12,254 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Lin S, Lytle KA, Fink N et al. · 2026 · Diabetes
Adipose tissue (AT) lipolysis insulin resistance results in excess free fatty acid (FFA) release. We tested the hypothesis that the ability of insulin to suppress AT lipolysis is unrelated to the ability of niacin to suppress lipolysis,…
View details →Takemura A, Egawa T, Uemichi K et al. · 2025 · Biochemistry and biophysics reports
Mild hyperbaric oxygen (MHO) attenuates the muscle atrophy caused by muscle disuse. Training cessation results in the partial or complete loss of training-induced adaptations, including mitochondrial enzyme activities. The present study…
View details →van de Wetering R, Alder AF, Biggerstaff A et al. · 2025 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
The development of safer mu opioid receptor (MOR) agonists with reduced side effects is a key focus of pain research. Some studies have suggested that MOR agonists with reduced β-arrestin 2 (βArr2) signaling (i.e. G-protein biased…
View details →Bearzi E, Sola S, Defferrari C et al. · 2026 · Dermatology reports
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor, mainly linked to Merkel cell polyomavirus (MCPyV) and less often to ultraviolet exposure. Additional risk factors include advanced age and immunosuppression.…
View details →Stringari C, Stringari H, de Queiroz E Silva TF et al. · 2026 · Inflammopharmacology
INTRODUCTION: There is a marked overlap among the neuronal pathogenetic pathways involved in ulcer genesis and depression, and antidepressants can also exert a protective effect against gastric ulcers. OBJECTIVE: To summarize and…
View details →Carroll I, Schievink W · 2024 · Headache
Spontaneous intracranial hypotension (SIH) commonly results from ventral spinal cerebrospinal fluid (CSF) leaks and epidural patches are advocated as first-line treatment. Complications such as superficial siderosis can arise but have…
View details →Nocera FP, Fantini O, Abate G et al. · 2026 · Veterinary medicine and science
Background Traumatic and surgical wounds are common in cats, but their management is often challenging due to anatomical factors, delayed presentation, behavioural issues and frequent bacterial colonization. Objectives This prospective,…
View details →Orji C · 2025 · Cureus
Vericiguat is used as an adjunct therapy for patients with heart failure with reduced ejection fraction (HFrEF). Despite its availability in clinical practice, it remains underutilized among eligible patients. This case report describes…
View details →Hotz JF, Kaindl L, Krebs S et al. · 2026 · European journal of neurology
Introduction Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient, unilateral motor weakness. Due to its rarity, treatment strategies are lacking. Monoclonal antibodies targeting the calcitonin…
View details →Haddad S, Jacobs E, Núñez-Pereira S et al. · 2025 · Spine
Study design Retrospective analysis of a prospective multicenter adult spinal deformity (ASD) registry. Objective Assess whether spinal alignment deteriorates postsurgery in the absence of mechanical complications and evaluate the…
View details →Wagstaff KM, Stein MS, Herschtal A et al. · 2025 · Pharmaceutics
Background: The efficacy of a single oral dose of Ivermectin as prophylaxis for SARS-CoV-2 is uncertain. This trial sought to evaluate the effectiveness of a single oral low dose of Ivermectin to prevent SARS-CoV-2 infection or reduce…
View details →Çevik N, Hazar Bodrumlu E · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Objective Colour stability is important in the long-term aesthetic success of restorative materials and is affected by both internal and external factors. Internal discolourations are due to the properties of the restorative materials.…
View details →Taguchi K, Chuang VTG, Ozawa M et al. · 2024 · Die Pharmazie
Urticaria is induced by the histamine released from mast cells which develops wheals (edema) as a visual feature. In clinical practice, second-generation histamine H 1 -receptor blockers are routinely used as the first-line symptomatic…
View details →Martins J, Eliseu A, Campos S et al. · 2024 · Animals : an open access journal from MDPI
The ovariectomy (OVE) procedure can trigger somatosensory and visceral peritoneal nociception. Sacrococcygeal epidural (ScE) anesthesia may complement or replace systemic analgesia used for feline OVE, reducing opioid consumption and their…
View details →Wu H, Jin J, Zhou D et al. · 2025 · BMC anesthesiology
Background Liposomal bupivacaine (LB) provides prolonged analgesia, but it remains unclear whether it prevents rebound pain or merely delays its onset. This study investigated the effect of LB on rebound pain in a mouse model of peripheral…
