12,380 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Takenaka Y, Maeda K, Yamada M et al. · 2026 · Behavioural brain research
Background Motor imagery (MI) improves motor performance, but standardized objective quality evaluation methods are lacking. The relationship between MI quality and actual performance improvements also remains unclear. Purpose We…
View details →Bandaru S, Bodduluri S, Swami R et al. · 2026 · Scientific reports
ADRB2 gene polymorphisms have been widely studied for their role in influencing asthma pathophysiology. Of particular note, the Gln27Glu (+ 79 C > G, rs1042714) polymorphism, which alters the extracellular domain at the N-terminus of β 2…
View details →Putzer M, De Decker S, Gutierrez Quintana R et al. · 2026 · Journal of feline medicine and surgery
ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific magnetic resonance imaging (MRI) sequences are used to demonstrate differences in endolymph composition between…
View details →Celik B, Kaya M, Emre S · 2026 · Parasite immunology
Chronic spontaneous urticaria (CSU) is a mast cell driven multifactorial disorder with complex pathogenesis. While the association between CSU and internal parasites has been investigated, the association of ectoparasites such as Demodex…
View details →Bajaj JS, Kamath PS, Wong F et al. · 2026 · Clinical and molecular hepatology
Background/aims Infections with drug-resistant organisms (DROs) are associated with poor outcomes in cirrhosis. Rifaximin, widely used for hepatic encephalopathy (HE) could promote cross-resistance, but data regarding clinical impact are…
View details →Prada-Rey N, Samal L, Rodriguez JA · 2026 · Journal of general internal medicine
Rationale & objective To describe kidney health evaluation rates in patients with type 2 diabetes mellitus overall and compare outcomes by language preference. Study design Retrospective cohort analysis. Setting & participants Adult…
View details →Mahar JH, Wayda B, Weng Y et al. · 2026 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Donor heart left ventricular hypertrophy (LVH) is a common reason for organ discard in the United States, despite limited contemporary data on its impact on transplant outcomes. Using Scientific Registry of Transplant Recipients data…
View details →Liu C · 2026 · Reproductive biology and endocrinology : RB&E
Arkfeld et al. reported that AMH predicts miscarriage in non-PCOS but not in PCOS ART cycles. We raise concerns regarding the biological plausibility and data interpretation of their findings. Extremely low AMH (<1 ng/mL) is…
View details →Wu P, Li L, An G et al. · 2026 · Ocular immunology and inflammation
Background Multiple studies have associated PTGER4 polymorphisms with susceptibility to several autoimmune diseases, particularly ankylosing spondylitis (AS)-a condition strongly linked to the onset of acute anterior uveitis (AAU). Given…
View details →Lucas A, Novebri NA, Heros PAI et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Background Biliary atresia (BA) is a serious condition and the leading cause for liver transplantation in children. The exact cause for BA is currently unknown, with one suggested mechanism being a viral infection. Cytomegalovirus (CMV) is…
View details →Athanasiadou A, Kroos S, van de Wetering R et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Objective Rheumatoid arthritis (RA) is characterized by anti-modified protein antibodies (AMPAs), including anti-citrullinated (ACPA), anti-carbamylated (anti-CarP), and anti-acetylated (AAPA) protein antibodies. In contrast to other…
View details →Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine
Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…
View details →de Oliveira RG, Fujii T, Younus I et al. · 2026 · Spine deformity
Purpose To evaluate the early postoperative relationship between changes in distal and proximal lumbar lordosis and the L1-pelvic angle in adult spinal deformity surgery. Methods A retrospective review was performed of 120 adult spinal…
View details →Binnie T, Smith A, Ng L et al. · 2026 · Gait & posture
Background Reduced knee confidence is common in people with knee osteoarthritis and may influence how they engage with physical activity. A lack of confidence may lead an individual to adopt compensatory movement strategies, such as…
View details →Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity
Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…
View details →Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology
Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…
View details →Lisa T, Maria CA, Luca BB et al. · 2026 · European journal of ophthalmology
PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0),…
View details →Dogan E, Sevinc N, Ozdemir M et al. · 2026 · Nutricion hospitalaria
Background it is known that aflatoxin M1 can be transmitted to newborns through breast milk and may cause serious health problems. We aimed to determine whether the presence of aflatoxin M1 in breast milk has a role in the etiology of…
View details →Akkurt B, Bülez A · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Objective: This study aimed to investigate the association between infant gender and both postpartum depression and breastfeeding duration at multiple time points during the postpartum period. Methods: A prospective longitudinal study was…
View details →Nemes A, Ambrus N, Lengyel C · 2026 · Journal of clinical medicine
Introduction. Left ventricular (LV) function can be characterized by numerous parameters, the most well-known being the ejection fraction (EF), derived from LV end-systolic and end-diastolic volumes (ESV and EDV, respectively) throughout…
View details →Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress
Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…
View details →Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition
Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…
View details →Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…
View details →Khabbazi A, Askari L, Faramarzi E et al. · 2026 · Clinical rheumatology
Aim Palindromic rheumatism (PR) is a periodic rheumatic disease characterized by recurrent attacks of pain and swelling, affecting articular and periarticular structures. Despite the evidence supporting the association between overweight…
View details →Kharouf F, Mehta P, Carrizo Abarza V et al. · 2025 · Rheumatology (Oxford, England)
Objectives Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive. We aimed to explore the frequency of liver fibrosis in PsA and identify associated factors including cumulative MTX dose and metabolic…
View details →Breen DM, Saavedra-Peña RM, Joaquim S et al. · 2026 · Diabetes, obesity & metabolism
Aims To evaluate the therapeutic potential of leptin treatment for weight loss maintenance preclinically, through a systematic evaluation of leptin efficacy (a) following a period of weight loss stability (as in published clinical…
View details →Jefferies S, Gilkison C, Duff P et al. · 2025 · Public health
Objectives Aotearoa New Zealand employed one of the most stringent public health pandemic responses internationally. We investigated whether ethnic health equity was achieved in the response and outcomes, from COVID-19 elimination in June…
View details →Park SJ, Park JS, Kang DH et al. · 2025 · Neurosurgery
Background and objectives Cement augmentation and hook fixation are popular prophylactic techniques against proximal junctional kyphosis (PJK) development. However, the efficacy of cement and hook has been inconsistent and conflicting.…
View details →Plastina L, Gähwiler K, Gaertner VD et al. · 2025 · BMC pediatrics
Background To evaluate changes in end-expiratory lung impedance (EELI), a surrogate for end-expiratory lung volume (EELV), during a minimal-handling extubation protocol in very preterm infants in prone position. The protocol aimed to…
View details →Grotemeyer A, Alexander S, Frieß L et al. · 2026 · NPJ Parkinson's disease
Neuroinflammation is deeply intertwined with dopaminergic (DA) neurodegeneration in Parkinson's disease (PD). We tested whether delphinidin, an anthocyanidin with reported inflammasome/NF-κB modulatory activity, alters neuroinflammation…
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