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WASTE Journal

Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Differential Impact of Concomitant Methotrexate and Glucocorticoids Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study.

Ebina K, Etani Y, Okita Y et al. · 2025 · International journal of rheumatic diseases

Aim This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic…

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Negative / Null Result ReportMedicine

Oral Peanut Immunotherapy With Butyrate Adjuvant (OPIA) in Children: A Randomised, Controlled Trial.

Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…

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Negative / Null Result ReportMedicine

Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment: A study in laparotomized mice.

Santos-Caballero M, Ruiz-Cantero MC, Mayr HK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Postoperative pain remains a major clinical challenge, as it often persists despite analgesic treatment even with opioids. We studied the effects of sigma-1 receptor antagonists (BD-1063 and S1RA), administered alone or in combination with…

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Negative / Null Result ReportMedicine

Patients Presenting to the Emergency Department with Bleeding in Early Pregnancy: Comparing Different Models to Predict Pregnancy Success.

Essel NOM, Couperthwaite S, Yang EH et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Objectives Bleeding in early pregnancy is a common obstetric presentation in the emergency department (ED), and the outcome is difficult to predict. We developed and compared random forest machine learning (Live Birth Risk Score [LiBRisk])…

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Negative / Null Result ReportMedicine

Validation and Modified Application of the 2023 International Expert Consensus Criteria for Diagnosing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Among Children With Acquired Demyelination in Resource-Limited Regions.

Sondhi V, Desai N, Lingappa L et al. · 2025 · Pediatric neurology

Background This study was undertaken to validate the 2023 myelin oligodendrocyte glycoprotein (MOG) antibody (Ab)-associated disease (MOGAD) diagnostic criteria among children with acquired demyelinating syndromes. Methods In this…

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Negative / Null Result ReportMedicine

Variability in adolescent reception of parental support: Testing the domain-matching hypothesis.

Altinoz ZS, Erath SA, Pettit GS et al. · 2024 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

The present study investigated matches and mismatches between adolescent and parent socialization domains (i.e., protection, guidance) as related to adolescent reception of parental support during a laboratory-based social evaluation…

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Negative / Null Result ReportMedicine

Effects of polyphenol-rich extracts and compounds on methane and ammonia emissions from pig slurry during 28-day incubation

Vazifehkhoran AH, Pedersen J, Guldberg LB et al. · 2024 · Biosystems engineering.

Animal manure in livestock production facilities is a major source of methane (CH₄) and ammonia (NH₃) emissions from agriculture. In this study, we investigated different polyphenol-rich extracts and chemicals including commercial chestnut…

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Negative / Null Result ReportOpen accessMedicine

Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

Zaki S, Berkachy R, Zein Eddine R et al. · 2026 · Current developments in nutrition

Background Yerba mate ( Ilex paraguariensis ) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed…

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Negative / Null Result ReportOpen accessMedicine

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Mazzini G, Tuerlings M, van der Stap V et al. · 2026 · Cartilage

BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on…

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Negative / Null Result ReportMedicine

Acute metformin intake on exercise performance in healthy participants during functional fitness training.

Pinheiro AH, Silva LG, Bastos-Silva VJ · 2025 · The Journal of sports medicine and physical fitness

Background The study aimed to assess whether prior intake of metformin enhances performance in the FRAN workout, a popular Functional Fitness Training protocol. Methods Fourteen men (mean±SD: 24.2±3.5 years; height: 173.3±7.8 cm; weight:…

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Negative / Null Result ReportMedicine

Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model.

Pereira M, Brandão Ostermann RA, de Fáveri W et al. · 2025 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Aspirin has significant antineoplastic effects on the colon, whereas the outcomes of Vitamin C and D supplementation have been inconsistent. This study addressed the isolated and combined effects of vitamins C and D with aspirin on…

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Negative / Null Result ReportMedicine

Roles of spermary-specific carboxylesterases in Nilaparvata lugens reproduction: Opposite between insecticide-induced upregulation and resistance-associated overexpression.

Zhang H, Yang B, Xu X et al. · 2025 · International journal of biological macromolecules

Seminal fluid proteins (SFPs) in insect males are critical for reproduction, being transported into female ovary. In Nilaparvata lugens, a significant rice pest, seven spermary-specific carboxylesterases (CarEs) were found abundantly in…

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Negative / Null Result ReportMedicine

The role of loading-induced convection versus diffusion on the transport of small molecules into the intervertebral disc.

Salzer E, Gorgin Karaji Z, van Doeselaar M et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Limited nutrient transport is hypothesized to be involved in intervertebral disc (IVD) degeneration. It is widely recognized that the dominant mode of transport of small molecules such as glucose is via diffusion, rather than…

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Negative / Null Result ReportOpen accessMedicine

Transcranial Direct Current Stimulation Does Not Enhance Perceptual Learning of Chinese Character Reading in Adults With Macular Degeneration.

Lyu A, Mungalsingh MA, Silva AE et al. · 2026 · Investigative ophthalmology & visual science

Purpose Macular degeneration impairs central vision, compelling patients to use their peripheral vision for reading, which is difficult due to reduced spatial resolution and crowding. Although perceptual learning improves reading,…

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Negative / Null Result ReportMedicine

Biological soil amendments can support survival of pathogenic and non-pathogenic Escherichia coli in soils and sporadic transfer to Romaine lettuce.

Xiong ZR, Gabriel E, Gutierrez A et al. · 2025 · International journal of food microbiology

Biological soil amendments (BSAs) are essential agricultural inputs that provide critical nutrients in organic leafy green production. Heat-treated poultry pellets (HTPP) and seabird guano (SBG), which have been treated to reduce microbial…

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Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses.

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Background Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic…

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Failed Experiment ReportOpen accessMedicine

High-dose beta-alanine supplementation for two weeks did not enhance intermittent endurance or sprint performance in trained futsal players.

Miraftabi H, Berjisian E, Nouri Dizicheh M et al. · 2025 · Journal of the International Society of Sports Nutrition

Background This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods…

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Negative / Null Result ReportOpen accessMedicine

Topical betulinic acid for treatment of equine melanoma and sarcoid.

Moreno C, Mudge M, Horne R et al. · 2026 · Frontiers in veterinary science

Introduction Betulinic acid, a natural pentacyclic triterpenoid, has demonstrated anti-inflammatory and anti-tumor properties in vitro, including activity against equine melanoma and sarcoid. However, there is limited in vivo evidence…

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Negative / Null Result ReportMedicine

Cryoprotective effects of cholesterol-loaded cyclodextrin and iodixanol on ram sperm: assessment of post-thaw quality and in vitro fertilization outcomes.

Arıcı R, Eser A, Yağcıoğlu S et al. · 2026 · BMC veterinary research

Background This study aimed to investigate the effects of cholesterol-loaded cyclodextrin (CLC) and iodixanol, added individually or in combination to a ram semen extender, on post-thaw sperm quality, in vitro fertilization outcomes, and…

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Negative / Null Result ReportOpen accessMedicine

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

Stanfield B, Leroux B, Kaeberlein M et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults…

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