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Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Hyperhomocysteinemia in chronic schizophrenia: prevalence, clinical correlates, and paradoxical associations with symptom severity.

Du J, Jiang R, Liu Y et al. · 2026 · European archives of psychiatry and clinical neuroscience

Background Elevated homocysteine levels, known as hyperhomocysteinemia (HHcy), have been implicated in the pathophysiology of schizophrenia. Most prior studies focused on first-episode or acute-phase schizophrenia patients, leaving the…

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Negative / Null Result ReportMedicine

Head Acceleration Event Magnitude and Incidence Rate in Academy Rugby Union: A Comparison Across Club and International Competition.

Ward J, Bonnet D, Roumeau M et al. · 2026 · Sports medicine (Auckland, N.Z.)

Background Head acceleration events (HAEs) are an increasing concern in rugby union due to their association with brain injury and long-term neurological health. Objectives This original research study aimed to establish essential baseline…

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Negative / Null Result ReportMedicine

The effects of processing speed and cognitive load demands on working memory performance in young adults born very preterm.

Mills T, Pascoe L, Spencer-Smith M et al. · 2025 · The Clinical neuropsychologist

Objective To examine working memory performance in young adults born very preterm (VP) and full-term (FT) in the context of information processing. Methods A cohort of 118 young adults born VP (mean age 20.1 years) and 48 young adults born…

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Negative / Null Result ReportOpen accessMedicine

Indomethacin Fails to Increase Intestinal Permeability in Healthy Volunteers.

Camilleri M, Busciglio I, Carlson P et al. · 2026 · Clinical and translational gastroenterology

Introduction Indomethacin is often used experimentally to induce intestinal hyperpermeability, enabling evaluation of interventions targeting barrier function. Methods We conducted a randomized, double-blind, placebo-controlled study…

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Negative / Null Result ReportMedicine

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance.

Williams EP, Harris LN, Moore JS et al. · 2025 · Journal of fish biology

Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult…

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Negative / Null Result ReportMedicine

Unveiling Incompatibility of High Nickel Cathode With p-xylene Solvent for Facile Wet-Slurry Process in All-Solid-State Batteries.

Kim J, Kim J, Park J et al. · 2025 · Small (Weinheim an der Bergstrasse, Germany)

All-solid-state batteries (ASSBs) are considered one of the most promising next-generation batteries due to their outstanding safety and superior energy density. For the commercial success of ASSBs, developing a scalable wet-slurry-based…

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Negative / Null Result ReportMedicine

Evaluating NLP Approaches to Extract Drug Indications.

Sarkar IN · 2026 · AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Reliable drug-indication knowledge is essential for clinical decision support and pharmacovigilance, yet manual curation is labor-intensive and difficult to scale. This study evaluated nine natural language processing approaches to extract…

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Failed Experiment ReportMedicine

Contribution of individual legs to overall attachment in the adult ladybird Harmonia axyridis depends on the relative leg orientation to an external force

Saitta V, Rebora M, Piersanti S et al. · 2025 · Entomologia Experimentalis et Applicata.

This study investigates the attachment ability of harlequin ladybird, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), focusing on the synergic action of opposite legs, the anisotropy of adhesive organs and sexual dimorphism.…

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Negative / Null Result ReportMedicine

Lighting Up MS2: Exploring Fluence Rates for Virus Inactivation

Pousty D, Betzalel Y, Mamane H · 2025 · AWWA Water Science

This study examined the impact of UV‐LED fluence rate (incident irradiance) and wavelengths on the inactivation of MS2 bacteriophage, determined by log reduction value (LRV). Three levels of fluence rates, each differing by an order of…

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Failed Experiment ReportMedicine

Population Genomics of <i>Macrophomina</i> spp. Reveals Cryptic Host Specialization and Evidence for Meiotic Recombination.

Pennerman KK, Goldman P, Dilla-Ermita CJ et al. · 2025 · Molecular plant-microbe interactions : MPMI

Knowledge of the factors structuring populations of pathogenic fungi is fundamental to disease management efforts and basic biology. However, this crucial information is missing for many important pathogens, including broad-host-range and…

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Negative / Null Result ReportMedicine

The effect of an Iyengar yoga-based exercise programme versus a seated yoga relaxation programme on falls in people aged 60 years and older (SAGE): a pragmatic, two-arm, parallel randomised controlled trial.

Oliveira JS, Sherrington C, Lord SR et al. · 2025 · The lancet. Healthy longevity

Background Exercises targeting balance and strength are proven to prevent falls. Yoga is growing in popularity and can improve balance and mobility in older adults, but its effects on falls have not been rigorously tested. In this study,…

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Negative / Null Result ReportOpen accessMedicine

Performance of next-generation AI chatbots in gynecological knowledge assessment: a comparative pilot study of ChatGPT-5, Gemini-3, DeepSeek-V3.2, and Claude-4.5-Opus.

Huan O, Wang Z · 2026 · Archives of gynecology and obstetrics

Purpose As artificial intelligence (AI) models evolve into their next generations, their application in specialized medical fields requires rigorous validation. While large language models (LLMs) have shown promise in general medicine,…

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Negative / Null Result ReportMedicine

Preferences for Gender Stereotypicality in Artificial Intelligence: Existence, Comparison to Human Biases, and Implications for Choice.

Spielmann J, Stern C · 2026 · Personality & social psychology bulletin

Do people prefer that artificial intelligence (AI) aligns with gender stereotypes when requesting help to answer a question? We found that people preferred gender stereotypicality (over counterstereotypicality and androgyny) in voice-based…

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