Failed Experiment ReportOpen accessMedicine
Fabbroni C, Grignani G, Vincenzi B et al. · 2024 · ESMO open
Background This is a multicentre, single-arm, phase II study aimed at further exploring the activity of trabectedin as second-/further-line treatment in retroperitoneal leiomyosarcoma (LMS) and well-differentiated/dedifferentiated…
View details →Negative / Null Result ReportOpen accessMedicine
Renwick JRM, Preobrazenski N, Giudice MD et al. · 2024 · International journal of exercise science
The purpose of the current study was to test the hypothesis that individual response classification for surrogate markers of cardiorespiratory fitness (CRF) will agree with response classification for VO 2peak . Surrogate markers of CRF…
View details →Failed Experiment ReportOpen accessMedicine
Joshi I, Devine AJ, Joshi R et al. · 2023 · Scientific reports
Progressive emphysema often leads to end-stage lung disease. Most mouse models of emphysema are typically modest (i.e. cigarette smoke exposure), and changes over time are difficult to quantify. The tracheal porcine pancreatic elastase…
View details →Negative / Null Result ReportOpen accessMedicine
Fujii N, Takahashi K, Kawama R et al. · 2026 · PloS one
Higher stiffness of the medial gastrocnemius (MG) has been reported to be associated with faster race time in 100-m sprint running. However, the association of muscle stiffness with spatiotemporal variables (i.e., step frequency, step…
View details →Negative / Null Result ReportOpen accessMedicine
· 2022 · Current developments in nutrition
Abstract Objectives To examine and compare reported food and nutrient intake in men and women who differ in cognitive restraint (CR) and disinhibition (D) scores. We hypothesize that average intake of sodium, total sugar, saturated fat,…
View details →Negative / Null Result ReportOpen accessMedicine
Pupo MR, Diepersloot EC, Wenzel MPR et al. · 2026 · JDS communications
Feeding spoiled silage with high yeast activity is commonly related to impaired lactation performance by dairy cows. However, rehydrated corn grain silage (RCGS) may be more prone to yeast proliferation and be greatly affected by high…
View details →Negative / Null Result ReportOpen accessMedicine
Yao Y, Liu SS, Jin L et al. · 2025 · Clinical and experimental dental research
Objectives Anterior disc displacement with reduction (ADDWR) and without reduction (ADDWOR) are two common clinical types of temporomandibular disorders. This study compared the levels of anxiety, depression, somatization, and jaw function…
View details →Negative / Null Result ReportOpen accessMedicine
Kjeldsted E, Ammitzbøll G, Lænkholm AV et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Preclinical studies have indicated that physical exercise may enhance chemotherapy efficacy. However, clinical trials are needed to investigate these findings. We hypothesized that an exercise program during neoadjuvant…
View details →Negative / Null Result ReportOpen accessMedicine
Gautier R, Latinus M, Briend F · 2025 · Psychophysiology
The heartbeat evoked potential (HEP) is a potential marker of cardiac signal integration at the cerebral level, obtained by averaging epochs time-locked to the ECG R-peaks. The HEP is modulated across different experimental conditions with…
View details →Negative / Null Result ReportMedicine
Itzhaky L, Chubarov E, Keilp JG et al. · 2023 · Psychiatry research
An increase in suicide rates during adolescence has made it the second leading cause of death for this age group. While potential deficits in cognitive flexibility have been thought to contribute to suicidality, this factor has been…
View details →Negative / Null Result ReportOpen accessMedicine
Marek MJ, Wolke D, Sorg C et al. · 2026 · NeuroImage. Clinical
This study investigates the long-term effects of very preterm (VPT) birth (<32 weeks of gestation) on cognitive control and structural brain network topology. Data were obtained from 61 very VPT and 79 full term (FT) individuals aged 26…
View details →Negative / Null Result ReportOpen accessMedicine
Park I, Campbell N, Nolte T et al. · 2026 · Acta neuropsychiatrica
Objective Borderline personality disorder (BPD) is characterised by instability in interpersonal relationships, self-image, and affect. Dysregulated negative emotional processing involving prefrontal and limbic circuits is considered a…
View details →Negative / Null Result ReportOpen accessMedicine
Doll-Lee J, Passarotto E, Altenmüller E et al. · 2025 · Journal of movement disorders
Objective This study investigated the impact of extrainstrumental workload on musician's dystonia (MD) and its relationship with playing ability by testing whether dystonia onset is more severe in the dominant hand and whether improvement…
View details →Negative / Null Result ReportOpen accessMedicine
Springer-Sapp CB, Ogbara OO, Addison O et al. · 2025 · The Journal of frailty & aging
Background The progression of sarcopenia with aging may be related to mitochondrial dysfunction due in part to altered mitochondrial dynamics (fusion, fission, mitophagy, and biogenesis). Previous work has identified altered expression of…
View details →Negative / Null Result ReportMedicine
Connor JJ, Johnson-Agbakwu C, Harlow BL et al. · 2026 · Journal of sex research
Female genital cutting (FGC) results in a higher risk for sexual issues in impacted women. This study examined this impact in a sample of 300 women identifying as Somali and living in the United States. FGC is highly prevalent in Somalia,…
