12,251 real negative results, null findings, and replication failures in Medicine. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Awaluddin K, Mayfield AB, Tew KS et al. · 2025 · Marine environmental research
Ocean acidification (OA) and warming pose significant threats to marine ecosystems, particularly by reducing calcium carbonate availability for marine calcifiers. Given that seagrasses can capture and store excess carbon, this study aimed…
View details →Vardarli E, Bhattarai N, El Ayadi A et al. · 2025 · PloS one
Introduction Major burns results in the rapid and profound accumulation of lipid in peripheral tissues, but its impact on muscle metabolic function is unclear. Given previous reports demonstrating that lipid oversupply compromises…
View details →Legrand FD, Jeandet P, Polidori G et al. · 2025 · Psychology of sport and exercise
This randomized controlled trial investigated the impact of a brief session of group-based running on feelings of energy and fatigue, comparing exercise in a local nature reserve versus an outdoor built environment, and a sedentary control…
View details →Kwon M, Kim SA, Kim J · 2025 · Healthcare (Basel, Switzerland)
Background/Objectives : This study investigated the mediating effects of instrumental activities of daily living (IADL) and depression on the relationship between the ability to perform movements and death preparation among older adults…
View details →Gordon G, Nadar T, Green A · 2026 · Journal of functional morphology and kinesiology
Background : Sprint performance, including acceleration, maximal velocity and deceleration, is crucial for athletic success in field and court-based sports; however, deceleration remains understudied despite its role in change of direction…
View details →Rössler J, Ott S, Li Y et al. · 2025 · Journal of clinical anesthesia
Background Chronic-kidney-disease (CKD) is prevalent among adults undergoing noncardiac surgery, with surgery-related factors potentially worsening CKD or triggering acute kidney injury (AKI). We hypothesized that CKD patients experience…
View details →Kormann S, Semadeni GM, Weber M et al. · 2024 · ACG case reports journal
Subepithelial gastric tumors are a diagnostic challenge. Endoscopic ultrasound allows differentiation. Lesions originating from the submucosal layer can be resected using endoscopic submucosal dissection (ESD). Surgery or endoscopic…
View details →Yöyen E, Barış TG · 2026 · World journal of psychiatry
Workplace violence (Type II), which is defined as verbal, physical and sexual assault behaviour directed at healthcare workers by patients and their relatives, is a complex concept arising from a variety of individual, social, economic,…
View details →Gordon P, Urquhart E, Oad S et al. · 2024 · Australian health review : a publication of the Australian Hospital Association
Objective To assess whether prostate biopsy rates have altered with the July 2018 change in Australian Medicare Benefits Schedule (MBS) rebates supporting multiparametric magnetic resonance imaging (mpMRI) for diagnosing prostate cancer.…
View details →Egger T, Gander M, Dumser B et al. · 2025 · European journal of psychotraumatology
Background: Refugees are at elevated risk of trauma-related disorders. Unresolved attachment is a vulnerability factor for post-traumatic stress, yet its role in Afghan refugees remains underexplored. This is the first study to assess…
View details →Ito K, Yamashita R, Kasai S et al. · 2026 · IJU case reports
Introduction Peritoneal carcinomatosis in patients with advanced bladder cancer is a rare but lethal event following robot-assisted radical cystectomy (RARC). We report a case of an unusual clinical course in which peritoneal dissemination…
View details →Leukel C, Loibl K, Leuders T · 2024 · Trends in neuroscience and education
Background Problem-solving and learning in mathematics involves sensory perception and processing. Multisensory integration may contribute by enhancing sensory estimates. This study aims to assess if combining visual and somatosensory…
View details →Struyf S, Koster EHW, Van Beveren ML et al. · 2026 · Psychologica Belgica
Introduction Emotion regulation (ER) plays a crucial role in children and adolescents' emotional well-being. However, the use of adaptive strategies often remains challenging during early adolescence, partly because cognitive functions…
View details →Lindelien CM, Xu X, Knox AS et al. · 2024 · Bulletin of environmental contamination and toxicology
Long-term metal remediation in wetland treatment systems (WTSs) involves facilitating dissimilatory sulfate reduction to produce sulfide and mineralize metals in deep sediments. We evaluated seasonal sulfur cycling in two constructed…
View details →Haslam A, Olivier T, Prasad V · 2023 · ESMO open
