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WASTE Journal

Browse the failure-mode index

12,262 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Clinical outcomes according to the location of graft retear after arthroscopy-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears.

Baek CH, Lim C, Kim JG et al. · 2025 · The bone & joint journal

Aims This study aimed to compare clinical outcomes according to the location of transferred graft retear in arthroscopy-assisted lower trapezius tendon transfer (aLTT) for posterosuperior irreparable rotator cuff tears (PSIRCTs). Methods…

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Negative / Null Result ReportMedicine

Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial.

Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine

Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…

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Negative / Null Result ReportMedicine

Rabies immunoglobulin overdose in post-exposure prophylaxis.

Łukasik AJ, Podlasin RB · 2025 · Przeglad epidemiologiczny

Rabies is a zoonotic viral infection caused by an RNA virus from the Rhabdoviridae family, a Lyssavirus species with the highest mortality rate among all infectious diseases. Post-exposure propylahis (PEP) should be applied as soon as…

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Negative / Null Result ReportOpen accessMedicine

Simulated brushing effects on surface roughness and color stability of coated additively manufactured dental resin: an in vitro study.

Alsalem Z, Alothemeen M, Alshehri D et al. · 2026 · Journal of medicine and life

This study aimed to evaluate the effect of a glaze coating on the surface roughness and color stability of 3D-printed temporary crown resin materials before and after simulated toothbrushing. Nano-filled ceramic resin specimens were…

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Negative / Null Result ReportMedicine

Prediction of the digestibility and digestible energy content of hay for horses using an enzymatic degradability method.

Andueza D, Martin-Rosset W · 2025 · Animal : an international journal of animal bioscience

The nutritive value of forage for horses is closely dependent on the digestibility of organic matter (OMD), which is typically measured in vivo. Researchers have developed a variety of prediction methods to estimate the digestibility value…

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Negative / Null Result ReportOpen accessMedicine

Variations in cow milk and teat skin microbiota across the lactation cycle with intramammary cephalosporin use at dry-off.

Van Beeck W, Lemos MLP, Niesen AM et al. · 2026 · Applied and environmental microbiology

Cephalosporins and other broad-spectrum antibiotics are frequently administered prophylactically into the udder when dairy cows end their lactation cycle, termed dry-off, to reduce mastitis risk. However, the use of antibiotics on cows…

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Negative / Null Result ReportOpen accessMedicine

Improving Diagnostic Quality of Anogenital Photodocumentation in Emergency Department Evaluations for Acute Child Sexual Assault.

Miller ZE, Digirolamo SJ, Molnar J et al. · 2026 · Pediatric quality & safety

Introduction Emergency department evaluations for acute child sexual assault include anogenital photodocumentation as a standard of care, which has implications for accurate clinical care and forensic significance. If photodocumentation…

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Negative / Null Result ReportMedicine

Alignment and early clinical outcomes following total knee arthroplasty using a handheld navigation system compared to conventional instruments.

Nishida C, Shimoda B, Weldon RH et al. · 2025 · Archives of orthopaedic and trauma surgery

Introduction Proper lower extremity alignment is important for success and longevity of total knee arthroplasty (TKA). Conventional instrumentation has demonstrated higher rates of mechanical axis (MA) malalignment compared to robotic or…

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Negative / Null Result ReportOpen accessMedicine

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Fenerich BA, Fernandes JC, Silva CLA et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Insulin Receptor Substrate 1 (IRS1) is differentially expressed in hematological neoplasms suggesting a role in hematopoiesis and neoplastic transformation. Irs1 knockout mice represent a tool to investigate IRS1 function.…

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Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

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Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

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Negative / Null Result ReportMedicine

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Kato S, Miwa K, Takano H et al. · 2025 · Inorganic chemistry

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole…

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Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

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Negative / Null Result ReportOpen accessMedicine

Determining the Minimal Number of Passive Hip and Knee Joint Movement Repetitions Recommended for the Stiff Rectus Femoris Muscle Due to Osgood-Schlatter Disease.

Ikeda N, Yoshikawa A, Yamaguchi S et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Osgood-Schlatter disease (OSD) is a common overuse condition in adolescents characterized by increased stiffness of the rectus femoris muscle, which contributes to pain and functional limitations around the knee. We…

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Negative / Null Result ReportMedicine

Vilobelimab to improve clinical outcomes in moderate-to-severe hidradenitis suppurativa through an adjunctive effect on draining tunnels: results of the SHINE double-blind placebo-controlled randomized trial.

Giamarellos-Bourboulis EJ, Jemec GBE, Prens EP et al. · 2026 · The British journal of dermatology

Background The results of a previous phase IIa trial suggested efficacy of the anti-C5a compound vilobelimab in a small number of patients with severe hidradenitis suppurativa (HS) refractory to adalimumab treatment. Objectives To study…

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Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of an Antibacterial Envelope in Patients at High Risk of Cardiac Implantable Electronic Device Infection in the Australian Public Healthcare System.

Hill M, Khalaj BH, Shawon MSR et al. · 2026 · Journal of arrhythmia

Background The Worldwide Randomized Antibiotic Envelope Infection Prevention Trial (WRAP-IT) demonstrated a 40% reduction of major cardiac implantable electronic device (CIED) infection with the use of an absorbable antibacterial envelope…

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Negative / Null Result ReportOpen accessMedicine

The impact paradox: mixed-methods evaluation of National Institute of Health and Care Research funding for intellectual disability research in the UK.

Goddard N, Dale M, Bishop R et al. · 2026 · BJPsych open

Background People with intellectual disability experience substantial health inequities, including higher multimorbidity, increased healthcare utilisation and markedly reduced life expectancy. High-quality research is essential to address…

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Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films - comparison with zeolite- and activated carbon-based carriers.

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International journal of biological macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

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Negative / Null Result ReportMedicine

Experimental and clinical evidence on radiofrequency electromagnetic field effects on the blood-brain barrier: a scoping review.

Simsek ET, Sumser K, Mansourinezhad P et al. · 2026 · Physics in medicine and biology

Objective. This scoping review evaluates evidence on whether radiofrequency electromagnetic field (RF-EMF) exposure influences blood-brain barrier (BBB) permeability. Given inconsistent findings across decades of research and expanding…

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Negative / Null Result ReportMedicine

Spectroscopic analysis of the N<sub>2</sub> B<sup>3</sup>Π<sub>g</sub>-A<sup>3</sup>Σ+u in radiation-induced air ionization.

Murzyn CM, Jans ER, Marshall GJ · 2026 · Physical chemistry chemical physics : PCCP

This article presents experimental results from probing atmospheric air irradiated by a Polonium-210 alpha particle source using both optical emission spectroscopy and continuous wave cavity ring down absorption spectroscopy to study the…

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Negative / Null Result ReportOpen accessMedicine

Gender Differences in Preoperative Anxiety and the Association with Early Maladaptive Schemas: A Cross-Sectional Correlational Study.

Abdelrazek MN, Mohamed HMM, El-Monshed AH et al. · 2026 · Healthcare (Basel, Switzerland)

Background : Preoperative anxiety is a common and clinically significant response among surgical patients, with prevalence estimates ranging from 30% to over 80% depending on measurement method and surgical context. Early maladaptive…

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Negative / Null Result ReportOpen accessMedicine

Safety of hepatitis E vaccine in pregnancy.

Zhang F, Yang G, Chen Y et al. · 2026 · Virology journal

This comment discusses the critical public health challenge of hepatitis E in pregnancy and highlights the significant safety evidence gap for the HEV239 vaccine in this vulnerable group. Focusing on a landmark study from South Sudan by…

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