12,254 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Adjekum R, Small SA, Chan S et al. · 2026 · American journal of audiology
Purpose Narrowband (NB) chirps have recently been of great interest in audiology for the electrophysiological assessment of hearing in infants, but clinicians have little information about these new stimuli and how they compare to more…
View details →Short C, Semple T, Abkir M et al. · 2026 · Thorax
Introduction The current cystic fibrosis (CF) care era, while hugely welcome, raises new challenges, particularly the need for more sensitive pulmonary outcome measures. Seeking further optimisation, we previously developed a Short…
View details →Mol BM, de Bresser CJM, de Kleijn PV et al. · 2026 · European stroke journal
Carotid endarterectomy (CEA) is performed to lower the long-term risk of stroke in patients with carotid stenosis. Data evaluating long-term outcomes after CEA are scarce, but crucial for accurately determining long-term benefits. We aimed…
View details →Yin J, Wu D, Cooledge EC et al. · 2026 · Global change biology
Extreme heat events have increased markedly over recent decades globally, with potentially severe impacts on soil carbon (C) cycling. Here, we conducted a mechanistic study to assess the impact of a single 3-day extreme heat event (30°C,…
View details →Harazin A, Reinert LS, Alam P et al. · 2026 · Cell biochemistry and function
Double-stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS-STING signaling pathway comprising the cyclic GMP-AMP synthase (cGAS) and the stimulator of interferon genes (STING) receptors.…
View details →Langeskov-Christensen M, Nygaard MKE, Eskildsen SF et al. · 2026 · Neurorehabilitation and neural repair
Objectives Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising…
View details →Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders
Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…
View details →van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology
Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…
View details →Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck
Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…
View details →Söylemez E, Dağ M · 2026 · Applied neuropsychology. Adult
This study examined how smartphone-related cognitive load interferes with motor control during static balance and mobility tasks. Excessive smartphone use has been associated with attentional shifts and divided cognitive resources,…
View details →Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology
The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…
View details →Hansen ESH, Håkansson KEJ, Brustad N et al. · 2026 · Respiratory medicine
Background After puberty asthma is more common and often more severe in females, indicating a potential role of sex steroids. Observational and genetic studies suggest that higher testosterone levels are associated with improved lung…
View details →Michienzie C, Galgiani J, Fitzwater SP · 2026 · Pediatrics
Objective Coccidioidomycosis (CM) is not as well described in children as it is in adults. The Kaiser Permanente Southern California (KPSC) system provides care within an endemic region for CM, affording the opportunity to describe the…
View details →Gilbert SJ, Vazquez SR, Gouripeddi R et al. · 2026 · Journal of thrombosis and thrombolysis
Increasing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) raises concern for interactions with warfarin. Although GLP-1 RAs do not affect warfarin pharmacokinetics, their appetite-reducing effects may decrease vitamin K…
View details →Liu GN, Chen C, Xu L et al. · 2026 · Microcirculation (New York, N.Y. : 1994)
Background Impaired opisthenar microvessel area (OMA) has been associated with adverse cardiac outcomes in acute myocardial infarction (AMI) patients. Here, we compared the characteristics of OMA of ischemic stroke (AIS) patients, National…
View details →Sönmez M, Alemdaroğlu E, Ata AM et al. · 2026 · Acta cardiologica
Background Cardiac rehabilitation (CR) has been shown to be beneficial in preventing and treating sarcopenia in those with cardiovascular disease. The aim of the study is to compare the effects of high intensity intermittent aerobic…
View details →Jonkers J, Elderman M, Salas M · 2026 · Zoo biology
Research on positive animal welfare has prompted exploration and implementation of methods to stimulate the behavioral repertoires of zoo-housed species. We investigated the impact of a modified feeding method on the behavioral diversity,…
View details →Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science
Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…
View details →Mwenechanya M, Tembo AM, Chomba E et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology
Objective To evaluate if the effect of low-dose aspirin (LDA) commenced between 6 and 13 weeks of gestational age (GA) on preterm delivery (PTD) is modified by total exposure. Design Post hoc analysis of a randomized controlled trial.…
View details →Pradhan A, Hughes RPJ, Woodman-Pieterse EC et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Purpose To determine how accommodation affects lens shape in myopic and non-myopic children. Methods Participants included 76 non-myopic (spherical equivalent refraction (SER): 0.00 to +1.75 D) and 18 myopic children (SER = -3.50 to -0.75…
View details →Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology
Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…
View details →Wenk MJ, Rademacher N, Liedl B et al. · 2026 · Urologia internationalis
Introduction The aim of the study was to prospectively evaluate patient and clinician reported outcomes of voiding function, pain levels and patient satisfaction of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2)…
View details →Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…
View details →Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal
This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…
View details →Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…
View details →Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany
Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…
View details →Metz AK, Loughmiller SK, Braathen DL et al. · 2026 · The Journal of arthroplasty
Background The use of alternative alignment strategies has become commonplace in performing total knee arthroplasty (TKA). A primary reported benefit of these techniques is a reduction in the need for soft-tissue releases for appropriate…
View details →Froon-Torenstra D, Renting L, Ijpma I et al. · 2026 · Clinical nutrition ESPEN
Background and aims Malnutrition is common among children with cancer and is related to treatment-related toxicity, mortality and lower quality of life. So far, it remains unknown whether changes in resting energy expenditure (REE)…
View details →Huffman J, Chapple AG, Armbruster P et al. · 2026 · European oral research
Purpose This study sought to compare mechanical properties of beta titanium orthodontic wires to stainless steel and NiTi archwires under different pH conditions and for different time intervals. Materials and methods Twenty samples of 5…
View details →Saber S, Rifat MMI, Rahimi F et al. · 2026 · Genetics
The rate, molecular spectrum, and fitness effects of mutations vary at all levels of the biological hierarchy, from within individual genomes to among taxonomic domains. Understanding the evolutionary factors underpinning that variation is…
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