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WASTE Journal

Browse the failure-mode index

12,254 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Maxillary Advancement and Impaction Increase the Size of the Nasal Airway Anterior to the Piriform Aperture, but Not Posterior to it.

Giotakis AI, Steinbichler TB, Heppt H et al. · 2026 · The Journal of craniofacial surgery

The exact nasal changes caused by several types of maxillofacial surgery are not yet thoroughly understood. The aim of the present study was to determine the exact nasal airway changes caused by maxillary advancement and impaction. In a…

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Negative / Null Result ReportOpen accessMedicine

Lean Mass Gains, Cardiac Remodeling, and Muscle Oxidative Changes With High-Dose Salbutamol During Resistance Training: A Randomized Controlled Trial.

Hostrup M, Jessen S, Tischer SG et al. · 2026 · Scandinavian journal of medicine & science in sports

Misuse of beta 2 -agonists to promote leanness is increasingly reported among young men undertaking resistance training. However, preclinical models demonstrate adverse cardiac remodeling with high-dose beta 2 -agonist. We investigated…

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Negative / Null Result ReportMedicine

Change in modified star excursion balance test performance between 6 and 12 months after anterior cruciate ligament reconstruction.

Rostron ZPJ, Feller JA, McClelland JA et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

Objectives To determine the change in modified star excursion balance test scores in patients between 6 and 12 months following anterior cruciate ligament (ACL) reconstruction and the change in the proportion of patients who met…

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Negative / Null Result ReportMedicine

Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial.

Dunseath GJ, Cheung WY, Luzio SD et al. · 2026 · Diabetes care

Objective To determine whether less invasive C-peptide tests, urine C-peptide-to-creatinine ratio (UCPCR) and dried blood spot (DBS), could replace the mixed-meal tolerance test (MMTT) in the context of an interventional clinical trial…

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Negative / Null Result ReportMedicine

More graminoids in community breaks the trade-off between forage production and quality to improve forage quality storage in alpine grasslands

Wu S, Liu Q, Li L et al. · 2025 · Agriculture, Ecosystems and Environment.

Forage production and quality, two crucial ecosystem functions of grasslands, often demonstrate a trade-off and are significantly affected by both grassland community characteristics and environmental factors. However, whether and how…

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Negative / Null Result ReportMedicine

Behavioral Adaptation to Neck Radio-Collars and Its Relations with Temperament in Two Neotropical Psittacid Species.

de Almeida GN, de Jesus LG, Branco MEC et al. · 2026 · Journal of applied animal welfare science : JAAWS

Track devices can cause behavioral, physical, and physiological adverse effects, with individuals varying in how quickly they adapt to them. We examined behavioral effects of replica radio-collars on two captive psittacid species,…

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Negative / Null Result ReportMedicine

Impact of tighter glycaemic targets on pregnancy outcomes in a multi-ethnic cohort with gestational diabetes: A retrospective, single centre observational study.

Huda MS, Margari N, Islam N et al. · 2026 · Obstetric medicine

Aims To determine the impact of tighter glycaemic targets for gestational diabetes. Methods Retrospective data analysis before and after introducing tighter glucose targets. Results In 2265 pregnancies there was no change in…

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Negative / Null Result ReportMedicine

Mental rotation performance after acute stress.

Richardson AE, VanderKaay Tomasulo MM · 2026 · BMC psychology

Background The need to mentally rotate objects is common in everyday activities (e.g., driving, loading suitcases in a car, playing 3D video games) and in specific professions (e.g., air traffic controllers, mechanics, pilots, surgeons).…

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Negative / Null Result ReportMedicine

The Importance of Objective Functional and Balance Testing in Pediatric Anterior Cruciate Ligament Reconstruction for a Safe Return-To-Sport: A Two-Year Prospective Study.

Crippa M, Turati M, Flumian C et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction/objectives Pediatric anterior cruciate ligament reconstruction (ACLR) outcomes, particularly long-term functional recovery and return-to-sport (RTS), remain debated and have not been well characterized in skeletally immature…

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Negative / Null Result ReportMedicine

The impact of hormonal contraceptives containing estradiol, estradiol valerate, and estetrol on liver proteins, lipids, glucose, blood pressure, and bone. A literature review.

Cagnacci A, Xholli A, Gabbi L et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

Objective We investigated the metabolic profile induced by contraceptives containing body-identical oestrogens. Methods A literature search was made for articles on contraceptives with oestradiol/nomegestrol acetate (E2/NOMAc), oestradiol…

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Negative / Null Result ReportMedicine

Quantification of Changes in Bifidobacteria and Lactobacilli Colony-forming Units During Rifaximin Treatment and Synbiotic Gel in Healthy Volunteers.

Cassís-Nosthas ML, Vorácková FV, Dzib FT et al. · 2026 · Journal of visualized experiments : JoVE

Although the gut microbiota is generally stable, it can be influenced by antibiotic treatment. Rifaximin, which is used to treat gastrointestinal disorders, is frequently administered with probiotics to reduce the risk of dysbiosis.…

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Negative / Null Result ReportMedicine

Cerebral physiology following general anaesthesia with sevoflurane or propofol in healthy volunteers - a randomised, single-blind cross-over trial.

Madsen SS, Asghar MS, Lindberg U et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Although general anaesthesia is a very common medical procedure, knowledge of how the brain physiologically recovers remains limited. In this randomized cross-over trial, we investigated brain physiology during recovery from general…

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Negative / Null Result ReportMedicine

Eight weeks of high-intensity interval training is insufficient to prevent sitting-induced endothelial dysfunction and microvascular impairment.

Kasai N, Ihara H, Iemitsu M et al. · 2026 · Experimental physiology

Prolonged sitting disrupts lower-limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata-style high-intensity interval training (HIIT) mitigates this…

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Negative / Null Result ReportMedicine

Sexual health following hyperbaric oxygen treatment in pelvic cancer survivors with radiation injuries: a longitudinal observational study.

Hauken MA, Gjestad R, Sekse RJT et al. · 2026 · The journal of sexual medicine

Background Hyperbaric oxygen therapy (HBOT) is an established treatment for pelvic late radiation tissue injuries (LRTIs) in cancer survivors, yet its impact on sexual health outcomes has previously not been examined. Aim To investigate…

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