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Browse the failure-mode index

12,260 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Nightmares, insomnia, and suicide within a trauma-exposed sample.

West Staples V, Angle E, Pickering A et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective The literature is mixed regarding the relationship between nightmares and suicide, with some suggesting that the variance in nightmares is explained by fear of sleep (FoS), insomnia, and/or obstructive sleep apnea (OSA). We add…

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Negative / Null Result ReportMedicine

Do Child Communicative Abilities Predict Subjective Wellbeing and Satisfaction With Family Life in Caregivers of Minimally Verbal Children?

Saul J, McGuinness L, Cooke M et al. · 2026 · Journal of autism and developmental disorders

Purpose Caregivers of children with neurodevelopmental conditions often experience poor mental wellbeing, which may be influenced by their child's behavioural or communicative profile. Few studies have focussed exclusively on caregivers of…

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Negative / Null Result ReportMedicine

The temporal interplay between physical activity, emotional well-being, and health-related quality of life in individuals with recently diagnosed type 2 diabetes mellitus: a cross-lagged panel analysis.

Kristoffersen SF, Domazet SL, Pouwer F et al. · 2026 · Diabetes research and clinical practice

Aims We investigated longitudinal, bidirectional associations between objectively measured moderate to vigorous physical activity (MVPA), health-related quality of life (HRQoL), and emotional well-being (EWB) in individuals recently…

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Negative / Null Result ReportMedicine

Effects of Impella 5.5 on right ventricular load and adaptation.

Silkowski MK, Olson A, Asempah M et al. · 2026 · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Background The Impella 5.5 is increasingly used as a bridge to durable left ventricular assist device (dLVAD) implantation or heart transplantation, yet its effects on right ventricular (RV) hemodynamics remain incompletely characterized.…

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Negative / Null Result ReportMedicine

Blinking mimicry predicts preference.

Amihai L, Shahab S, Kligman T et al. · 2026 · Acta psychologica

Face-to-face conversations involve a rich array of social signals - facial expressions, gestures, vocal prosody, and gaze. While interpersonal mimicry of these signals has been extensively studied and shown to carry evaluative…

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Negative / Null Result ReportMedicine

Achieving therapeutic antibiotic levels during intermittent dosing of meropenem and piperacillin-tazobactam in critically ill children: the ATACC study.

Joffe AR, Humber A, Bates A et al. · 2026 · Antimicrobial agents and chemotherapy

Achieving antibiotic pharmacodynamic targets is critical to surviving sepsis. The purpose of this study was to determine the achievement of pharmacodynamic target-free minimum plasma concentration (fCmin)-during the first 2 days of…

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Negative / Null Result ReportMedicine

Predictive value of thromboelastography with platelet mapping on hematoma expansion in spontaneous intracerebral hemorrhage.

Sammani N, Radosevich JJ, Martinez S et al. · 2026 · Journal of thrombosis and thrombolysis

Spontaneous intracerebral hemorrhage (ICH) accounts for about 10% of strokes in the United States and is linked to high mortality and morbidity. Hematoma expansion independently predicts poor outcomes. Thromboelastography with platelet…

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Negative / Null Result ReportMedicine

Broad skill generalization with an extra robotic body part.

Molina-Sanchez M, Dowdall L, Dominijanni G et al. · 2026 · Current biology : CB

Our ability to transfer motor skills across tools and contexts is central to how we adapt to an increasingly technological world. From smartphones to wearable robotics, modern technologies demand flexible motor control that generalizes…

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Negative / Null Result ReportMedicine

Radiopaque markers in children with functional constipation: Potential role in diagnosis, therapy, and outcomes.

Gomez-Suarez R, Lin E, Gershon E et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives To evaluate the clinical utility of the simplified colon transit protocol of radiopaque markers (SROM) in pediatric functional constipation (FC). Methods Retrospective study of children meeting Rome IV criteria for FC undergoing…

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