Negative / Null Result ReportOpen accessMedicine
Chen Yang, Shun-Nan Ge, Jia-Rui Zhang et al. · 2013 · PLoS ONE
High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus pallidus (GP) and motor cortex of freely moving rats. However, it is unclear whether dopamine regulates HVS activity by acting on dopamine D₁-like receptors or D₂-like receptors. We employed local-field potential and electrocorticogram methods to simultaneously record the oscillatory activities in the GP and primary motor cortex (M1) in freely
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Mohamad Hosein Toodeh Zaeim, Soghra Yassaei, Hosein Aghili et al. · 2008 · Iranian Journal of Orthodontics
Aim: Nasopharyngeal space is estimated from a point on the posterior part of the soft palate till the nearest point on the wall of the pharynx and the aim of the present study was to study the nasopharyngeal indices in nasal breathers with class I and III malocclusions.Materials and Methods: This was a descriptive analytical study done by the case - control method on 35 lateral cephalometries of patients with skeletal Class III malocclusion as the study group and 30 lateral cephalometries of patients with skeletal Class I malocclusion as the control group. The population under study included p
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Sirous Nazari pirdoosti, Vahid Valipour dehnou, Ehsan Gharamanlou · 2019 · Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction: Transcranial direct current stimulation (tDCS) is a non-invasive technique used to modify the activity of the cortex of the brain. This form of current is capable of inducing changes in the electrical activity inside and outside of the neurons, which leads to a change in the resting membrane potential and thus improves the efficiency of the neural synapse. Therefore, the aim of this study was to investigate the effect of tDCS over motor cortex on strength and endurance performance of healthy collegiate subjects. Materials & Methods: In total, 10 young and healthy male subjects (a
View details →Negative / Null Result ReportOpen accessMedicine
Gabriel Danyagri, Qing-Lai Dang · 2013 · PLoS ONE
Global climate change is expected to affect how plants respond to their physical and biological environments. In this study, we examined the effects of elevated CO2 ([CO2]) and low soil moisture on the physiological responses of mountain maple (Acer spicatum L.) seedlings to light availability. The seedlings were grown at ambient (392 µmol mol(-1)) and elevated (784 µmol mol(-1)) [CO2], low and high soil moisture (M) regimes, at high light (100%) and low light (30%) in the greenhouse for one growing season. We measured net photosynthesis (A), stomatal conductance (g s), instantaneous water use
View details →Negative / Null Result ReportOpen accessMedicine
Arne Bilet, Christiane K Bauer · 2012 · PLoS ONE
NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents. We now investigated whether NS1643 is also able to act as an activator of Kv11.3 (erg3) channels expressed in CHO cells. Activation of rat Kv11.3 current occurred in a dose-dependent manner and maximal current increasing effects were obtained with 10 µM NS1643. At this concentration, steady-state outward current increased by about 80% and the current increase was associated with a significant shift in the voltage dependence of activation to more negative potentials b
View details →Negative / Null Result ReportOpen accessMedicine
Roni F Rayes, Tamás Kálai, Kálmán Hideg et al. · 2011 · PLoS ONE
The dynamics of four regions of tropomyosin was assessed using saturation transfer electron paramagnetic resonance in the muscle fiber. In order to fully immobilize the spin probe on the surface of tropomyosin, a bi-functional spin label was attached to i,i+4 positions via cysteine mutagenesis. The dynamics of bi-functionally labeled tropomyosin mutants decreased by three orders of magnitude when reconstituted into "ghost muscle fibers". The rates of motion varied along the length of tropomyosin with the C-terminus position 268/272 being one order of magnitude slower then N-terminal domain or
View details →Negative / Null Result ReportOpen accessMedicine
Anita Raj, Mohan Ghule, Julie Ritter et al. · 2016 · PLoS ONE
Background Despite ongoing recommendations to increase male engagement and gender-equity (GE) counseling in family planning (FP) services, few such programs have been implemented and rigorously evaluated. This study evaluates the impact of CHARM, a three-session GE+FP counseling intervention delivered by male health care providers to married men, alone (sessions 1&2) and with their wives (session 3) in India. Methods and findings A two-armed cluster randomized controlled trial was conducted with young married couples (N = 1081 couples) recruited from 50 geographic clusters (25 clusters randomi
View details →Negative / Null Result ReportOpen accessMedicine
Shiro Okumura, Hironori Koga, Kuniyo Inouye et al. · 2014 · Toxins
