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WASTE Journal

Browse the failure-mode index

12,262 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Preoperative Short-Term Nutrition and Exercise Trial Program for Patients with Esophageal Cancer: A Randomized Clinical Trial: Thoracic Oncology.

Kawata S, Hiramatsu Y, Honke J et al. · 2026 · Annals of surgical oncology

Background Esophagectomy confers high postoperative morbidity and mortality. To improve postoperative outcomes, this study investigated the effectiveness of a 2-week prehabilitation program on the preoperative cardiopulmonary function of…

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Negative / Null Result ReportMedicine

Effect of femtosecond-assisted vs manual descemetorhexis on the posterior corneal surface after DMEK: A fellow eye comparison.

Arnalich-Montiel F, Aguado-Casanova V, Vicente-Antolin M et al. · 2026 · European journal of ophthalmology

PurposeThis study aimed to evaluate anatomical changes in the posterior corneal surface in a cohort of patients who underwent Descemet membrane endothelial keratoplasty (DMEK) with manual descemetorhexis in one eye and femtosecond-assisted…

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Negative / Null Result ReportMedicine

Alcohol-impregnated port protectors to reduce central line-associated bloodstream infection in the neonatal intensive care unit: a quality improvement study.

Payne V, Hall M, Johnson MJ · 2025 · Archives of disease in childhood. Fetal and neonatal edition

Objective To investigate the effect of alcohol-impregnated port protectors (AIPPs) on neonatal central line-associated bloodstream infection (CLABSI) rates. Design A quality improvement study. Setting A tertiary neonatal unit in the UK.…

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Negative / Null Result ReportMedicine

Effect of clinically relevant iron oxide nanoparticles on macrophage polarization, tumor growth and tumor microenvironment modulation.

Roemhild K, Li Y, Barmin RA et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society

Macrophages are key regulators of the tumor microenvironment (TME) and attractive targets for nanomedicine therapies. Because intracellular iron can promote pro-inflammatory macrophage polarization, superparamagnetic iron oxide…

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Negative / Null Result ReportMedicine

A Phase 1b/2, Randomised, Placebo-controlled Study to Evaluate Safety, Tolerability, Efficacy, and Immunogenicity of VTP-200, a Chimpanzee Adenovirus and Modified Vaccinia Ankara-vectored Multigenotype High-Risk Human Papillomavirus Vaccine in Women with Low-grade Cervical Lesions.

Hellner K, Simon P, De Sutter P et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background The clearance of high-risk oncogenic HPV (hrHPV) and related cervical lesions is associated with the development of a robust T cell response. Therapeutic vaccination that induces HPV antigen-specific T cells is a promising…

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Negative / Null Result ReportMedicine

Effect of different definitive restoration resins and postpolymerization durations on the trueness of 3D printed one-piece endodontic crowns.

Kahraman Z, Özden S · 2026 · The Journal of prosthetic dentistry

Statement of problem Because of the multivariable nature of the 3-dimensional (3D) printing process, each stage must be performed under optimal conditions to ensure the trueness and reliability of dental restorations. However, information…

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Negative / Null Result ReportMedicine

Cognitive Function Among Heart Transplant Recipients Before and After Intravenous Iron Supplement for Iron Deficiency: Results From a Randomized, Placebo-Controlled, Double-Blind Treatment Trial.

Bürker BS, Brautaset Englund KV, Myrdal Østby C et al. · 2025 · Clinical transplantation

Background Cognitive dysfunction after successful heart transplantation (HTx) is not uncommon. Lower hemoglobin levels have previously been associated with cognitive dysfunction in heart transplant recipients (HTx recipients). In a…

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Negative / Null Result ReportMedicine

Randomized Cross-Over Study to Examine Associations Between Dialyzer Clotting, Uremic Toxin Removal, and Hemocompatibility During Post-Dilution Hemodiafiltration With Reduced Anticoagulation.

Eloot S, Erlenkötter A, Zawada AM et al. · 2026 · Artificial organs

To date, it remains unclear to what extent dialyzer performance is affected by clotting, and which hemocompatibility parameters can reliably predict this phenomenon. This study investigated the relationship between dialyzer clotting,…

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Negative / Null Result ReportMedicine

Waggle-dance-recruited honeybees expect landscape structures.

