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WASTE Journal

Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Comparative evaluation of <i>Calotropis gigantea</i> latex and sodium hypochlorite as tissue-dissolving agents - an <i>in vitro</i> study on concentration and time-dependent proficiency.

Ravi M, Annadurai P, Gupta R · 2026 · Biomaterial investigations in dentistry

Background Complete removal of organic tissue and microorganisms from the root canal system is essential for successful endodontic therapy. Sodium hypochlorite (NaOCl) remains the gold standard irrigant for its tissue-dissolving and…

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Negative / Null Result ReportOpen accessMedicine

Some carcass and meat quality characteristics of Anatolian local and Mast geese in semi-intensive conditions.

Ürer H, Yıldırım İ, Asker G et al. · 2026 · Tropical animal health and production

In this study, meat quality characteristics of Anatolian local geese (Anser anser domesticus) and Mast geese (Anser anser) reared under semi-intensive conditions were compared. A total of 100 geese were used: 50 from each breed, 25 males…

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Negative / Null Result ReportMedicine

Intermittent hemodialysis with regional citrate anticoagulation vs. priming heparin and pre-dilution HDF in patients at Risk Of Bleeding in Nephrology (the ROBIN randomized control trial).

Moranne O, Gerbal M, Chkair S et al. · 2026 · Blood purification

Introduction This single center randomized controlled trial (NCT03562754) compared pre-diluted IHDF (PIHDF) without systemic anticoagulation and the Prometheus system with regional citrate anticoagulation (IHD-RCA) in high-bleeding-risk…

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Negative / Null Result ReportMedicine

Association between short (≤ 30-day) dual antiplatelet therapy and 1-year major adverse cardiac events after drug-coated balloon-based non-stent percutaneous coronary intervention following optimal lesion preparation: a propensity score-based cohort study.

Kuroda S, Sawada T, Yui R et al. · 2026 · Cardiovascular intervention and therapeutics

Drug-coated balloon (DCB)-based non-stent percutaneous coronary intervention (PCI) may allow shorter dual antiplatelet therapy (DAPT), but whether a ≤ 30-day regimen is associated with worse outcomes remains unclear, particularly in…

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Negative / Null Result ReportOpen accessMedicine

The influence of different skeletal patterns on TMJ anatomy: a comprehensive CBCT study across various sagittal and vertical skeletal patterns in adults.

Eslami S, Sayahpour B, Tashakor A et al. · 2026 · Clinical oral investigations

Objective This study aimed to evaluate the impact of sagittal and vertical skeletal patterns as well as gender on temporomandibular joint (TMJ) morphology using Cone Beam Computed Tomography (CBCT). Methods A cross-sectional analysis was…

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Negative / Null Result ReportMedicine

Phacoemulsification Combined With 360° Gonioscopy-Assisted Transluminal Trabeculotomy: Prospective 12-Month Outcomes in Primary Open-Angle and Primary Angle-Closure Glaucoma.

Maheshwari D, Nagdev NG, Pillai MR et al. · 2026 · Journal of glaucoma

Precis This study concludes that combined gonioscopy assisted transluminal trabeculotomy-phacoemulsification have similar efficacy in terms of intraocular pressure and antiglaucoma medication reduction in primary open angle and primary…

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Negative / Null Result ReportMedicine

The Effect of Smoking History on Inflammatory Biomarkers in Synovial Fluid of Patients Undergoing Arthroscopic Knee Surgery for Meniscal Injury.

Kurtz JL, Ehlers M, Montgomery SR Jr et al. · 2026 · The American journal of sports medicine

Background Smoking has been linked to alterations in cellular inflammatory pathways and adverse outcomes in orthopaedic procedures. It is unclear how patient smoking affects the intra-articular microenvironment in the setting of…

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Negative / Null Result ReportOpen accessMedicine

Nano-magnolol enhances the modulatory effects of magnolol on cognitive performance and BACE1-related biochemical changes in an STZ-induced rat model of Alzheimer's disease.

Youssef B, Ibrahim EA, Moselhy SS et al. · 2026 · Discover nano

Background The Late-onset Alzheimer's disease (LOAD) is progressive cognitive deficits associated with different abnormalities as cholinergic dysfunction, amyloid accumulation, inflammation, and oxidative stress. Magnolol is a polyphenolic…

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Negative / Null Result ReportOpen accessMedicine

Clinical study on the efficacy comparison between ileotransverse colon overlap anastomosis and π-shaped anastomosis in laparoscopic radical right hemicolectomy.

Fangxin W, Bin L, Haocheng Z et al. · 2026 · Frontiers in surgery

Objective To compare the safety and efficacy of ileotransverse colon Overlap and π-shaped anastomosis in laparoscopic radical right hemicolectomy (LRRH). Methods A prospective RCT enrolled 120 right colon cancer patients (Dec 2022-Dec…

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Negative / Null Result ReportMedicine

Vision-related quality of life following trabeculectomy versus Baerveldt glaucoma implant: Five-year results from a randomized clinical trial.

Popescu-Giovanitsas I, Woudstra-de Jong JE, Vingerling JR et al. · 2026 · Acta ophthalmologica

Purpose To assess the vision-related quality of life (VRQoL) in glaucoma patients over 5 years after primary Baerveldt glaucoma implant (BGI) or trabeculectomy (TE) using a secondary analysis of a randomized clinical trial. Methods…

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Negative / Null Result ReportOpen accessMedicine

Comparative efficacy and safety of different posterior surgical approaches for Intra-articular distal humerus fractures.

Yao H, Chen W, Lin Z et al. · 2026 · Journal of orthopaedic surgery and research

Objective To systematically compare the clinical efficacy and safety of four posterior surgical approaches-olecranon osteotomy (OO), triceps-reflecting approach (TRA), triceps-splitting approach (TS), and triceps tongue approach (TT)-for…

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Negative / Null Result ReportOpen accessMedicine

Reporting of patient-reported outcomes (PROs) in randomized controlled trials of anemia treatments for people with CKD: a scoping review.

Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes

BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…

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Negative / Null Result ReportOpen accessMedicine

Amniotic Membrane Versus Platelet-Rich Fibrin for the Treatment of Gingival Recession Using the Vestibular Incision Subperiosteal Tunnel Access Technique: A Randomized Controlled Clinical Trial.

Advani H, Dixit A, Kumar S et al. · 2026 · Cureus

Background Gingival recession (GR) results in significant functional and cosmetic concerns and manifests as a disintegration of soft and hard tissues. Recently, clinical research has increasingly focused on the development of minimally…

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Negative / Null Result ReportOpen accessMedicine

Accuracy of Marginal and Internal Adaptation of Advanced Lithium Disilicate Crowns Using Different Margin Designs (In Vitro Study).

Mohamed HA, Azer A, AboElHassan RG · 2026 · International journal of dentistry

Background Advanced lithium disilicate glass ceramics offer excellent esthetics, but conservative crown preparations are not always the preferred choice. Various margin designs are available; however, more conservative vertical…

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