Parasporin-4 (PS4) is an aerolysin-type β-pore-forming toxin produced by Bacillus thuringiensis strain A1470. It exhibits specific cytotoxicity against human cancer cell lines; therefore, it is expected to be useful for the diagnosis and treatment of particular types of cancer cells. We examined the acute toxicity of PS4 on ICR mice. The LD50 value was 160 μg/kg by a subcutaneous route. Potassium, ammonium, magnesium ion, creatinine, and urea nitrogen decreased in urine by the injection of PS4. Simultaneously, creatinine and urea nitrogen in mice serum increased. These results imply that PS4 i
View details →Negative / Null Result ReportOpen accessMedicine
Yanwei Li, Dongchuan Yu · 2015 · PLoS ONE
Children's emotion word comprehension (EWC) has constantly received a great deal of attention in developmental science. However, since previous reports focused on only English emotion vocabulary, researchers thus far remained unclear as to the developmental trajectories of EWC (to Chinese emotion words) in Chinese children, let alone the cross-cultural difference of EWC in different languages (i.e., English V.S. Chinese). Furthermore, the influence of valence on EWC, as well as the interaction mechanism between EWC and empathy, has not been fully investigated. Finding answers to these research
View details →Negative / Null Result ReportOpen accessMedicine
Yan Michael Li, Richard Francis Frisch, Zheng Huang et al. · 2021 · Asian Spine Journal
Study Design Retrospective chart review. Purpose This study compared the clinical and radiographic outcomes of patients treated with expandable and static interbody spacers following minimally invasive lateral lumbar interbody fusion (MIS-LLIF) with 12-month follow-up. Overview of Literature A common surgical option for the treatment of degenerative disk disease (DDD) is MIS-LLIF using static or expandable spacers to restore disk height (DH), neuroforaminal height (NH), and segmental lordosis. Static spacers may require excessive trialing and aggressive impaction, potentially leading to endpla
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Shermineh Heydari, Ladan Kashani, Mehrdad Noruzinia · 2021 · Iranian Journal of Allergy, Asthma and Immunology
Endometriosis is a common, chronic, inflammatory disorder in women, characterized by the presence of endometrial tissue outside the uterus cavity. The disease affects ~10% of women during their reproductive age. There is some debates on the pathogenesis of endometriosis and its mechanism among the scientists; therefore, different hypotheses have been suggested. According to Sampson theory, a possible mechanism for seeding ectopic endometriotic lesions is a dysregulation of endometrial mesenchymal stem cells (eMSCs). In the present study, we evaluated the expression of candidate genes in eMSCs
View details →Negative / Null Result ReportOpen accessMedicine
Koji Komatsu, Yoichiro Masuda, Hoshiho Kubota et al. · 2025 · Scientific Reports
Abstract The study aimed to investigate whether eosinophil major basic protein (MBP), which is linked to cataract formation due to lens epithelial cell (LEC) damage in atopic dermatitis (AD), is associated with intraocular lens (IOL) dislocation. This retrospective observational study was conducted at a Medical University Hospital and included 22 eyes (10 AD, 12 non-AD [NAD]) that underwent IOL explantation and fixation. Surgeries were conducted to extract the intraocular lens capsule for morphological evaluations. Quantitative analysis of the MBP staining was conducted using the staining area
View details →Negative / Null Result ReportOpen accessMedicine
Lin C, Mei YM, Yan Y et al. · 2026 · Head & face medicine
AIM: To evaluate the adjunctive clinical efficacy of manual root planing following ultrasonic subgingival debridement (SD) in the treatment of generalized severe periodontitis. MATERIAL AND METHODS: Twenty-nine patients diagnosed with…
View details →Negative / Null Result ReportOpen accessMedicine
Bilinç Doğruöz Karatekin, Şeyhmus Yasin, Yasemin Yumuşakhuylu et al. · 2021 · Bagcilar Medical Bulletin
Objective:Sarcopenia and osteoporosis share common risk factors and biological pathways. In the present study, patients with postmenopausal osteoporosis were screened for sarcopenia using the algorithm proposed by the European Working Group on Sarcopenia in Older People (EWGSOP) and balance impairment was investigated in sarcopenic patients.Method:Fifty three postmenopausal osteoporotic patients were evaluated for sarcopenia as per the algorithm proposed by the EWGSOP. Among the parameters included in the algorithm, gait speed was assessed using the timed up&go test (TUG), Jamar hand dynamomet
View details →Negative / Null Result ReportOpen accessMedicine
Qais A. AL-Oqaily · 2016 · The Iraqi Journal of Medical Sciences
Background:Several studies have demonstrated the role of hematological parameters like hemoglobin (Hb), white blood cells (WBC) count and platelet count in the assessment of patients with coronary artery disease; some studies suggest an additional role of platelet indices in the prognosis of patients with coronary artery disease. Objective:To assess complete blood count and platelet indices in patients with coronary artery disease. Methods: Blood sample of 42 newly diagnosed ischemic heart disease patients including 20 patients with myocardial infarction (MI) and 22 patients with unstable angi
