Negative / Null Result ReportOpen accessMedicine
Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
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Chen X, Wen W, Zheng L · 2026 · Shock (Augusta, Ga.)
Background Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly…
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Nicholas Judd, Rogier Kievit · 2025 · eLife
Education is related to a wide variety of beneficial health, behavioral, and societal outcomes. However, whether education causes long-term structural changes in the brain remains unclear. A pressing challenge is that individuals self-select into continued education, thereby introducing a wide variety of environmental and genetic confounders. Fortunately, natural experiments allow us to isolate the causal impact of increased education from individual (and societal) characteristics. Here, we exploit a policy change in the UK (the 1972 ROSLA act) that increased the amount of mandatory schooling
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Seyyed Abolfazl Tabatabaie-Zadeh, Nazanin Mahdavi, Behnaz Mahdaviani et al. · 2024 · PLoS ONE
Purpose Oral cancers are the 6th most common malignancy worldwide and oral squamous cell carcinoma, comprises over 90% of oral cancers. This study investigates the relationship between physical activity level during the lifetime and oral squamous cell carcinoma risk. Methods 100 oral squamous cell carcinoma patients and 200 healthy individuals participated in this case-control study. Physical activity level was evaluated via the Lifetime Physical Activity Questionnaire. The occupational, household, and sports domains of lifetime physical activity were determined. Case and control groups' parti
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Renata Jabłońska, Marta Gralik, Agnieszka Królikowska et al. · 2016 · Pielęgniarstwo Neurologiczne i Neurochirurgiczne
Introduction. In the occupational medicine back pain is treated as a paraoccupational disease, mainly related to specific professional groups. They include those employed in the sector of health care, who are at the highest risk of developing back pain, nurses in particular. Aim. Assessment of back pain occurrence among nurses and determining the factors affecting this condition. Material and Methods. The study group consisted of 76 nurses working in neurology and neurosurgery wards/clinics. The research methodology applied consisted of diagnostic survey method, and as the technique, a survey
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Kataruka M, Sannyashi P, Bhattacharjee S et al. · 2026 · Cureus
Introduction Neuropathic ulcers occur mainly at the plantar aspect and correspond to areas with peak plantar pressure, usually seen in a sensory-deficient foot. Trophic ulcers are seen in diabetic neuropathy, post-leprosy, and any other…
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Michele L Ybarra, Sheana S Bull, Tonya L Prescott et al. · 2013 · PLoS ONE
Cost-effective, scalable programs are urgently needed in countries deeply affected by HIV.This parallel-group RCT was conducted in four secondary schools in Mbarara, Uganda. Participants were 12 years and older, reported past-year computer or Internet use, and provided informed caregiver permission and youth assent. The intervention, CyberSenga, was a five-hour online healthy sexuality program. Half of the intervention group was further randomized to receive a booster at four-months post-intervention. The control arm received 'treatment as usual' (i.e., school-delivered sexuality programming).
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Patil VE, Barick D, Degloorkar P et al. · 2026 · Hip & pelvis
Purpose There is ongoing debate on the haemoglobin level at which red cell transfusion should be administered following surgery. This study aimed to evaluate the benefits of a restrictive blood transfusion strategy and assess potential…
View details →Negative / Null Result ReportOpen accessMedicine
Elham Tabesh, Farzad Yadmehr, Awat Feizi et al. · 2024 · Health Science Reports
Abstract Backgrounds and Aims This controlled randomized clinical trial was designed to compare effectiveness, side effects, and severity of symptoms before and after therapy between quadruple (QT) and sequential regimens (SQ) for Helicobacter Pylori (H. pylori). Methods Patients were randomly allocated into two groups. Group A received a 14‐day QT including pantoprazole 40 mg q12 h, bismuth subcitrate 240 mg q12 h, clarithromycin 500 mg q12 h, and amoxicillin 1000 mg q12 h and group B received ST including pantoprazole 40 mg q12 h and amoxicillin 1000 mg q12 h for the initial 5 days followed
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Subh Salem Al-Mudallal, Muna Abd Al-Moeen Al- Habbobi · 2016 · The Iraqi Journal of Medical Sciences
Background: Hematological values at birth encompass broader ranges of normal than at any other time in life, and despite advances in perinatology over the past years, the exact influence of perinatal factors on hematological values in cord blood in normal pregnancy is still unclear. Moreover there was a wide variation and overlap in values between normal and abnormal infants with early symptoms and signs of neonatal sepsis. Objectives: 1. To obtain the values of hematological parameters including complete blood picture, red cell indices, nucleated red blood cells and reticulocyte count in heal
