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Browse the failure-mode index

12,263 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Optimising the implementation of adolescent-friendly health services and its effects on contraceptive uptake and adolescent pregnancy in rural Mozambique: an implementation research study of the S-NICE intervention.

Chilundo, Xinavane, Huo et al. · 2026 · Frontiers in reproductive health

Despite national policies promoting adolescent- and youth-friendly health services, implementation gaps hinder improvements in adolescent sexual and reproductive health outcomes in Mozambique. S-NICE is a structured, participatory…

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Negative / Null Result ReportMedicine

Persuasive Gamified Virtual Reality Experience to Enhance Engagement and Focus in Young Adults With Mild Anxiety Symptoms: Randomized Pilot Experimental Study.

Argaw, Jingili, Oyelere et al. · 2026 · JMIR XR and spatial computing

Anxiety-related symptoms are prevalent and can negatively affect concentration, motivation, and overall well-being. Traditional treatments such as cognitive behavioral therapy and medication work well for clinical anxiety disorders.…

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Negative / Null Result ReportMedicine

Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors.

Sheikh, Singh, Smith et al. · 2026 · Frontiers in cardiovascular medicine

The impact of catheter-directed thrombolysis (CDT), catheter-directed embolectomy (CDE) and surgical pulmonary embolectomy (SPE) on long term RV function among patients with acute PE remains unclear. We investigated the association of…

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Negative / Null Result ReportMedicine

Nutritional indicators and fluid self-efficacy among hemodialysis patients in the Qassim region, Saudi Arabia: a multicenter descriptive cross-sectional study.

Elmansy, Elbqry, Qalawa et al. · 2026 · Frontiers in nutrition

Hemodialysis is a life-sustaining renal replacement therapy that removes metabolic waste products normally eliminated by the kidneys. Patients undergoing hemodialysis are required to adhere to strict fluid and dietary restrictions to…

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Negative / Null Result ReportMedicine

Dietary inclusion of black cumin ( Nigella sativa L.) seed meal in broiler chickens: Effects on growth performance, cecal microbiota, and cost efficiency.

Tilahun, Urge, Girma et al. · 2026 · Veterinary and animal science

The current study evaluated the effects of black cumin seed meal (BCSM) on growth performance, cecal microbiota, production efficiency, and cost efficiency in broiler chickens. A total of 144 one-day-old unsexed Cobb 500 broiler chicks…

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Negative / Null Result ReportMedicine

Pre-synchronization with GnRH or hCG enhances fertility outcomes of heat synch protocol in Holstein dairy cows across parities: A pilot study.

Navidifar, Kaveh, Hosseini et al. · 2026 · Veterinary and animal science

Efficient estrus synchronization is important for improving reproductive performance in dairy herds; however, variations in ovarian activity among cows of different parities may influence responses to synchronization protocols. The present…

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Negative / Null Result ReportMedicine

Effect of Chitosan Modification and Support Type on the Catalytic Properties of Supported Palladium Catalysts in Hydrogenation of 2-Propen-1-ol.

Naizabayev, Talgatov, Auyezkhanova et al. · 2026 · Molecules (Basel, Switzerland)

Palladium catalysts modified with chitosan (CS) and supported on MgO, SiO 2 , TiO 2 , and Al 2 O 3 were prepared by a precipitation method and evaluated in the low-temperature hydrogenation of 2-propen-1-ol. Chitosan was first deposited…

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Negative / Null Result ReportMedicine

Optimized Extraction of Medicinal Mushroom Polysaccharides and Their Protective Effects Against 5-Fluorouracil-Induced Gastrointestinal Mucositis.

Dos Santos, Sauruk da Silva, Iacomini et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background : Ganoderma lucidum is a medicinal mushroom widely recognized for its high content of bioactive polysaccharides, particularly β-glucans with immunomodulatory properties. This study aimed to optimize polysaccharide…

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Negative / Null Result ReportMedicine

A Randomized Study Evaluating the Effect of Ossein-Hydroxyapatite Complex on the Functional Outcomes of Patients After Conservative Treatment of Distal Radius Fracture.

