} is a prototypical rutile antiferromagnet recently proposed as an altermagnet, with a magnetic symmetry that permits spin-split electronic bands and chiral magnons. Using very-high-resolution inelastic neutron scattering on a single…
View details →Negative / Null Result ReportMedicine
Sağbaş M, Oktaysoy O, Topcuoglu E · 2026 · Journal of health organization and management
Purpose This study aims to investigate the mediating roles of job performance and job satisfaction in the effect of digital leadership on heavy workloads among healthcare workers. By focusing on the phenomenon of leadership in digital…
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