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Elsayed Said, Khaled H. Mosallam, Abdelrahman MK Maala* et al. · 2023 · SVU - International Journal of Medical Sciences
Background: Coronal deformities around the knee are most commonly presented in paediatric orthopaedic. Physiological deformities are most often managed conservatively, but severe deformities that cause pain and dysfunction require surgical intervention with acute correction (osteotomy), or gradually by hemiepiphyseodesis. Objectives: The main objective of this prospective study is to assess and compare short term results following correction by osteotomy versus 8-plate hemiepiphyseodesis. Patients and Methods: 30 skeletally immature patient, aged (3-14 years); presented with angular deformitie
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Bruna Cassia Dal Vesco, Ana Carolina de Miranda, Fernanda do Carmo De Stefani et al. · 2026 · Einstein (São Paulo)
ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed to investigate whether peripheral hypoperfusion in septic patients is associated with serum levels of damage-associated molecular patterns. Methods: A retrospective cohort study was conducted to compare serum levels of damage-associated molecular patterns - histone H3, histone H4, and high-mobility group box-1 protein (HMGB1) - with markers of tissue hypoperfusion - the peripheral perfusion index and the capillary refill time, using a single measuremen
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Anderson RE, Dolney NA · 2026 · Journal of child sexual abuse
The Sexual Experiences Survey (SES) is a widely used measure of sexual victimization. The most recent version of the SES, the Sexual Experiences Survey-Victimization (SES-V), released in 2024 is longer than prior versions. This raises…
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Alexandre Almeida, Vinícius Atti, Daniel Cecconi Agostini et al. · 2015 · Revista Brasileira de Ortopedia
OBJECTIVE: To analyze the results from arthroscopic suturing of large and extensive rotator cuff injuries, according to the patient's degree of osteopenia.METHOD: 138 patients who underwent arthroscopic suturing of large and extensive rotator cuff injuries between 2003 and 2011 were analyzed. Those operated from October 2008 onwards formed a prospective cohort, while the remainder formed a retrospective cohort. Also from October 2008 onwards, bone densitometry evaluation was requested at the time of the surgical treatment. For the patients operated before this date, densitometry examinations p
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Hsin-Hua Lee, Ming-Feng Hou, Shu-Yi Wei et al. · 2016 · PLoS ONE
To compare the long-term clinical outcomes of postmastectomy radiotherapy (PMRT) between breast cancer patients with and without immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction.The study included 492 patients with stage II or III breast cancer who underwent modified radical mastectomy (MRM) and chemotherapy followed by PMRT between 1997 and 2011. Cox regression model and Kaplan-Meier curves were calculated, and the log-rank test was used to evaluate the differences between overall and disease-free survival rates in the 2 groups.Among 492 patients, 213 patients had
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Abbas Abbaszadegan, Zeinab Rafiee, Bahar Asheghi et al. · 2025 · PLoS ONE
Tooth discoloration caused by intracanal medicaments and irrigants presents a significant aesthetic challenge in dentistry. This study aimed to investigate the discoloration effects on tooth of nanographene oxide and positively charged silver nanoparticles and compares them with other commonly used materials in endodontic treatment. A total of 108 single-rooted, single-canal anterior mandibular and maxillary premolar teeth, extracted for orthodontic or periodontal reasons, were selected and prepared. The specimens were randomly divided into seven experimental groups and two control groups, eac
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Serpi M, Çakan A, Akpınar A · 2026 · Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Vertebral fractures result from degenerative, osteoporotic, or traumatic spinal loading. Treatment options include conservative management, segmental fusion, and percutaneous vertebroplasty/kyphoplasty (PVP/BKP) performed using…
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Đorđević Dragan, Lović Branko, Deljanin-Ilić Marina et al. · 2008 · Srpski Arhiv za Celokupno Lekarstvo
INTRODUCTION The prognostic significance of QTc dispersion changes during exercise testing (ET) in patients with left ventricular hypertrophy is not clear. OBJECTIVE The aim was to study the dynamics of QTc interval dispersion (QTcd) in patients (pts) with left ventricular hypertrophy (LVH) during the exercise testing and its prognostic significance. METHOD In the study we included 55 men (aged 53 years) with hypertensive left ventricular hypertrophy and a negative ET (LVH group), 20 men (aged 58 years) with a positive ET and 20 healthy men (aged 55 years). There was no statistically significa