View details →Negative / Null Result ReportOpen accessMedicine
LI Yongxu, LIN Libin, LU Taotao et al. · 2023 · 康复学报
ObjectiveTo observe the effect of swimming exercise preconditioning on neurological function and expression levels of brain derived neurotrophic factor (BDNF), serine-threonine kinase (Akt) and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) proteins in perihematoma tissues of mice with intracerebral hemorrhage (ICH).MethodsA total of 60 male C57BL/6 mice were randomly divided into sham group, ICH 7 d group, SEP+ICH 7 d group (preconditioning group 1), ICH 14 d group and SEP+ICH 14 d group (preconditioning group 2), with 12 cases in each group. The preconditioning group 1
View details →Negative / Null Result ReportOpen accessMedicine
Ted Lee, Heiko Yang, David Haneuer et al. · 2018 · Hospital Practices and Research
Background: Iatrogenic urethral injury is a well-known risk of urinary catheter insertion. Associated morbidities include stricture formation, catheter associated infection, risk for instrumentation, and extended length of stay. Yet, insufficient attention is paid to its prevention. Objective: This study aimed to assess the effectiveness of a computerized ordering system in reducing iatrogenic urethral injuries in men at high risk for iatrogenic urethral injury from traumatic catheterization. Methods: A pre-post study was performed to assess the impact of a computerized ordering system that re
View details →Negative / Null Result ReportOpen accessMedicine
Ghalib A Akinlabi, Paul L Kaufman, Julie A Kiland · 2021 · PLoS ONE
Purpose In earlier experiments in Nigeria, aqueous extract of Pleurotus tuber-regium (PT) had been shown to lower intra ocular pressure (IOP) in a feline model. The aim of the current study was to determine whether PT had the same or a similar IOP-lowering effect in ocularly normal non-human primates. Methods Four monkeys were treated twice daily for 4 days with 2 x 20 μl drops of 50 mg/ml PT (pH = 4.3). The monkeys were sedated with 5-10 mg/kg ketamine HCl IM. PT was administered to the right eye and BSS to the left eye. Baseline IOP was measured just prior to beginning treatment, and on day
View details →Negative / Null Result ReportOpen accessMedicine
Shurong Huang, Zhe Su, Huiping Su et al. · 2022 · Scientific Reports
Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of puberty (EOP). This case–control study enrolled 254 girls with EOP from the Endocrinology Department at Shenzhen Children’s Hospital between December 2018 and August 2019. Ultra-performance liquid chromatography and tandem mass spectrometry were used to analyze the 10 metabolites of PAEs (mPAEs) in urine samples. BA was measured using an artificial intelligen
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Christine B. French, Sharon L. McDonnell, Reinhold Vieth · 2019 · Journal of Medical Case Reports
Abstract Background Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation is affected by the pre-dose versus post-dose timing of the blood draw. Case presentation The participant in this case study was a generally healthy Caucasian woman in her 40s who has taken 5000 IU vitamin D3 supplement at midday for over 1 year. Each blood sample was drawn individually from
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ZHANG Yanan, MAO Chuanwu, XIONG Chenglong et al. · 2022 · Shanghai yufang yixue
ObjectiveTo explore the effects of different dietary induction models of inulin， resistant starch RS3 and their complexes on the body weight and intestinal flora in mice.MethodsA total of 64 C57BL/6 mice were randomly divided into low-fat control group， low-fat inulin group， low-fat resistant starch RS3 group， low-fat composite group and high-fat control group， high-fat inulin group， high-fat resistant starch RS3 group and high-fat composite group for dietary intervention. The mice were weighed and fresh feces were collected weekly. Diet intervention was continued until the weight of the high-
View details →Negative / Null Result ReportMedicine
Vermot-Desroches V, Rezkallah A, Kodjikian L et al. · 2026 · Journal francais d'ophtalmologie
Purpose The goal of the present study was to compare the effect of nasal versus temporal placement of the iStent Inject W® during phacoemulsification on intraocular pressure (IOP). Design and participants Over 5 consecutive years, 389 eyes…
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Falcão MG, Suarez MA, Ferreira ACOP et al. · 2026 · Acta ortopedica brasileira
Objective To analyze the outcomes related to partial and total hip arthroplasties in elderly patients with femoral neck fractures at a hospital in the city of São Paulo. Material and methods We reviewed the medical records of patients…
View details →Negative / Null Result ReportOpen accessMedicine
Qina Ye, Shaodan Sun, Jian Deng et al. · 2023 · Scientific Reports
