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Browse the failure-mode index

12,251 real negative results, null findings, and replication failures in Medicine. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Does treating emotional memories come at a price? Effects of single-session EMDR, imaginal exposure, and imagery rescripting on forced-choice recognition of event details in healthy adults - a laboratory study.

Aleksic M, Ehring T, Kunze A et al. · 2025 · Behaviour research and therapy

Eye Movement Desensitization and Reprocessing (EMDR), Imaginal Exposure (IE), and Imagery Rescripting (ImRs) are effective trauma-focused interventions. However, concerns persist that they may impair the accuracy of memories addressed in…

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Negative / Null Result ReportMedicine

The 3,4-methylenedioxymethamphetamine (MDMA) reduces prosocial behavior in the social preference test in male and female rats.

Palacios-Lagunas DA, Hernández-Mondragón JC, Fuxe K et al. · 2026 · Pharmacology, biochemistry, and behavior

The promotion of prosocial behavior is a remarkable MDMA property. Such an effect is rather uncommon among other psychoactive substances and has been proposed to be of relevance for the potential therapeutic utility of MDMA. We aim to…

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Replication FailureMedicine

Ambivalent sexism and opposition toward public breastfeeding.

Jedinger A, Feldhausen M · 2025 · The Journal of social psychology

The study examines the impact of hostile and benevolent sexism on attitudes toward public versus private breastfeeding. According to ambivalent sexism theory, we hypothesized that hostile sexism would result in disapproval of public…

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Negative / Null Result ReportMedicine

Why the present is not the key to past or future: moving beyond restricted relict habitat conditions to improve outcomes in mountain woodland restoration

Watts SH, Barsoum N, Park KJ et al. · 2025 · Restoration Ecology

INTRODUCTION: Mountain woodland restoration can enhance upland biodiversity and contribute to nature‐based solutions mitigating climate change impacts. However, high‐altitude planting of trees and shrubs requires considerable commitment of…

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Negative / Null Result ReportMedicine

Exploring the influence of job characteristics on the adoption of driver advisory systems for energy-efficient driving: Insights from a longitudinal field study in rail operations.

Schnücker GN, Salge J, Onnasch L · 2025 · Applied ergonomics

This study investigates the impact of Driver Advisory Systems (DAS) for eco-efficient driving on train drivers' job characteristics and job satisfaction, and their effects on acceptance and compliance with the system. Driving and…

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Negative / Null Result ReportMedicine

Response Inhibition in Autistic Children Predicts Positive Psychotic Symptoms in Young Adulthood-Results from an 8-Year Follow-up Study.

Ziermans T, Kok B, van Rijn S · 2025 · Journal of autism and developmental disorders

Purpose Attenuated positive symptoms constitute the most validated vulnerability marker for psychosis in non-autistic young adults. Early deviations in executive functioning and social cognition are believed to contribute to the onset of…

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Negative / Null Result ReportMedicine

The Role of Supportive Adults: Are These Relationships Able to Mitigate the Effects of Adverse Childhood Experiences on Adolescent Adjustment?

Wilde ZC, Smith SD, Murphy MB et al. · 2026 · Journal of child & adolescent trauma

Adverse childhood experiences (ACEs) place adolescents at higher risk of developing physical and mental health problems later in life. Further, vulnerable adolescents-those from resource-limited households, communities, or schools; exposed…

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Negative / Null Result ReportOpen accessMedicine

Drug-Induced Anaphylaxis in Children: A Comparative Analysis of Inpatient versus Outpatient Settings.

Koken G, Ertoy Karagol HI, Terece SP et al. · 2026 · International archives of allergy and immunology

Introduction Studies specifically focusing on drug-induced anaphylaxis (DIA) in children are few. There is no study comparing inpatient (IP) and outpatient (OP) settings in DIA, either in children or in adults. We aimed to compare the…

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Negative / Null Result ReportMedicine

The influence of algae habitat refuge complexity on juvenile fish growth, condition, and survival under the presence or absence of predators.

Hinz H, Del Mar Gil M, Anglada P et al. · 2026 · Marine environmental research

Macrophyte habitats are key for juvenile fish survival in coastal littoral zones, yet they are increasingly degraded by human activities. While macrophytes offer both shelter and food, their protective function may be context-dependent,…

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Negative / Null Result ReportOpen accessMedicine

From Evidence to Practice: Implementation and Evaluation of the Discontinuation of Patient Contact Shielding in Paediatric Radiography.

Ryan E, Norynberg K, Connor P et al. · 2026 · Journal of medical radiation sciences

Introduction Patient contact shielding has been used in paediatric radiography as standard practice for decades. Contemporary evidence no longer supports its use in routine clinical practice. The Medical Imaging Department of an Australian…

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Negative / Null Result ReportMedicine

Disentangling the effects of environmental and anthropogenic drivers on fungal fruitbody and spore diversity in a Mediterranean coniferous forest

Centenaro G, Ponce Á, de-Miguel S et al. · 2025 · Journal of Environmental Management

Wild macrofungal species are important non-wood forest products in Mediterranean forests, where their ability to release and disperse spores is crucial for completing their life cycle. However, the ecological drivers behind fruitbody…

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Negative / Null Result ReportMedicine

How are host-parasite interactions affected by veterinary anti-parasitic treatment? An experimental approach.

Lorrain-Soligon L, Agostini S, Biard C et al. · 2025 · Environmental toxicology and pharmacology

The effects of veterinary anti-parasitic compounds on wild fish species and their parasites are poorly investigated. Bithionol, an antibacterial, anthelmintic, and algaecide, is commonly used in aquaculture to control parasitic infections,…

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Negative / Null Result ReportMedicine

Audit and feedback: effects on professional practice.

Ivers N, Yogasingam S, Lacroix M et al. · 2026 · The Cochrane database of systematic reviews

Background Audit and feedback (A&F) is a widely used strategy to improve professional practice. This is supported by prior Cochrane reviews and behavioural theories describing how healthcare professionals are prompted to modify their…

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Negative / Null Result ReportOpen accessMedicine

Is Religious Coping a Protective Factor, and for Whom? A Moderation and Subgroup Analysis on Loneliness and Suicide Attempts Among LGBTQ+ Adults Raised as Latter-Day Saints.

Kim S, Lefevor GT, Miller CK et al. · 2026 · Suicide & life-threatening behavior

Introduction LGBTQ+ adults face elevated rates of loneliness and suicide attempts, yet little research has examined whether religious coping-a protective factor for people generally-effectively mitigates these risks for LGBTQ+ adults…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Stereotype Threat on Aggressive Reactions.

Fourgassie L, Subra B, Sanitioso RB · 2026 · International journal of psychology : Journal international de psychologie

Two studies investigated the impact of stereotype threat on aggressive reactions. Female participants performed a working memory task under a stereotype threat or a control condition. Following this task, they had the opportunity to…

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