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WASTE Journal

Browse the failure-mode index

12,262 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Medial Patellofemoral Ligament Reconstruction in Adolescent Patellofemoral Instability With High Tibial Tubercle-Trochlear Groove Intervals: A Comparison of With or Without Tibial Tubercle Osteotomy.

Grewal RS, Berger GK, Pennock AT et al. · 2026 · Journal of pediatric orthopedics

Background Patellofemoral instability is common in adolescent patients and is frequently associated with increased tibial tuberosity-trochlear groove (TT-TG) distances. Medial patellofemoral ligament (MPFL) reconstruction is a standard…

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Negative / Null Result ReportMedicine

Efficacy of a Phase III Cardiac Rehabilitation Program on Physical Exercise in Patients with Ischemic Heart Disease: A Cluster Randomized Controlled Trial.

Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention

Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…

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Negative / Null Result ReportMedicine

Rediscovering a Neotropical anuran fluke: a morphological and phylogenetic study of <i>Rauschiella proxima</i> (Trematoda: Plagiorchioidea).

Queiroz MS, López-Hernández D, Anjos LA et al. · 2025 · Journal of helminthology

Species of the genus Rauschiella are trematodes of frogs and snakes in the Americas. The taxonomy of the group is complex, and most of the 18 currently valid species are known only from the original description. Moreover, genetic data are…

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Negative / Null Result ReportMedicine

Outcomes of Pars Plana Vitrectomy in Inherited Retinal Degenerations.

Al-Moujahed A, Lu ES, Zhou HW et al. · 2026 · Ophthalmology. Retina

Purpose To describe the management and outcomes of pars plana vitrectomy (PPV) for common surgical retinal conditions, including epiretinal membrane (ERM), full-thickness macular hole (FTMH), and retinal detachment, in patients with…

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Negative / Null Result ReportMedicine

Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature.

Mosallami Aghili SM, Santori D, Denice C et al. · 2025 · Journal of neurointerventional surgery

Introduction Pretreatment with dual antiplatelet agents (DAPT) has been standard practice for patients undergoing aneurysm treatment with flow diversion (FD). Rates of periprocedural diffusion lesions observed after FD procedures remain…

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Negative / Null Result ReportMedicine

Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

Richter J, Hamm AO, Lang T et al. · 2026 · Behaviour research and therapy

The efficacy of exposure-based cognitive behavioral therapy (eCBT) for panic disorder and agoraphobia (PD/AG) is well established, but the mechanisms of action are still under debate. Here we investigated whether increased fear activation…

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Negative / Null Result ReportMedicine

Improvements in pharmacokinetics, bleeding control, and cost analysis after PK-guided transition to extended-half-life factor IX in hemophilia B: A multicentric study.

Chovi-Trull M, Megías-Vericat JE, Palanques-Pastor T et al. · 2026 · Thrombosis research

Introduction Extended half-life factor IX concentrates (FIX-EHL) have been shown to improve clinical outcomes and reduce treatment burden in patients with hemophilia B (HB). Objectives To analyze the differences in pharmacokinetic (PK) and…

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Negative / Null Result ReportMedicine

Exploring Dynamic Brain Oscillations in Motor Imagery and Low-frequency Sound.

Dupont W, Poulin-Charronnat B, Madden-Lombardi C et al. · 2025 · Journal of cognitive neuroscience

Although both motor imagery (MI) and low-frequency sound listening have independently been shown to modulate brain activity, the potential synergistic effects that may arise from their combined application remains unexplored. Any further…

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Negative / Null Result ReportMedicine

Long-Term Survival of Cronobacter sakazakii, Salmonella enterica, Listeria monocytogenes, and Enterobacter spp. in Powdered Infant Formula Based on Relative Humidity.

