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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of water and fertilizer coupling on growth and development of Chinese dwarf cherry (<i>Cerasus humilis</i>) and evaluation of water and fertilizer use efficiency.

Liu S, Li Z, Chen S et al. · 2026 · Frontiers in plant science

Introduction In recent years, the demand for high-nutrition fruits has increased. As a unique fruit tree in China, Cerasus humilis has both ecological and nutritional value. Water and fertilizer nutrition is closely related to plant growth…

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Negative / Null Result ReportOpen accessMedicine

Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering.

van Mourik M, Spierings J, Koca P et al. · 2026 · Journal of tissue engineering and regenerative medicine

Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Outcomes of Combined Phacoemulsification and Non-Penetrating Deep Sclerectomy versus Standalone Non-Penetrating Deep Sclerectomy.

Safadi K, Gutierrez Vargas GA, Cnaany Y et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To compare the efficacy and safety of combined phacoemulsification and non-penetrating deep sclerectomy (Phaco-NPDS) with standalone NPDS in a large glaucoma cohort with long-term follow-up. Methods This retrospective cohort study…

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Negative / Null Result ReportOpen accessMedicine

Vonoprazan as an adjuvant to cisplatin: enhancing antitumor efficacy while mitigating nephrotoxicity and gastrointestinal adverse effects.

Alenezi FN, Abdelmageed ME, Nader MA et al. · 2026 · Frontiers in pharmacology

Background/objective Cisplatin is a popular platinum-containing chemotherapeutic agent that has been used clinically since the 1970s to manage a wide range of hematologic and solid tumors. However, its therapeutic purpose is restricted by…

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Negative / Null Result ReportOpen accessMedicine

Effects of 3',4'-dihydroxyflavonol treatment on Neu N and BDNF and ICAM levels in the striatum of rats subjected to transient bilateral carotid occlusion-induced ischemia-reperfusion.

Hoşgör M, Uzdil EK, Aladag T et al. · 2026 · Journal of bioenergetics and biomembranes

Cerebral infarction is a leading cause of severe long-term disability and functional and cognitive impairment. With the advancement of acute stroke treatment, more patients are now experiencing stroke with varying degrees of impairment.…

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Negative / Null Result ReportOpen accessMedicine

Hemodynamic effects of high frequency oscillatory ventilation versus conventional mechanical ventilation in term neonates with persistent pulmonary hypertension: a single-center randomized trial.

El Amrousy D, Koura H, Abdou N et al. · 2026 · Italian journal of pediatrics

Background We aimed to evaluate the hemodynamics in full-term neonates with persistent pulmonary hypertension (PPH) on high frequency oscillatory ventilation (HFOV) versus conventional mechanical ventilation (CMV). Methods This trial was…

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Negative / Null Result ReportMedicine

The effect of video assisted instruction on central venous catheter application skills, anxiety and satisfaction in nursing students: a randomised controlled study.

Koç G, Yüce Başaran HD, Yavuz B et al. · 2026 · BMC medical education

Objective This study aimed to evaluate the effect of video-assisted instruction on central venous catheter (CVC)-related psychomotor skills (blood collection, drug administration, and dressing care), anxiety levels, and student…

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Negative / Null Result ReportOpen accessMedicine

Large language models perpetuate bias in palliative care: Development and analysis of the Palliative Care Adversarial Dataset (PCAD).

Akhras N, Antaki F, Mottet F et al. · 2026 · PLOS digital health

Bias and inequity in palliative care disproportionately affect marginalised groups. Large language models (LLMs), such as GPT-4o, hold potential to enhance care but risk perpetuating biases present in their training data. This study aimed…

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Negative / Null Result ReportOpen accessMedicine

Enhanced efficacy of tylvalosin tartrate enteric-coated granules against <i>Mycoplasma hyopneumoniae</i> in pigs: <i>in vitro</i> activity and clinical dosage optimization.

Li J, Zhou X, Wang W et al. · 2026 · Frontiers in microbiology

Background Mycoplasma hyopneumoniae (Mhp), the etiological agent of enzootic pneumonia in pigs, poses significant challenges to swine production. This study evaluated the anti-Mhp efficacy of a novel enteric-coated granules of tylvalosin…

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Negative / Null Result ReportOpen accessMedicine

Comparison of the Effects of Local Heat and Massage Using the Flick Application on Pain Caused by Vitamin K Injection in Neonates.

Momenisoroshk J, Sadeghi T, Seyedbagheri S · 2026 · Pediatric health, medicine and therapeutics

Purpose Healthy neonates experience pain during procedures such as vitamin K injections. Pain adversely affects the neonate, so it is important to control it. This study compared the effects of local heat and massage using the flick…

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Negative / Null Result ReportOpen accessMedicine

The Effect of the combination therapy of statin and dapagliflozin, a selective inhibitor of sodium_glucose Co-transporter type 2, in the treatment of Ischemic heart disease with heart failure: A randomized controlled trial.