Background The statistical plan of a phase II trial should balance minimizing the premature termination of potentially beneficial therapies (i.e. false negatives) and the further, costly testing of ineffective drugs (i.e. false positives).…
View details →Nemcova Y, Knotek P, Jadrná I et al. · 2024 · Journal of phycology
Mallomonas thrive primarily in freshwaters and dominate plankton communities, especially in oligotrophic waters. The cells have a siliceous cell covering of regularly arranged scales. Despite their ecological importance, the intricate…
View details →Wang J, Lan X, Chen P et al. · 2024 · Crop Protection
Unmanned Aerial Spraying Systems (UASS) have garnered substantial market attention as efficient tools for applying Plant Protection Products (PPPs). However, their application has primarily focused on low-growing crops such as rice and…
View details →Pahwa R, Elble R, Hauser RA et al. · 2026 · Parkinsonism & related disorders
Introduction Effective treatments for essential tremor (ET) are needed. EveresT (NCT05122650) examined the efficacy and safety of suvecaltamide in patients with moderate to severe ET. Methods In this phase 2 b, 12-week, double-blind,…
View details →Atthakitmongkol T, Chotiyaputta W, Lertwattanarak R et al. · 2026 · Journal of the Formosan Medical Association = Taiwan yi zhi
Background Tenofovir disoproxil fumarate (TDF) is an important drug to treat chronic hepatitis B (CHB) patients. However, long-term TDF therapy decreases renal function and bone mineral density (BMD). This study compared bone turnover…
View details →· 2026 · Cancer discovery
The NHS-Galleri trial, the first randomized, controlled trial of the multi-cancer early detection test Galleri, found that the test from GRAIL did not meet its primary endpoint, a reduction in late-stage cancers. Researchers say the result…
View details →Burton JO, Izquierdo MJ, Linde C et al. · 2026 · Clinical kidney journal
Background and hypothesis Hyperkalaemia is common and potentially life-threatening in individuals with chronic kidney disease (CKD). While sodium zirconium cyclosilicate (SZC) is used in the hospital setting for hyperkalaemia management,…
View details →Colombel JF, Garcia Olmo D, Chen ST et al. · 2026 · Gastroenterology
Background & aims The ADMIRE CD trial demonstrated the efficacy and safety of darvadstrocel in patients with complex perianal fistulas from Europe and Israel. The efficacy and safety of darvadstrocel in an expanded patient population was…
View details →Mummery CJ, Mayorga AJ, Simmons A et al. · 2026 · Nature medicine
Triggering receptor expressed on myeloid cells 2 (TREM2) regulates microglial function and is implicated in Alzheimer's disease (AD) pathogenesis. Here we conducted a phase 2, randomized, double-blind, placebo-controlled trial of a…
View details →Lu F, Lv C, Yang X et al. · 2025 · Lung cancer (Amsterdam, Netherlands)
Background EGFR tyrosine kinase inhibitors (EGFR-TKIs) have shown activity in the neoadjuvant setting of EGFR-mutant (EGFRm) non-small cell lung cancer; however, data on the combination of neoadjuvant EGFR-TKIs plus chemotherapy are…
View details →Nikolcheva T, Pagano G, Anzures-Cabrera J et al. · 2026 · Lancet (London, England)
Background Prasinezumab has previously shown potential for reducing the progression of motor signs (Movement Disorder Society-sponsored Revision of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] Part III) in patients with…
View details →Kjærsgaard L, Wiedemann J, Singer W et al. · 2026 · The Lancet. Neurology
Background Pathological aggregation and propagation of α-synuclein species drive disease progression in multiple system atrophy (MSA). We assessed the efficacy and safety of amlenetug, a monoclonal antibody targeting aggregated…
View details →Folkert IW, Mehran R, Sun R et al. · 2026 · Annals of surgical oncology
Background Hepatectomy for isolated colorectal liver metastases is associated with 5 year overall survival (OS) of 58% and is accepted as standard of care. However, the role of liver resection with unresectable low-volume lung metastases…
View details →Kircik L, Tsianakas A, Valenzuela F et al. · 2025 · The British journal of dermatology
Background Atopic dermatitis (AD), the most common inflammatory skin disorder, carries a significant public health burden. Many patients with moderate-to-severe AD are unable to achieve adequate disease control with topical treatment and…
View details →Roupret M, Bertaut A, Pignot G et al. · 2026 · Annals of oncology : official journal of the European Society for Medical Oncology
Background Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…
View details →Falkenhorst J, Ivanyi P, Schulz T et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Imatinib resistance is conferred by secondary mutations within the ATP-binding pocket or the activation loop of KIT in gastrointestinal stromal tumors (GIST). Ponatinib is active against KIT secondary activation loop and the…
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