e-ISSN: Pending

Browse the failure-mode index

12,254 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Towards maintaining canine training aid integrity: Effects of environmental factors and operational use on the triacetone triperoxide polymer odor capture-and-release system.

Cropper E, Riley P, Simon AG · 2024 · Journal of forensic sciences

There are many factors that may affect the longevity of or guide the use of canine training aids. Literature to date has mainly focused on identifying the headspace volatiles associated with training aids or odors and only minimal research…

View details →
Negative / Null Result ReportOpen accessMedicine

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis.

Carr JF, Basurto De Santiago C, Bhut SA et al. · 2026 · mBio

In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane…

View details →
Negative / Null Result ReportMedicine

Dynamic inflation prevents and standardized lung recruitment reverts volume loss associated with percutaneous tracheostomy during volume control ventilation: results from a Neuro-ICU population.

Bastia L, Garberi R, Querci L et al. · 2024 · Journal of clinical monitoring and computing

To determine how percutaneous tracheostomy (PT) impacts on respiratory system compliance (C rs ) and end-expiratory lung volume (EELV) during volume control ventilation and to test whether a recruitment maneuver (RM) at the end of PT may…

View details →
Negative / Null Result ReportMedicine

Effects of mindfulness-based stress reduction on levels of depression, anxiety, stress, and hopelessness in parents of children with autism: A randomized controlled trial.

Yurttutan S, Geçkil E · 2026 · Journal of pediatric nursing

Aim This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on depression, anxiety, stress, and hopelessness among parents of children with autism (Autism Spectrum Disorder [ASD]). Method A…

View details →
Failed Experiment ReportMedicine

Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2.

Ahmed Eltayeb S, Dressler JM, Schlatt L et al. · 2024 · Archives of toxicology

Oxaliplatin (OHP) is effective in colorectal cancer treatment but induces peripheral neurotoxicity (OHP-induced peripheral neurotoxicity, OIPN), diminishing survivor quality of life. Organic cation transporter 2 (OCT2) is a key OHP uptake…

View details →
Failed Experiment ReportMedicine

Lisdexamfetamine dimesylate (Vyvanse) toxicosis in a dog.

Martindale DM, Haraschak JL, Thiel AJ et al. · 2024 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To describe the presentation, management, and postmortem examination findings in a dog with confirmed lisdexamfetamine dimesylate (LDX) toxicosis. Case summary A 3-year-old female neutered mixed breed dog initially presented with…

View details →
Negative / Null Result ReportOpen accessMedicine

Computer-Assisted Intramedullary Nailing of Intertrochanteric Fractures Did Not Prevent Tip-Apex Distance Outliers.

Hansen RH, Rölfing JD, Nielsen CL et al. · 2023 · Journal of clinical medicine

Intertrochanteric femoral fractures are commonly treated with intramedullary nails (IMNs). A tip-apex distance (TAD) of more than 20-25 mm is associated with an increased risk of cut-out. The Stryker Adaptive Positioning System (ADAPT) is…

View details →
Negative / Null Result ReportMedicine

Pre-Post Evaluation of Documentation Burden, Time Perception, and Cognitive Workload of Ambient AI Scribe Tools.

Arko L, Nguyen TH, Stoffel M et al. · 2026 · AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Documentation burden and cognitive load contribute to clinician burnout, and ambient AI scribes offer a promising solution, though real-world evaluations remain limited. This study evaluated the impact of an ambient AI scribe on…

View details →
Negative / Null Result ReportOpen accessMedicine

The launch and diffusion of new patented medicines by therapeutic value.

Zhang W, Guh DP, Tam ACT et al. · 2026 · Health affairs scholar

Introduction Evidence on the launch and diffusion of therapeutically important new medicines is limited. We examined the launch and diffusion of new patented medicines in 14 countries by therapeutic value. Methods We analyzed IQVIA MIDAS®…

View details →
Negative / Null Result ReportMedicine

Effects of a game-based learning ıntervention on self-reported learning strategies and professional attitudes in kinesiophobia management education: a parallel-group randomized controlled trial.

Yılmaz NA, Caner İ · 2026 · BMC medical education

Innovative educational strategies are increasingly needed in physiotherapy education to support students' learning and professional development. Game-based learning (GBL) is an interactive, student-centered approach that may enhance…

View details →
Negative / Null Result ReportMedicine

Engineering a Fungal Non-Reducing Polyketide Synthase with an Apparently Inactive Product-Template Domain Reveals Insights into the Catalytic Reprogramming.

Yin R, Qin Y, Liang X et al. · 2026 · International journal of molecular sciences

Fungal iterative non-reducing polyketide synthases (NR-PKS) contain a unique product template (PT) domain for aromatic cyclization. Among them, some NR-PKSs, such as the sorbicillin NR-PKS (SorB), have an apparently inactive PT. It is…

View details →