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Browse the failure-mode index

12,254 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Age, Intersectional Discrimination, and Health in Black Transgender Women.

Grant S, Goldberg E, Gadipudi A et al. · 2025 · Journal of racial and ethnic health disparities

Black transgender women report high levels of discrimination, which is associated with poor health outcomes. Some evidence suggests that intersectional discrimination-that is, interacting forms of marginalization related to one's real or…

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Negative / Null Result ReportOpen accessMedicine

Understanding how a tap on/tap off system supports clinical work in an emergency department: a qualitative study.

Baysari M, Stanceski K, Bamgboje-Ayodele A et al. · 2026 · BMC medical informatics and decision making

Background Single sign-on (SSO), tap-on-tap-off (TOTO) and virtual desktops (VD) are increasingly being used in hospitals to reduce the burden and risks of password management, but we know little about how these systems are used in…

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Negative / Null Result ReportMedicine

AI and healthcare: surveying patient perspectives on artificial intelligence in neurosurgery.

Shah H, Ali M, Kilgallon JL et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Neurosurgery and neurosurgical care continues to evolve and to embrace technological advances. AI is used to interpret radiological studies and to distill medical information, with the potential to help guide physicians and patients in…

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Failed Experiment ReportMedicine

The Adherence Conundrum of Sleep Restriction Therapy for Insomnia.

Looman MI, Klau MM, Schoenmakers TM et al. · 2026 · Journal of sleep research

While time in bed restriction is a core treatment mechanism of Sleep Restriction Therapy (SRT), empirical research has not yielded a relationship between insomnia improvement and adherence to the prescribed time in bed. We coin this…

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Negative / Null Result ReportMedicine

Changes in Peri-Implant Soft Tissue Dimensions Following Soft Tissue Contour Augmentation: A 3-Year Follow-Up of a Multi-Center RCT.

Jepsen K, Jepsen S, Hämmerle CHF et al. · 2026 · Clinical oral implants research

Aim To assess 3-year changes of peri-implant tissues following previous soft tissue (volume) augmentation (STA) with a volume-stable collagen matrix (VCMX) or connective tissue (SCTG) at single-implant restorations. Material and methods In…

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Negative / Null Result ReportMedicine

Parental care liberates juvenile growth: a common-garden test of the evolutionary benefits of care.

Eggert AK, Prang MA, Capodeanu-Nägler A et al. · 2026 · Evolution; international journal of organic evolution

Effects on juvenile growth have long been considered an important benefit of parental care, but they have rarely been tested empirically. Protection and feeding by parents might accelerate offspring growth by allowing offspring to allocate…

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Failed Experiment ReportOpen accessMedicine

Potential Causes of Shedding Aggregations in Prairie Rattlesnakes.

Martin E, Conway CJ · 2026 · Ecology and evolution

Aggregation is common across taxa and typically confers clear benefits to group members (e.g., allo-parenting, group defense, thermoregulation, access to resources). But aggregation can also be costly. The mechanisms that underpin…

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Negative / Null Result ReportMedicine

Evaluation of passive immunity from dams previously immunized with an inactivated glycoprotein E-deleted infectious bovine rhinotracheitis marker vaccine after challenge infection with wild-type bovine alphaherpesvirus 1 in calves

Petrini S, Martucciello A, Righi C et al. · 2025 · Vaccine: X

Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen that causes infectious bovine rhinotracheitis (IBR) and other respiratory and reproductive disorders, resulting in substantial global economic losses to the cattle industry.…

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Negative / Null Result ReportMedicine

Comparative population genetic structure of the mitochondrial 16S ribosomal RNA gene of Haemaphysalis flava (Acari: Ixodidae) between Nantong, China, and regions along the East Asia-Australasian Flyway.

Su J, Zhang WB, Sun B et al. · 2025 · Experimental & applied acarology

Haemaphysalis flava Neumann, 1897 is recognized as a vector for Dabie bandavirus (severe fever with thrombocytopenia syndrome virus, SFTSV), which is the etiological agent of severe fever with thrombocytopenia syndrome (SFTS). The tick…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research.

Edsor E, Jose M, Sajesh S et al. · 2025 · Journal of pharmacy & bioallied sciences

Background The aim of this study is to assess whether there is a difference in the wound healing process following the extraction of a tooth between type 2 diabetes patients on oral hypoglycemic medications and nondiabetic patients.…

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Failed Experiment ReportMedicine

Pembrolizumab in recurrent or metastatic medullary thyroid cancer.

Del Rivero J, Donahue RN, Marte JL et al. · 2025 · The oncologist

Background It has been hypothesized that sequencing antigen-directed immunotherapy with immune checkpoint inhibitors could prime a tumor for immune response to immune checkpoint inhibitors. Methods This study (NCT03072160) was designed to…

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Failed Experiment ReportMedicine

Behavior of Listeria monocytogenes in commercial queso fresco and queso cotija and investigation of salt concentration as a control factor.

Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of dairy science

Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…

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Abandoned HypothesisOpen accessMedicine

Engaging in the Life-planning in Early Alzheimer's and other Dementias advance care planning intervention is associated with perceived advance care planning concordance and interpersonal connectedness.

Bybee SG, Clayton JL, Aruscavage N et al. · 2025 · The Gerontologist

Background and objectives Persons living with dementia often rely upon a care partner as their surrogate medical decision maker, yet little is known about how dementia care dyads achieve advance care planning (ACP) concordance: when a care…

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Negative / Null Result ReportMedicine

<i>N</i>-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transport.

Achilles S, Tomczak JN, Baumann FS et al. · 2025 · American journal of physiology. Gastrointestinal and liver physiology

DRA (Downregulated in adenoma, SLC26A3) is a major apical intestinal Cl - /HCO 3 - exchanger, which is expressed in complex and hybrid N -glycosylated forms. Although the importance of N -glycosylation is evident from the significantly…

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