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WASTE Journal

Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Lack of association between cytomegalovirus infection and liver fibrosis in patients with biliary atresia after the Kasai procedure.

Lucas A, Novebri NA, Heros PAI et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Background Biliary atresia (BA) is a serious condition and the leading cause for liver transplantation in children. The exact cause for BA is currently unknown, with one suggested mechanism being a viral infection. Cytomegalovirus (CMV) is…

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Negative / Null Result ReportMedicine

The role of IgM anti-acetylated protein antibodies and B cells in the origin of anti-modified protein autoimmunity in rheumatoid arthritis.

Athanasiadou A, Kroos S, van de Wetering R et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective Rheumatoid arthritis (RA) is characterized by anti-modified protein antibodies (AMPAs), including anti-citrullinated (ACPA), anti-carbamylated (anti-CarP), and anti-acetylated (AAPA) protein antibodies. In contrast to other…

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Negative / Null Result ReportMedicine

Circulating GPER-1, 8-Iso-Prostaglandin F<sub>2</sub>α, and Raftlin-1 in Hypertensive Women During the Menopausal Transition: Associations with BMI and Diagnostic Performance.

Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine

Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…

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Negative / Null Result ReportMedicine

Mobility measures and waking-day movement behaviour composition among older adults: a compositional data analysis of the McMaster Monitoring My Mobility study.

Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity

Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…

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Negative / Null Result ReportMedicine

Lipoprotein(a) levels and common LPA gene variants in patients with chronic coronary syndrome: Genetic determinants and clinical associations.

Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology

Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…

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Negative / Null Result ReportMedicine

Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.

Lisa T, Maria CA, Luca BB et al. · 2026 · European journal of ophthalmology

PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0),…

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Negative / Null Result ReportMedicine

The Lack of Association of Infant Gender with Postpartum Depression and Breastfeeding Duration.

Akkurt B, Bülez A · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: This study aimed to investigate the association between infant gender and both postpartum depression and breastfeeding duration at multiple time points during the postpartum period. Methods: A prospective longitudinal study was…

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Negative / Null Result ReportOpen accessMedicine

Three-Dimensional Speckle-Tracking Echocardiography-Derived Left Ventricular Volumes Show No Associations with Mitral Annular Plane Systolic Excursion in Healthy Adults (Findings from the MAGYAR-Healthy Study).

Nemes A, Ambrus N, Lengyel C · 2026 · Journal of clinical medicine

Introduction. Left ventricular (LV) function can be characterized by numerous parameters, the most well-known being the ejection fraction (EF), derived from LV end-systolic and end-diastolic volumes (ESV and EDV, respectively) throughout…

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Negative / Null Result ReportMedicine

Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level.

Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…

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Negative / Null Result ReportMedicine

Lack of association between Helicobacter pylori and pediatric atopy: Evidence from a Latin American multicenter cohort.

Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…

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Negative / Null Result ReportMedicine

Spatial Association between Air Pollution and Non-communicable Diseases and their Distribution in India.

Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…

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Negative / Null Result ReportMedicine

Preventive Effects of Cement and Hook Augmentation on Proximal Junctional Kyphosis Development in Adult Spinal Deformity Surgery: Multiple Regression Analyses With Adjustment for Confounding Factors.

Park SJ, Park JS, Kang DH et al. · 2025 · Neurosurgery

Background and objectives Cement augmentation and hook fixation are popular prophylactic techniques against proximal junctional kyphosis (PJK) development. However, the efficacy of cement and hook has been inconsistent and conflicting.…

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Negative / Null Result ReportOpen accessMedicine

Effects of a whole-school relationships and sexual health intervention on non-competent sexual debut: cluster-randomised trial.

Ponsford R, Meiksin R, Sturgess J et al. · 2026 · Journal of epidemiology and community health

Background Relationships and sex education (RSE) impacts some sexual behaviours but could be strengthened by incorporating whole-school approaches (eg, building engagement, providing contraception). These can prevent pregnancies and…

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Negative / Null Result ReportMedicine

Efficiency of Cinnamomum camphora var. linaloofera Fujita essential oil, MS-222, and linalool on anesthesia and transportation of spotted seabass (Lateolabrax maculatus).

Cao J, Guo M, Wang J et al. · 2025 · Fish physiology and biochemistry

Plant-based essential oils have been considered to be used as fish anesthetics and as suitable alternatives to synthetic anesthetics. In this study, we evaluated the effect of Cinnamomum camphora var. linaloofera Fujita essential oil…

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Failed Experiment ReportMedicine

Insights into Alternaria in apple fruit causing mouldy core, external infection and mycotoxin production under retail and storage conditions.

Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International journal of food microbiology

Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…

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Negative / Null Result ReportMedicine

Evaluation of the efficacy of polymeric antigen BLSOmp31 formulated in a new cage-like particle adjuvant (ISPA YOLK) administered by parenteral or mucosal routes against Brucella ovis in rams.

Moran MC, Tammone Santos A, Dominguez P et al. · 2025 · Veterinary immunology and immunopathology

Brucella ovis (B. ovis) is the etiological agent of ram-contagious epididymitis, the leading cause of reproductive disorders in flocks worldwide. Although the attenuated B. melitensis Rev.1 strain gives heterologous protection against this…

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Negative / Null Result ReportOpen accessMedicine

Fungal vaccines: so needed, so feasible, and yet so far off.

Casadevall A · 2025 · The Journal of clinical investigation

Invasive fungal infections carry high morbidity and mortality, but there are no fungal vaccines. In this issue of the JCI, Okaa et al. report that endonuclease 2 (Eng2), an antigen shared by the Blastomyces, Histoplasma, and Coccidioides…

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