12,262 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mohamed, Alharbi, Alanazi et al. · 2026 · Cureus
Internuclear ophthalmoplegia (INO) is a distinct ocular motility disorder localizing to the medial longitudinal fasciculus (MLF). Because the MLF is a microscopic, highly myelinated tract, small inflammatory lesions can cause significant…
View details →Mohamed, Farah, Elhamaky et al. · 2026 · Radiology case reports
Inferior vena cava (IVC) filter penetration is an increasingly recognized complication, particularly after prolonged dwell time or failed retrieval. Although often asymptomatic, multidirectional penetration into adjacent structures may…
View details →Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports
Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…
View details →Niu, Liu, Sun et al. · 2026 · Journal of nanobiotechnology
Urethral reconstruction often fails due to the foreign body reaction (FBR) triggered by the graft, leading to chronic inflammation, fibrosis, and lumen obstruction. To address this challenge, we developed an innovative strategy: a…
View details →Ciani Berlingeri, Phillips, Mejia Bibriesca et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor behaviors is difficult because most…
View details →Chen, Yang, Liu et al. · 2026 · Journal of hazardous materials
Assessing water quality comprehensively is crucial for predicting environmental risks. However, existing toxicity assessments are limited to specific physiological processes or reference organisms, failing to capture holistic hazards. Here…
View details →Tan, Gao, Huang et al. · 2026 · Journal of the American Chemical Society
Sulfur(VI) fluoride exchange (SuFEx) has emerged as a powerful click reaction for constructing diverse S(VI)-based linkages across chemical biology, materials science, and drug discovery. However, the diversity of SuFEx hubs and native…
View details →Fujikata, Muramatsu, Mizoguchi · 2026 · The Journal of chemical physics
X-ray absorption near-edge structure (XANES) provides element-specific insights into local electronic and structural environments, but quantitative interpretation of molecular XANES under periodic boundary conditions (PBC) remains…
View details →Pizza, Perelli, Grassi et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
To investigate whether posterior tibial slope (PTS) is associated with failure after posterior cruciate ligament reconstruction (PCLR) in a cohort of patients undergoing isolated PCLR and PCL-based multiligament knee injuries (MLKI)…
View details →Vivanco-Aravena, Leiva, Hidalgo · 2026 · The journal of spinal cord medicine
Ventilator dependence is a major cause of morbidity and mortality in patients with high cervical spinal cord injury (CSCI), largely due to diaphragmatic dysfunction. Conventional assessment of inspiratory muscle strength, such as maximal…
View details →Hu, Yang, Li et al. · 2026 · Frontiers in pediatrics
Catch-up growth (CUG) before two years of age in small-for-gestational-age (SGA) infants is a key predictor of adult short stature. We aimed to establish and temporally validate a prediction nomogram for faltering CUG (FCUG) in full-term…
View details →Enomoto, Tamura, Iwama et al. · 2026 · Surgical neurology international
Apical petrositis is a rare but serious infection, often accompanied by osteomyelitis, that may cause cranial neuropathies and typically responds to antibiotics. However, surgical intervention may be required when medical therapy fails or…
View details →Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international
Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…
View details →Zhou, Xia, Zhao et al. · 2026 · European journal of pharmacology
This study aimed to investigate the anti-tumor effects and mechanisms of propranolol (Prop) in mice with colorectal cancer (CRC) combined with chronic stress, as well as its potential impact when used in combination with high-mobility…
View details →Su, Huang, Wang · 2026 · SLAS technology
The accumulation of pathological bronchial secretions compromises ventilation and oxygenation in critically ill patients and may lead to atelectasis or secondary infection in severe cases, making timely identification and removal of…
View details →Alomar-Dominguez, Bauer, Fries et al. · 2026 · Thrombosis research
Massive blood loss during surgery or trauma leads to dilutional coagulopathy. While fibrinogen is typically the first factor to reach critical levels, factor XIII (FXIII) also decreases proportionally, further impairing clot stability.…
View details →Haider, Kamran · 2026 · Cureus
Penile intraepithelial neoplasia (PeIN) is a premalignant lesion with clinical features that often overlap with benign inflammatory dermatoses. Although biopsy remains the diagnostic gold standard, topical acetic acid application producing…
View details →Liao, Xiang, Chen et al. · 2026 · PloS one
The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…
View details →Ippoliti, Gori, Coscarella et al. · 2026 · Skin health and disease
Abrocitinib, a selective Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy in moderate-to-severe atopic dermatitis (AD), although data in patients whose AD is resistant to multiple systemic therapies remain limited. We report the…
View details →Terry, Isenberg, Gomoll et al. · 2026 · Video journal of sports medicine
Multifocal cartilage defects about the knee have become increasingly prevalent. When left untreated, these injuries may progress to diffuse knee osteoarthritis. Operative management for patients with multifocal chondral defects typically…
View details →Wang, Yu · 2026 · SAGE open medical case reports
A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…
View details →Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics
Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…
View details →Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders
Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…
View details →Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports
A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…
View details →Dong, Patel, Wang et al. · 2026 · Environment international
Phthalates are pervasive endocrine-disrupting chemicals widely used in consumer products. The wide use of many phthalates results in chronic human exposure to complex mixtures rather than single compounds. Despite extensive studies on…
View details →Moses K, Kamaraj, Konda Ramachary Subramanian · 2026 · Drug delivery
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar…
View details →Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…
View details →Malzahn, Höft Budde, Kneißl et al. · 2026 · Innere Medizin (Heidelberg, Germany)
The German healthcare system, despite its high performance, fails to achieve the goal of needs-based service provision. Supply-induced demand, regional disparities and misaligned financial incentives lead to overuse, underuse and misuse of…
View details →Shigemoto, Kim · 2026 · Psychology, health & medicine
Chronic pain among people of color is influenced by biological, structural, and social forces. While network models have been applied to chronic pain symptoms, research on resource disparities often isolates factors such as income, failing…
View details →Thiede, Haris, Damjanović et al. · 2026 · Journal of mass spectrometry : JMS
In conventional native mass spectrometry (MS), one faces severe limitations when challenged with heterogeneous, high-mass samples, commonly failing to resolve clear peak distributions, and thus mass determination. Charge detection MS…
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