12,260 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Podoly TY, Even-Ezra H, Doron G · 2025 · Journal of affective disorders
Misophonia is a condition characterized by strong, aversive reactions to specific sounds produced by others, often manifesting as intense negative emotions like anger or rage in response to nearby noises. The present study aimed to…
View details →Ala-Jaakkola R, Forssten SD, Cheng J et al. · 2025 · Molecular nutrition & food research
Functional constipation (FC) is characterized by difficult, infrequent, or incomplete bowel movements without clear physiological cause. Daily intake of Bifidobacterium lactis HN019 has been shown to reduce colonic transit time or…
View details →El-Nagdy NK, Mansour NO, Diab AAA et al. · 2025 · Pharmacotherapy
Background Midodrine has been primarily studied as an adjunctive oral therapy to reduce the need for vasopressors in intensive care units (ICU). Nonetheless, the available results evaluating midodrine as an adjuvant therapy in the…
View details →Barbakoff D, Glennie K, Yan M et al. · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
Supportive environmental features (SEFs) are attributes of homes that help people overcome activity limitations. Evidence suggests that SEFs may facilitate aging in place. However, real-life SEF implementation patterns are not fully…
View details →Mest J, Flood A, Preston P et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine
Objectives To investigate if sensorimotor function predicts pain-related cognition in people with lower limb tendinopathy. Design Single-cohort, cross-sectional study. Setting Sports and exercise research laboratory. Participants…
View details →Rilveria JRC, Grepo LC, Lim PMQ et al. · 2026 · Npj mental health research
Mental health mobile applications are increasingly used to address psychological distress and promote well-being, yet evidence on how and when these tools exert their effects over time and what constitutes meaningful engagement remains…
View details →Zhang S, Song Y, Steptoe A et al. · 2026 · Psychology of sport and exercise
Previous research has demonstrated a link between physical activity and loneliness, though the direction of this relationship remains unclear. This study explored daily fluctuations in the temporal relationship between physical activity…
View details →Büyükdemirtaş B, Benn M, Kwon HB et al. · 2026 · Psychopharmacology
Rationale Binge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolescence and is under…
View details →Isaacson BN, Serbin SP, Grabosky JC · 2025 · Forest Ecology and Management.
There is a vigorous debate around whether and how to manage forests for climate mitigation or for other goals such as biodiversity. To achieve any of these goals it is necessary to define the parameters within which they can exist;…
View details →Kanyorszky ET, Sterczer Á, Vizi Z et al. · 2026 · BMC veterinary research
BACKGROUND: Acute pancreatitis triggers the production of acute-phase proteins (APPs) in the body, among which C-reactive protein (CRP) is the most extensively studied and widely used for both diagnosis and prognosis. The diagnostic value…
View details →Yang T, Yuan X, Gao W et al. · 2024 · Internal and emergency medicine
Observational studies revealed paradoxically inverse associations between diabetes and aortic diseases (aortic aneurysm or aortic dissection), yet the causality remains to be determined. To investigate the causal associations between…
View details →Zhang H, Zhao T, Zheng H et al. · 2026 · BMC neurology
Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder caused by abnormal GGC repeat expansions in the NOTCH2NLC gene, leading to multisystem involvement. Electrophysiological abnormalities in NIID…
View details →Berger M, Bruggisser F, Schwarz A et al. · 2025 · Physiology & behavior
Objectives To investigate whether a single session of aerobic exercise improves inhibitory control in preadolescent children and whether this effect is mediated by changes in parasympathetic activity. Design In this experimental study, an…
View details →Martinez G, Tolentino K, Sukheja P et al. · 2025 · Bioorganic & medicinal chemistry letters
Screening of the ChemDiv molecular library in cholesterol media against Mycobacterium tuberculosis (Mtb) H37Rv strain identified a novel isoxazole thiophene hit as a putative Rv1625c/Cya activator with a promising in vitro activity and…
View details →de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy
OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…
View details →Xiang C, Zheng M, Li Y et al. · 2025 · Annals of vascular surgery
Background Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial…
View details →Matsuzaki S · 2026 · Reproductive medicine and biology
Background Endometriosis is often diagnosed late due to a lack of noninvasive diagnostic tools and the varied presentation of its symptoms. Identifying risk factors for endometriosis is crucial for reducing diagnosis delays, mitigating the…
View details →Rolver MG, Emanuelsson F, Nordestgaard BG et al. · 2025 · Cardiovascular diabetology
Background and objectives Elevated C-reactive protein (CRP) is a well-established marker of low-grade systemic inflammation often accompanying cardiometabolic diseases like type 2 diabetes. We sought to determine if plasma CRP…
View details →Chen D, Zhu T, Liu C et al. · 2025 · Medicine
Several observational studies have reported the change in gut microbiota (GM) composition in individuals with osteoporosis (OP); however, the genetic correlation and causal association between GM and OP remain undetermined. Large-scale…
View details →Wagner H, Lam D, Nguyen AL · 2025 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose Appropriate framing of health information influences the adoption of health behaviors. This study explored whether (1) gain- or loss-framed health promotion messages, emphasizing positive or negative consequences, respectively,…
View details →Sirirungreung A, Lee PC, Hu YH et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background The safety of using acetaminophen (paracetamol) during pregnancy has been questioned because of concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to…
View details →Prince Czarnecki JM, Shockley JM, Wasson L et al. · 2024 · Precision Agriculture
Cloudy skies reduce image quality obtained from unmanned aerial vehicles (UAV) due to variable lighting conditions imposed on the surface. This study provides a novel approach for identifying temporal windows of opportunity that show…
View details →Peltonen K, Tammilehto J, Flykt M et al. · 2025 · Cognition & emotion
Research suggests that adverse childhood experiences (ACEs) can have life-long consequences on emotional functioning. However, it is unclear how ACEs shape the dynamic features of everyday emotions. In the current preregistered study with…
View details →· 2024 · Journal of cellular and molecular medicine
Xin Li, Hao Xu, Jianfeng Yi, Chunlu Dong, Hui Zhang, Zhengfeng Wang, Long Miao, Wence Zhou. miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT…
View details →Power MC, Lynch KM, Fang V et al. · 2025 · Environmental research
Background As dementia has a decades-long preclinical phase, earlier air pollution exposures may be more etiologically relevant to dementia risk than more recent exposures. Methods We estimated exposures at Atherosclerosis Risk in…
View details →Kömürcü HF, Sever N, Gökdereli NS et al. · 2025 · Neurological research
Background It has been suggested that smokers have higher recanalization rate, lower risk of cerebral hemorrhage and better prognosis than non-smokers (smoking paradox) after reperfusion therapy in patients with acute ischemic stroke (IS).…
View details →Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of Dairy Science
Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…
View details →Toyoshima M, Toyofuku R, Shimoda S et al. · 2026 · Neuropsychopharmacology reports
Adolescence is a sensitive developmental stage in which exposure to addictive substances can produce long-lasting changes in the neural circuits that regulate reward. Nicotine and ethanol are frequently co-used among adolescents, and…
View details →McVige J, Masset L, Mechtler L et al. · 2026 · Journal of child neurology
Mass psychogenic illness (MPI), also known as mass sociogenic illness, is a functional neurologic symptom disorder affecting multiple people simultaneously. This study presents a pediatric MPI outbreak involving abrupt-onset tics in LeRoy,…
View details →Ferreira HRS, Hadden AC, Champagnon J et al. · 2025 · The Science of the total environment
Despite the vital importance of wetlands globally, these habitats have increasingly received anthropogenic materials, such as plastics, which can impact the wildlife these habitats support. Despite commonly found in the nests of Eurasian…
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