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Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Disentangling the effects of environmental and anthropogenic drivers on fungal fruitbody and spore diversity in a Mediterranean coniferous forest.

Centenaro G, Ponce Á, de-Miguel S et al. · 2025 · Journal of environmental management

Wild macrofungal species are important non-wood forest products in Mediterranean forests, where their ability to release and disperse spores is crucial for completing their life cycle. However, the ecological drivers behind fruitbody…

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Negative / Null Result ReportMedicine

Earth's record-high greenness and its attributions in 2020

Zhang Y, Mao J, Sun G et al. · 2025 · Remote Sensing of Environment

Terrestrial vegetation is a crucial component of Earth's biosphere, regulating global carbon and water cycles and contributing to human welfare. Despite an overall greening trend, terrestrial vegetation exhibits a significant inter-annual…

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Negative / Null Result ReportOpen accessMedicine

Spurious effects in random-intercept cross-lagged panel models: Results from simulations and reanalyses of data on self-esteem and problematic eating behaviors used by Beckers et al. (2023).

Sorjonen K, Nilsonne G, Ghaderi A et al. · 2026 · PloS one

The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the…

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Negative / Null Result ReportMedicine

Are horned cows in loose housing more stressed than hornless cows? a cross-sectional study in organic dairy farms.

Ebinghaus A, Thiessen G, Ivemeyer S et al. · 2025 · Animal : an international journal of animal bioscience

In commercial dairy farming, the majority of cows are dehorned or genetically hornless. It is argued that this reduces the risk of injurious and stressful social conflicts. On the other hand, in horned herds, management and housing may be…

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Negative / Null Result ReportOpen accessMedicine

Masked and elusive: congruency fails in video-to-photo face matching.

Sagana A, Zhang M, Bekemeier L et al. · 2026 · Cognitive research: principles and implications

Recognizing masked perpetrators in real-world surveillance scenarios poses significant challenges due to facial occlusion and degraded image quality. This study investigated the effects of contextual congruency on matching surveillance…

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Negative / Null Result ReportMedicine

Limited association between central pain processing and clinical outcomes in non-specific chronic neck pain after a manual therapy intervention: A secondary analysis.

Zabala-Mata J, Azkue JJ, Bialosky JE et al. · 2025 · Musculoskeletal science & practice

Background Non-specific chronic neck pain (NSCNP) is a prevalent condition causing significant disability. While manual therapy is recommended, its clinical benefits are limited. The relationship between central pain processing and…

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Negative / Null Result ReportMedicine

The impact of reducing cognitive load in RT and P300 concealed information tests with importance related fillers.

Wojciechowski J, Olson JM, Subramanian G et al. · 2025 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology

Lukács et al. (2017) enhanced the Reaction Time Concealed Information Test (RT CIT) by incorporating "filler" items. Fillers are intended to increase attention and cognitive load, which should potentially enhance the P300 based CIT…

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Negative / Null Result ReportOpen accessMedicine

Earlier first-time memory clinic visits during the COVID-19 pandemic: A comparison of dementia severity and caregiver burden.

Maeda A, Suzuki M, Suzumura S et al. · 2026 · Journal of family medicine and primary care

Introduction The coronavirus disease 2019 pandemic prompted widespread restrictions on daily activities, leading to concerns over delayed medical consultations. However, limited social interaction outside the home may have increased the…

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Negative / Null Result ReportMedicine

Skittering locomotion in cricket frogs: a form of porpoising.

Weiss T, Gillis GB, Van Mullekom J et al. · 2024 · The Journal of experimental biology

Multiple species of frogs in the Ranidae family have been observed to 'skitter' across the water surface, but little is understood about the biomechanical or physical mechanisms that underlie this behavior. All documented descriptions are…

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Negative / Null Result ReportOpen accessMedicine

Mentalizing on the edge: borderline traits and their association with real-time self-reflection - an ecological momentary assessment study.

Höller I, Schwitzky S, Forkmann T et al. · 2026 · Borderline personality disorder and emotion dysregulation

Background Mentalization plays a key role in borderline personality disorder (BPD), yet its moment-to-moment fluctuations remain understudied. This study is the first to use established self-report items within an Ecological Momentary…

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Negative / Null Result ReportMedicine

Nanopatterns on silica scales of Mallomonas (Chrysophyceae, Stramenopiles): Unraveling UV resistance potential and diverse response to UVA and UVB radiation

Němcová Y, Knotek P, Jadrná I et al. · 2024 · Journal of phycology

Mallomonas thrive primarily in freshwaters and dominate plankton communities, especially in oligotrophic waters. The cells have a siliceous cell covering of regularly arranged scales. Despite their ecological importance, the intricate…

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Negative / Null Result ReportMedicine

Exposure to structural racism-related state laws is associated with worse cardiovascular health among US adults, BRFSS 2011 and 2013.

Needham BL, Dokshina D, Ali T et al. · 2025 · American journal of epidemiology

The objective of this study was to determine whether exposure to structural racism-related state laws is associated with cardiovascular health among a racially and ethnically diverse sample of US adults. Data were from the Database of…

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Negative / Null Result ReportMedicine

Expression of CD226 on γδ T cells is lower in advanced chronic lymphocytic leukemia and correlates with IgA, IgG and LDH levels.

Zarobkiewicz MK, Lehman N, Kowalska W et al. · 2025 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Gamma-delta (γδ) T cells comprise an important subset of human T cells, responding to viral and bacterial infections, and are significant for cancer immunosurveillance. Human γδ T cells are divided into 5 major subsets, namely…

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Negative / Null Result ReportMedicine

Exploring fonts as retrieval cues in text-based learning.

Krieglstein F, Jansen S, Meusel F et al. · 2024 · Acta psychologica

A growing body of research focuses on optimizing retrieval processes to help learners recall information from memory. The context-dependent memory effect suggests that information retrieval is more effective when the retrieval context…

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Negative / Null Result ReportOpen accessMedicine

Low neuroticism as an indicator of resilience: a longitudinal study of Danish soldiers before, during and after deployment.

Melkevik O, Jeppesen LS, Folke S et al. · 2025 · European journal of psychotraumatology

Background : Posttraumatic stress disorder (PTSD) is a serious and debilitating condition among military veterans. Exposure to potentially traumatic events (PTEs) may lead to PTSD and PTE sensitivity may be influenced by the personality…

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