Wang Z, Mach J, Chen X et al. · 2025 · Current biology : CB

Honeybee foragers explore the environment before they start foraging, following dances, or performing dances. Foragers are therefore familiar with the landscape surrounding the hive during their foraging career. Here, we ask whether…

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Negative / Null Result ReportMedicine

Comparison of a novel culture-based selection for dry cow therapy with somatic cell count-based selection: comparing detection rates for major pathogens and subsequent udder health outcomes.

Cuttance E, Nortje R, Laven R et al. · 2025 · The Journal of dairy research

This study compared a culture-based protocol in which only cows identified as having intramammary infections due to major pathogens (major IMI) were treated with dry cow antibiotics (DCAT) compared with the current New Zealand somatic cell…

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Negative / Null Result ReportMedicine

HNF4A intestinal ablation positively influences the fate of ileal goblet cells during <i>Salmonella typhimurium</i> infection.

Gómez DP, Nicolás VR, Marrero GC et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology

Hepatocyte nuclear factor 4 A (HNF4A) is a transcription factor that regulates a diverse range of intestinal epithelial genes involved in tissue renewal, differentiation, and metabolism, among other functions. The HNF4A locus is associated…

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Negative / Null Result ReportOpen accessMedicine

Positive effect of evobrutinib in CNS remyelination models and lack of synergy with clemastine-A dose response study.

Martin E, Aigrot MS, Frère N et al. · 2025 · Multiple sclerosis journal - experimental, translational and clinical

Background To recover normal functions, remyelination in multiple sclerosis is crucial. Although endogenous remyelination occurs, it is often insufficient, and finding molecules promoting repair of demyelinated lesions is needed.…

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Negative / Null Result ReportMedicine

Correlation of Body Mass Index with Overall Survival Among Patients with Metastatic Hormone-sensitive Prostate Cancer: Analysis of Patient-level Data from SWOG-1216.

Swami U, Jo Y, Narang A et al. · 2025 · European urology oncology

Although obesity has been associated with better overall survival (OS) among patients with metastatic castration-resistant prostate cancer, its association with OS has not been extensively explored in metastatic hormone-sensitive prostate…

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Negative / Null Result ReportOpen accessMedicine

Deucravacitinib in patients with inflammatory bowel disease: 12-week efficacy and safety results from 3 randomized phase 2 studies in Crohn's disease and ulcerative colitis.

D'Haens G, Danese S, Panaccione R et al. · 2025 · Journal of Crohn's & colitis

Background and aims Tyrosine kinase 2 is a downstream intracellular mediator of interleukin-23 signaling, which has a key role in the pathogenesis of inflammatory bowel disease. Deucravacitinib is a novel, oral, selective, allosteric…

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Negative / Null Result ReportMedicine

Zuranolone in Major Depressive Disorder: Results From MOUNTAIN-A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.

Clayton AH, Lasser R, Nandy I et al. · 2023 · The Journal of clinical psychiatry

Objective: To evaluate the efficacy and safety of zuranolone, an investigational neuroactive steroid and GABA A receptor positive allosteric modulator, in major depressive disorder (MDD). Methods: The phase 3, double-blind, randomized,…

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Negative / Null Result ReportMedicine

Stereotactic radiosurgery versus whole-brain radiotherapy in patients with 4-10 brain metastases: A nonrandomized controlled trial.

Bodensohn R, Kaempfel AL, Boulesteix AL et al. · 2023 · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Background and purpose There is no randomized evidence comparing whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. This prospective nonrandomized controlled single arm trial…

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Negative / Null Result ReportMedicine

Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.

Gondi V, Pugh SL, Mehta MP et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Hippocampal avoidance (HA) during therapeutic whole-brain radiotherapy reduces the risk of neurocognitive function (NCF) toxicity in patients with brain metastasis. This trial hypothesized that HA during prophylactic cranial…

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Negative / Null Result ReportMedicine

Pharmaceutical-induced behavioural changes in freshwater species and mesocosm insights into potential population-level consequences.

Versteegen E, Wang A, Wang X et al. · 2025 · Aquatic toxicology (Amsterdam, Netherlands)

Pharmaceutical contamination in aquatic environments, particularly from neuroactive drugs like antidepressants, potentially affects the behaviour of non-target organisms due to their effects on conserved neuroendocrine systems. Behavioural…

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