Zaborska, Sobczak, Kubas et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: Distal radius fractures (DRFs) are the most common upper limb fractures worldwide. The main goal of DRF treatment is to achieve optimal functional outcomes with the lowest complication rate as rapidly as possible. Achieving…

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Negative / Null Result ReportMedicine

Phytochemicals from Agro-Industrial By-Products for Breast Cancer Prevention and Therapy: Molecular Mechanisms and Circular Bioeconomy Perspective.

Maffia, Marra, Battaglia et al. · 2026 · Pharmaceuticals (Basel, Switzerland)

Breast cancer remains one of the most frequently diagnosed malignancies and a leading cause of cancer-related mortality among women worldwide. The growing interest in natural bioactive compounds has highlighted plant-derived phytochemicals…

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Failed Experiment ReportMedicine

Loureirin B Attenuates Methotrexate-Induced Liver Injury Associated with Oxidative Stress, SIRT1 Alterations, and TGF-β/SMAD3-Related Profibrotic Responses.

Hengirmen Acu, Erbaş · 2026 · Pharmaceuticals (Basel, Switzerland)

Background: Methotrexate-induced oxidative stress is mechanistically linked not only to hepatocellular injury but also to DNA damage, indicating that oxidative stress, hepatotoxicity, and genotoxicity represent interconnected…

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Negative / Null Result ReportMedicine

Residual biological surrogate aerosol risk reduction during disrobing litter-bound manikin patients using two dry air treatments for cold regions.

Garner C, Sleeth D, Slagley J et al. · 2026 · American journal of disaster medicine

Objective Determine relative effectiveness of two dry air decontamination methods to reduce residual airborne surrogate biological agent on litter-bound manikin patients during disrobing. Design Fluorescent 1 µm polystyrene latex (PSL)…

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Negative / Null Result ReportMedicine

[Comparison of CNV-seq and chromosomal microarray analyses of abortive tissues].

Fu Y, Liu J, Sun H et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To compare the performance of copy number variation sequencing (CNV-seq) and chromosomal microarray analysis (CMA) for the analysis of abortive tissues. Methods Tissue samples were collected from 396 patients with missed abortion…

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Negative / Null Result ReportOpen accessMedicine

Perception of the patient safety culture among healthcare workers.

Ibrahim MG, Hassan MH, Lotfy AMM · 2026 · BMC health services research

Background Patient safety culture (PSC) is a key determinant of care quality, influencing clinical outcomes, staff functioning, and the resiliency of organizations. While PSC has evolved globally, it remains established in developing…

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Negative / Null Result ReportMedicine

Comparison of Super Mini Percutaneous Nephrolithotomy (smPCNL) and Extracorporeal Shock Wave Lithotripsy (ESWL) in Pediatric 1-2 cm Kidney Stones: A Single-Center Retrospective Controlled Study.

Sevim M, Demir M, Eryılmaz R et al. · 2026 · Urology journal

Purpose To compare outcomes of super mini percutaneous nephrolithotomy (smPCNL) with extracorporeal shock wave lithotripsy (ESWL) for stones 1-2 cm. Materials and methods After receiving ethics committee approval for this study (Date:…

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Negative / Null Result ReportOpen accessMedicine

Effects of Different Carbohydrate Level Diets on Growth Performance and Glycometabolism in Mandarin Fish (<i>Siniperca chuatsi</i>) Under Saline-Alkali Stresses.

Kong Y, Fan J, Li Y et al. · 2026 · Aquaculture nutrition

Saline-alkali cultivation is a crucial approach to alleviate the fresh water crisis. However, prolonged saline-alkali stresses might bring adverse effects on fish growth, health, and even death. This study evaluated the effects of…

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Negative / Null Result ReportMedicine

Consistency and Objectivity in Assignment Evaluation in Dental Education: A Comparison of Different Assessment Methods.

Yiğit E, Atsü S · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective This study examines differences in scores assigned to dental students' assignments when evaluated by two instructors and compares assessments conducted with a structured preclinical assessment form versus those without one.…

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