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Kričković Zoran, Simatović Milan, Lukić Darko et al. · 2020 · Scripta Medica
Background/Aim: Benign prostatic hyperplasia (BPH) is a very common disease in older men. BPH involves the presence of signs of hyperplasia of the stromal and epithelial elements in the prostate with consequent enlargement of its volume. The aim of this study is to analyse the frequency of typical complications in the treatment of patients with benign prostatic hyperplasia and the effect of medicamentous treatment. Method: Patients diagnosed BPH were included in the prospective, one-year study. They were divided into 2 groups. The first group (30 patients) consisted of those ones, whose prosta
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Rokaya D, Al Jaghsi A, Masri M et al. · 2026 · Frontiers in dental medicine
Objectives This study aimed to investigate the accuracy of two intraoral scanners at different post space preparation depths and widths for CAD/CAM fabricated post and core fabrication. Methods A total of 36 extracted anterior teeth were…
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Malvandi H, Shamabadi MH, Vaezi I · 2026 · Bulletin of environmental contamination and toxicology
In the present study, thirteen urban bird species were used as bioindicators to monitor metal concentrations in the metropolis of Mashhad. The concentrations of lead (Pb), zinc (Zn), and copper (Cu) ranged from 0.004 to 0.073, 0.750 to…
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Zaharovs V, Pilmane M · 2026 · Journal of molecular histology
The anti-apoptotic genes DAD-1 and HAX-1 and the pro-apoptotic GZMB gene have a significant role in the regulation of apoptosis in heart tissue. However, investigation into these genes and their proteins in the pathogenesis of…
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Clukey J, Locascio J, Semler J et al. · 2026 · Journal of clinical gastroenterology
Goals We aimed to evaluate the efficacy and safety of IFT for the treatment of CC in a pilot randomized controlled trial (RCT). Background Subjects with refractory chronic constipation (CC) have limited treatment options. Interferential…
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Vatan A, Karabay O, Moralı H et al. · 2026 · BMC infectious diseases
Background Tenofovir alafenamide (TAF) is widely used in antiretroviral therapy due to its improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF). However, concerns remain regarding its potential metabolic effects…
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Shikama T, Otaki Y, Kinoshita D et al. · 2026 · Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
Objective Nodular calcifications occupying the lumen in the femoropopliteal artery, known as "Black Rock (BR)" lesions, are associated with poor patency. We focused on the drug-coated balloon (DCB) and examined whether the impact of final…
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Wu G, Ou X, Zou M et al. · 2026 · Journal of cancer research and clinical oncology
OBJECTIVE: This study aimed to compare the outcomes of no-touch radiofrequency ablation (NT-RFA) and conventional RFA (C-RFA) in the treatment of solitary recurrent hepatocellular carcinoma (rHCC) ≤ 3 cm. METHODS: 255 patients with rHCC…
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Mostamand S, Merchant Q, Ji Y et al. · 2026 · Neurogastroenterology and motility
Background Anorectal manometry (ARM) is a commonly performed motility test in pediatrics. Currently, adult ARM normative data are extrapolated to pediatric assessments due to few validated pediatric studies. We share a single center…
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Salık M, Bakır EP · 2026 · Journal of functional biomaterials
Aim: The aim of this study was to comparatively evaluate the shear bond strengths between different calcium silicate-based biomaterials and glass ionomer-based restorative materials. Materials and Methods: In this in vitro study, a total…
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Liang H, Gui Y, Lv K et al. · 2026 · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Objective To compare the imaging efficacy and patient tolerability of a novel cellulose-based oral contrast agent with a conventional starch-based agent in gastric contrast-enhanced ultrasound,thus providing evidence-based support for…
View details →Failed Experiment ReportOpen accessMedicine
Princiotta SD, Ostergaard E, Carroll E · 2026 · microPublication biology
Lakes often exist in two alternative stable states: clear waters dominated by submerged aquatic vegetation and turbid states with an abundance of phytoplankton. Management decisions must balance the value of primary producers with…
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