View details →Failed Experiment ReportOpen accessMedicine
Miranda MC, Hyde J, Salazar K et al. · 2024 · microPublication biology
Prenatal stress is hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined that prenatal stress in rats decreases levels of Dpysl2, which is found to be inactivated in schizophrenic patients. UNC-33 ,…
View details →Negative / Null Result ReportOpen accessMedicine
Fusagawa H, Sato T, Naito A et al. · 2025 · Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Overuse-induced muscle disorders (OIMD) frequently occur in athletes due to excessive and improper use under high physical demand, often leading to muscle pain and weakness. Limited studies have shown intramuscular fibrosis in OIMD, with…
View details →Negative / Null Result ReportMedicine
Foster BA, Zhou C, Canty E et al. · 2023 · Hospital pediatrics
Background Tolerance of uncertainty may influence how physicians and other providers practice and make clinical decisions. We hypothesized that increased tolerance of uncertainty would be associated with an increased uptake of a quality…
View details →Negative / Null Result ReportMedicine
Yee CS, Demirdji M, Bailey KN et al. · 2026 · Osteoarthritis and cartilage
Objective Cartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression of osteocytic perilacunocanalicular remodeling…
View details →Negative / Null Result ReportOpen accessMedicine
Byg LM, Wang CA, Attia J et al. · 2026 · Communications medicine
Background Early life nutrition is associated with child behaviour; however, the interplay with genetic vulnerability is understudied. We hypothesised that psychiatric genetic risk interacted with early nutrition to predict behavioural…
View details →Negative / Null Result ReportOpen accessMedicine
Najberg H, Tapparel M, Holmann JN et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)
Response training, such as with the Go/NoGo task, reduces the value of trained items by requiring participants to repeatedly inhibit their responses to appetitive cues that typically elicit approach tendencies. This devaluation is thought…
View details →Negative / Null Result ReportMedicine
van Timmeren T, Piray P, Goudriaan AE et al. · 2023 · Addictive behaviors
The development of addictive behaviors has been suggested to be related to a transition from goal-directed to habitual decision making. Stress is a factor known to prompt habitual behavior and to increase the risk for addiction and…
View details →Negative / Null Result ReportOpen accessMedicine
Eldesouky L, Gross JJ, English T · 2025 · Scientific reports
The ways people manage their emotions (emotion regulation; ER) have been found to affect their own well-being and the well-being of others. In the present research, we extended prior work by examining whether similarity between people's ER…
View details →Negative / Null Result ReportOpen accessMedicine
Hernandez C, Jensen CD, Duraccio KM · 2025 · Sleep advances : a journal of the Sleep Research Society
Study objectives This secondary data analysis study was designed to evaluate demographic and socioeconomic characteristics that may increase the magnitude of the impact of experimentally induced shortened sleep on suboptimal eating…
View details →Negative / Null Result ReportMedicine
McDonald MJ, Marsh ML, Fears SD et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)
Chronic exposure to shortened sleep is associated with an increased risk of Alzheimer's disease and dementia. Previous studies show insufficient (e.g., poor or fragmented) sleep impairs cerebrovascular reactivity to metabolic stress and…
View details →Negative / Null Result ReportOpen accessMedicine
Cagigas ML, Fiorito G, Bertozzi B et al. · 2024 · Biomarker research
Background Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However, it is unclear…
View details →Negative / Null Result ReportOpen accessMedicine
Saito S, Tsukamoto H, Karaki M et al. · 2025 · Experimental physiology
Individuals who experience prolonged sitting daily are reported to be at risk of developing cerebrovascular disease, which is associated, in part, with attenuation in cerebral blood flow regulation. However, the effect of prolonged sitting…
View details →Negative / Null Result ReportOpen accessMedicine
Suzuki K, Kamijo F, Nishinaka N · 2025 · Journal of physical therapy science
[Purpose] The purpose of this study was to compare the trunk displacement and ground reaction force during hand-behind-back (HBB) movements between the right and left hands. [Participants and Methods] Twenty healthy right-handed men…
View details →Negative / Null Result ReportMedicine
Williams CD, Sobolewski CM, Cage J et al. · 2026 · Journal of American college health : J of ACH
Black American women are disproportionately affected by diseases, such as obesity, heart disease, and cancer, and risks are reduced by better physical activity and nutrition. Given these disparities, it is particularly important to…
View details →Negative / Null Result ReportMedicine
Campos KL, Rolim GG, Silva RS et al. · 2026 · Entomologia Experimentalis et Applicata.
The boll weevil, Anthonomus grandis grandis Boh., presents significant management challenges due to its persistent presence and prolonged cropping season. One hypothesis posits that favorable factors, such as host availability and climatic…
View details →