12,251 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zhang CD, Zhou JS, He LY et al. · 2025 · Frontiers in cardiovascular medicine
Objective The aim of this study was to investigate the quantitative flow ratio (QFR) outcomes in the left circumflex artery (LCX) following the placement of a crossover stent from the left main coronary artery (LM) to the left anterior…
View details →Raychaudhuri R, Cheng HH, Gulati R et al. · 2026 · European urology oncology
Background and objective Our aim was to determine whether induction chemotherapy followed by PARP inhibitor (PARPi) maintenance improves outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) harboring…
View details →Choi SW, Jung HA, Cho HJ et al. · 2023 · Cancer medicine
Background We evaluated the therapeutic efficacy of GC1118, a novel anti-epidermal growth factor receptor (EGFR) monoclonal antibody, in recurrent glioblastoma (GBM) patients with EGFR amplification. Methods This study was a multicenter,…
View details →Voglová B, Hladíková Z, Nemétová L et al. · 2020 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Early worsening of diabetic retinopathy due to sudden glucose normalization is a feared complication of pancreas transplantation; however, its rate or severity has not been studied prospectively. We followed up 43 pancreas and kidney…
View details →Breen WG, Dixon JG, Anderson SK et al. · 2025 · Neuro-oncology
Background Dasatinib is an oral inhibitor of the Src kinase family, with preclinical data indicating impact on gliomagenesis, tumor invasion, and radiosensitivity. Methods North Central Cancer Treatment Group N0877 is a phase 1 dose…
View details →Jacobsen LM, Schatz D · 2025 · Hormone research in paediatrics
Background Type 1 diabetes (T1D) is more than an insulin-deficiency disease - it is an autoimmune disease, and the field is moving toward adopting disease-modifying immunotherapy as part of clinical care during T1D development. Summary…
View details →Çalışkan B · 2025 · International ophthalmology
Purpose To evaluate serum lipid profiles with triglyceride-Glucose (TyG) and TG/HDL-c indices in patients with exudative type age-related macular degeneration. Methods A total of 71 participants were included in the study: 35 with…
View details →Davidson TM, Lebreton CL, Hendricksen AEW et al. · 2023 · Gynecologic oncology
Background IGF signaling has been implicated in the pathogenesis and progression of ovarian carcinoma (OC). Single agent activity and safety of ganitumab (AMG 479), a fully human monoclonal antibody against IGF1R that blocks binding of…
View details →O'Hara MH, Jegede O, Dickson MA et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Amplification of cyclin-dependent kinase 4 (CDK4) and CDK6 is a feature of a variety of malignancies, and preclinical evidence suggests that inhibition of CDK4/6 is a plausible treatment strategy in these tumors. Subprotocol Z1C of…
View details →Taccetti G, Terlizzi V, Campana S et al. · 2024 · European journal of pediatrics
Bacterial infections of the lower airways are the main cause of mortality and morbidity in cystic fibrosis. The most frequently isolated pathogens are S. aureus and P. aeruginosa; bacterial co-infections are frequently observed. The aim of…
View details →Schott CA, Mohning MP, Cooley JC · 2025 · Seminars in respiratory and critical care medicine
Idiopathic pulmonary fibrosis (IPF) is a rare but devastating diagnosis for patients with only two approved drug therapies. Extensive preclinical studies have identified and characterized novel pathways driving IPF pathogenesis, and…
View details →Mosca M, Arnaud L, Askanase A et al. · 2025 · Lupus science & medicine
Objective In PAISLEY, a 48-week, phase II, randomised controlled trial that assessed deucravacitinib in patients with active SLE, all primary and secondary endpoints were met with the deucravacitinib 3 mg two times per day dose. Changes in…
View details →Bateman RJ, Li Y, McDade EM et al. · 2025 · The Lancet. Neurology
Background Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people is unknown. The…
View details →Hamamoto H, Suzuki Y, Takano Y et al. · 2022 · BMC surgery
Background This retrospective study aimed to compare long-term oncological outcomes between laparoscopic-assisted colectomy (LAC) with extracorporeal anastomosis (EA) and totally laparoscopic colectomy (TLC) with intracorporeal anastomosis…
View details →Borghaei H, O'Byrne KJ, Paz-Ares L et al. · 2023 · ESMO open
Background In CheckMate 227 Part 1, first-line nivolumab plus ipilimumab prolonged overall survival (OS) in patients with metastatic non-small-cell lung cancer (NSCLC) and tumor programmed death-ligand 1 (PD-L1) expression ≥1% versus…