View details →Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2025 · BMC cancer
Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →Pintus E, Scaringi M, Engelen J et al. · 2026 · Theriogenology
Impaired seminal redox balance is a main factor that contributes to male fertility disorders and reduced sperm survival during storage. Although several methods are available to measure antioxidant and reactive oxygen species (ROS) levels,…
View details →Liñares A, Tan HJ, Muñoz F et al. · 2025 · Journal of clinical periodontology
Aim To evaluate early buccal bone resorption (BBR) in areas with or without buccal keratinized tissue (KT), and different mucosal thickness (MT) following implant placement at healed sites. Materials and methods In 9 beagle dogs, three…
View details →McNee A, Vanover D, Rijal P et al. · 2023 · Frontiers in immunology
Monoclonal antibodies (mAbs) can be used to complement immunization for the therapy of influenza virus infection. We have established the pig, a natural large animal host for influenza A, with many physiological, immunological, and…
View details →Autio KJ, Koivisto H, Schmitz W et al. · 2024 · The Journal of nutritional biochemistry
Mitochondrial fatty acids synthesis (mtFAS) is a conserved metabolic pathway essential for mitochondrial respiration. The best characterized mtFAS product is the medium-chain fatty acid octanoate (C8) used as a substrate in the synthesis…
View details →Chinitz L, Böhm M, Evonich R 3rd et al. · 2024 · JACC. Clinical electrophysiology
Background The autonomic nervous system plays an important role in atrial fibrillation (AF) and hypertension. Renal denervation (RDN) lowers blood pressure (BP), but its role in AF is poorly understood. Objectives The purpose of this study…
View details →Navaneetha Krishnan S, Jaiswal A, Mohan A et al. · 2026 · Gut microbes
Increasing evidence implicates mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease (IBD), with the IBD-associated pathobiont adherent-invasive E. coli -LF82 (AIEC) promoting epithelial mitochondrial depolarization…
View details →Flores Ramos S, Fogelson KA, Muti VB et al. · 2026 · Journal of biological rhythms
Time-restricted feeding (TRF), a dietary intervention that consolidates food intake to specific hours of the day, ameliorates key metabolic risk factors for metabolic-associated steatohepatitis (MASH), including adiposity, insulin…
View details →Nikolaev MV, Fedorova IM, Chistyakova OV et al. · 2025 · International journal of molecular sciences
The search for novel compounds with anticonvulsant properties remains a key focus in neuropharmacology. Recently, the diazepine-benzimidazole derivative, DAB-19, has emerged as a promising candidate due to its demonstrated anxiolytic and…
View details →Aung T, Cheah JX · 2025 · Cureus
Livedoid vasculopathy (LV) is a rare, chronic occlusive dermopathy causing recurrent painful ulcerations, impaired healing, and significant morbidity. Historically considered a thrombotic microangiopathy, emerging evidence suggests an…
View details →Ayusso LL, Girol AP, Ribeiro Souza H et al. · 2024 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
We assessed in vivo the protective effects and underlying antioxidant and anti-inflammatory properties of dry green tee extract (GTE) on glomerular and tubular kidney function and structure in an experimental model of gentamicin…
View details →de Lazzari E, Nomah DK, Blanco JL et al. · 2024 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives The prevalence and risk factors of SARS-CoV-2 infection among unvaccinated people living with HIV (PWH) are not well understood, and the protective role of tenofovir remains controversial. This study aimed to assess the…
View details →Gabaldon-Albero A, Martin-Grau C, Marti-Masanet M et al. · 2024 · Pediatric rheumatology online journal
Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage. Approximately 7% of Aicardi-Goutières Syndrome cases are caused by pathogenic…
View details →Tang F, Zhang L, Lu S et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background Hyperbaric oxygen therapy (HBOT) is widely used as a therapeutic intervention for various types of wounds. Studies have shown that in addition to improving local oxygen supply to the wound site, HBOT can also influence cytokine…
View details →Gao J, Mathias RT, Varadaraj K et al. · 2025 · Investigative ophthalmology & visual science
Purpose The lens has a feedback control system made by transient receptor potential vanilloid 4 (TRPV4) and TRPV1 to sense pressure and activate ion transport to maintain intracellular hydrostatic pressure close to zero at the lens…
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