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WASTE Journal

Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Resting-state functional connectivity of the default mode network as a predictor for escitalopram response in adolescents with depression.

Jang M, Lee KH, Shin J et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Adolescent depression differs from adult depression in neurobiology and treatment response. Although resting-state functional connectivity (rsFC) of the default mode network (DMN) has been linked to treatment response in adults, its value…

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Negative / Null Result ReportOpen accessMedicine

Predicting Positive Affect in Infancy.

Grossmann T, Miller H, Allison O · 2026 · Developmental science

Positive affect (PA) is integral to health and development, yet its early origins remain largely unexplored. In this pre-registered study (N = 78), we investigated whether infant-specific biological and social-behavioral factors predict PA…

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Negative / Null Result ReportMedicine

Comparative Validation of Scoring Systems in Acute Traumatic Central Cord Syndrome: Acute Traumatic Central Cord Syndrome Score, Central Cord Score, and Subaxial Cervical AO Spine Injury Score for Surgical Decision Making, Recovery, and Timing of Surgery.

Kumar AA, Lim HL, Saffari SE et al. · 2025 · Journal of neurotrauma

Acute traumatic central cord syndrome (ATCCS) is the most common form of incomplete spinal cord injury. Treatment recommendations for ATCCS patients are largely from North America, and their applicability to Asian populations remains…

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Negative / Null Result ReportMedicine

Longitudinal Bidirectional Associations Between Early Adolescents' Externalizing and Posttraumatic Stress Symptoms and Substance Use Patterns.

Dunn CB, Farrell AD · 2026 · Research on child and adolescent psychopathology

Prior research has identified externalizing and internalizing pathways to adolescent-onset substance use, but few studies have considered how psychopathology is associated with the development of polysubstance use during early adolescence.…

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Negative / Null Result ReportMedicine

Parental Psychological Distress and Perceived Child Externalizing Behaviors: Examining Mediators and Bidirectional Effects.

Anderson AJ, Rodriguez CM, Henson JM · 2026 · Child psychiatry and human development

Parental psychological distress is a commonly examined risk factor for the emergence of child problem behaviors, but the factors that contribute to that relationship-such as limited parental resources like greater social support and coping…

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Negative / Null Result ReportMedicine

Ethnic-racial socialization and sociopolitical development among emerging adult college students of color.

Berkley S, Hoyt LT, Zeiders KH et al. · 2026 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

This study used multilevel growth modeling to examine associations between ethnic-racial socialization (ERS) and sociopolitical development among undergraduates of color (N = 125) attending predominantly White institutions during the 2016…

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Negative / Null Result ReportMedicine

Performance validity tests in a large racially and linguistically diverse pediatric and young adult clinical sample: Investigations of the TOMM, MVP, and MSVT.

MacAllister WS, Désiré N, Brooks BL · 2026 · The Clinical neuropsychologist

Objective There is strong support for the use of performance validity tests (PVTs) in all neuropsychological evaluations, however, research examining racial, ethnic, and linguistic differences in failure rates remains scarce, particularly…

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Negative / Null Result ReportMedicine

Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer.

Cronblad IA, Warvik CE, Bjerkli IH et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Background Oral tongue squamous cell carcinomas (OTSCC) frequently metastasise via lymphatic vessels, thus lymphangiogenesis may enhance tumour cell dissemination by increasing tumour-lymphatic interactions. The prognostic significance of…

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Negative / Null Result ReportMedicine

The HBA-3 score: a simple bedside tool to predict cage subsidence after TLIF.

Najjar E, Khan S, Quraishi NA et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Background Cage subsidence is a common radiographic finding following transforaminal lumbar interbody fusion (TLIF), but its clinical relevance remains uncertain. Hounsfield Unit (HU) values from preoperative CT scans have emerged as…

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Negative / Null Result ReportMedicine

Impact of patient-reported taxane-induced peripheral neuropathy on dose reductions or worsening quality of life in Black women with breast cancer: Analysis from ECOG-ACRIN EAZ171.

Ballinger TJ, Zhao F, Jiang G et al. · 2026 · Cancer

Background Black patients with breast cancer experience higher rates of taxane-induced peripheral neuropathy (TIPN), which may compromise chemotherapy dose delivery and health-related quality of life (HRQOL). Using the prospective…

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Negative / Null Result ReportMedicine

Longitudinal Associations Among Avoidant/Restrictive Food Intake Disorder Symptoms, Body Dissatisfaction, Restriction, and Suicide Ideation Among Adolescents.

Sahlan RN, Frietchen R, Billman Miller MG et al. · 2025 · Suicide & life-threatening behavior

Objective Although previous research has established bidirectional links between many eating disorder (ED) symptoms and suicidal ideation (SI), no research has examined how symptoms of avoidant/restrictive food intake disorder (ARFID)…

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Negative / Null Result ReportMedicine

Feasibility of the pre-operative measurement of fractional exhaled nitric oxide and respiratory mechanics to predict respiratory outcomes in children undergoing general anaesthesia.

Hauser N, Sommerfield D, Nguyen J et al. · 2026 · Anaesthesia

Introduction Peri-operative respiratory adverse events remain a major cause of morbidity and mortality in children undergoing general anaesthesia; those with asthma are at higher risk. The aim of this feasibility study was to determine…

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Negative / Null Result ReportMedicine

Death Conceptualizations: How do Youth Presenting to a Pediatric Psychiatric Emergency Department View the End of their Lives?

Tezanos KM, Simeone A, Gerson R et al. · 2026 · Child psychiatry and human development

Youth are presenting to Emergency Departments (EDs) following a suicide-related crisis at higher rates and younger ages. Clinicians lack tools to effectively discern suicide risk in younger patients. The present investigation examines how…

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Negative / Null Result ReportMedicine

Prenatal echocardiographic diagnosis and outcomes of fetal sustained supraventricular tachycardia: a ten-year single-center experience.

Ciriello GD, Colonna D, Morelli C et al. · 2026 · Indian pacing and electrophysiology journal

Fetal echocardiography plays a pivotal role in the diagnosis and management of fetal arrhythmias, allowing evaluation of the electrophysiological mechanism and guiding appropriate medical therapy. Herein, we describe our ten-year…

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Negative / Null Result ReportMedicine

The interdependence of health and grandparenting intensity: A dyadic perspective from grandparent couples in the Health and Retirement Study.

Chan ACY, Stephan AT, Sneed RS · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives While the intensity of grandparent caregiving has been linked to older adults' health, limited research has examined the bidirectional associations between grandparenting intensity and health, particularly within grandparent…

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