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Browse the failure-mode index

12,254 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Active Aging: Learning English and Developing Fine Psychomotor Abilities.

Baranowska K, Dylewski R, Fugiel J et al. · 2026 · Experimental aging research

Background Recent studies highlight that cognitive processes involved in learning share neural pathways with those controlling fine motor skills. Building on this insight, the mini-EDUball method was developed to integrate cognitive and…

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Negative / Null Result ReportMedicine

Profession-Specific Ageism Changes Following a Two-Day Long-Term Care Placement in Dental Students.

Izumi M, Mizutani S, Fujimoto A et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Background Ageism among dental students can impede equitable geriatric care. Developing educational interventions to reduce profession-specific and general ageist attitudes is an urgent priority in aging societies. Objective To determine…

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Negative / Null Result ReportMedicine

Impact of Emicizumab on Coagulation Potential in Plasma From Healthy Women and Carriers of Haemophilia A During Late Pregnancy.

Takeyama M, Kimura F, Furukawa S et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Background Intra-cranial haemorrhage (ICH) in neonates with haemophilia A (HA) remains a serious perinatal complication. Prophylactic administration of emicizumab (Emi) to pregnant HA carriers has been discussed as a potential preventive…

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Null DatasetMedicine

Integrating systemic toxicity and toxicokinetic data to inform the need for subchronic dog studies in human health safety assessments of agrochemicals.

Murphy L, Mingoia R, Bianchi E et al. · 2026 · Regulatory toxicology and pharmacology : RTP

Regulatory testing for agrochemicals has traditionally included a 90-day toxicity study in a non-rodent species, usually the dog. With growing emphasis on the 3Rs-replacement, reduction, and refinement of animal use-and increased adoption…

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Negative / Null Result ReportMedicine

A Video Analysis Study Examining Neuromuscular Training Warm-Up Practices in Youth Soccer.

Lutz D, van den Berg C, Neill MG et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Objectives To investigate time spent completing neuromuscular training (NMT) exercises in youth soccer team warm-up across a season considering sex, level of play, session type, and coach exposure and awareness of NMT. Design…

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Negative / Null Result ReportMedicine

Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT).

Pathak BK, Maurya M, Mishra N et al. · 2026 · Clinical pediatrics

Microcytic hypochromic anemia is common in severe acute malnutrition (SAM) children, but macrocytic anemia (vitamin B12/folate deficiency) is not uncommon. Vitamin B12 deficiency leads to anemia and developmental slowing. We looked for the…

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Negative / Null Result ReportOpen accessMedicine

An Online Pilates Program for People with Hypermobility: A Pragmatic Clinical Trial Looking at Function, Interoception, Kinesiophobia, and Physical Activity Levels.

Russek LN, Di Bon J, Herbland A et al. · 2026 · Journal of multidisciplinary healthcare

Purpose This study evaluated whether an independent, online modified Pilates program alters function, interoception (internal body awareness), activity levels, and kinesiophobia (fear of movement) in people with symptomatic joint…

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Negative / Null Result ReportMedicine

Variations in outcomes following burn injury and admission to an Australian or New Zealand intensive care unit: A retrospective data linkage cohort study.

Garside T, Udy A, Reade MC et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Introduction The Burns Registry of Australia and New Zealand (BRANZ) has been used to identify significant variation in burn injury management and outcomes across Australia and New Zealand. This study aimed to assess variation in clinical…

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Negative / Null Result ReportMedicine

The Effect of a Mobile Game Developed for Children with Familial Mediterranean Fever on Disease Management and Quality of Life: A Randomized Controlled Trial.

Kaş Alay G, Mutlu B · 2026 · Games for health journal

Objective To determine the effect of training children with familial Mediterranean fever (FMF) using a mobile game (MG) or training booklet (TB) on self-efficacy, symptom management, and quality of life (HRQoL) compared with a control…

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Negative / Null Result ReportMedicine

Body temperature and time perception in morning and evening types

Erdoğan Ş, Tavat BC · 2025 · Physiology & behavior

Previous studies have suggested that time perception fluctuates throughout the day in relation to daily fluctuations of body temperature, and that there is a negative relationship between body temperature and time perception. The aim of…

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Negative / Null Result ReportMedicine

Treatment in Public Centers for Adult Jewish Women Survivors of Childhood Sexual Abuse in Israel: Abuse Characteristics, Psychiatric Profiles, and One-Year Treatment Outcomes.

Lev-Ari L, Mintz Malchi K, Ludmir E et al. · 2026 · Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)

Background Childhood sexual abuse (CSA) is associated with significant psychiatric morbidity and has been reported at notable rates among Jewish Israeli women. Yet data regarding abuse characteristics, psychiatric history and longitudinal…

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Negative / Null Result ReportMedicine

Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis.

Reil JC, Sequeira V, Coppée C et al. · 2026 · Circulation. Heart failure

Background Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by left ventricular (LV) outflow tract obstruction, which increases afterload and chronically activates the Anrep response, a compensatory (afterload-driven) state…

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Replication FailureOpen accessMedicine

The Effect of Hip Arthroplasty on Gait Function: Comparison of Ceramic-On-Ceramic Hip Resurfacing, Metal-On-Metal Hip Resurfacing, and Total Hip Arthroplasty.

Leon D, Maslivec A, Guest B et al. · 2026 · Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Ceramic-on-ceramic hip resurfacing arthroplasty (CoC-HRA) has been developed to eliminate metal ion concerns which have been associated with metal-on-metal hip resurfacing arthroplasty (MoM-HRA) while maintaining similar functionality. The…

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Replication FailureMedicine

Acute overfeeding impairs meal-stimulated adipose tissue microvascular blood flow in healthy adults independent of changes in adiposity.

Brayner B, Mason S, Karimi E et al. · 2026 · American journal of physiology. Endocrinology and metabolism

Subcutaneous adipose tissue microvascular blood flow (MBF) increases in response to insulin or a meal, with gastric inhibitory polypeptide (GIP) being a proposed mechanism. This vascular response is blunted in people with insulin…

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