Abdelkader AM, Osama H, Hassan ES et al. · 2026 · European journal of clinical pharmacology

Purpose Gliflozins (SGLT2 inhibitors) and statins are key treatments commonly used in patients with ischemic heart failure. Although both are well known for diminishing cardiovascular risk and heart failure-related mortality, the possible…

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Negative / Null Result ReportMedicine

PERFECT MATCH: can you fit the personality to the service? Understanding personality traits of hospital pharmacists in different clinical services-an observational study.

Brideau S, Duong T, Nacevska I et al. · 2026 · The International journal of pharmacy practice

Objectives The objective of the study was to evaluate if using a validated psychometric test, The Big Five Personality Test, would identify an association between personality traits among hospital pharmacists and certain clinical services.…

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Negative / Null Result ReportOpen accessMedicine

The abilities of nitrogen-fixing bacteria to produce siderophores affect their promoting effects on cucumber growth and antiphytopathogenic fungus activities.

Wang EX, Li J, Zhang YT et al. · 2026 · Frontiers in microbiology

Introduction Many nitrogen-fixing bacteria (NFB) can synthesize siderophores. However, the contribution of NFB siderophore synthesis to plant growth has not been evaluated, and its impact on NFB's antifungal activity remains unclear.…

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Negative / Null Result ReportOpen accessMedicine

Oral Health and Idiopathic Female Infertility: A Potential Association.

Kovács D, Boda K, Badó A et al. · 2026 · Oral health & preventive dentistry

Purpose To explore the possible link between periodontal and dental health and idiopathic female infertility in South East Hungary, along with identifying relevant sociodemographic factors. Methods and materials The study included women…

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Negative / Null Result ReportOpen accessMedicine

Antibacterial and anti-biofilm effects of postbiotic mediator derived from <i>Jeotgal</i> isolate <i>Lactiplantibacillus plantarum</i> KMC12 against <i>Streptococcus mutans</i>.

Oh H, Kim J, Bai J · 2026 · Journal of oral microbiology

Background Dental caries, commonly known as tooth decay, is a progressive breakdown of tooth tissues caused by the biofilm-producing bacteria, Streptococcus mutans . S. mutans plays a primary role in the initiation and progression of…

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Negative / Null Result ReportOpen accessMedicine

Empagliflozin enhances cisplatin activity in chemo-resistant EJ138 bladder cancer cells: The importance of anti-diabetic medications in cancer treatment.

Shariati S, Mohtadi S, Molavinia S et al. · 2026 · Scientific reports

Anti-diabetic medications have been found to reduce chemotherapy resistance. This study sought to investigate the role of Empagliflozin (Empa) as an anti-diabetic medication in reversing Cisplatin (Cis) resistance in EJ138 bladder cancer…

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Negative / Null Result ReportOpen accessMedicine

Selected immunoendocrine and performance adaptations to upper-body plyometric training and β-alanine supplementation in male swimmers.

Gao H, Yu X, Guo Z · 2026 · Journal of the International Society of Sports Nutrition

Background Upper-body plyometric training (PT) enhances neuromuscular performance and power production. However, its application in swimming and its potential interaction with β-alanine (BA) supplementation remain largely unexplored.…

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Negative / Null Result ReportMedicine

Evaluation of Point-of-Care Coagulation Measurement Systems for Activated Clotting Time and Partial Thromboplastin Time in Heparinized and Non-Heparinized Equine Blood.

Hobbs KJ, Ueda Y, Qu Y et al. · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objectives To compare the performance of one point-of-care activated clotting time (ACT) machine (Vet-Tube), one point-of-care activated partial thromboplastin time (aPTT) machine (Coagulation DX), and one bench-top ACT machine (Medtronic…

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Negative / Null Result ReportMedicine

Homemade Ultrasound Stand-Off Gel Pads: A Multi-Parameter Performance Study.

William MFGBMF, Jamil NAB, Leong SS et al. · 2026 · Australasian journal of ultrasound in medicine

Aim Stand-off gel pads made of natural ingredients may provide a low-cost option in clinical ultrasound imaging. This study investigated the performance and safety of homemade pads. Methods Thirty stand-off gel pads were made of aloe vera,…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of soluble transferrin receptor and malondialdehyde levels associated with ferroptosis in children with familial Mediterranean fever in remission.

Dogantan S, Keskin A, Yücel BB et al. · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective Familial Mediterranean fever, an autoinflammatory disease, is characterized by recurrent stereotypic febrile attacks associated with an inflammatory syndrome. Malondialdehyde, a lipid peroxidation marker, and soluble transferrin…

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