12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Shimada T, Iwahashi T, Suzuki K et al. · 2025 · Journal of pharmacological sciences
Chronic nerve compression disorders, such as carpal tunnel syndrome, are common and can significantly impair daily activities due to motor and sensory dysfunctions. Currently, no systemic pharmacotherapy exists for preventing or treating…
View details →Guo Z, Hu Y, Zhou J et al. · 2025 · Biochemical and biophysical research communications
Iron overload leads to apoptosis and increased expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) in osteocytes, which in turn accelerates osteoclastogenesis. Since osteocytes are the main RANKL producers, we…
View details →Wilson KF, Fox AE · 2024 · Appetite
A high-fat diet has negative effects on physical, neurological, and behavioral outcomes. One consistent finding is that a diet high in fat increases impulsive choice behavior-behavior that is linked to a wide range of other negative health…
View details →Shatsnimitkul E, Laopeamthong I, Tansawet A et al. · 2024 · BJS open
Background Adverse events after endoscopic retrograde cholangiopancreatography (ERCP) are rare, and post-ERCP pancreatitis is a serious adverse event. This study aimed to determine the role of aggressive intravenous hydration with lactated…
View details →Dragan E, Ghinea M, Haba D et al. · 2025 · Dentistry journal
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a…
View details →Ramasubbu D, Lewney J · 2025 · Evidence-based dentistry
Design The Brushing RemInder 4 Good oral HealTh (BRIGHT) multi-centre randomized controlled trial was based in state-funded secondary schools in England, Wales and Scotland. It had two arms, aiming to assess the clinical and cost…
View details →Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior
Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…
View details →Lima da Silva AP, de Oliveira TP, Nogueira RD et al. · 2025 · Journal of clinical and experimental dentistry
Background The objective was to evaluate the surface hardness of white spot lesions (WSL) treated with different caries prevention methods. Material and methods The Knoop microhardness (µKH) of 50 bovine dental enamel fragments was…
View details →Correia de Lima Junior N, Fernandes-Batista T, Ferreira-Serra L et al. · 2025 · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
The consumption of Western diet, characterized by high sugar and saturated fat content, often leads to weight gain and promotes oxidative stress. Intermittent fasting has emerged as a potential strategy to combat obesity, but its effects…
View details →Rajsiglova L, Babic M, Krausova K et al. · 2024 · Journal of immunotoxicology
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles…
View details →de Araújo IM, Le PT, de Carvalho Picoli C et al. · 2026 · JBMR plus
Caloric restriction (CR) alters energy metabolism and increases systemic glucocorticoid production, contributing to bone loss and bone marrow adipose tissue (BMAT) expansion. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)…
View details →Damica FZ, Lucas DR, Toledo EB et al. · 2025 · Biochimica et biophysica acta. General subjects
Antimicrobial peptides (AMPs) are promising drugs, though their fungal combat mechanisms remain partly unclear. We designed three AMPs (dAMPs) based on the γ-core of the Vu-Def 1 seed defensin from Vigna unguiculata L. Walp. named RR,…
View details →Magnuson JR, Bruce CD, Dalton BH et al. · 2024 · Journal of neurophysiology
The increasing descending drive needed to sustain submaximal isometric torque makes it difficult to isolate fatigue-related changes to neural excitability because evoked electromyography (EMG) responses are influenced by the relative…
View details →Wang L, Wang X, Zhang R et al. · 2025 · The American journal of clinical nutrition
Background Gestational diabetes mellitus (GDM) affects millions of females and their children. Effective dietary strategies for early prevention are controversial. Objectives This study aims to investigate whether an individualized…
View details →Shaidullov I, Bouchareb D, Sorokina D et al. · 2025 · Naunyn-Schmiedeberg's archives of pharmacology
Irritable bowel syndrome (IBS) is a multifactorial disorder, with altered intestinal motility, visceral hypersensitivity, and dysfunction of the gut-brain axis. The aim of our study was to analyze the role of nitric oxide (NO) in the…
View details →Villa M, Martínez-Vega M, Silva L et al. · 2024 · Pediatric research
Background Neonatal rats can manifest post-stroke mood disorders (PSMD) following middle cerebral artery occlusion (MCAO). We investigated whether cannabidiol (CBD) neuroprotection, previously demonstrated in neonatal rats after MCAO,…
View details →Gam S, Hermann AP, Juhl CB et al. · 2026 · Obesity (Silver Spring, Md.)