Abstract To investigate the gut microbiota distribution and its functions in children with avoidant/restrictive food intake disorder (ARFID). A total of 135 children were enrolled in the study, including 102 children with ARFID and 33 healthy children. Fecal samples were analyzed to explore differences in gut microbiota composition and diversity and functional differences between the ARFID and healthy control (HC) groups via 16S rDNA and metagenomic sequencing. The gut microbiota composition and diversity in children with ARFID were different from those in heathy children, but there is no diff
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Sabah Jalal Sherif, Baderkhan Saeed Ahmed, Botan Abdul Kadir Ali · 2023 · Advanced Medical Journal
Background and objective: Acute appendicitis is one of the most common surgical emergency con-ditions. This study was done to clarify the effect of antibiotics in reducing post appendectomy com- plications after open and laparoscopic appendectomy in patients with non-perforated appendicitis. Methods:This is a randomized controlled trial. Three hundred and twenty one patients, who underwent appendectomy for non-perforated appendicitis and fulfilled the selection criteria, were randomly divided into two groups. The patients in group A received double dose of pre-operative and postoperative antib
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Mustafa Umut Somuncu, Huseyin Karakurt · 2019 · Türk Kardiyoloji Derneği Arşivi
Objective: Primary prevention of sudden cardiac death in ST-elevation myocardial infarction (STEMI) is a complicated issue due to the highly heterogeneous population. The effect of T-wave alternans (TWA) on cardiac mortality has been examined in various populations, most often in patients with a high risk of fatal arrhythmia, such as patients with a low left ventricular ejection fraction (LVEF). The aim of the present study was to investigate the prevalence of TWA and its relationship to cardiac mortality in young STEMI patients with preserved LVEF. Methods: A total of 108 STEMI patients with
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Yasser Rezapour, Kianoush Abdi, Hossein Rezai et al. · 2011 · Iranian Rehabilitation Journal
Objectives: The spontaneous language sample analysis is an important part of the language assessment protocol. Language samples give us useful information about how children use language in the natural situations of daily life. The purpose of this study was to compare Conversation, Freeplay, and narrative speech in aspects of Mean Length of Utterance (MLU), Type-token ratio (TTR), and the number of utterances. Methods: By cluster sampling method, a total of 30 Semnanian five-year-old boys with normal speech and language development were selected from the active kindergartens in Semnan city. Co
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Tryness Munyapa, Thokozani Mzumara, Grace Ogbonna et al. · 2023 · Health Science Reports
Abstract Background and Aim Goldman Applanation Tonometry (GAT), the gold standard of tonometry, is used without fluorescein in low‐resource settings. Nevertheless, corneal biomechanics differ among population groups. Purpose The aim of the study is to assess the relationship between GAT findings with and without fluorescein among glaucomatous and nonglaucomatous adults in Malawi. Methods This was a cross‐sectional quantitative study involving 22 glaucoma patients and 22 nonglaucoma patients at Mzuzu Central Hospital. We used a purposive sampling technique to select participants into the two g
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Esma Altan, Elife Barmak, Ebru Karaca Umay et al. · 2025 · Gazi Medical Journal
Objective: Spasmodic dysphonia (SD) is a neurological movement disorder involving the laryngeal muscles. There are three main types: adductor, abductor, and mixed type. Adductor type is the most common and mixed type is the rarest. Botox, the gold standard in treatment, is applied to the affected muscle group according to the type of SD. Dysphagia often occurs as a side effect of botulinum toxin injection treatment in spasmodic dystonia. Dysphagia may sometimes be seen secondary to SD. Methods: This study included 8 patients with adductor SD without dysphagia and 8 healthy subjects. The total
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Quamrun Nahar, Farhana Sultana, Anadil Alam et al. · 2014 · PLoS ONE
Background There has been no population-based study on human papillomavirus (HPV) prevalence or its genotypes in Bangladesh; a country eligible for GAVI funding for HPV vaccine. Methods We used baseline survey data of a prospective cohort study that was conducted in one urban and one rural area of Bangladesh. A total of 997 urban and 905 rural married women, aged 13 to 64 years, were enrolled in the baseline during July-December, 2011. Information was collected on socio-demographic characteristics and potential risk factors for HPV infection followed by gynecological examination and collection
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