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WASTE Journal

Browse the failure-mode index

12,262 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Multicenter Analytical Comparison of Automated Quantitative Assays Versus Line Immunoassay for Anti-Ro/La Antibody Detection in Primary Sjögren's Syndrome.

Chen, Hu, Peng et al. · 2026 · Journal of immunology research

This multicenter study aimed to analytically compare the performance of automated quantitative assays-chemiluminescence immunoassay (CLIA) and multiplexed bead immunoassay (MBI)-for detecting anti-Ro/La antibodies in Chinese patients with…

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Negative / Null Result ReportMedicine

The prenylated pUS2 protein of pseudorabies virus contributes to phosphorylation of connexin 43 and suppression of gap junctional intercellular communication.

Tishchenko, De Boeck, Van Waesberghe et al. · 2026 · Journal of virology

Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We…

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Negative / Null Result ReportMedicine

Case Report: Retrospective surgeon-guided reassessment of clinical target volume delineation in low-dose radiotherapy for postoperative chylothorax: an eight-patient case series.

Lin, Lin, Chen · 2026 · Frontiers in medicine

Postoperative chylothorax is an uncommon but challenging complication after thoracic surgery. Low-dose external beam radiotherapy (RT) has been proposed as an adjunct treatment when conservative management or surgical intervention fails,…

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Negative / Null Result ReportMedicine

Protective Effect of Salidroside Against Multiple Organs Ischemia-Reperfusion Injury: New Insights From Common and Specific Pharmacological Mechanisms.

Chi, Zheng, Guo et al. · 2026 · Drug design, development and therapy

Ischemia-percussion (I/R) injury describes a paradoxical phenomenon in which blood flow restoration following ischemia not only fails to salvage the tissue but also exacerbates tissue injury. Due to the unique physiological functions, cell…

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Negative / Null Result ReportMedicine

Comparison of augmented reality computed tomography-based and portable computed tomography-based navigation systems for acetabular cup placement in total hip arthroplasty.

Kobayashi, Naito, Tone et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

This study aimed to compare the accuracy of acetabular cup placement in total hip arthroplasty (THA) using a computed tomography (CT)-based augmented reality (AR) navigation system and a CT-based portable navigation system, both employed…

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Negative / Null Result ReportMedicine

Fish oil supplements in patients with chronic kidney disease.

Ferro, Thomas, Khattak et al. · 2026 · Clinical kidney journal

Cardiovascular disease (CVD) accounts for most of the increased morbidity and mortality associated with in chronic kidney disease (CKD). Cardiovascular risk emerges early in CKD, initially driven by atherosclerotic events but later…

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ProtocolMedicine

Protocol: Comparative efficacy of 2 mL vs. 5 mL 0.375% ropivacaine in subparaneural upper trunk brachial plexus block for postoperative analgesia after arthroscopic shoulder surgery-a randomized noninferiority trial.

Lou, Zhang, Chen et al. · 2026 · Frontiers in medicine

Interscalene brachial plexus block (ISB) is the first-line analgesic technique for arthroscopic shoulder surgery, but it is associated with a > 90% incidence of ipsilateral hemidiaphragmatic paresis (HDP), which severely…

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Negative / Null Result ReportMedicine

HbF/F-cell and the Phenotype of Sickle Cell Disease.

Lofters, Wilks, Lee et al. · 2026 · medRxiv : the preprint server for health sciences

Fetal hemoglobin (HbF) prevents the polymerization of sickle hemoglobin (HbS). HbF, measured usually as a percent of total hemoglobin (%HbF), is inversely associated with the severity of sickle cell disease (SCD) but fails to capture the…

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Negative / Null Result ReportMedicine

Diffuse Cortical, Basal Ganglia, and Bilateral Middle Cerebellar Peduncle Diffusion Restriction in Severe Alcohol-Related Hypoglycemic Encephalopathy: A Case Report.

Rachidi, Amanallah, Benzakour et al. · 2026 · Cureus

Alcohol-induced hypoglycemia is an uncommon but potentially life-threatening metabolic complication, particularly in the setting of prolonged fasting and chronic alcohol use. We report the case of a 63-year-old man with a history of…

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Negative / Null Result ReportMedicine

Angelica dahurica alleviates peripheral nerve injury-induced muscle atrophy via the Phlpp2-Akt-FoxO3α axis independently of analgesia.

Wu, Wang, Liu et al. · 2026 · Phytomedicine : international journal of phytotherapy and phytopharmacology

Peripheral nerve injury frequently causes refractory neuropathic pain and muscle atrophy. While clinical care focuses on analgesia, effective therapies for muscle wasting are lacking. Angelica dahurica (BZ) is known for its analgesic…

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Negative / Null Result ReportMedicine

VC-VTON: Toward Across-View and Multi-Posture-Driven Virtual Try-On via Spatiotemporal-Aware View-Consistency Training.

Ma, Wei, Cai et al. · 2026 · IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Virtual try-on (VTON) aims to synthesize specific fashion images dressed in given garments, which possesses great potential in real-world scenarios. Existing methods generally stand on the shoulder of the single-view VTON to train a…

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Negative / Null Result ReportMedicine

Defective inducible T cell costimulator signalling drives neuropilin-1 hi CD4 + T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model.

Kang, Kim, Kim et al. · 2026 · Experimental & molecular medicine

Inducible T cell costimulator (ICOS) signalling is essential for follicular helper T (Tfh) cell activation and has emerged as a therapeutic target in B cell-dependent autoimmune diseases such as systemic lupus erythematosus (SLE). However,…

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Negative / Null Result ReportMedicine

The Indian Smell Identification Test for Parkinson's Disease: Limitations of Binary Scoring and Proposal of a Modified Graded Approach.

Nagaraj, Prasad, Bhat et al. · 2026 · Annals of Indian Academy of Neurology

Olfactory dysfunction is a common nonmotor symptom and prodromal marker of Parkinson's disease (PD). Despite its early occurrence, hyposmia is frequently underrecognized, emphasizing the need for objective, culturally appropriate tools.…

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Negative / Null Result ReportMedicine

Clinical and radiological outcomes of a cartilage-preserving pinhole transtibial technique versus standard pull-out repair for traumatic posterior meniscal root tears.

Gezer, Demir · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Traumatic posterior meniscal root tears disrupt normal load transmission, resulting in meniscal extrusion and accelerated osteoarthritis. Although transtibial pull-out repair is widely used, creation of a 4.5-mm tibial tunnel at the joint…

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