Objective This study aimed to investigate whether a single infusion of 5 mg zoledronic acid, given before bariatric surgery to prevent bone loss, could also hinder the loss of muscle mass, strength, and physical function. Methods In this…
View details →Dubourg V, Akhtar N, Kopf M et al. · 2026 · iScience
Vascular smooth muscle cells (VSMCs) are at the center of vascular diseases but studies on VSMCs from human females are rare and the medical need for female-specific vascular research is urgent. VSMCs are simultaneously subjected to…
View details →Lyons J, Chatha HN, Boutros C et al. · 2025 · Surgical endoscopy
Background Fundoplication at the time of paraesophageal hernia (PEH) repair is thought to help prevent the development or persistence of postoperative gastroesophageal reflux (GERD) and might also prevent hernia recurrence. However, the…
View details →Weerts EM, Jenkins BW, Kuang RY et al. · 2024 · Pharmacology, biochemistry, and behavior
Cannabigerol (CBG) is a phytocannabinoid found in cannabis that is promoted for medical use and other health benefits, but current empirical data on the behavioral effects of CBG are lacking. The purpose of this study was to evaluate the…
View details →Maier KS, Schiener T, Frigg A · 2025 · Journal of orthopaedic surgery and research
Background Short femoral stems were introduced for total hip arthroplasty (THA) to preserve bone stock, increase proximal load transfer, and enable minimal invasive approaches. However, after implanting the short curved Fitmore hip stem,…
View details →Comboni LM, Glover ES, Napolitano SC et al. · 2026 · Foods (Basel, Switzerland)
We assessed whether consuming UV light-exposed mushrooms (UVMs) would offset the seasonal decline in circulating total 25-hydroxyvitamin D (25OHD), an index of vitamin D status. During late fall and winter, 41 adults (19 M/22 F, age 43 ±…
View details →Tuffs C, Dupovac M, Richter K et al. · 2025 · The American journal of pathology
Liver fibrosis is characterized by excessive deposition of extracellular matrix due to chronic inflammation of the liver. Hepatic stellate cells (HSCs) become activated and produce increased amounts of extracellular matrix. Loss of…
View details →Quan J, Kriebel M, Anunu R et al. · 2026 · Scientific reports
The Median Raphe (MR) provides a major, mainly serotonergic, input to the hippocampus, particularly influencing the dentate gyrus (DG), but its specific role remains unclear. Here, focusing on the dorsal DG, we investigated its…
View details →Chia A, Burkill S, Ling Y et al. · 2026 · The British journal of ophthalmology
Aim To evaluate the effectiveness of atropine 0.01% in young premyopic and low-myopic children. Methods Children (5-9 years old) with premyopia (spherical equivalent refraction, SER+1.00 to -0.49D, n 156) or low myopia (SER -0.50 to…
View details →McDaniel AL, Gadoury DM, Moyer MM · 2024 · Crop Protection
Germicidal ultraviolet-C light (UV–C) has been used to effectively suppress grapevine powdery mildew (Erysiphe necator). However, effects on arthropod pests that would be simultaneously exposed to UV-C during applications directed at E.…
View details →Nilsson KH, Henning P, Lagerquist MK et al. · 2026 · Calcified tissue international
Osteoporosis is characterized by an imbalance in bone remodeling, resulting in bone loss and increased fracture risk. Inflammatory diseases, such as rheumatoid arthritis, are strongly associated with secondary osteoporosis due to…
View details →Leal R, Fragoso P, Venda J et al. · 2025 · Renal failure
Background The optimal immunosuppressive (IS) withdrawal strategy after kidney allograft failure remains unclear. This study evaluated the effects of prolonged calcineurin inhibitor (CNI) therapy on HLA sensitization, graft intolerance…
View details →Krikelis M, Gazi S, Trovas G et al. · 2024 · Joint bone spine
Introduction Denosumab (Dmab) is widely used for the treatment of post-menopausal osteoporosis. Its discontinuation is sometimes accompanied by multiple vertebral fractures. Romosozumab (Rmab) has not been tested for its ability to prevent…
View details →Zhou AL, Ward RE · 2024 · Journal of dairy science
The focus of this work is the role milk polar lipids play in affecting gut permeability, systemic inflammation, and lipid metabolism during acute and chronic inflammation induced by a single subcutaneous injection of lipopolysaccharide.…
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