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WASTE Journal

Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Guiding connections: The role of therapist interventions in facilitating couples' vulnerability and responsiveness in enactments.

Kula O, Machluf Ruttner R, Shahar B et al. · 2026 · Psychotherapy (Chicago, Ill.)

The primary proposed change process in emotion-focused therapy models for couples involves partners accessing and revealing vulnerable emotions and responding to such disclosures with empathy and compassion. Therapists often use enactments…

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Negative / Null Result ReportMedicine

Retrospective Multicenter Analysis of Withdrawal Syndrome in Parkinson's Disease Patients After Cessation of Deep Brain Stimulation.

Özden HÖ, Çelik FND, Üstüner FŞ et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: Abrupt cessation of deep brain stimulation (DBS) in Parkinson's disease (PD), most commonly due to implantable pulse generator (IPG) battery depletion, may lead to DBS withdrawal syndrome (DBS-WDS). However, withdrawal syndrome…

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Negative / Null Result ReportMedicine

Prediction of Anthracycline Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early-Stage Breast Cancer by the MammaPrint 70-Gene Signature for Patients Enrolled in the FLEX Study.

O'Shaughnessy J, Brufsky AM, Layeequr Rahman R et al. · 2026 · JCO precision oncology

Purpose Randomized trials have not demonstrated clear benefit from anthracyclines for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (EBC). The MammaPrint 70-gene…

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Negative / Null Result ReportMedicine

Longitudinal associations of cardiorespiratory fitness and physical activity with changes in cognitive function in breast cancer patients undergoing chemotherapy: a prospective matched-control study.

Xiao H, Warner E, Ryan J et al. · 2026 · Cancer causes & control : CCC

Purpose Cancer-related cognitive impairment (CRCI) is a common concern among breast cancer (BC) patients receiving chemotherapy, yet predictors of short-term cognitive change remain unclear. This study examined whether baseline…

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Negative / Null Result ReportMedicine

Trauma-focused or non-trauma-focused? Treatment preferences and expectancies among veterans with co-occurring posttraumatic stress disorder and substance use disorder.

Alpert E, Kaplan A, Nelson D et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective Among patients with co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUDs), little is known about early PTSD treatment processes, including treatment preference and outcome expectancy. This study…

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Negative / Null Result ReportMedicine

Kidney Transplantation for Lithium Nephrotoxicity is Associated With Noninferior Graft and Patient Survival: A National Donor-Stratified Registry Analysis.

Cohen H, Toro D, Zuluaga D et al. · 2026 · Clinical transplantation

Introduction To evaluate donor-stratified graft and patient survival following kidney transplantation (KT) for lithium-associated end-stage kidney disease (ESKD). Methods This retrospective analysis utilized the Organ Procurement and…

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Negative / Null Result ReportOpen accessMedicine

Predictive Factors of Augmented Reality-Based Clinical Task Performance Among Novice Users: Cross-Sectional Quantitative Study.

Vellore AJ, Bhatia S, Kann MR et al. · 2026 · JMIR XR and spatial computing

Background Augmented reality (AR) can provide risk-free training for medical trainees, yet little is known about which learner characteristics facilitate adoption or inform training design. Objective We aimed to identify which learner…

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Negative / Null Result ReportMedicine

Does Misinformation Have Spillover Effects on Unrelated Health Behaviors? Promising Null Results from a Longitudinal Study of U.S. Adults.

Kikut-Stein A, Jesch E, Dhawan D et al. · 2026 · Journal of health communication

In the wake of the COVID-19 pandemic, a critical question for health communication is whether misinformation exposure and misperceptions about one health topic have far-reaching, or "spillover," effects on health behavior in general. The…

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Negative / Null Result ReportMedicine

Effect of high-dose methotrexate infusion duration on 48-hour drug levels and toxicity in children with acute lymphoblastic leukaemia: a quality-of-care study.

Raha SJ, Bhatia P, Bansal D et al. · 2026 · Cancer chemotherapy and pharmacology

Background High‑dose methotrexate (HD‑MTX) is a cornerstone of pediatric acute lymphoblastic leukaemia (ALL) therapy. However, deviations from protocol-mandated infusion durations need regular monitoring as part of standard quality care.…

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Negative / Null Result ReportMedicine

Are neural and behavioural measures of cognitive control associated with adaptive and maladaptive risk-taking in adolescence and young adulthood?

Hunter M, Skippen P, Templio SL et al. · 2026 · Cognitive, affective & behavioral neuroscience

Risk-taking in young people is often attributed to a mismatch between slowly maturing cognitive control networks and overactive reward networks, leading to impulsive actions. However, evidence is inconsistent, and these models do not…

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Negative / Null Result ReportMedicine

Influence of Neurovascular Conflict on the Outcome of Primary Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Single-Center Retrospective Study.

Pizzi A, Cotrufo PP, Farinaro G et al. · 2026 · Stereotactic and functional neurosurgery

Introduction Gamma knife radiosurgery (GKRS) is an established effective treatment for medically intractable trigeminal neuralgia (TN), but outcome predictors remain controversial. Notably, the influence of neurovascular conflict (NVC)…

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Negative / Null Result ReportMedicine

Are dating and sexual Protective Behavioral Strategies (PBS) associated with alcohol-related consequences at all levels of alcohol use?

Peterson R, Paitan SC, Belitsos OA et al. · 2026 · Experimental and clinical psychopharmacology

Alcohol use is common among college students and often linked to negative consequences. Protective behavioral strategies (PBS) can reduce alcohol use and related harms. This study examined whether dating/sexual PBS provide unique…

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Negative / Null Result ReportMedicine

Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.

Koch M, Mostert J, Strijbis EM et al. · 2026 · Journal of neurology, neurosurgery, and psychiatry

Background Phase 2 clinical trials in primary progressive multiple sclerosis (PPMS) often use MRI brain volume measures as their primary endpoint. Here, we investigate the longitudinal association between change in MRI outcomes and change…

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Negative / Null Result ReportMedicine

High-frequency Ultrasound Evaluation of Midline Crossing-over Vessel: Correlation with Perfusion of Deep Inferior Epigastric Perforator Flap.

Lee SJ, Han HH, Eom JS et al. · 2026 · Plastic and reconstructive surgery

Background The deep inferior epigastric perforator (DIEP) flap is widely used in autologous breast reconstruction, with its success heavily reliant on the vascular anatomy, particularly midline crossing-over vessels that facilitate…

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Negative / Null Result ReportMedicine

Investigating the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Executive Errors Scale in Adults With Schizophrenia Spectrum Disorders.

Raudeberg R, Iverson GL · 2026 · Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Objective The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief neuropsychological screening battery that measures aspects of attention, immediate and delayed memory, and verbal and…

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Negative / Null Result ReportMedicine

Prospective evaluation of recombinant Herpes zoster vaccine in SSc: immunogenicity, safety and disease outcomes.

Luppino-Assad AP, Mello RP, Medeiros-Ribeiro AC et al. · 2026 · Rheumatology (Oxford, England)

Objectives To evaluate humoral immune response to recombinant zoster vaccine (RZV) in immunosuppressed patients with SSc compared with healthy controls, to identify factors influencing vaccine response and to assess RZV safety and impact…

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