Fay ML, Khouja BA, Newkirk R et al. · 2025 · Journal of food protection

Powdered infant formula (PIF) has previously been shown to support the survival of bacterial foodborne pathogens including Cronobacter sakazakii, Listeria monocytogenes, and Salmonella enterica at various storage temperatures. However, the…

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Negative / Null Result ReportOpen accessMedicine

Investigating the Antioxidant and Immunomodulatory Effects of Quercetin Using Porcine PBMCs as an Inflammatory In Vitro Model.

Somogyi F, Pézsa NP, Jerzsele Á et al. · 2026 · Antioxidants (Basel, Switzerland)

As the human population continues to grow, the demand for pork increases, and the management of infectious diseases in swine from a One Health standpoint is becoming more important than ever. To prevent antimicrobial use as much as…

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Negative / Null Result ReportMedicine

Folded-flap palatoplasty and traditional staphylectomy yield similar postoperative soft palate geometry in French Bulldogs undergoing airway surgery.

Farrell M, Singh A, Mayhew PD et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To compare CT-derived anatomical geometry of the soft palate and clinical outcome following folded-flap palatoplasty (FFP) or traditional staphylectomy (TS). Methods Client-owned French Bulldogs were prospectively enrolled…

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Negative / Null Result ReportMedicine

The Effect of Surgeon Vocal Pitch and Gender on Patient Satisfaction.

Nuyen BA, Kruglik CP, Wang A et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective Patient satisfaction scores, especially the "likelihood to recommend" (LTR) a provider, are becoming increasingly important as measures of surgical quality. In this study, we examined the influence of a surgeon's vocal pitch and…

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Negative / Null Result ReportMedicine

The combination of lomustine and corticosteroids is a valid chemotherapeutic option in cats with presumptive central nervous system lymphoma.

Pauciulo C, Corda A, Tartari I et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To describe the clinical outcomes of 10 cats diagnosed with CNS lymphoma treated with lomustine and corticosteroids. Animals Clinical records of privately owned cats diagnosed with CNS lymphoma and presented to a neurological…

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Negative / Null Result ReportMedicine

Hydroxyl-radical process for reducing Salmonella and Campylobacter jejuni on inoculated and naturally contaminated raw poultry parts with no change in quality metrics

Camacho-Martinez SV, Zai B, Hasani M et al. · 2025 · LWT.

The study aimed to optimize the performance of a gas phase hydroxyl radical process to inactivate Salmonella and Campylobacter jejuni associated with raw poultry meat. Chicken parts were inoculated with Salmonella or C. jejuni before…

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Negative / Null Result ReportMedicine

The Effect of Postexposure Sleep Deprivation on Anxiety-Related Behaviours and Hippocampal Neuropathological Changes in a Rat Model of Posttraumatic Stress Disorder.

Karabulut S, Topcu H, Er SN et al. · 2025 · International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Sleep problems are a hallmark of posttraumatic stress disorder (PTSD). Although the critical role of sleep for memory consolidation is well known, there is no consensus on the effect of sleep interruption or increased sleep duration…

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Negative / Null Result ReportMedicine

The diagnostic accuracy of [99mTc]Tc-PSMA SPECT/CT for recurrent prostate cancer based on individual patient attributes.

Liepe K, Hoang TM, Baehr M · 2026 · European journal of nuclear medicine and molecular imaging

Purpose The diagnostic performance of [ 99m Tc]Tc-PSMA SPECT/CT is contingent upon the individual attributes of the patients' prostate cancer. The aim of the study was to analyse these relationships in order to suggest thresholds that may…

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Negative / Null Result ReportMedicine

Impacts of X-ray beam angulation and image receptor positioning on the quantification of alveolar bone mineral density using intraoral radiographic technique.

Watanabe Y, Kohinata K, Tome W et al. · 2026 · Oral radiology

Objectives The purpose of this study was to evaluate the impact of X-ray beam angulation and image receptor positioning on the quantification of alveolar bone mineral density (BMD) using intraoral radiographic technique. Methods Intraoral…

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