View details →Cacko A, Kozyra-Pydyś E, Gawałko M et al. · 2021 · Cardiology journal
Background Among patients with an implanted cardiac implantable electronic device (CIED), ipsilateral upper extremity vein stenosis or occlusion (VSO) is observed more frequently than in the general population. However, there are no data…
View details →Choueiri TK, Albiges L, Barthélémy P et al. · 2024 · Lancet (London, England)
Background Immune checkpoint inhibitors (ICIs) and vascular endothelial growth factor receptor tyrosine kinase inhibitors are cornerstones of first-line treatment for advanced renal cell carcinoma; however, optimal treatment sequencing…
View details →Konno Y, Mayama M, Takehara K et al. · 2025 · Journal of gynecologic oncology
Objective This study aimed to assess the prognostic significance of para-aortic lymphadenectomy (PALX) and para-aortic lymph node metastasis in endometrial cancer (EC) patients at risk of post-operative recurrence. Methods Japanese…
View details →Pettengell R, Długosz-Danecka M, Andorsky D et al. · 2020 · British journal of haematology
PIX306 was a phase 3, randomised, single-blind, multicentre trial conducted in adult patients with diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL) grade 3 who relapsed after ≥1 rituximab-containing regimen and were not…
View details →Tolaney SM, Sahebjam S, Le Rhun E et al. · 2020 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary to hormone receptor-positive (HR + ) metastatic breast…
View details →Rascol O, Tönges L, deVries T et al. · 2022 · Parkinsonism & related disorders
Background Immediate-release (IR) amantadine has been used for treatment of levodopa induced dyskinesia (LID). The immediate-release/extended-release (IR/ER) amantadine formulation OS320 (OSMOLEX ER®) contains an IR outer layer and ER core…
View details →Takenaka Y, Maeda K, Yamada M et al. · 2026 · Behavioural brain research
Background Motor imagery (MI) improves motor performance, but standardized objective quality evaluation methods are lacking. The relationship between MI quality and actual performance improvements also remains unclear. Purpose We…
View details →Bandaru S, Bodduluri S, Swami R et al. · 2026 · Scientific reports
ADRB2 gene polymorphisms have been widely studied for their role in influencing asthma pathophysiology. Of particular note, the Gln27Glu (+ 79 C > G, rs1042714) polymorphism, which alters the extracellular domain at the N-terminus of β 2…
View details →Putzer M, De Decker S, Gutierrez Quintana R et al. · 2026 · Journal of feline medicine and surgery
ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific magnetic resonance imaging (MRI) sequences are used to demonstrate differences in endolymph composition between…
View details →Celik B, Kaya M, Emre S · 2026 · Parasite immunology
Chronic spontaneous urticaria (CSU) is a mast cell driven multifactorial disorder with complex pathogenesis. While the association between CSU and internal parasites has been investigated, the association of ectoparasites such as Demodex…
View details →Bajaj JS, Kamath PS, Wong F et al. · 2026 · Clinical and molecular hepatology
Background/aims Infections with drug-resistant organisms (DROs) are associated with poor outcomes in cirrhosis. Rifaximin, widely used for hepatic encephalopathy (HE) could promote cross-resistance, but data regarding clinical impact are…
View details →Prada-Rey N, Samal L, Rodriguez JA · 2026 · Journal of general internal medicine
Rationale & objective To describe kidney health evaluation rates in patients with type 2 diabetes mellitus overall and compare outcomes by language preference. Study design Retrospective cohort analysis. Setting & participants Adult…
View details →Mahar JH, Wayda B, Weng Y et al. · 2026 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Donor heart left ventricular hypertrophy (LVH) is a common reason for organ discard in the United States, despite limited contemporary data on its impact on transplant outcomes. Using Scientific Registry of Transplant Recipients data…
View details →Liu C · 2026 · Reproductive biology and endocrinology : RB&E
Arkfeld et al. reported that AMH predicts miscarriage in non-PCOS but not in PCOS ART cycles. We raise concerns regarding the biological plausibility and data interpretation of their findings. Extremely low AMH (<1 ng/mL) is…
View details →Wu P, Li L, An G et al. · 2026 · Ocular immunology and inflammation
Background Multiple studies have associated PTGER4 polymorphisms with susceptibility to several autoimmune diseases, particularly ankylosing spondylitis (AS)-a condition strongly linked to the onset of acute anterior uveitis (AAU). Given…
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